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Prof

Tim Stinear

Professorial Fellow
pathogenesis
polyketides
science & technology
life sciences & biomedicine
humans
microbiology
mycobacterium ulcerans
buruli ulcer
genome, bacterial
Tim Stinear's Profile Picture
Prof

Tim Stinear

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Bacterial genomics
Tim Stinear's Profile Picture
Prof

Tim Stinear

 

Projects

Displaying the 44 most recent projects by Tim Stinear.

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Apr Intern Agreement - Apr Int-0722

2020 - 2020
Active
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Funding Research At Ip Cambodia

2019 - 2021
Active
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C-Find Project Research Collaboration Agreement

2019 - 2020
Active
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Obtaining Wastewater Samples: Indemnity Agreement

2019 - 2022
Active
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Understanding The Mechanisms Of Gastrointestinal Colonisation With Vancomycin-Resistant Enterococcus Faecium (Vre)

This project will use state-of-the-art molecular biology to understand how the superbug vancomycin-resistant Enterococcus (VRE) colonises pa..

2019 - 2021
Active
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Controlling Buruli Ulcer In Victoria

Buruli ulcer is an ulcerative skin disease caused by the bacterium, Mycobacterium ulcerans. Buruli ulcer cases have been increasing alarming..

2018 - 2020
Active
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Controlling Buruli Ulcer In Victoria

Buruli ulcer is an ulcerative skin disease caused by the bacterium, Mycobacterium ulcerans. Buruli ulcer cases have been increasing alarming..

2018 - 2020
Active
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Controlling Buruli Ulcer In Victoria

Buruli ulcer is an ulcerative skin disease caused by the bacterium, Mycobacterium ulcerans. Buruli ulcer cases have been increasing alarming..

2018 - 2020
Active
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Controlling Buruli Ulcer In Victoria

Buruli ulcer is an ulcerative skin disease caused by the bacterium, Mycobacterium ulcerans. Buruli ulcer cases have been increasing alarming..

2018 - 2020
Active
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Controlling Buruli Ulcer In Victoria

Buruli ulcer is an ulcerative skin disease caused by the bacterium, Mycobacterium ulcerans. Buruli ulcer cases have been increasing alarming..

2018 - 2020
Active
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Clinical Utility Of A Novel Mycobacterium Chimaera Specific Pcr

2018 - 2020
Completed
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An Evidence Based Framework For Establishing Public Health Microbial Genomics In Australia

Microbial genomics is a powerful laboratory tool to characterise human pathogens at the highest level, allowing greater understanding of the..

2018 - 2022
Active
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An Evidence Based Framework For Establishing Public Health Microbial Genomics In Australia

Microbial genomics is a powerful laboratory tool to characterise human pathogens at the highest level, allowing greater understanding of the..

2018 - 2022
Active
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Testing Of Activity Of Spr719 Against Mycobacterium Ulcerans

2018 - 2018
Completed
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Essential Gene Regulation In Multi-Drug Resistant Golden Staph: A New Path Towards Control

New antibiotics effective against Golden Staph are urgently needed. This project will investigate a new approach to weaken Golden Staph defe..

2018 - 2021
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Understanding Virulence Of Invasive Staphylococcus Aureus

Staph aureus (Golden staph) is a major cause of disease in humans. In this project we will use state-of-the-art molecular biology and genomi..

2018 - 2020
Active
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Chemosensitivity Screen

2017 - 2017
Completed
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Genomic Approaches In Human Health Microbiology

This project uses latest genomic technologies to advance our understanding of how bacteria cause disease and finding new antibiotics/approac..

2016 - 2020
Active
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New Antbiotics From Old Microbes

Once treatable infections are becoming deadly because bacteria are developing broad antibiotic resistance. New medicines are urgently needed..

2016 - 2019
Completed
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Biocatalysis Inspired By The Mycolactone Polyketide Synthases

1. Scientific goal of the project The main scientific objective of this project is to answer the question what are the cortical mechanisms o..

2015 - 2016
Completed
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Dissecting The Molecular Basis For Emerging Alcohol Tolerance In Vre

Infections caused by vancomycin resistant Enterococcus faecium (VREfm) are a major and growing problem in health care facilities around Aust..

2015 - 2018
Completed
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A Single Molecule Real-Time Dna Sequencing Facility

A PacBio SMRT sequencing facility will be established and used to accelerate ten specific research programs across a breadth of biological d..

2015 - 2015
Completed
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A Single Molecule Real-Time Dna Sequencing Facility - Matching Contribution

A PacBio SMRT sequencing facility will be established and used to accelerate ten specific research programs across a breadth of biological d..

