Tony Papenfuss

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath

Journal article  |  2023  |  ELIFE

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly an..

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin

Gwo Yaw Ho, Elizabeth L Kyran, Justin Bedo, Matthew J Wakefield, Darren P Ennis, Hasan B Mirza, Cassandra J Vandenberg, Elizabeth Lieschke, Andrew Farrell, Anthony Hadla, Ratana Lim, Genevieve Dall, James E Vince, Ngee Kiat Chua, Olga Kondrashova, Rosanna Upstill-Goddard, Ulla-Maja Bailey, Suzanne Dowson, Patricia Roxburgh, Rosalind M Glasspool, et al.

Journal article  |  2022  |  CANCER RESEARCH

UNLABELLED: Ovarian carcinosarcoma (OCS) is an aggressive and rare tumor type with limited treatment options. OCS is hypothesized ..

A G358S mutation in the Plasmodium falciparum Na pump PfATP4 confers clinically-relevant resistance to cipargamin

Deyun Qiu, Jinxin V Pei, James EO Rosling, Vandana Thathy, Dongdi Li, Yi Xue, John D Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K Tripathi, Nina F Gnadig, Tomas Yeo, Kate J Fairhurst, Barbara H Stokes, James M Murithi, Krittikorn Kumpornsin, Heath Hasemer, Adelaide SM Dennis, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Diverse compounds target the Plasmodium falciparum Na+ pump PfATP4, with cipargamin and (+)-SJ733 the most clinically-advanced. In..

Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass

Michael F Duffy, Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh HT Nguyen, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham V Brown, Ric N Price, Nicholas M Anstey, Karen P Day, Anthony T Papenfuss

Journal article  |  2022  |  NATURE COMMUNICATIONS

Removing unwanted variation from large-scale RNA sequencing data with PRPS

Ramyar Molania, Momeneh Foroutan, Johann A Gagnon-Bartsch, Luke C Gandolfo, Aryan Jain, Abhishek Sinha, Gavriel Olshansky, Alexander Dobrovic, Anthony T Papenfuss, Terence P Speed

Journal article  |  2022  |  NATURE BIOTECHNOLOGY

Accurate identification and effective removal of unwanted variation is essential to derive meaningful biological results from RNA ..

Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers

Tingting Gong, Weerachai Jaratlerdsiri, Jue Jiang, Cali Willet, Tracy Chew, Sean M Patrick, Ruth J Lyons, Anne-Maree Haynes, Gabriela Pasqualim, Ilma Simoni Brum, Phillip D Stricker, Shingai BA Mutambirwa, Rosemarie Sadsad, Anthony T Papenfuss, Riana MS Bornman, Eva KF Chan, Vanessa M Hayes

Journal article  |  2022  |  GENOME MEDICINE

BACKGROUND: African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in sub-Saharan Afric..

Abstract 6232: Defining the cellular composition and associated molecular phenotypes of malignant and non-malignant cells in breast cancer pleural effusions

Holly J Whitfield, Jean Berthelet, Stefano Mangiola, Caroline Bell, Robin L Anderson, Bhupinder Pal, Anthony T Papenfuss, Belinda Yeo, Delphine Merino, Melissa J Davis

Journal article  |  2022  |  Cancer Research

Abstract Malignant pleural effusions (MPE) are a common complication of advanced cancers, particularly those adjace..

Tissue-resident memory T cells from a metastatic vaginal melanoma patient are tumor-responsive T cells and increase after anti-PD-1 treatment

Angela Pizzolla, Simon Paul Keam, Ismael A Vergara, Franco Caramia, Niko Thio, Minyu Wang, Nikolce Kocovski, Daniela Tantalo, Jafar Jabbari, George Au-Yeung, Shahneen Sandhu, David E Gyorki, Alison Weppler, Maurizio Perdicchio, Grant A McArthur, Anthony T Papenfuss, Paul Joseph Neeson

Journal article  |  2022  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Vaginal melanoma (VM) is a rare cancer and has a poor response to immune checkpoint blockade (ICB). CD8+Tissue Residen..

Unscrambling cancer genomes via integrated analysis of structural variation and copy number.

Charles Shale, Daniel L Cameron, Jonathan Baber, Marie Wong, Mark J Cowley, Anthony T Papenfuss, Edwin Cuppen, Peter Priestley

Journal article  |  2022  |  Cell Genom

Complex somatic genomic rearrangements and copy number alterations are hallmarks of nearly all cancers. We have developed an algor..

StructuralVariantAnnotation: a R/Bioconductor foundation for a caller-agnostic structural variant software ecosystem

Daniel L Cameron, Ruining Dong, Anthony T Papenfuss

Journal article  |  2022  |  BIOINFORMATICS

SUMMARY: StructuralVariantAnnotation is an R/Bioconductor package that provides a framework for decoupling downstream analysis of ..