Robert Center

A pan-genotype hepatitis C virus viral vector vaccine generates T cells and neutralizing antibodies in mice

Timothy Donnison, Joey McGregor, Senthil Chinnakannan, Claire Hutchings, Rob J Center, Pantelis Poumbourios, Paul Klenerman, Heidi E Drummer, Eleanor Barnes

Journal article  |  2022  |  HEPATOLOGY

BACKGROUND AND AIMS: A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organi..

Virus-Like Particles Containing the E2 Core Domain of Hepatitis C Virus Generate Broadly Neutralizing Antibodies in Guinea Pigs.

Joey McGregor, Joshua M Hardy, Chan-Sien Lay, Irene Boo, Michael Piontek, Manfred Suckow, Fasséli Coulibaly, Pantelis Poumbourios, Rob J Center, Heidi E Drummer

Journal article  |  2022  |  J Virol

A vaccine to prevent hepatitis C virus (HCV) infection is urgently needed for use alongside direct-acting antiviral drugs to achie..

A lateral flow assay to detect neutralising antibodies against SARS-CoV-2

Thomas S Fulford, Huy Van, Nicholas A Gherardin, Shuning Zheng, Marcin Ciula, Heidi E Drummer, Samuel Redmond, Hyon-Xhi Tan, Rob J Center, Fan Li, Samantha Grimley, Bruce D Wines, Mark Hogarth, Zoe McQuilten, Kanta Subbarao, Katherine Kedzierska, Jennifer J Juno, Adam K Wheatley, Stephen J Kent, Deborah A Williamson, et al.

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites

Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson

Journal article  |  2021  |  NATURE COMMUNICATIONS

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..

Immunogenicity of HIV-1-Based Virus-Like Particles with Increased Incorporation and Stability of Membrane-Bound Env

Christopher A Gonelli, Hannah AD King, Charlene Mackenzie, Secondo Sonza, Rob J Center, Damian FJ Purcell

Journal article  |  2021  |  VACCINES

An optimal prophylactic vaccine to prevent human immunodeficiency virus (HIV-1) transmission should elicit protective antibody res..

Enhancing the antigenicity and immunogenicity of monomeric forms of hepatitis C virus E2 for use as a preventive vaccine

Rob J Center, Irene Boo, Lilian Phu, Joey McGregor, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The E2 glycoprotein of hepatitis C virus (HCV) is the major target of broadly neutralizing antibodies (bNAbs) that are critical fo..

Boosting of Markers of Fc gamma Receptor Function in Anti-HIV Antibodies During Structured Treatment Interruption

Hugh Billings, Bruce D Wines, Wayne B Dyer, Robert J Center, Halina M Trist, Stephen J Kent, P Mark Hogarth

Journal article  |  2019  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Anti-HIV envelope (Env) antibodies elicit important Fc receptor functions, including FcγRIIIa-mediated natural killer cell killing..

Conjugation of an scFab domain to the oligomeric HIV envelope protein for use in immune targeting

Hannah AD King, Christopher A Gonelli, Kirsteen M Tullett, Mireille H Lahoud, Damian FJ Purcell, Heidi E Drummer, Pantelis Poumbourios, Rob J Center

Journal article  |  2019  |  PLOS ONE

A promising strategy for the enhancement of vaccine-mediated immune responses is by directly targeting protein antigens to immune ..

HIV-1-Based Virus-like Particles that Morphologically Resemble Mature, Infectious HIV-1 Virions

Christopher A Gonelli, Georges Khoury, Rob J Center, Damian FJ Purcell

Journal article  |  2019  |  VIRUSES-BASEL

A prophylactic vaccine eliciting both broad neutralizing antibodies (bNAbs) to the HIV-1 envelope glycoprotein (Env) and strong T ..

Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda WS Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane R Thomas, Stephen J Kent, Nicola Ternette, Damian FJ Purcell, Jamie Rossjohn, Anthony W Purcell

Journal article  |  2018  |  Proteomics

The recognition of pathogen‐derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antig..