2015 - 2015
Completed
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Global Spread And Transmission Dynamics Of Mycobacterium Ulcerans

2014 - 2019
Completed
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Understanding How Bacteria Cause Persistent Infection

Golden staph still causes significant human infections and resistance to antibiotics is an ever growing problem with this bacteria. This pro..

2014 - 2017
Completed
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Understanding The Role Of The Essential Regulator Walkr In Staphylococcus Aureus

Staphylococcus aureus is one of the most common human bacterial pathogens. This project aims to characterise an important global control sys..

2013 - 2015
Completed
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Is Mycobacterium Ulcerans A Zoonotic Agent Spread By Mosquitoes?

Last year record numbers of a mysterious flesh-eating bacterial disease called Buruli ulcer were reported in Australia. Wild animals such as..

2013 - 2015
Completed
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Expansion And Transmission Of Mycobacterium Ulcerans In Changing Environments: Multidisciplinary Studies

2013 - 2014
Completed
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Investigation Into The Ecology And Epidemiology Of An Emerging Cause Of Feline Leprosy Syndrome In Victoria; Mycobacterium Species Tarwin.

2012 - 2013
Completed
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Stop Buruli Ii

2012 - 2015
Completed
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Why Is Vre (A Resistant Hospital Infection) Becoming More Common In Australia?

VRE is a serious hospital superbug that has been increasing in many major hospitals around Australia, while at the same time MRSA (Golden St..

2012 - 2015
Completed
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Why Is Vre (A Resistant Hospital Infection) Becoming More Common In Australia?

VRE is a serious hospital superbug that has been increasing in many major hospitals around Australia, while at the same time MRSA (Golden St..

2012 - 2015
Completed
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Understanding How Staphylococci Respond To Antibiotics

Golden Staph is a major problem in Australian hospitals. This project will use cutting edge technology to investigate how Golden Staph respo..

2012 - 2015
Completed
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A High-Thoughput Screening And Sequencing Facility For Single Cell Genomics

Genomics has revolutionised biology, but for most microorganisms this revolution has not arrived because very few can be grown in pure cultu..

2012 - 2012
Completed
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How Bacteria Evolve And Cause Disease

Bacteria have evolved different ways of causing disease in humans. Some bacteria produce toxins that attack the host or they have developed ..

2011 - 2015
Completed
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Why Is Golden Staph Now Causing Serious Disease In The Community?

Golden Staph is a major problem in our hospitals but serious Golden Staph infections are increasingly common in the community, among otherwi..

2011 - 2013
Completed
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Understanding How Golden Staph Causes Disease

Golden Staph remains an important cause of serious infections in Australian patients. New strategies to combat this disease require a better..

2011 - 2013
Completed
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A Microbiological Platform For The Production Of Complex Small Molecules With Important Biological Activities

Currently making complex chemicals such as medicines relies on harvesting rare natural resources or using complicated, energy intensive labo..

2011 - 2014
Completed
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How Bacteria Make Toxic Lipids That Cause Disease

Some major infectious diseases such as tuberculosis are caused by bacteria that make very unusual lipids (fats) that can kill human cells or..

2010 - 2012
Completed
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Understanding Antibiotic Resistance In Golden Staph

The common bacteria Staphylococcus aureus causes many infections in humans, and is becoming more resistant to antibiotic treatments, especia..

2010 - 2012
Completed
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Stop Buruli Of The Buruli Consortium

2009 - 2011
Completed
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R Douglas Wright Biomedical Career Development Award

nan

2009 - 2010
Completed
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Stop Buruli Initiative

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Stop Buruli Initiative

44

Projects

Project Types

31

Research Grant

12

Research Contracts

1

Internal Research Grant

Scholarly Works

Displaying the 230 most recent scholarly works by Tim Stinear.

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Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model

Kirstie M Mangas, Andrew H Buultjens, Jessica L Porter, Sarah L Baines, Estelle Marion, Laurent Marsollier, Nicholas J Tobias, Sacha J Pidot, Kylie M Quinn, David J Price, Katherine Kedzierska, Weiguang Zeng, David C Jackson, Brendon Y Chua, Timothy P Stineara

Journal article  |  2020  |  Infection and Immunity

The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no ef..

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Mining Symbionts of a Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones.

Sarah P Niehs, Benjamin Dose, Sophie Richter, Sacha J Pidot, Hans-Martin Dahse, Timothy P Stinear, Christian Hertweck

Journal article  |  2020  |  Angewandte Chemie International Edition

A spider-transmitted fungus (Rhizopus microsporus) that was isolated from necrotic human tissue was found to harbor endofungal bac..

