Professor James Best MBBS, MD, FRACP, FRCPath, FRCP Edin
Prof James Best is Head, Melbourne Medical School, University of Melbourne and Chair, NHMRC Research Committee, and member of Council.
Prof Best graduated in the Faculty of Medicine, University of Melbourne in 1972.
He trained in Endocrinology at SVH and in diabetes research at the University of Washington, Seattle, USA.
Prof Best was appointed as Prof of Medicine at the University of Melbourne and Head, Dept of Medicine (SVH) from 1999, resigning in 2007 to become Head, Melbourne Medical School.
Prof Best has had a major commitment to clinical research for over 30 years, with more than 125 peer-reviewed clinical publications, particularly in the fields of diabetes, insulin resistance, lipid disorders, renal disease and cardiovascular disease (CVD) risk. Clinical research has included studies of glucose and lipid metabolism in insulin resistant states, pharmacological treatments for diabetes and lipid disorders (within and separate from clinical trials), epidemiology of CVD risk factors and nutritional markers in Indigenous Australian communities and other community and patient cohorts. Prof Best is a Chief Investigator on an NHMRC Program Grant in Indigenous Health and is on the management committee executive for the FIELD study (a clinical trial in 10,000 people with type 2 diabetes) run by the NHMRC Clinical Trials Centre. He is a Chief Investigator on the Greater Green Triangle Diabetes Prevention Project which led to the development and rollout of the Life! Program for diabetes prevention in 25,000 people at high risk.
Prof Best has taught extensively during his career, especially on the topic of diabetes and metabolism. He was actively involved in development of the current University of Melbourne medical curriculum, particularly the subject "Nutrition, Digestion and Metabolism" that includes diabetes. Prof Best’s research has involved physiological and molecular studies of glucose disposal, as well as studies of lipid biochemistry and epidemiological and clinical studies of risk factors for cardiovascular disease in diabetes. He is the leading Chief Investigator and convener for the NHMRC CCRE - Clinical Science in Diabetes.
Prof Best has contributed to and led development of guidelines for lipid management, particularly in relation to diabetes and to kidney disease for NHMRC, Heart Foundation and Diabetes Australia over the past 15 years.
Find out more about James Best's experience
James Best's highlights
James Best's selected work
Letter to the Editor Regarding "Public Health Approaches to Type 2 Diabetes Prevention: Th..
GooD4Mum: A general practice-based quality improvement collaborative for diabetes preventi..
Displaying the 15 most recent projects by James Best.
Peach Study-Patient Engagement And Coaching For Health: An Intensive Treatment Intervention For Patients With Type 2 Diabetes In Disadvantaged Communities
This study uses practice nurses integrated in existing general practice structures to implement telephone coaching for patients with type 2 ..
Internal Research Grant
Displaying the 117 most recent scholarly works by James Best.
Letter to the Editor Regarding "Public Health Approaches to Type 2 Diabetes Prevention: The US National Diabetes Prevention Program and Beyond".
James A Dunbar, Vincent Versace, Edward Janus, Tiina Laatikainen, Erkki Vartiainen, Pilvikki Absetz, James D Best, Craig Bennett
Journal article | 2019 | Current Diabetes Reports
GooD4Mum: A general practice-based quality improvement collaborative for diabetes prevention in women with previous gestational diabetes
SL O'Reilly, JA Dunbar, JD Best, V Versace, D Ford, A Young, S Shih, R Bills, W Shepherdley, ED Janus, Rob Carter, Jeremy Oats, Timothy Skinner, Micheal Ackland, Paddy Phillips, Alison Nankervis, Greg Johnson, John Catford, Bill Jeffries, John Rasa, et al.
Journal article | 2019 | Primary Care Diabetes
Results of the first recorded evaluation of a national gestational diabetes mellitus register: Challenges in screening, registration, and follow-up for diabetes risk
Douglas IR Boyle, Vincent L Versace, James A Dunbar, Wendy Scheil, Edward Janus, Jeremy JN Oats, Timothy Skinner, Sophy Shih, Sharleen O'Reilly, Ken Sikaris, Liza Kelsall, Paddy A Phillips, James D Best
Journal article | 2018 | PLOS ONE
Effect of fenofibrate on uric acid and gout in type 2 diabetes: a post-hoc analysis of the randomised, controlled FIELD study.
