Paul Mitchell

Occult Gastrointestinal Perforation in a Patient With EGFR-Mutant Non-Small-Cell Lung Cancer Receiving Combination Chemotherapy With Atezolizumab and Bevacizumab: Brief Report.

Ashray Gunjur, Geoff Chong, Adeline Lim, Eddie Lau, Paul Mitchell, Thomas John, Surein Arulananda

Journal article  |  2019  |  Clinical Lung Cancer

Standard dose osimertinib for erlotinib refractory T790M-negative EGFR-mutant non-small cell lung cancer with leptomeningeal disease

Surein Arulananda, Hongdo Do, Gareth Rivalland, Zoe Loh, Ashan Musafer, Eddie Lau, Paul Mitchell, Alexander Dobrovic, Thomas John

Journal article  |  2019  |  Journal of Thoracic Disease

Mesenchyme to epithelial transition protein expression, gene copy number and clinical outcome in a large non-small cell lung cancer surgical cohort

Gareth Rivalland, Paul Mitchell, Carmel Murone, Khashayer Asadi, Adrienne L Morey, Maud Starmans, Paul C Boutros, Marzena Walkiewicz, Benjamin Solomon, Gavin Wright, Simon Knight, Thomas John

Journal article  |  2019  |  Translational Lung Cancer Research

The immune checkpoint, HVEM may contribute to immune escape in non-small cell lung cancer lacking PD-L1 expression.

Shengxiang Ren, Qinrui Tian, Nadav Amar, Hui Yu, Christopher J Rivard, Charles Caldwell, Terry L Ng, Megan Tu, Yiwei Liu, Dexiang Gao, Kim Ellison, Kenichi Suda, Leslie Rozeboom, Gareth Rivalland, Paul Mitchell, Caicun Zhou, Fred R Hirsch

Journal article  |  2018  |  Lung Cancer

BACKGROUND: Herpes Virus Entry Mediator (HVEM) is an important immune checkpoint in cancer recognition. HVEM expressed on tumor ce..

NIVORAD: A randomised phase 2 trial of nivolumab and stereotactic ablative body radiotherapy (SABR) in advanced non-small cell lung cancer (NSCLC), progressing after first- or second-line chemotherapy

Paul Mitchell, Shankar Siva, Antony Mersiades, Ken O'Byrne, Sarah Chinchen, Chris Brown, Sonia Yip, Martin R Stockler

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Impact of Incidence and Progression of Diabetic Retinopathy on Vision-Specific Functioning

Preeti Gupta, Alfred Tau Liang Gan, Ryan Eyn Kidd Man, Eva K Fenwick, Neelam Kumari, Gavin Tan, Paul Mitchell, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, Ecosse L Lamoureux

Journal article  |  2018  |  Ophthalmology

BRAF Mutations-A Good News Story for Immune Checkpoint Inhibitors in Oncogene-Addicted NSCLC?

Surein Arulananda, Paul Mitchell

Journal article  |  2018  |  Journal of Thoracic Oncology

The LEAD study protocol: a mixed-method cohort study evaluating the lung cancer diagnostic and pre-treatment pathways of patients from Culturally and Linguistically Diverse (CALD) backgrounds compared to patients from Anglo-Australian backgrounds

Danielle Mazza, Xiaoping Lin, Fiona M Walter, Jane M Young, David J Barnes, Paul Mitchell, Bianca Brijnath, Andrew Martin, Jon D Emery

Journal article  |  2018  |  BMC Cancer

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, Rene Hoehn, Henriet Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polasek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, et al.

Journal article  |  2018  |  Nature Communications

Lung cancer in Asian women and health system implications for Australia

Jon David Emery, Paul L Mitchell

Journal article  |  2017  |  The Lancet Oncology

Combination Osimertinib and Gefitinib in C797S and T790M EGFR-Mutated Non-Small Cell Lung Cancer

Surein Arulananda, Hongdo Do, Ashan Musafer, Paul Mitchell, Alexander Dobrovic, Thomas John

Journal article  |  2017  |  Journal of Thoracic Oncology

Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase

Hongdo Do, Ramyar Molania, Paul L Mitchell, Rita Vaiskunaite, John D Murdoch, Alexander Dobrovic

Journal article  |  2017  |  Clinical Chemistry

De novo activating epidermal growth factor mutations (EGFR) in small-cell lung cancer

Alesha Thai, Puey L Chia, Prudence A Russell, Hongdo Do, Alex Dobrovic, Paul Mitchell, Thomas John

Journal article  |  2017  |  Internal Medicine Journal

Treatment of ALK-rearranged non- small cell lung cancer: A review of the landscape and approach to emerging patterns of treatment resistance in the Australian context

M Itchins, PL Chia, SA Hayes, VM Howell, AJ Gill, WA Cooper, T John, P Mitchell, M Millward, SJ Clarke, B Solomon, N Pavlakis

Journal article  |  2017  |  Asia-Pacific Journal of Clinical Oncology

The Immune Microenvironment, Genome-wide Copy Number Aberrations, and Survival in Mesothelioma