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Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering.

Brendon M Lee, Liam K Harold, Deepak V Almeida, Livnat Afriat-Jurnou, Htin Lin Aung, Brian M Forde, Kiel Hards, Sacha J Pidot, F Hafna Ahmed, A Elaaf Mohamed, Matthew C Taylor, Nicholas P West, Timothy P Stinear, Chris Greening, Scott A Beatson, Eric L Nuermberger, Gregory M Cook, Colin J Jackson

Journal article  |  2020  |  PLOS Pathogens

Our inability to predict which mutations could result in antibiotic resistance has made it difficult to rapidly identify the emerg..

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Comparative Transcriptomic and Functional Assessments of Linezolid-Responsive Small RNA Genes in Staphylococcus aureus.

Wei Gao, Romain Guérillot, Ya Hsun Lin, Jai Tree, Marie Beaume, Patrice François, Ian R Monk, Torsten Seemann, Jacques Schrenzel, Benjamin P Howden, Timothy P Stinear

Journal article  |  2020  |  mSystems

Staphylococcus aureus contains a repertoire of at least 50 and possibly 500 small RNAs (sRNAs). The functions of most sRNAs are no..

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Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment

Chenghao Ge, Ian R Monk, Angela Pizzolla, Nancy Wang, James G Bedford, Timothy P Stinear, Glen P Westall, Linda M Wakim

Journal article  |  2019  |  Cell Reports

Tissue-resident memory T (Trm) cells are described as having a "sensing and alarming" function, meaning they can rapidly release c..

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Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria.

Evgeni V Bratovanov, Keishi Ishida, Beatrix Heinze, Sacha J Pidot, Timothy P Stinear, Julian D Hegemann, Mohamed A Marahiel, Christian Hertweck

Journal article  |  2019  |  ACS Chemical Biology

Genome mining identified the fungal-bacterial endosymbiosis Rhizopus microsporus-Mycetohabitans (previously Burkholderia) rhizoxin..

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Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia

Serina Robinson, Barbara Terlouw, Megan Smith, Sacha Pidot, Tim Stinear, Marnix Medema, Lawrence Wackett

Journal article  |  2019

ABSTRACT Enzymes that cleave ATP to activate carboxylic acids play essential roles in primary and secondary metabolism in all doma..

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Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Nocardia Isolate.

Marion Herisse, Keishi Ishida, Jessica L Porter, Ben Howden, Christian Hertweck, Timothy P Stinear, Sacha J Pidot

Journal article  |  2019  |  ACS Chemical Biology

The genus Nocardia contains >50 human pathogenic species that cause a range of illnesses from skin and soft tissue infections to l..

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Genomic investigation of Staphylococcus aureus recovered from Gambian women and newborns following an oral dose of intra-partum azithromycin

Abdoulie Bojang, Sarah L Baines, Liam Donovan, Romain Guerillot, Kerrie Stevens, Charlie Higgs, Christian Bottomley, Ousman Secka, Mark B Schultz, Anders Goncalves da Silva, Torsten Seemann, Timothy P Stinear, Anna Roca, Benjamin P Howden

Journal article  |  2019  |  Journal of Antimicrobial Chemotherapy

BACKGROUND: Oral azithromycin given during labour reduces carriage of bacteria responsible for neonatal sepsis, including Staphylo..

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Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification

Jean YH Lee, Glen P Carter, Sacha J Pidot, Romain Guerillot, Torsten Seemann, Anders Goncalves da Silva, Timothy J Foster, Benjamin P Howden, Timothy P Stinear, Ian R Monk

Journal article  |  2019  |  mBio

Staphylococcus epidermidis is a significant opportunistic pathogen of humans. Molecular studies in this species have been hampered..

