Wai Tham

Complement in malaria immunity and vaccines

Liriye Kurtovic, Michelle J Boyle, D Herbert Opi, Alexander T Kennedy, Wai-Hong Tham, Linda Reiling, Jo-Anne Chan, James G Beeson

Journal article  |  2020  |  Immunological Reviews

Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this..

CHARACTERIZATION OF NATURALLY-ACQUIRED HUMAN ANTIBODIES TO PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2)

Christopher L King, Li-Jin Chan, Lenore Carias, Melanie Dietrich, Camila Franca, Sebastian Menant, Wai-Hong Tham

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Cryo-EM structure of an essential Plasmodium vivax invasion complex

Jakub Gruszczyk, Rick K Huang, Li-Jin Chan, Sebastien Menant, Chuan Hong, James M Murphy, Yee-Foong Mok, Michael DW Griffin, Richard D Pearson, Wilson Wong, Alan F Cowman, Zhiheng Yu, Tham Wai-Hong

Journal article  |  2018  |  Nature

Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand

Rhea J Longley, Camila T Franca, Michael T White, Chalermpon Kumpitak, Patiwat Sa-angchai, Jakub Gruszczyk, Jessica B Hostetler, Anjali Yadava, Christopher L King, Rick M Fairhurst, Julian C Rayner, Wai-Hong Tham, Wang Nguitragool, Jetsumon Sattabongkot, Ivo Mueller

Journal article  |  2017  |  Malaria Journal

Plasmodium vivax vaccine research - we've only just begun.

Wai-Hong Tham, James G Beeson, Julian C Rayner

Journal article  |  2017  |  International Journal for Parasitology

Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are increasingly being acknowledged as a cause ..

Gene Models, Expression Repertoire, and Immune Response of Plasmodium vivax Reticulocyte Binding Proteins

Jenni Hietanen, Anongruk Chim-ong, Thanprakorn Chiramanewong, Jakub Gruszczyk, Wanlapa Roobsoong, Wai-Hong Tham, Jetsumon Sattabongkot, Wang Nguitragool

Journal article  |  2016  |  Infection and Immunity

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes

Wai-Hong Tham, Nicholas TY Lim, Greta E Weiss, Sash Lopaticki, Brendan RE Ansell, Megan Bird, Isabelle Lucet, Dominique Dorin-Semblat, Christian Doerig, Paul R Gilson, Brendan S Crabb, Alan F Cowman

Journal article  |  2015  |  PLOS Pathogens

Characterization of Inhibitors and Monoclonal Antibodies That Modulate the Interaction between Plasmodium falciparum Adhesin PfRh4 with Its Erythrocyte Receptor Complement Receptor 1

Nicholas TY Lim, Markus J Harder, Alexander T Kennedy, Clara S Lin, Christopher Weir, Alan F Cowman, Melissa J Call, Christoph Q Schmidt, Wai-Hong Tham

Journal article  |  2015  |  Journal of Biological Chemistry

More than just immune evasion: Hijacking complement by Plasmodium falciparum

Christoph Q Schmidt, Alexander T Kennedy, Wai-Hong Tham

Journal article  |  2015  |  Molecular Immunology

MALARIA A master lock for deadly parasites

Wai-Hong Tham, Alexander T Kennedy

Journal article  |  2015  |  Nature

Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

Greta E Weiss, Paul R Gilson, Tana Taechalertpaisarn, Wai-Hong Tham, Nienke WM de Jong, Katherine L Harvey, Freya JI Fowkes, Paul N Barlow, Julian C Rayner, Gavin J Wright, Alan F Cowman, Brendan S Crabb

Journal article  |  2015  |  PLOS Pathogens

Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor

Hyon Ju Park, Mara Guariento, Mateusz Maciejewski, Richard Hauhart, Wai-Hong Tham, Alan F Cowman, Christoph Q Schmidt, Haydyn DT Mertens, M Kathryn Liszewski, Dennis E Hourcade, Paul N Barlow, John P Atkinson

Journal article  |  2014  |  Journal of Biological Chemistry

The Plasmodium falciparum Erythrocyte Invasion Ligand Pfrh4 as a Target of Functional and Protective Human Antibodies against Malaria

Linda Reiling, Jack S Richards, Freya JI Fowkes, Danny W Wilson, Watcharee Chokejindachai, Alyssa E Barry, Wai-Hong Tham, Janine Stubbs, Christine Langer, John Donelson, Pascal Michon, Livingstone Tavul, Brendan S Crabb, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson

Journal article  |  2012  |  PLoS One

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn DT Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow

Journal article  |  2012  |  PLoS One

Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

Wai-Hong Tham, Julie Healer, Alan F Cowman

Journal article  |  2012  |  Trends in Parasitology

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum

Lin Chen, Sash Lopaticki, David T Riglar, Chaitali Dekiwadia, Alex D Uboldi, Wai-Hong Tham, Matthew T O'Neill, Dave Richard, Jake Baum, Stuart A Ralph, Alan F Cowman

Journal article  |  2011  |  PLoS Pathogens

Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes

Wai-Hong Tham, Christoph Q Schmidt, Richard E Hauhart, Mara Guariento, Patience B Tetteh-Quarcoo, Sash Lopaticki, John P Atkinson, Paul N Barlow, Alan F Cowman

Journal article  |  2011  |  Blood

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

Wai-Hong Tham, Danny W Wilson, Sash Lopaticki, Christoph Q Schmidt, Patience B Tetteh-Quarcoo, Paul N Barlow, Dave Richard, Jason E Corbin, James G Beeson, Alan F Cowman

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Transcription and coregulation of multigene families in Plasmodium falciparum

Michael F Duffy, Wai-Hong Tham

Journal article  |  2007  |  Trends in Parasitology

Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults

Salenna R Elliott, Paul D Payne, Michael F Duffy, Timothy J Byrne, Wai-Hong Tham, Stephen J Rogerson, Graham V Brown, Damon P Eisen

Journal article  |  2007  |  American Journal of Tropical Medicine and Hygiene

Identification of basic transcriptional elements required for rif gene transcription

Wai-Hong Tham, Paul D Payne, Graham V Brown, Stephen J Rogerson

Journal article  |  2007  |  International Journal for Parasitology