Boris Waldman, Jean-Claude Ansquer, David R Sullivan, Alicia J Jenkins, Neil McGill, Luke Buizen, Timothy ME Davis, James D Best, Liping Li, Michael D Feher, Christelle Foucher, Y Antero Kesaniemi, Jeffrey Flack, Michael C d'Emden, Russell S Scott, John Hedley, Val Gebski, Anthony C Keech, undefined FIELD investigators
Journal article | 2018 | The Lancet Diabetes & Endocrinology
BACKGROUND: Gout is a painful disorder and is common in type 2 diabetes. Fenofibrate lowers uric acid and reduces gout attacks in ..
Baseline Circulating FGF21 Concentrations and Increase after Fenofibrate Treatment Predict More Rapid Glycemic Progression in Type 2 Diabetes: Results from the FIELD Study
Kwok-Leung Ong, Rachel O'Connell, Andrzej S Januszewski, Alicia J Jenkins, Aimin Xu, David R Sullivan, Philip J Barter, Russell S Scott, Marja-Riitta Taskinen, Boris Waldman, Peter G Colman, James D Best, John R Simes, Kerry-Anne Rye, Anthony C Keech
Journal article | 2017 | Clinical Chemistry
Supporting insulin initiation in type 2 diabetes in primary care: results of the Stepping Up pragmatic cluster randomised controlled clinical trial
John Furler, David O'Neal, Jane Speight, Jo-Anne Manski-Nankervis, Alexandra Gorelik, Elizabeth Holmes-Truscott, Louise Ginnivan, Doris Young, James Best, Elizabeth Patterson, Danny Liew, Leonie Segal, Carl May, Irene Blackberry
Journal article | 2017 | BMJ
Mothers after Gestational Diabetes in Australia (MAGDA): A Randomised Controlled Trial of a Postnatal Diabetes Prevention Program
Sharleen L O'Reilly, James A Dunbar, Vincent Versace, Edward Janus, James D Best, Rob Carter, Jeremy JN Oats, Timothy Skinner, Michael Ackland, Paddy A Phillips, Peter R Ebeling, John Reynolds, Sophy TF Shih, Virginia Hagger, Michael Coates, Carol Wildey
Journal article | 2016 | PLOS Medicine
Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study (vol 57, pg 2296, 2014)
Michael C d'Emden, Alicia J Jenkins, Liping Li, Diana Zannino, Kristy P Mann, James D Best, Bronwyn GA Stuckey, Kris Park, Juha Saltevo, Anthony C Keech
Journal article | 2015 | Diabetologia
An exploratory trial of basal and prandial insulin initiation and titration for type 2 diabetes in primary care with adjunct retrospective continuous glucose monitoring: INITIATION study
Irene D Blackberry, John S Furler, Louise E Ginnivan, Jo-Anne Manski-Nankervis, Alicia Jenkins, Neale Cohen, James D Best, Doris Young, Danny Liew, Glenn Ward, David N O'Neal
Journal article | 2014 | Diabetes Research and Clinical Practice
Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Michael C d'Emden, Alicia J Jenkins, Liping Li, Diana Zannino, Kristy P Mann, James D Best, Bronwyn GA Stuckey, Kris Park, Juha Saltevo, Anthony C Keech
Journal article | 2014 | Diabetologia
Plasma semicarbazide-sensitive amine oxidase activity in type 1 diabetes is related to vascular and renal function but not to glycaemia
Andrzej S Januszewski, Nick Mason, Connie S Karschimkus, Kevin G Rowley, James D Best, David N O'Neal, Alicia J Jenkins
Journal article | 2014 | Diabetes and Vascular Disease Research
Mothers After Gestational Diabetes in Australia Diabetes Prevention Program (MAGDA-DPP) post-natal intervention: an update to the study protocol for a randomized controlled trial
Sophy TF Shih, Nathalie Davis-Lameloise, Edward D Janus, Carol Wildey, Vincent L Versace, Virginia Hagger, Dino Asproloupos, Sharleen L O'Reilly, Paddy A Phillips, Michael Ackland, Timothy Skinner, Jeremy Oats, Rob Carter, James D Best, James A Dunbar
Journal article | 2014 | Trials
Scaling Up Diabetes Prevention in Victoria, Australia: Policy Development, Implementation, and Evaluation
James A Dunbar, Abirami Jayawardena, Greg Johnson, Karen Roger, Amy Timoshanko, Vincent L Versace, Jane Shill, Benjamin Philpot, Erkki Vartiainen, Tiina Laatikainen, James D Best, Edward D Janus
Journal article | 2014 | Diabetes Care
Can primary care team-based transition to insulin improve outcomes in adults with type 2 diabetes: the stepping up to insulin cluster randomized controlled trial protocol
John S Furler, Doris Young, James Best, Elizabeth Patterson, David O'Neal, Danny Liew, Jane Speight, Leonie Segal, Carl May, Jo-Anne Manski-Nankervis, Elizabeth Holmes-Truscott, Louise Ginnivan, Irene D Blackberry
Journal article | 2014 | Implementation Science
Optimizing care and outcomes for people with type 2 diabetes - lessons from a translational research program on insulin initiation in general practice.