Bibhusal Thapa, Adriana Salcedo, Xihui Lin, Marzena Walkiewicz, Carmel Murone, Malaka Ameratunga, Khashyar Asadi, Siddhartha Deb, Stephen Arthur Barnett, Simon Knight, Paul Mitchell, D Neil Watkins, Paul C Boutros, Thomas John

Journal article  |  2017  |  Journal of Thoracic Oncology

Calretinin but not caveolin-1 correlates with tumour histology and survival in malignant mesothelioma

Bibhusal Thapa, Marzena Walkiewicz, Carmel Murone, Khashayar Asadi, Siddhartha Deb, Stephen Barnett, Simon Knight, Paul Mitchell, Danny Liew, D Neil Watkins, Thomas John

Journal article  |  2016  |  Pathology

Lung cancer in 2016: immunotherapy comes of age.

Paul LR Mitchell, Thomas John

Journal article  |  2016  |  The Lancet Respiratory Medicine

Temporal changes of EGFR mutations and T790M levels in tumour and plasma DNA following AZD9291 treatment

Puey Ling Chia, Hongdo Do, Adrienne Morey, Paul Mitchell, Alexander Dobrovic, Thomas John

Journal article  |  2016  |  Lung Cancer

Combined BRAF and MEK inhibition in BRAF-mutant NSCLC

Gareth Rivalland, Paul Mitchell

Journal article  |  2016  |  The Lancet Oncology

PD-L1 and Tumor Infiltrating Lymphocytes as Prognostic Markers in Resected NSCLC

Malaka Ameratunga, Khashayar Asadi, Xihui Lin, Marzena Walkiewicz, Carmel Murone, Simon Knight, Paul Mitchell, Paul Boutros, Thomas John

Journal article  |  2016  |  PLOS ONE

Digital PCR of Genomic Rearrangements for Monitoring Circulating Tumour DNA

Hongdo Do, Daniel Cameron, Ramyar Molania, Bibhusal Thapa, Gareth Rivalland, Paul L Mitchell, Carmel Murone, Thomas John, Anthony Papenfuss, Alexander Dobrovic

Journal article  |  2016  |  Advances in Experimental Medicine and Biology

Hypertension, antihypertensive treatment and cancer incidence and mortality: a pooled collaborative analysis of 12 Australian and New Zealand cohorts

Jessica L Harding, Manoshayini Sooriyakumaran, Kaarin J Anstey, Robert Adams, Beverley Balkau, Sharon Brennan-Olsen, Tom Briffa, Timothy ME Davis, Wendy A Davis, Annette Dobson, Graham G Giles, Janet Grant, Rachel Huxley, Matthew Knuiman, Mary Luszcz, Paul Mitchell, Julie A Pasco, Christopher M Reid, David Simmons, Leon A Simons, et al.

Journal article  |  2016  |  Journal of Hypertension

Progression-free and overall survival in ovarian cancer patients treated with CVac, a mucin 1 dendritic cell therapy in a randomized phase 2 trial.

HJ Gray, B Benigno, J Berek, J Chang, J Mason, L Mileshkin, P Mitchell, M Moradi, FO Recio, CM Michener, A Alvarez Secord, NE Tchabo, JK Chan, J Young, H Kohrt, SE Gargosky, JC Goh

Journal article  |  2016  |  Journal for ImmunoTherapy of Cancer

BACKGROUND: CAN-003 was a randomized, open-label, Phase 2 trial evaluating the safety, efficacy and immune outcomes of CVac, a muc..

Update on Mucin-1 immunotherapy in cancer: a clinical perspective

Gareth Rivalland, Bruce Loveland, Paul Mitchell

Journal article  |  2015  |  Expert Opinion on Biological Therapy

Tecemotide in unresectable stage III non-small-cell lung cancer in the phase III START study: updated overall survival and biomarker analyses.

P Mitchell, N Thatcher, MA Socinski, E Wasilewska-Tesluk, K Horwood, A Szczesna, C Martín, Y Ragulin, M Zukin, C Helwig, M Falk, C Butts, FA Shepherd

Journal article  |  2015  |  Annals of Oncology

BACKGROUND: Tecemotide is a MUC1-antigen-specific cancer immunotherapy. The phase III START study did not meet its primary end poi..

Evolving treatment paradigms in lung cancer: role of immuno-oncology INTRODUCTION

Paul Mitchell

Journal article  |  2015  |  Asia-Pacific Journal of Clinical Oncology

Differing associations of white matter lesions and lacunar infarction with retinal microvascular signs

Gerald Liew, Michelle L Baker, Tien Y Wong, Peter J Hand, Jie Jin Wang, Paul Mitchell, Deidre A De Silva, Meng-Cheong Wong, Elena Rochtchina, Richard I Lindley, Joanna M Wardlaw, Graeme J Hankey

Journal article  |  2014  |  International Journal of Stroke

The Victorian Lung Cancer Registry Pilot: Improving the Quality of Lung Cancer Care Through the Use of a Disease Quality Registry

