Jai Rautela

Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development

Dawn S Lin, Luyi Tian, Sara Tomei, Daniela Amann-Zalcenstein, Tracey M Baldwin, Tom S Weber, Jaring Schreuder, Olivia J Stonehouse, Jai Rautela, Nicholas D Huntington, Samir Taoudi, Matthew E Ritchie, Philip D Hodgkin, Ashley P Ng, Stephen L Nutt, Shalin H Naik

Journal article  |  2021  |  Nature Cell Biology

Regulation of haematopoietic stem and progenitor cell (HSPC) fate is crucial during homeostasis and under stress conditions. Here ..

Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

Wilford Goh, Sebastian Scheer, Jacob T Jackson, Soroor Hediyeh-Zadeh, Rebecca B Delconte, Iona S Schuster, Christopher E Andoniou, Jai Rautela, Mariapia A Degli-Esposti, Melissa J Davis, Matthew P McCormack, Stephen L Nutt, Nicholas D Huntington

Journal article  |  2020  |  Cell Reports

Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed ..

Harnessing Natural Killer Immunity in Metastatic SCLC

Sarah A Best, Jonas B Hess, Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Ariena Kersbergen, Xueyi Dong, Jai Rautela, Stephanie R Hyslop, Matthew E Ritchie, Melissa J Davis, Tracy L Leong, Louis Irving, Daniel Steinfort, Nicholas D Huntington, Kate D Sutherland

Journal article  |  2020  |  Journal of Thoracic Oncology

INTRODUCTION: SCLC is the most aggressive subtype of lung cancer, and though most patients initially respond to platinum-based che..

Drug target validation in primary human natural killer cells using CRISPR RNP

Jai Rautela, Elliot Surgenor, Nicholas D Huntington

Journal article  |  2020  |  Journal of Leukocyte Biology

The cancer-natural killer cell immunity cycle

Nicholas D Huntington, Joseph Cursons, Jai Rautela

Journal article  |  2020  |  Nature Reviews Cancer

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at si..

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells

Kerstin Brinkmann, Ashley P Ng, Carolyn A de Graaf, Ladina Di Rago, Craig D Hyland, Eugenio Morelli, Jai Rautela, Nicholas D Huntington, Andreas Strasser, Warren S Alexander, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

The miR17~92 cluster plays important roles in haematopoiesis. However, it is not clear at what stage of differentiation and throug..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (vol 217, e20191421, 2020)

Cynthia Louis, Fernando Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS

Rebecca B Delconte, Geoffrey Guittard, Wilford Goh, Soroor Hediyeh-Zadeh, Robert J Hennessy, Jai Rautela, Melissa J Davis, Fernando Souza-Fonseca-Guimaraes, Jacques A Nunes, Nicholas D Huntington

Journal article  |  2020  |  Frontiers in Immunology

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells

Jai Rautela, Laura F Dagley, Tobias Kratina, Angaleena Anthony, Wilford Goh, Elliot Surgenor, Rebecca B Delconte, Andrew I Webb, Ngaire Elwood, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Lynn Corcoran, Nicholas D Huntington

Journal article  |  2019  |  Molecular Immunology

NK cells are cytotoxic lymphocytes with a key role in limiting tumour metastases. In mice, the NK cell lineage continually express..