John Furler, Irene Blackberry, Jo-Anne Manski-Nankervis, David O'Neal, James Best, Doris Young
Journal article | 2014 | Frontiers in Medicine
BACKGROUND: Clinical inertia, failure to intensify treatment according to evidence-based guidelines, leads to prolonged, avoidable..
Response to the Letter by Kawada et al. regarding the manuscript entitled "The metabolic syndrome and CVD outcomes for a central Australian cohort"
Joanne N Luke, Alex Brown, Mark Daniel, Kerin O'Dea, James D Best, Alicia J Jenkins, Zhiqiang Wang, Robyn A McDermott, Zaimin Wang, Kevin G Rowley
Journal article | 2013 | Diabetes Research and Clinical Practice
Mothers After Gestational Diabetes in Australia Diabetes Prevention Program (MAGDA-DPP) post-natal intervention: study protocol for a randomized controlled trial
Sophy TF Shih, Nathalie Davis-Lameloise, Edward D Janus, Carol Wildey, Vincent L Versace, Virginia Hagger, Dino Asproloupos, Sharleen O'Reilly, Paddy A Phillips, Michael Ackland, Timothy Skinner, Jeremy Oats, Rob Carter, James D Best, James A Dunbar
Journal article | 2013 | Trials
Effectiveness of general practice based, practice nurse led telephone coaching on glycaemic control of type 2 diabetes: the Patient Engagement And Coaching for Health (PEACH) pragmatic cluster randomised controlled trial
Irene D Blackberry, John S Furler, James D Best, Patty Chondros, Margarite Vale, Christine Walker, Trisha Dunning, Leonie Segal, James Dunbar, Ralph Audehm, Danny Liew, Doris Young
Journal article | 2013 | British Medical Journal
Scaling-up from an implementation trial to state-wide coverage: results from the preliminary Melbourne Diabetes Prevention Study
Edward D Janus, James D Best, Nathalie Davis-Lameloise, Benjamin Philpot, Andrea Hernan, Catherine M Bennett, Sharleen O'Reilly, Rob Carter, Erkki Vartiainen, James A Dunbar
Journal article | 2012 | Trials
Glycemic Control Over 5 Years in 4,900 People With Type 2 Diabetes Real-world diabetes therapy in a clinical trial cohort
James D Best, Paul L Drury, Timothy ME Davis, Marja-Riitta Taskinen, Y Antero Kesaniemi, Russell Scott, Christopher Pardy, Merryn Voysey, Anthony C Keech
Journal article | 2012 | Diabetes Care
The delivery of a telephone coaching programme to people with type 2 diabetes by practice nurses in Victoria, Australia: a qualitative evaluation
Christine Walker, John Furler, Irene Blackberry, James Dunbar, Doris Young, James Best
Journal article | 2011 | Journal of Nursing and Healthcare of Chronic Illness: an international interdisciplinary journal
An Algorithm Guiding Patient Responses to Real-Time-Continuous Glucose Monitoring Improves Quality of Life
Alicia J Jenkins, Balasubramanian Krishnamurthy, James D Best, Fergus J Cameron, Peter G Colman, Peter S Hamblin, Michele A O'Connell, Christine Rodda, Helena Teede, David N O'Neal
Journal article | 2011 | Diabetes Technology & Therapeutics
Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
TME Davis, R Ting, JD Best, MW Donoghoe, PL Drury, DR Sullivan, AJ Jenkins, RL O'Connell, MJ Whiting, PP Glasziou, RJ Simes, YA Kesaniemi, VJ Gebski, RS Scott, AC Keech
Journal article | 2011 | Diabetologia
Evaluation of an Algorithm to Guide Patients With Type 1 Diabetes Treated With Continuous Subcutaneous Insulin Infusion on How to Respond to Real-Time Continuous Glucose Levels A randomized controlled trial