Rob G Stirling, SM Evans, P McLaughlin, M Senthuren, J Millar, J Gooi, L Irving, P Mitchell, A Haydon, J Ruben, M Conron, T Leong, N Watkins, JJ McNeil

Journal article  |  2014  |  Lung

Surgical resection and long-term survival outcome for non-small cell lung cancer: A comparison of Victorian population-based studies spanning a decade

Gavin M Wright, Vicky J Thursfield, David L Ball, Gary E Richardson, Louis Irving, Graham G Giles, Paul Mitchell

Journal article  |  2014  |  Asia-Pacific Journal of Clinical Oncology

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

Hongdo Do, Nicholas C Wong, Carmel Murone, Thomas John, Benjamin Solomon, Paul L Mitchell, Alexander Dobrovic

Journal article  |  2014  |  Scientific Reports

Pertuzumab and Erlotinib in Patients With Relapsed Non-Small Cell Lung Cancer: A Phase II Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging

Brett Hughes, Linda Mileshkin, Peter Townley, Barbara Gitlitz, Keith Eaton, Paul Mitchell, Rodney Hicks, Katie Wood, Lucas Amler, Bernard M Fine, David Loecke, Andrea Pirzkall

Journal article  |  2014  |  The Oncologist

Feasibility of adding everolimus to carboplatin and paclitaxel, with or without bevacizumab, for treatment-naive, advanced non-small cell lung cancer

Wilfried EE Eberhardt, Paul Mitchell, Joan H Schiller, Michael P Brown, Michael Thomas, Glenn Mills, Valentine Jehl, Shweta R Urva, Jeffrey J De Leo, Sven Gogov, Vassiliki Papadimitrakopoulou

Journal article  |  2014  |  Investigational New Drugs

A phase 2, single-arm study of an autologous dendritic cell treatment against mucin 1 in patients with advanced epithelial ovarian cancer.

Paul Lr Mitchell, Michael A Quinn, Peter T Grant, David G Allen, Thomas W Jobling, Shane C White, Anne Zhao, Vaios Karanikas, Hilary Vaughan, Geoffrey Pietersz, Ian Fc McKenzie, Sharron E Gargosky, Bruce E Loveland

Journal article  |  2014  |  Journal for ImmunoTherapy of Cancer

BACKGROUND: Mucin 1 antigen, highly expressed by epithelial ovarian cancer (EOC), is a potential target for immunotherapy. A previ..

Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors

Puey Ling Chia, Paul Mitchell, Alexander Dobrovic, Thomas John

Journal article  |  2014  |  Clinical Epidemiology

Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial

Charles Butts, Mark A Socinski, Paul L Mitchell, Nick Thatcher, Libor Havel, Maciej Krzakowski, Sergiusz Nawrocki, Tudor-Eliade Ciuleanu, Lionel Bosquee, Jose Manuel Trigo, Alexander Spira, Lise Tremblay, Jan Nyman, Rodryg Ramlau, Gun Wickart-Johansson, Peter Ellis, Oleg Gladkov, Jose Rodrigues Pereira, Wilfried Ernst Erich Eberhardt, Christoph Helwig, et al.

Journal article  |  2014  |  The Lancet Oncology

Comparison of toxicity and outcomes of concurrent radiotherapy with carboplatin/paclitaxel or cisplatin/etoposide in stage III non-small cell lung cancer

Mun Sem Liew, Joseph Sia, Maud HW Starmans, Ali Tafreshi, Sam Harris, Malcolm Feigen, Shane White, Allan Zimet, Philippe Lambin, Paul C Boutros, Paul Mitchell, Thomas John

Journal article  |  2013  |  Cancer Medicine

Lung cancer in Victoria: are we making progress?

Paul LR Mitchell, Vicky Thursfleld, David L Ball, Gary E Richardson, Louis B Irving, Yvonne Torn-Broers, Graham G Giles, Gavin M Wright

Journal article  |  2013  |  Medical Journal of Australia

Should we screen for lung cancer in Australia?

Paul LR Mitchell, Thomas John

Journal article  |  2013  |  Medical Journal of Australia

Evaluation of the Simplified Comorbidity Score (Colinet) as a prognostic indicator for patients with lung cancer: A cancer registry study

David Ball, Vicky Thursfield, Louis Irving, Paul Mitchell, Gary Richardson, Yvonne Torn-Broers, Gavin Wright, Graham Giles

Journal article  |  2013  |  Lung Cancer

What constitutes best supportive care in the treatment of advanced non-small cell lung cancer patients?--Results from the lung cancer economics and outcomes research (LUCEOR) study.

JF Lester, J Agulnik, O Akerborg, C Chouaid, A De Geer, HW Finnern, GJM Herder, J Lungershausen, PLR Mitchell, J Vansteenkiste, C Ziske, E Goker

Journal article  |  2013  |  Lung Cancer

BACKGROUND: A significant proportion of advanced non-small cell lung cancer (NSCLC) patients receive supportive treatments to mana..

