Wai Tham

Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels.

Arman Namvar, Adam J Blanch, Matthew W Dixon, Olivia MS Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopal, Leann Tilley

Journal article  |  2020  |  Cellular Microbiology

The remarkable deformability of red blood cells (RBCs) depends on the viscoelasticity of the plasma membrane and cell contents and..

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  NATURE MEDICINE

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Paola Favuzza, Manuel de Lera Ruiz, Jennifer K Thompson, Tony Triglia, Anna Ngo, Ryan WJ Steel, Marissa Vavrek, Janni Christensen, Julie Healer, Christopher Boyce, Zhuyan Guo, Mengwei Hu, Tanweer Khan, Nicholas Murgolo, Lianyun Zhao, Jocelyn Sietsma Penington, Kitsanapong Reaksudsan, Kate Jarman, Melanie H Dietrich, Lachlan Richardson, et al.

Journal article  |  2020  |  CELL HOST & MICROBE

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmo..

Complement in malaria immunity and vaccines

Liriye Kurtovic, Michelle J Boyle, D Herbert Opi, Alexander T Kennedy, Wai-Hong Tham, Linda Reiling, Jo-Anne Chan, James G Beeson

Journal article  |  2020  |  IMMUNOLOGICAL REVIEWS

Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this..

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.

Journal article  |  2019  |  NATURE

Plasmodium falciparum causes the severe form of malaria that has high levels of mortality in humans. Blood-stage merozoites of P. ..

CHARACTERIZATION OF NATURALLY-ACQUIRED HUMAN ANTIBODIES TO PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2)

Christopher L King, Li-Jin Chan, Lenore Carias, Melanie Dietrich, Camila Franca, Sebastian Menant, Wai-Hong Tham

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Development and validation of serological markers for detecting recent exposure to Plasmodium vivax infection

Rhea Longley, Michael White, Eizo Takashima, Jessica Brewster, Masayuki Morita, Matthias Harbers, Leanne Robinson, Fumie Matsuura, Shih-Jung Zoe Liu, Connie Li-Wai-Suen, Wai-Hong Tham, Julie Healer, Christele Huon, Chetan Chitnis, Wang Nguitragool, Wuelton Monteiro, Carla Proietti, Denise Doolan, Xavier Ding, Iveth Gonzalez, et al.

Journal article  |  2018

In order to accelerate towards malaria elimination, improved targeting of limited resources is essential. A major gap in our elimi..

Cryo-EM structure of an essential Plasmodium vivax invasion complex

Jakub Gruszczyk, Rick K Huang, Li-Jin Chan, Sebastien Menant, Chuan Hong, James M Murphy, Yee-Foong Mok, Michael DW Griffin, Richard D Pearson, Wilson Wong, Alan F Cowman, Zhiheng Yu, Tham Wai-Hong

Journal article  |  2018  |  NATURE

Plasmodium vivax is the most widely distributed malaria parasite that infects humans1. P. vivax invades reticulocytes exclusively,..

Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand

Rhea J Longley, Camila T Franca, Michael T White, Chalermpon Kumpitak, Patiwat Sa-angchai, Jakub Gruszczyk, Jessica B Hostetler, Anjali Yadava, Christopher L King, Rick M Fairhurst, Julian C Rayner, Wai-Hong Tham, Wang Nguitragool, Jetsumon Sattabongkot, Ivo Mueller

Journal article  |  2017  |  MALARIA JOURNAL

BACKGROUND: Thailand is aiming to eliminate malaria by the year 2024. Plasmodium vivax has now become the dominant species causing..

Plasmodium vivax vaccine research - we've only just begun.

Wai-Hong Tham, James G Beeson, Julian C Rayner

Journal article  |  2017  |  Int J Parasitol

Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are increasingly being acknowledged as a cause ..