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Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

Romain Guerillot, Xenia Kostoulias, Liam Donovan, Lucy Li, Glen P Carter, Abderrahman Hachani, Koen Vandelannoote, Stefano Giulieri, Ian R Monk, Mayu Kunimoto, Lora Starrs, Gaetan Burgio, Torsten Seemann, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

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Genomics‐Driven Discovery of NO‐Donating Diazeniumdiolate Siderophores in Diverse Plant‐Associated Bacteria

Ron Hermenau, Jule L Mehl, Keishi Ishida, Benjamin Dose, Sacha J Pidot, Timothy P Stinear, Christian Hertweck

Journal article  |  2019  |  Angewandte Chemie

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Genomics for Molecular Epidemiology and Detecting Transmission of Carbapenemase-Producing Enterobacterales in Victoria, Australia, 2012 to 2016

Norelle L Sherry, Courtney R Lane, Jason C Kwong, Mark Schultz, Michelle Sait, Kerrie Stevens, Susan Ballard, Anders Goncalves da Silva, Torsten Seemann, Claire L Gorrie, Timothy P Stinear, Deborah A Williamson, Judith Brett, Annaliese van Diemen, Marion Easton, Benjamin P Howden

Journal article  |  2019  |  Journal of Clinical Microbiology

Background Carbapenemase-producing Enterobacterales (CPE) are being increasingly reported in Australia, and i..

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Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria

Ron Hermenau, Jule L Mehl, Keishi Ishida, Benjamin Dose, Sacha Pidot, Timothy P Stinear, Christian Hertweck

Journal article  |  2019  |  Angewandte Chemie International Edition

Siderophores are key players in bacteria-host interactions, with the main function to provide soluble iron for their producers. Gr..

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Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis

Sarah P Niehs, Benjamin Dose, Kirstin Scherlach, Sacha J Pidot, Timothy P Stinear, Christian Hertweck

Journal article  |  2019  |  ACS Chemical Biology

The bacterial endosymbiont (Burkholderia rhizoxinica) of the rice seedling blight fungus (Rhizopus microsporus) harbors a large nu..

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Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian R Monk, Nausad Shaikh, Stephanie L Begg, Mike Gajdiss, Liam KR Sharkey, Jean YH Lee, Sacha J Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M Collins, Gabriele Bierbaum, Saumya R Udagedara, Jacqueline R Morey, Neha Pulyani, Benjamin P Howden, Megan J Maher, Christopher A McDevitt, Glenn F King, et al.

Journal article  |  2019  |  Nature Communications

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Genomics of vancomycin-resistant Enterococcus faecium

Claire Gorrie, Charlie Higgs, Glen Carter, Timothy P Stinear, Benjamin Howden

Journal article  |  2019  |  Microbial Genomics

Vancomycin-resistant Enterococcus faecium (VREfm) is a globally significant public health threat and was listed on the World Healt..

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Functional genomics reveals extensive diversity in Staphylococcus epidermidis restriction modification systems compared to Staphylococcus aureus

Jean YH Lee, Glen Carter, Sacha Pidot, Romain Guérillot, Torsten Seemann, Anders Gonçalves da Silva, Timothy Foster, Benjamin Howden, Timothy Stinear, Ian Monk

Journal article  |  2019

Abstract Staphylococcus epidermidis is a significant opportunistic pathogen of humans. Molecular studies in this species have been..

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Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance

Rachel L Darnell, Melanie K Knottenbelt, Francesca O Todd Rose, Ian R Monk, Timothy P Stinear, Gregory M Cook

Journal article  |  2019  |  mSphere

Teixobactin is a new antimicrobial of significant interest. It is active against a number of multidrug-resistant pathogens, includ..

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Remodeling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in a Dominant Hospital Lineage of Methicillin-Resistant Staphylococcus aureus

Sarah L Baines, Slade O Jensen, Neville Firth, Anders Goncalves da Silva, Torsten Seemann, Glen P Carter, Deborah A Williamson, Benjamin P Howden, Timothy P Stinear

Journal article  |  2019  |  Antimicrobial Agents and Chemotherapy

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Dual Gene Expression Analysis Identifies Factors Associated with Staphylococcus aureus Virulence in Diabetic Mice

Rudy Jacquet, Annette E LaBauve, Lavoisier Akoolo, Shivani Patel, Abdulelah A Alqarzaee, Tania Wong Fok Lung, Kunal Poorey, Timothy P Stinear, Vinai C Thomas, Robert J Meagher, Dane Parker

Journal article  |  2019  |  Infection and Immunity

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Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie International Edition

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Biosynthesis and Ether‐Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie

The nargenicin family of antibiotics are macrolides containing a rare ether‐bridged cis‐decalin motif. Several of these compounds ..