A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma

Anna K Nowak, Chris Brown, Michael J Millward, Jenette Creaney, Michael J Byrne, Brett Hughes, Gabriel Kremmidiotis, David C Bibby, Annabell F Leske, Paul LR Mitchell, Nick Pavlakis, Michael Boyer, Martin R Stockler

Journal article  |  2013  |  Lung Cancer

Health-related quality of life and utility in patients with advanced non-small-cell lung cancer: a prospective cross-sectional patient survey in a real-world setting.

Christos Chouaid, Jason Agulnik, Erdem Goker, Gerarda JM Herder, Jason F Lester, Johann Vansteenkiste, Henrik W Finnern, Juliane Lungershausen, Jennifer Eriksson, Kun Kim, Paul LR Mitchell

Journal article  |  2013  |  Journal of Thoracic Oncology

BACKGROUND: Non-small-cell lung cancer (NSCLC) has a significant impact on patients' health-related quality of life (HRQOL). This ..

Pulmonary metastases: A rare manifestation of the most common cancer

Surein Arulananda, Mun Sem Liew, Shane Battye, Christine F McDonald, Paul Mitchell

Journal article  |  2013  |  Australasian Journal of Dermatology

The Role of Cancer-Testis Antigens as Predictive and Prognostic Markers in Non-Small Cell Lung Cancer

Thomas John, Maud HW Starmans, Yao-Tseng Chen, Prudence A Russell, Stephen A Barnett, Shane C White, Paul L Mitchell, Marzena Walkiewicz, Arun Azad, Philippe Lambin, Ming-Sound Tsao, Siddhartha Deb, Nasser Altorki, Gavin Wright, Simon Knight, Paul C Boutros, Jonathan S Cebon

Journal article  |  2013  |  PLoS One

Smoking History as a Predictive Factor of Treatment Response in Advanced Non-Small-Cell Lung Cancer: A Systematic Review

Paul Mitchell, Tony Mok, Helen Barraclough, Alena Strizek, Rebecca Lew, Maximiliano van Kooten

Journal article  |  2012  |  Clinical Lung Cancer

Pharmacodynamic analysis of tumour perfusion assessed by O-15-water-PET imaging during treatment with sunitinib malate in patients with advanced malignancies

Andrew M Scott, Paul L Mitchell, Graeme O'Keefe, Timothy Saunder, Rodney J Hicks, Aurora Poon, Charles Baum, Nicoletta Brega, Timothy J McCarthy, Guy C Toner

Journal article  |  2012  |  EJNMMI Research

Randomized phase 2 sequencing and pharmacokinetic study of gemcitabine and oxaliplatin in advanced non-small cell lung cancer

Paul L Mitchell, Adam Broad, Mark A Rosenthal, Peter Galettis, Rick Abraham, Ivon Burns, Stephen Clarke, Alvin Milner, Juliana Diiulio, Matthew Links

Journal article  |  2011  |  Asia-Pacific Journal of Clinical Oncology

Bronchoepidural Fistula in a Man with Actinomycosis Complicated Non-small Cell Lung Cancer

Mun Sem Liew, Surein Arulananda, James Seow, Paul Mitchell, Thomas John

Journal article  |  2011  |  Journal of Thoracic Oncology

Changes in F-18-Fluorodeoxyglucose and F-18-Fluorodeoxythymidine Positron Emission Tomography Imaging in Patients with Non-Small Cell Lung Cancer Treated with Erlotinib

Linda Mileshkin, Rodney J Hicks, Brett GM Hughes, Paul LR Mitchell, Veena Charu, Barbara J Gitlitz, David Macfarlane, Benjamin Solomon, Lukas C Amler, Wei Yu, Andrea Pirzkall, Bernard M Fine

Journal article  |  2011  |  Clinical Cancer Research

Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung

Hongdo Do, Renato Salemi, Carmel Murone, Paul L Mitchell, Alexander Dobrovic

Journal article  |  2010  |  Cell Cycle

High Impact of F-18-FDG-PET on Management and Prognostic Stratification of Newly Diagnosed Small Cell Lung Cancer

Arun Azad, Fiona Chionh, Andrew M Scott, Szeting T Lee, Sam U Berlangieri, Shane White, Paul L Mitchell

Journal article  |  2010  |  Molecular Imaging and Biology

Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab

Hui K Gan, Arun Azad, Lawrence Cher, Paul LR Mitchell

Journal article  |  2010  |  Neuro-Oncology

Prognostic Value of F-18-FDG PET/CT in Patients with Malignant Pleural Mesothelioma

ST Lee, M Ghanem, RA Herbertson, SU Berlangieri, AJ Byrne, K Tabone, P Mitchell, SR Knight, M Feigen, AM Scott

Journal article  |  2009  |  Molecular Imaging and Biology

Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer

W Chua, D Goldstein, CK Lee, H Dhillon, M Michael, P Mitchell, SJ Clarke, B Iacopetta

Journal article  |  2009  |  British Journal of Cancer

Motesanib diphosphate (AMG 706), an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma

Arun Azad, Rebecca A Herbertson, David Pook, Shane White, Paul LR Mitchell, Niall C Tebbutt

Journal article  |  2009  |  Acta Oncologica

High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies

Hongdo Do, Michael Krypuy, Paul L Mitchell, Stephen B Fox, Alexander Dobrovic

Journal article  |  2008  |  BMC Cancer

Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.