Alicia J Jenkins, Balasubramanium Krishnamurthy, James D Best, Fergus Cameron, Peter G Colman, Steven Farish, Peter S Hamblin, Michele A O'Connell, Christine Rodda, Kevin Rowley, Helena Teede, David N O'Neal
Journal article | 2010 | Diabetes Care
A Novel Method to Adjust Efficacy Estimates for Uptake of Other Active Treatments in Long-Term Clinical Trials
John Simes, Merryn Voysey, Rachel O'Connell, Paul Glasziou, James D Best, Russell Scott, Christopher Pardy, Karen Byth, David R Sullivan, Christian Ehnholm, Anthony Keech
Journal article | 2010 | PLoS One
Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial
Kushwin Rajamani, Peter G Colman, Li Ping Li, James D Best, Merryn Voysey, Michael C D'Emden, Markku Loakso, John R Baker, Anthony C Keech
Journal article | 2009 | The Lancet
C-Reactive Protein Concentrations Are Very High and More Stable over Time Than the Traditional Vascular Risk Factors Total Cholesterol and Systolic Blood Pressure in an Australian Aboriginal Cohort
Tomer Shemesh, Kevin G Rowley, Alicia J Jenkins, James D Best, Kerin O'Dea
Journal article | 2009 | Clinical Chemistry
Depression: An Important Comorbidity With Metabolic Syndrome in a General Population
James A Dunbar, Prasuna Reddy, Nathalie Davis-Lameloise, Benjamin Philpot, Tiina Laatikainen, Annamari Kilkkinen, Stephen J Bunker, James D Best, Erkki Vartiainen, Sing Kai Lo, Edward D Janus
Journal article | 2008 | Diabetes Care
The emotional context of self-management in chronic illness: A qualitative study of the role of health professional support in the self-management of type 2 diabetes
John Furler, Christine Walker, Irene Blackberry, Trisha Dunning, Nabil Sulaiman, James Dunbar, James Best, Doris Young
Journal article | 2008 | BMC Health Services Research
Glutathionyl haemoglobin is not increased in diabetes nor related to glycaemia, complications, dyslipidaemia, inflammation or other measures of oxidative stress.
Peter Hoffmann, Jade Woon, Kevin G Rowley, Connie Karschimkus, Craig L Nelson, George Dragicevic, David O'Neal, Andrew Wilson, Kevin D Croft, Trevor A Mori, Bruce E Kemp, James D Best, Alicia J Jenkins
Journal article | 2008 | Diabetes Research and Clinical Practice
Modified haemoglobin levels were quantified in 21 Type 1 and 21 Type 2 diabetic patients and two groups of 17 non-diabetic subject..
Lower than expected morbidity and mortality for an Australian Aboriginal population: 10-year follow-up in a decentralised community
Kevin G Rowley, Kerin O'Dea, Ian Anderson, Robyn McDermott, Karmananda Saraswati, Ricky Tilmouth, Iris Roberts, Joseph Fitz, Zaimin Wang, Alicia Jenkins, James D Best, Zhiqiang Wang, Alex Brown
Journal article | 2008 | Medical Journal of Australia
Low high-density lipoprotein-cholesterol is the most prevalent metabolic abnormality for Australian Aboriginal men and women even when lean
Tomer Shemesh, Kevin G Rowley, Leonard S Piers, James D Best, Kerin O'Dea
Journal article | 2008 | European Journal of Cardiovascular Prevention & Rehabilitation
Longitudinal analysis of low-molecular weight fluorophores in type 1 diabetes mellitus.
Andrzej S Januszewski, Merlin C Thomas, Connie S Karschimkus, Jasmine S Chung, Kevin G Rowley, Craig L Nelson, David N O'Neal, George Dragicevic, Colin A Harper, James D Best, Alicia J Jenkins
Journal article | 2008 | Journal of Medical Investigation
OBJECTIVES: Circulating low molecular weight (<10 kDa) fluorophores (LMW-F) measured by non-specific fluorescence spectroscopy may..
Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes
AJ Jenkins, SX Zhang, KG Rowley, CS Karschimkus, CL Nelson, JS Chung, DN O'Neal, AS Januszewski, KD Croft, TA Mori, G Dragicevic, CA Harper, JD Best, TJ Lyons, J-X Ma
Journal article | 2007 | Diabetic Medicine
Prevention of type 2 diabetes by lifestyle intervention in an Australian primary health care setting: Greater green triangle (GGT) diabetes prevention project
Tiina Laatikainen, James A Dunbar, Anna Chapman, Annamari Kilkkinen, Erkki Vartiainen, Sami Heistaro, Ben Philpot, Pilvikki Absetz, Stephen Bunker, Adrienne O'Neil, Prasuna Reddy, James D Best, Edward D Janus
Journal article | 2007 | BMC Public Health
Patient Engagement and Coaching for Health: The PEACH study a cluster randomised controlled trial using the telephone to coach people with type 2 diabetes to engage with their GPs to improve diabetes care: a study protocol
Doris Young, John Furler, Margarite Vale, Christine Walker, Leonie Segal, Patricia Dunning, James Best, Irene Blackberry, Ralph Audehm, Nabil Sulaiman, James Dunbar, Patty Chondros
Journal article | 2007 | BMC Family Practice
A collaborative cardiovascular health program for Aboriginal and Torres Strait Islander people in the Goulburn-Murray region: Development and risk factor screening at indigenous community organisations
Leeandra Aitken, Ian Anderson, Vicki Atkinson, James D Best, Paul Briggs, Julie Calleja, Sharon Charles, Joyce Doyle, Justin Mohamed, Rochelle Patten, Kevin Rowley, David Simmons
Journal article | 2007 | Australian Journal of Primary Health
Blood pressure and hypertension for Australian Aboriginal and Torres Strait Islander people
Zaimin Wang, Sabina Knight, Andrew Wilson, Kevin G Rowley, James D Best, Robyn McDermott, Dympna Leonard, Jonathan E Shaw, Kerin O'Dea
Journal article | 2006 | European Journal of Cardiovascular Prevention & Rehabilitation
Traditional risk factor assessment does not capture the extent of cardiovascular risk in systemic lupus erythematosus
AB Lee, T Godfrey, KG Rowley, CS Karschimkus, G Dragicevic, E Romas, L Clemens, AM Wilson, M Nikpour, DL Prior, JD Best, AJ Jenkins
Journal article | 2006 | Internal Medicine Journal
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
A Keech, RJ Simes, P Barter, J Best, R Scott, MR Taskinen, P Forder, A Pillai, T Davis, P Glasziou, P Drury, YA Kesaniemi, D Sullivan, D Hunt, P Colman, M d'Emden, M Whiting, C Ehnholm, M Laakso
Journal article | 2005 | The Lancet
Systemic and vascular inflammation is elevated in early IgA and type 1 diabetic nephropathies and relates to vascular disease risk factors and renal function
CL Nelson, CS Karschimkus, G Dragicevic, DK Packham, AM Wilson, D O'Neal, GJ Becker, JD Best, AJ Jenkins
Journal article | 2005 | Nephrology, Dialysis, Transplantation
Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose - Results from the LIPID trial
A Keech, D Colquhoun, J Best, A Kirby, RJ Simes, D Hunt, W Hague, E Beller, M Arulchelvam, J Baker, A Tonkin
Journal article | 2003 | Diabetes Care
Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk factors and inflammation
M Wong, L Toh, A Wilson, K Rowley, C Karschimkus, D Prior, E Romas, L Clemens, G Dragicevic, H Harianto, I Wicks, G McColl, J Best, A Jenkins
Journal article | 2003 | Arthritis and Rheumatism
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators
HG Joost, GI Bell, JD Best, MJ Birnbaum, MJ Charron, YT Chen, H Doege, DE James, HF Lodish, KH Moley, JF Moley, M Mueckler, S Rogers, A Schurmann, S Seino, B Thorens
Journal article | 2002 | American Journal of Physiology - Endocrinology and Metabolism
High prevalence of obesity, diabetes and associated cardiovascular risk factors among indigenous people of the Torres Strait and Northern Peninsula Area.
undefined Leonard, undefined McDermott, K O'DEA, K ROWLEY, undefined Pensio, undefined Sambo, undefined Twist, undefined Toolis, undefined Lowson, J BEST
Journal article | 2002 | Australian and New Zealand Journal of Public Health
Honours, Awards and Fellowships
FRCP(Edin) - Fellowship of the Royal College of Physicians Edinburgh
FRCPath - Fellowship of the Royal College of Pathologists
FRACP - Fellow of the Royal Australasian College of Physicians
Medicine And Radiology
University of St Andrews
Doctor of Medicine
University of Melbourne
Bachelor of Medicine & Bachelor of Surgery
University of Melbourne