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Reconstruction of the Genomes of Drug-Resistant Pathogens for Outbreak Investigation through Metagenomic Sequencing

Andre Mu, Jason C Kwong, Nicole S Isles, Anders Goncalves da Silva, Mark B Schultz, Susan A Ballard, Courtney R Lane, Glen P Carter, Deborah A Williamson, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2019  |  mSphere

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Buruli ulcers in a Spanish aid worker after a stay in Peru

Jose Manuel Guerra Laso, Teresa Nebreda Mayoral, Juan Jose Palacios Gutierrez, Elia Samaniego Gonzalez, Barbara Rodriguez Martin, Leticia Barrio Rodriguez, Nieves Alonso Orcajo, Elena Magaz Garcia, Timothy Stinear, Andrew H Buultjens, Jose Antonio Perez Molina

Journal article  |  2019  |  International Journal of Infectious Diseases

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Mycobacterium ulcerans Population Genomics To Inform on the Spread of Buruli Ulcer across Central Africa

Koen Vandelannoote, Delphin Mavinga Phanzu, Kapay Kibadi, Miriam Eddyani, Conor J Meehan, Kurt Jordaens, Herwig Leirs, Francoise Portaels, Timothy P Stinear, Simon R Harris, Bouke C de Jong

Journal article  |  2019  |  mSphere

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In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model

Till F Omansen, Renee A Marcsisin, Brendon Y Chua, Weiguang Zeng, David C Jackson, Jessica L Porter, Ymkje Stienstra, Tjip S van der Werf, Timothy P Stinear

Journal article  |  2019  |  The American Journal of Tropical Medicine and Hygiene

Buruli ulcer (BU) is a neglected tropical disease caused by infection with Mycobacterium ulcerans. Unclear transmission, no availa..

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The changing landscape of vancomycin-resistant Enterococcus faecium in Australia: a population-level genomic study

Robyn S Lee, Anders Goncalves da Silva, Sarah L Baines, Janet Strachan, Susan Ballard, Glen P Carter, Jason C Kwong, Mark B Schultz, Dieter M Bulach, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  Journal of Antimicrobial Chemotherapy

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Genomic Analysis of Multiresistant Staphylococcus capitis Associated with Neonatal Sepsis

Glen P Carter, James E Ussher, Anders Gonsalves Da Silva, Sarah L Baines, Helen Heffernan, Thomas Riley, Roland Broadbent, Antje van der Linden, Jean Lee, Ian R Monk, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy

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Burkholderia lata Infections from Intrinsically Contaminated Chlorhexidine Mouthwash, Australia, 2016

Lex EX Leong, Diana Lagana, Glen P Carter, Qinning Wang, Kija Smith, Tim P Stinear, David Shaw, Vitali Sintchenko, Steven L Wesselingh, Ivan Bastian, Geraint B Rogers

Journal article  |  2018  |  Emerging Infectious Diseases

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Remodelling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in Methicillin-ResistantStaphylococcus aureus

Sarah Baines, Slade Jensen, Neville Firth, Anders Gonçalves da Silva, Torsten Seemann, Glen Carter, Deborah Williamson, Benjamin Howden, Timothy Stinear

Journal article  |  2018

Abstract Staphylococcus aureus is a significant human pathogen whose evolution and adaptation has been shaped in part by mobile ge..

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CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz, Julia E Prier, David Freestone, Thiago M Steiner, Kieran English, Darryl N Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M Davey, Dale Godfrey, Katsuyuki Yui, Laura K Mackay, Mireille H Lahoud, Irina Caminschi, Geoffrey McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R Heath

Journal article  |  2018  |  Cell Reports

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Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis

Jean YH Lee, Ian R Monk, Anders Goncalves da Silva, Torsten Seemann, Kyra YL Chua, Angela Kearns, Robert Hill, Neil Woodford, Mette D Bartels, Birgit Strommenger, Frederic Laurent, Magali Dodemont, Ariane Deplano, Robin Patel, Anders R Larsen, Tony M Korman, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  Nature Microbiology

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Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Ian Monk, Nausad Shaikh, Stephanie Begg, Mike Gajdiss, Jean Lee, Sacha Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett Collins, Gabriele Bierbaum, Benjamin Howden, Christopher McDevitt, Glenn King, Timothy Stinear

Journal article  |  2018

ABSTRACT WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates ..

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Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

Romain Guerillot, Lucy Li, Sarah Baines, Brian Howden, Mark B Schultz, Torsten Seemann, Ian Monk, Sacha J Pidot, Wei Gao, Stefano Giulieri, Anders Goncalves da Silva, Anthony D'Agata, Takehiro Tomita, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  Genome Medicine

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Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia

Stefano G Giulieri, Sarah L Baines, Romain Guerillot, Torsten Seemann, Anders Goncalves da Silva, Mark Schultz, Ruth C Massey, Natasha E Holmes, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  Genome Medicine

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Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy

Justin T Denholm, David B Ascher

Journal article  |  2018  |  American Journal of Respiratory and Critical Care Medicine

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Increasing tolerance of hospital Enterococcus faecium to handwash alcohols

Sacha J Pidot, Wei Gao, Andrew H Buultjens, Ian R Monk, Romain Guerillot, Glen P Carter, Jean YH Lee, Margaret MC Lam, M Lindsay Grayson, Susan A Ballard, Andrew A Mahony, Elizabeth A Grabsch, Despina Kotsanas, Tony M Korman, Geoffrey W Coombs, J Owen Robinson, Anders Goncalves da Silva, Torsten Seemann, Benjamin P Howden, Paul DR Johnson, et al.