Hongdo Do, Benjamin Solomon, Paul L Mitchell, Stephen B Fox, Alexander Dobrovic

Journal article  |  2008  |  BMC Research Notes

BACKGROUND: A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the AKT1 gene, has been recently described in..

Population pharmacokinetics of gemcitabine and its metabolite in patients with cancer: effect of oxaliplatin and infusion rate

Xuemin Jiang, Peter Galettis, Matthew Links, Paul L Mitchell, Andrew J McLachlan

Journal article  |  2008  |  British Journal of Clinical Pharmacology

A phase II study of liposomal daunorubicin, in combination with cyclophosphamide, vincristine and prednisolone, in elderly patients with previously untreated aggressive non-Hodgkin lymphoma

Paul LR Mitchell, Paula Marlton, Andrew Grigg, John F Seymour, Mark Hertzberg, Arno Enno, Richard Herrmann, Rodney Bond, Chris Arthur

Journal article  |  2008  |  Leukemia and Lymphoma

Prevalence of occult metastatic disease in patients undergoing F-18-FDG PET for primary diagnosis or staging of lung carcinoma and solitary pulmonary nodules

ST Lee, SU Berlangieri, AMT Poon, P Mitchell, K Pathmaraj, K Tabone, AJ Byrne, GJ O'Keefe, SR Knight, CP Clarke, AM Scott

Journal article  |  2007  |  Internal Medicine Journal

Modification of leucovorin dose within a simplified FOLFOX regimen improves tolerability without compromising efficacy

Stephen Clarke, David Goldstein, Paul Mitchell, Michael Michael, Philip Beale, Michael Friedlander, John Zalcberg, Shane White

Journal article  |  2007  |  Clinical Colorectal Cancer

Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93

Marco Colleoni, Shari Gelber, Edda Simoncini, Olivia Pagani, Richard D Gelber, Karen N Price, Monica Castiglione-Gertsch, Alan S Coates, Aron Goldhirsch, A Goldhirsch, AS Coates, B Thuerlimann, M Castiglione, AS Coates, JP Collins, H Cortes Funes, RD Gelber, A Goldhirsch, M Green, A Hiltbrunner, et al.

Journal article  |  2007  |  Annals of Oncology

Prognostic factors predictive of response and survival to a modified FOLFOX regimen: Importance of an increased neutrophil count

Michael Michael, David Goldstein, Stephen J Clarke, Alvin D Milner, Phillip Beale, Michael Friedlander, Paul Mitchell

Journal article  |  2006  |  Clinical Colorectal Cancer

Relationship of hepatic functional Imaging to irinotecan pharmacokinetics and genetic parameters of drug elimination

Michael Michael, Mick Thompson, Rod J Hicks, Paul L Mitchell, Andrew Ellis, Alvin D Milner, Julia Di Iulio, Andrew M Scott, Volker Gurtler, Janelle M Hoskins, Stephen J Clarke, Niall C Tebbut, Kian Foo, Michael Jefford, John R Zalcberg

Journal article  |  2006  |  Clinical Oncology

A phase 1 and pharmacokinetic study of gemcitabine and oxaliplatin in patients with solid tumors

HK Gan, PL Mitchell, P Galettis, ID Davis, J Cebon, P de Souza, M Links

Journal article  |  2006  |  Cancer Chemotherapy and Pharmacology

Addition of gabapentin to a modified FOLFOX regimen does not reduce oxaliplatin-induced neurotoxicity

Paul L Mitchell, David Goldstein, Michael Michael, Philip Beale, Michael Friedlander, John Zalcberg, Shane White, Jacquelyn A Thomson, Stephen Clarke

Journal article  |  2006  |  Clinical Colorectal Cancer

Lack of evidence of disease contamination in ovarian tissue harvested for cryopreservation from patients with Hodgkin lymphoma and analysis of factors predictive of oocyte yield

T Seshadri, D Gook, S Lade, A Spencer, A Grigg, K Tiedemann, J McKendrick, P Mitchell, C Stern, JF Seymour

Journal article  |  2006  |  British Journal of Cancer

Mannan-MUC1 - Pulsed dendritic cell immunotherapy: A phase I trial in patients with adenocarcinoma

BE Loveland, A Zhao, S White, H Gan, K Hamilton, PX Xing, GA Pietersz, V Apostolopoulos, H Vaughan, V Karanikas, P Kyriakou, IFC McKenzie, PLR Mitchell

Journal article  |  2006  |  Clinical Cancer Research

Positron emission tomography with selected mediastinoscopy compared to routine mediastinoscopy offers cost and clinical outcome benefits for pre-operative staging of non-small cell lung cancer

KK Yap, KSK Yap, AJ Byrne, SU Berlangieri, A Poon, P Mitchell, SR Knight, PC Clarke, A Harris, A Tauro, CC Rowe, AM Scott

Journal article  |  2005  |  European Journal of Nuclear Medicine and Molecular Imaging

