Tim Stinear

Systematic review of M. Bovis BCG and other candidate vaccines for Buruli ulcer prophylaxis.

Stephen Muhi, Timothy P Stinear

Journal article  |  2021  |  Vaccine

Buruli ulcer, caused by Mycobacterium ulcerans, is a neglected tropical disease endemic to over 30 countries, with increasing inci..

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda E Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca L Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Timothy P Stinear, Sarah L Londrigan, Michael B Clark, Deborah A Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2021  |  CELL REPORTS

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses subgenomic RNA (sgRNA) to produce viral proteins for replication..

Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii

Tao Luo, Peng Xu, Yangyi Zhang, Jessica L Porter, Marwan Ghanem, Qingyun Liu, Yuan Jiang, Jing Li, Qing Miao, Bijie Hu, Benjamin P Howden, Janet AM Fyfe, Maria Globan, Wencong He, Ping He, Yiting Wang, Houming Liu, Howard E Takiff, Yanlin Zhao, Xinchun Chen, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Mycobacterium kansasii can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous my..

Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study

Stephen Muhi, Nick Tayler, Tuyet Hoang, Susan A Ballard, Maryza Graham, Amanda Rojek, Jason C Kwong, Jason A Trubiano, Olivia Smibert, George Drewett, Fiona James, Emma Gardiner, Socheata Chea, Nicole Isles, Michelle Sait, Shivani Pasricha, George Taiaroa, Julie McAuley, Eloise Williams, Katherine B Gibney, et al.

Journal article  |  2021  |  LANCET REGIONAL HEALTH-WESTERN PACIFIC

Background: In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming. To date, few ..

Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy

Natalie J Bitto, Lesley Cheng, Ella L Johnston, Rishi Pathirana, Kha Phan Thanh, Ivan KH Poon, Neil M O'Brien-Simpson, Andrew F Hill, Timothy P Stinear, Maria Kaparakis-Liaskos

Journal article  |  2021  |  JOURNAL OF EXTRACELLULAR VESICLES

Gram-positive bacteria ubiquitously produce membrane vesicles (MVs), and although they contribute to biological functions, our kno..

Intracellular Staphylococcus aureus and host cell death pathways

Ye Mon Soe, Sammy Bedoui, Timothy P Stinear, Abderrahman Hachani

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have c..

From cloning to mutant in 5 days: rapid allelic exchange in Staphylococcus aureus.

Ian R Monk, Timothy P Stinear

Journal article  |  2021  |  Access Microbiol

In the last 10 years, the barriers preventing the uptake of foreign DNA by clinical Staphylococcus aureus isolates have been ident..

Multi-Site Assessment of Rapid, Point-of-Care Antigen Testing for the Diagnosis of SARS-CoV-2 Infection in a Low-Prevalence Setting: A Validation and Implementation Study

Stephen Muhi, Nick Tayler, Tuyet Hoang, Susan Ballard, Maryza Graham, Amanda Rojek, Jason Kwong, Jason Trubiano, Olivia Smibert, George Drewett, Fiona James, Emma Gardiner, Socheata Chea, Nicole Isles, Michelle Sait, Shivani Pasricha, George Taiaroa, Julie McAuley, Eloise Williams, Katherine Gibney, et al.

Journal article  |  2021

Background: In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming. To date, no s..

Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA

Nick Neubacher, Nicholas J Tobias, Michaela Huber, Xiaofeng Cai, Timo Glatter, Sacha J Pidot, Timothy P Stinear, Anna Lena Luetticke, Kai Papenfort, Helge B Bode

Journal article  |  2020  |  NATURE MICROBIOLOGY

Photorhabdus and Xenorhabdus species have mutualistic associations with nematodes and an entomopathogenic stage1,2 in their life c..

Complete microbial genomes for public health in Australia and the Southwest Pacific

Sarah L Baines, Anders Goncalves da Silva, Glen P Carter, Amy Jennison, Irani Rathnayake, Rikki M Graham, Vitali Sintchenko, Qinning Wang, Rebecca J Rockett, Verlaine J Timms, Elena Martinez, Susan Ballard, Takehiro Tomita, Nicole Isles, Kristy A Horan, William Pitchers, Timothy P Stinear, Deborah A Williamson, Benjamin P Howden, Torsten Seemann

Journal article  |  2020  |  MICROBIAL GENOMICS

Complete genomes of microbial pathogens are essential for the phylogenomic analyses that increasingly underpin core public health ..