Journal article  |  2018  |  Science Translational Medicine

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Low incidence of recurrent Buruli ulcers in treated Australian patients living in an endemic region

James W Wynne, Timothy P Stinear, Eugene Athan, Wojtek P Michalski, Daniel P O'Brien

Journal article  |  2018  |  PLOS Neglected Tropical Diseases

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IFN-gamma and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection

Aloysius D Loglo, Michael Frimpong, Mabel Sarpong Duah, Fred Sarfo, Francisca N Sarpong, Bernadette Agbavor, Justice K Boakye-Appiah, Kabiru M Abass, Mathias Dongyele, Margaret Frempong, Sacha Pidot, Mark Wansbrough-Jones, Timothy P Stinear, Virginie Roupie, Kris Huygen, Richard O Phillips

Journal article  |  2018  |  PeerJ

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1,2,4-Oxadiazole antimicrobials act synergistically with daptomycin and display rapid kill kinetics against MDR Enterococcus faecium

Glen P Carter, Jitendra R Harjani, Lucy Li, Noel P Pitcher, Yi Nong, Thomas V Riley, Deborah A Williamson, Timothy P Stinear, Jonathan B Baell, Benjamin P Howden

Journal article  |  2018  |  Journal of Antimicrobial Chemotherapy

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The First Isolation and Whole Genome Sequencing of Murray Valley Encephalitis Virus from Cerebrospinal Fluid of a Patient with Encephalitis

Jessica S Russell, Leon Caly, Renata Kostecki, Sarah L McGuinness, Glen Carter, Dieter Bulach, Torsten Seemann, Tim P Stinear, Rob Baird, Mike Catton, Julian Druce

Journal article  |  2018  |  Viruses

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The Phi BT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia

Marion Herisse, Jessica L Porter, Romain Guerillot, Takehiro Tomita, Anders Goncalves Da Silva, Torsten Seemann, Benjamin P Howden, Timothy P Stinear, Sacha J Pidot

Journal article  |  2018  |  PeerJ

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Human blood MAIT cell subsets defined using MR1 tetramers

Nicholas A Gherardin, Michael NT Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia BG Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov, David P Fairlie, David S Ritchie, Paul J Neeson, Daniel G Pellicci, Adam P Uldrich, James McCluskey, Dale I Godfrey

Journal article  |  2018  |  Immunology and Cell Biology

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Comparative Genomics Shows That Mycobacterium ulcerans Migration and Expansion Preceded the Rise of Buruli Ulcer in Southeastern Australia

Andrew H Buultjens, Koen Vandelannoote, Conor J Meehan, Miriam Eddyani, Bouke C de Jong, Janet AM Fyfe, Maria Globan, Nicholas J Tobias, Jessica L Porter, Takehiro Tomita, Ee Laine Tay, Torsten Seemann, Benjamin P Howden, Paul DR Johnson, Timothy P Stinear

Journal article  |  2018  |  Applied and Environmental Microbiology

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The changing landscape of VREfm in Victoria, Australia: a State-wide genomic snapshot

Robyn Lee, Anders Gonçalves da Silva, Sarah Baines, Janet Strachan, Susan Ballard, Glen Carter, Jason Kwong, Mark Schultz, Dieter Bulach, Torsten Seemann, Timothy Stinear, Benjamin Howden

Journal article  |  2018

Abstract Vancomycin-resistant Enterococcus faecium (VREfm) represent a major source of nosocomial infection worldwide. In Australi..