Australian experience of a modified schedule of FOLFOX with high activity and tolerability and improved convenience in untreated metastatic colorectal cancer patients

D Goldstein, P Mitchell, M Michael, P Beale, M Friedlander, J Zalcberg, S White, S Clarke

Journal article  |  2005  |  British Journal of Cancer

Oxaliplatin combined with infusional 5-fluorouracil and concomitant radiotherapy in inoperable and metastatic rectal cancer: a phase I trial

S Loi, SYK Ngan, RJ Hicks, B Mukesh, P Mitchell, M Michael, J Zalcberg, T Leong, D Lim-Joon, J Mackay, D Rischin

Journal article  |  2005  |  British Journal of Cancer

Positron emission tomography scanning in the assessment of patients with lymphoma

SS Foo, PL Mitchell, SU Berlangieri, CL Smith, AM Scott

Journal article  |  2004  |  Internal Medicine Journal

Austin Bowel Cancer Consortium: changing culture in bowel cancer care.

Paul LR Mitchell, Craig A White, undefined Austin Bowel Cancer Consortium

Journal article  |  2004  |  Medical Journal of Australia

The Austin Bowel Cancer Consortium aimed to identify drivers of clinical decision-making so as to inform a continuous practice imp..

A phase II study of escalated-dose docetaxel with granulocyte colony-stimulating factor support in patients with advanced breast cancer

PLR Mitchell, R Basser, M Chipman, A Grigg, R Mansfield, J Cebon, ID Davis, F Appia, M Green

Journal article  |  2004  |  Annals of Oncology

Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age

L Mileshkin, JJ Biagi, P Mitchell, C Underhill, A Grigg, R Bell, J McKendrick, P Briggs, JF Seymour, K Lillie, JG Smith, JB Zeldis, HM Prince

Journal article  |  2003  |  Blood

Targeting primary human Ph( ) B-cell precursor leukemia-engrafted SCID mice using radiolabeled anti-CD19 monoclonal antibodies.

Paul Mitchell, Fook-Thean Lee, Cathrine Hall, Angela Rigopoulos, Fiona E Smyth, Anne-Marie Hekman, Gijs M van Schijndel, Ray Powles, Martin W Brechbiel, Andrew M Scott

Journal article  |  2003  |  Journal of Nuclear Medicine

UNLABELLED: The Philadelphia chromosome translocation (Ph(+)) confers a poor prognosis in patients with acute lymphocytic leukemia..

A phase I study of recombinant human leukemia inhibitory factor in patients with advanced cancer

DH Gunawardana, RL Basser, ID Davis, J Cebon, P Mitchell, C Underhill, TJ Kilpatrick, K Reardon, MD Green, P Bardy, P Amor, D Crump, S Ng, RL Nation, CG Begley

Journal article  |  2003  |  Clinical Cancer Research

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer.

Andrew M Scott, Greg Wiseman, Sydney Welt, Alex Adjei, Fook-Thean Lee, Wendie Hopkins, Chaitan R Divgi, Lorelei H Hanson, Paul Mitchell, Denise N Gansen, Steven M Larson, James N Ingle, Eric W Hoffman, Paul Tanswell, Gerd Ritter, Leonard S Cohen, Peter Bette, Lisa Arvay, Andree Amelsberg, Dan Vlock, et al.

Journal article  |  2003  |  Clinical Cancer Research

PURPOSE: The purpose of this research was to determine the safety, immunogenicity, pharmacokinetics, biodistribution, and tumor up..

A phase I dose-escalation study of docetaxel with granulocyte colony-stimulating factor support in patients with solid tumours

PLR Mitchell, R Basser, M Chipman, A Grigg, J Cebon, ID Davis, J Zalcberg, S Ng, F Appia, M Green

Journal article  |  2003  |  Annals of Oncology

Outcome of patients admitted to the intensive care unit with newly diagnosed small cell lung cancer

RR Jennens, MA Rosenthal, P Mitchell, JJ Presneill

Journal article  |  2002  |  Lung Cancer

A multicentre phase II study of cisplatin and gemcitabine for malignant mesothelioma.

AK Nowak, MJ Byrne, R Williamson, G Ryan, A Segal, D Fielding, P Mitchell, AW Musk, BWS Robinson

Journal article  |  2002  |  British Journal of Cancer

Our previous phase II study of cisplatin and gemcitabine in malignant mesothelioma showed a 47.6% (95% CI 26.2-69.0%) response rat..

Phase II study of paclitaxel and oral etoposide in patients with locally advanced or metastatic non-small cell lung cancer.

MJ Boyer, P Mitchell, D Goldstein, MJ Millward, IN Olver, SJ Clarke, G Richardson, I Davis

Journal article  |  2001  |  Lung Cancer

The combination of paclitaxel and etoposide was evaluated in a phase II study in patients with locally advanced or metastatic non ..