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Vancomycin-resistant Enterococcus faecium sequence type 796-rapid international dissemination of a new epidemic clone

Andrew A Mahony, Andrew H Buultjens, Susan A Ballard, Elizabeth A Grabsch, Shirley Xie, Torsten Seemann, Rhonda L Stuart, Despina Kotsanas, Allen Cheng, Helen Heffernan, Sally A Roberts, Geoffrey W Coombs, Narin Bak, John K Ferguson, Glen C Carter, Benjamin P Howden, Timothy P Stinear, Paul DR Johnson

Journal article  |  2018  |  Antimicrobial Resistance & Infection Control

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Whole-genome sequencing reveals transmission of gonococcal antibiotic resistance among men who have sex with men: an observational study

Jason C Kwong, Eric PF Chow, Kerrie Stevens, Timothy P Stinear, Torsten Seemann, Christopher K Fairley, Marcus Y Chen, Benjamin P Howden

Journal article  |  2018  |  Sexually Transmitted Infections

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Genomic Exploration of Within-Host Microevolution Reveals a Distinctive Molecular Signature of Persistent Staphylococcus aureus Bacteraemia

Stefano Giulieri, Sarah Baines, Romain Guerillot, Torsten Semann, Anders Goncalves da Silva, Mark Schultz, Ruth Massey, Natasha Holmes, Timothy Stinear, Benjamin Howden

Journal article  |  2018  |  Genome Medicine

Background: Large-scale genomic studies of within-host evolution during Staphylococcus aureus bacteraemia (SAB) are needed to unde..

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Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand

Robyn S Lee, Torsten Seemann, Helen Heffernan, Jason C Kwong, Anders Goncalves da Silva, Glen P Carter, Rosemary Woodhouse, Kristin H Dyet, Dieter M Bulach, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson

Journal article  |  2018  |  Journal of Antimicrobial Chemotherapy

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Evolution of virulence in Enterococcus faecium, a hospital-adapted opportunistic pathogen

Wei Gao, Benjamin P Howden, Timothy P Stinear

Journal article  |  2018  |  Current Opinion in Microbiology

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Topical Antibiotic Use Coselects for the Carriage of Mobile Genetic Elements Conferring Resistance to Unrelated Antimicrobials in Staphylococcus aureus

Glen P Carter, Mark B Schultz, Sarah L Baines, Anders Goncalves da Silva, Helen Heffernan, Audrey Tiong, Peter H Pham, Ian R Monk, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy

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Translating genomics into practice for real-time surveillance and response to carbapenemase-producing Enterobacteriaceae: evidence from a complex multi-institutional KPC outbreak

Jason C Kwong, Courtney R Lane, Finn Romanes, Anders Goncalves da Silva, Marion Easton, Katie Cronin, Mary Jo Waters, Takehiro Tomita, Kerrie Stevens, Mark B Schultz, Sarah L Baines, Norelle L Sherry, Glen P Carter, Andre Mu, Michelle Sait, Susan A Ballard, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  PeerJ

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Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant &ITStaphylococcus aureus&IT

Romain Guerillot, Anders Goncalves da Silva, Ian Monk, Stefano Giulieri, Takehiro Tomita, Eloise Alison, Jessica Porter, Sacha Pidot, Wei Gao, Anton Y Peleg, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  mSphere

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Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus

Nicholas J Tobias, Hendrik Wolff, Bardya Djahanschiri, Florian Grundmann, Max Kronenwerth, Yi-Ming Shi, Svenja Simonyi, Peter Gruen, David Shapiro-Ilan, Sacha J Pidot, Timothy P Stinear, Ingo Ebersberger, Helge B Bode

Journal article  |  2017  |  Nature Microbiology

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Recommendations for the control of carbapenemase-producing Enterobacteriaceae (CPE): A guide for acute care health facilities Australian Commission on Safety and Quality in Health Care

Michael Richards, Marilyn Cruickshank, Allen Cheng, Sylvia Gandossi, Cate Quoyle, Rhonda Stuart, Brett Sutton, John Turnidge

Journal article  |  2017  |  Infection, Disease & Health

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A Supervised Statistical Learning Approach for Accurate Legionella pneumophila Source Attribution during Outbreaks

Andrew H Buultjens, Kyra YL Chua, Sarah L Baines, Jason Kwong, Wei Gao, Zoe Cutcher, Stuart Adcock, Susan Ballard, Mark B Schultz, Takehiro Tomita, Nela Subasinghe, Glen P Carter, Sacha J Pidot, Lucinda Franklin, Torsten Seemann, Anders Goncalves Da Silva, Benjamin P Howden, Timothy P Stinear

Journal article  |  2017  |  Applied and Environmental Microbiology

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Methicillin Resistant Staphylococcus aureus Transmission in a Ghanaian Burn Unit: The Importance of Active Surveillance in Resource-Limited Settings