Mannan mucin-1 peptide immunization: Influence of cyclophosphamide and the route of injection

V Karanikas, G Thynne, P Mitchell, CS Ong, D Gunawardana, R Blum, J Pearson, J Lodding, G Pietersz, R Broadbent, B Tait, IFC McKenzie

Journal article  |  2001  |  Journal of Immunotherapy

Interferon-α-2b (IF) can be combined with thalidomide (Thai) in patients with multiple myeloma (MM)

HM Prince, JJ Biagi, P Mitchell

Journal article  |  2000  |  Blood

Quality of life and cisplatin-gemcitabine chemotherapy.

PL Mitchell

Journal article  |  2000  |  Journal of Clinical Oncology

Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma.

R Saso, S Kulkarni, P Mitchell, J Treleaven, GJ Swansbury, J Mehta, R Powles, S Ashley, A Kuan, T Powles

Journal article  |  2000  |  British Journal of Cancer

Of 1774 patients with breast cancer given mitoxantrone (MTZ) with methotrexate (n = 492) or with methotrexate and mitomycin C (n =..

Open label, multi-centre phase II study of raltitrexed ('Tomudex') in patients with inoperable squamous-cell carcinoma of head and neck

SJ Clarke, J Zalcberg, I Olver, PLR Mitchell, D Rischin, D Dalley, M Green, YE Davidson

Journal article  |  2000  |  Annals of Oncology

Granulocyte-macrophage colony-stimulating factor in established febrile neutropenia

PLR Mitchell, CR Pinkerton

Journal article  |  1999  |  Journal of Clinical Oncology

Treatment of nondysgerminomatous ovarian germ cell tumors: an analysis of 69 cases.

PL Mitchell, N Al-Nasiri, R A'Hern, C Fisher, A Horwich, CR Pinkerton, JH Shepherd, C Gallagher, M Slevin, P Harper, R Osborne, J Mansi, T Oliver, ME Gore

Journal article  |  1999  |  Cancer

BACKGROUND: Combination chemotherapy has dramatically improved the prognosis of patients with nondysgerminomatous ovarian germ cel..

Correction: Positron emission tomography in assessing response to neoadjuvant chemotherapy for non-small-cell lung cancer (Medical Journal of Australia (1998) 169 (227))

DM Thomas, PLR Mitchell, SU Berlangieri, H Tochon-Danguy, S Knight, CP Clarke, AM Scott

Journal article  |  1998  |  Medical Journal of Australia

Positron emission tomography in assessing response to neoadjuvant chemotherapy for non-small-cell lung cancer

DM Thomas, PLR Mitchell, SU Berlangieri, H Tochon-Danguy, S Knight, CP Clarke, AM Scott

Journal article  |  1998  |  Medical Journal of Australia

Liposomal vincristine for the treatment of human acute lymphoblastic leukaemia in severe combined immunodeficient (SCID) mice.

JL Millar, BC Millar, RL Powles, JP Steele, RD Clutterbuck, PL Mitchell, G Cox, E Forssen, D Catovsky

Journal article  |  1998  |  British Journal of Haematology

Non-obese diabetic NOD/SCID mice have been used to grow human leukaemia as a systemic disease. The animals were inoculated with le..

Growth of human T-cell lineage acute leukemia in severe combined immunodeficiency (SCID) mice and non-obese diabetic SCID mice.

JP Steele, RD Clutterbuck, RL Powles, PL Mitchell, C Horton, R Morilla, D Catovsky, JL Millar

Journal article  |  1997  |  Blood

Primary leukemic cells from patients with acute lymphoblastic leukemia (ALL) can be injected intravenously into mice with severe c..

Granulocyte colony-stimulating factor in established febrile neutropenia: A randomized study of pediatric patients

PLR Mitchell, B Morland, MCG Stevens, G Dick, D Easlea, LC Meyer, CR Pinkerton

Journal article  |  1997  |  Journal of Clinical Oncology

Interleukin-4 enhances the survival of severe combined immunodeficient mice engrafted with human B-cell precursor leukemia.

PL Mitchell, RD Clutterbuck, RL Powles, C De Lord, R Morilla, LR Hiorns, J Titley, D Catovsky, JL Millar

Journal article  |  1996  |  Blood

Human interleukin-4 (huIL-4) has been shown to inhibit the growth in vitro of cells from patients with acute lymphoblastic leukemi..

Platinum-Taxol non-cross resistance in epithelial ovarian cancer.

ME Gore, N Preston, RP A'Hern, C Hill, P Mitchell, J Chang, M Nicolson

Journal article  |  1995  |  British Journal of Cancer

The aim of this study was to assess the clinical evidence for platinum-Taxol non-cross-resistance in patients with epithelial ovar..

Deletions and rearrangement of CDKN2 in lymphoid malignancy.

G Stranks, SE Height, P Mitchell, D Jadayel, MA Yuille, C De Lord, RD Clutterbuck, JG Treleaven, RL Powles, E Nacheva

Journal article  |  1995  |  Blood

Recurrent abnormalities of the short arm of chromosome 9, including translocations and interstitial deletions, have been reported ..

Fatal pneumococcal infections following allogeneic bone marrow transplant.

K Rege, J Mehta, J Treleaven, B Jameson, ST Meller, P Mitchell, S Milan, RL Powles

Journal article  |  1994  |  Bone Marrow Transplantation

Six cases of fatal pneumococcal sepsis are described, occurring in the post-allograft setting, between 3 and 39 months after trans..

Graft failure after bone marrow transplantation from unrelated donors using busulphan and cyclophosphamide for conditioning.

J Mehta, RL Powles, P Mitchell, K Rege, C De Lord, J Treleaven

Journal article  |  1994  |  Bone Marrow Transplantation

Five patients received bone marrow allografts for leukaemia from serologically fully matched unrelated donors. The conditioning re..

Cimetidine-induced myelosuppression after bone marrow transplantation.

J Mehta, RL Powles, J Treleaven, M Shields, S Agrawal, K Rege, P Mitchell, S Allard

Journal article  |  1994  |  Leukemia & Lymphoma

A strong temporal correlation was observed between cessation of cimetidine and a sustained increase in blood counts in two marrow ..

Peripheral blood stem cells used to augment autologous bone marrow transplantation.

PL Mitchell, VB Shepherd, HM Proctor, M Dainton, SD Cabral, CR Pinkerton

Journal article  |  1994  |  Archives of Disease in Childhood

Peripheral blood stem cells (PBSC) were used to augment autologous bone marrow transplantation (ABMT), aiming to hasten engraftmen..

Carboplatin and chlorambucil combination chemotherapy as treatment for patients with ovarian cancer

BD Evans, P Chapman, P Dady, G Forgeson, D Perez, M McKeage, P Mitchell

Journal article  |  1994  |  International Journal of Gynecologic Cancer

Fifty-six patients with ovarian cancer (three stage IC, nine stage II, 33 stage III and II stage IV) were treated with carboplatin..

Phase II trial of procarbazine, vincristine and lomustine (POC) chemotherapy in metastatic cutaneous malignant melanoma.

LM Samuel, VJ Harvey, PL Mitchell, PI Thompson, D Mak, P Melville, BD Evans

Journal article  |  1994  |  European Journal of Cancer

40 patients with symptomatic metastatic melanoma were treated with procarbazine, vincristine and lomustine (POC). 4 patients had r..

An unusual presentation of acute myeloid leukaemia with pericardial and pleural effusions due to granulocytic sarcoma.

K Rege, R Powles, J Norton, P Mahendra, P Mitchell, S Agrawal, J Mehta, J Treleaven

Journal article  |  1993  |  Leukemia & Lymphoma

We describe a case of acute myeloid leukaemia (Mo) presenting with pericardial and pleural effusions due to a granulocytic sarcoma..

Palliation of biliary obstruction in patients with advanced breast cancer using endoscopic stents.

PL Mitchell, VJ Harvey, MR Lane, BD Evans, PI Thompson, I Hamilton

Journal article  |  1993  |  British Journal of Surgery

Endoscopic insertion of a biliary endoprosthesis was successful in eight patients with extrahepatic biliary obstruction caused by ..

Phenoxyethanol is effective topical therapy of gram-negative cellulitis in neutropenic patients.

P Mitchell, R Powles, K Rege, J Treleaven, D Catovsky, J Mehta, B Jameson

Journal article  |  1993  |  Journal of Hospital Infection

In neutropenic patients cellulitis caused by Gram-negative organisms may prove difficult to control and cause considerable tissue ..

Patient assessment of a combined medical and nursing preparation to cytotoxic chemotherapy.

C Ellis, BD Evans, D Mak, P Mitchell, P Melville, C Stone, P Thompson, V Harvey

Journal article  |  1993  |  Supportive Care in Cancer

At Auckland hospital there is a combined medical and nursing preparation for patients receiving cytotoxic chemotherapy. The aim of..

Ondansetron reduces chemotherapy induced nausea and vomiting refractory to standard antiemetics.

PL Mitchell, BD Evans, SG Allan, GV Forgeson, D Mak, L Neave, G Humm, G Langley, D Dickson, VJ Harvey

Journal article  |  1992  |  New Zealand Medical Journal

Ondansetron, a selective 5HT3 (serotonin) antagonist, was used in patients refractory to standard antiemetics. Seventy-five patien..

Mitozantrone-induced onycholysis.

PL Mitchell, VJ Harvey

Journal article  |  1992  |  European Journal of Cancer

Reduction of carboplatin induced emesis by ondansetron.

VJ Harvey, BD Evans, PL Mitchell, D Mak, LM Neave, GB Langley, DS Dickson

Journal article  |  1991  |  British Journal of Cancer

Ondansetron is a selective 5-HT3 antagonist with significant antiemetic properties in patients receiving cytotoxic chemotherapy. P..

Prevalence of occult metastatic disease in patients undergoing18F-FDG PET for primary diagnosis or staging of lung carcinoma and solitary pulmonary nodules

ST Lee, SU Berlangieri, AMT Poon, P Mitchell, K Pathmaraj, K Tabone, AJ Byrne, GJ O?Keefe, SR Knight, CP Clarke, AM Scott

Journal article  |  Internal Medicine Journal