Nana Ama Amissah, Andrew H Buultjens, Anthony Ablordey, Lieke van Dam, Ampomah Opoku-Ware, Sarah L Baines, Dieter Bulach, Caitlin S Tetteh, Isaac Prah, Tjip S van der Werf, Alexander W Friedrich, Torsten Seemann, Jan Maarten van Dijl, Ymkje Stienstra, Timothy P Stinear, John W Rossen

Journal article  |  2017  |  Frontiers in Microbiology

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Vancomycin-intermediate Staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors

DR Cameron, Y-H Lin, S Trouillet-Assant, V Tafani, X Kostoulias, E Mouhtouris, N Skinner, K Visvanathan, SL Baines, B Howden, IR Monk, F Laurent, TP Stinear, BP Howden, AY Peleg

Journal article  |  2017  |  Clinical Microbiology and Infection

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Bacterial membrane vesicles transport their DNA cargo into host cells

Natalie J Bitto, Ross Chapman, Sacha Pidot, Adam Costin, Camden Lo, Jasmine Choi, Tanya D'Cruze, Eric C Reynolds, Stuart G Dashper, Lynne Turnbull, Cynthia B Whitchurch, Timothy P Stinear, Katryn J Stacey, Richard L Ferrero

Journal article  |  2017  |  Scientific Reports

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In silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages (vol 2, e000064, 2016)

Danielle J Ingle, Mary Valcanis, Alex Kuzevski, Marija Tauschek, Michael Inouye, Tim Stinear, Myron M Levine, Roy M Robins-Browne, Kathryn E Holt

Journal article  |  2017  |  Microbial Genomics

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Emergence of multidrug resistance in locally-acquired human infections with Salmonella Typhimurium in Australia owing to a new clade harbouring bla(CTX-M-9)

Sarah J Sparham, Jason C Kwong, Mary Valcanis, Marion Easton, Darren J Trott, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2017  |  International Journal of Antimicrobial Agents

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Target-Specific Assay for Rapid and Quantitative Detection of Mycobacterium chimaera DNA

Enrique Zozaya-Valdes, Jessica L Porter, John Coventry, Janet AM Fyfe, Glen P Carter, Anders Goncalves da Silva, Mark B Schultz, Torsten Seemann, Paul DR Johnson, Andrew J Stewardson, Ivan Bastian, Sally A Roberts, Benjamin P Howden, Deborah A Williamson, Timothy P Stinear

Journal article  |  2017  |  Journal of Clinical Microbiology

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A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule

Anna Mularski, Jonathan Wilksch, Eric Hanssen, Jian Li, Takehiro Tomita, Sacha James Pidot, Tim Stinear, Frances Separovic, Dick Strugnell

Journal article  |  2017  |  European Biophysics Journal

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Exposure Risk for Infection and Lack of Human-to-Human Transmission of Mycobacterium ulcerans Disease, Australia

Daniel P O'Brien, James W Wynne, Andrew H Buultjens, Wojtek P Michalski, Timothy R Stinear, N Deborah Friedman, Andrew Hughes, Eugene Athan

Journal article  |  2017  |  Emerging Infectious Diseases

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Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Go66

Xiaofeng Cai, Yi-Ming Shi, Nicole Poehlmann, Ole Revermann, Isabel Bahner, Sacha J Pidot, Frank Wesche, Helmut Lackner, Claudia Buechel, Marcel Kaiser, Christian Richter, Harald Schwalbe, Timothy P Stinear, Axel Zeeck, Helge B Bode

Journal article  |  2017  |  Angewandte Chemie International Edition

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Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer

John R Wallace, Kirstie M Mangas, Jessica L Porter, Renee Marcsisin, Sacha J Pidot, Brian Howden, Till F Omansen, Weiguang Zeng, Jason K Axford, Paul DR Johnson, Timothy P Stinear

Journal article  |  2017  |  PLOS Neglected Tropical Diseases

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Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa

Koen Vandelannoote, Conor J Meehan, Miriam Eddyani, Dissou Affolabi, Delphin Mavinga Phanzu, Sara Eyangoh, Kurt Jordaens, Francoise Portaels, Kirstie Mangas, Torsten Seemann, Laurent Marsollier, Estelle Marion, Annick Chauty, Jordi Landier, Arnaud Fontanet, Herwig Leirs, Timothy P Stinear, Bouke C de Jong

Journal article  |  2017  |  Genome Biology and Evolution

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Genomic analysis of ST88 community-acquired methicillin resistant Staphylococcus aureus in Ghana

Grace Kpeli, Andrew H Buultjens, Stefano Giulieri, Evelyn Owusu-Mireku, Samuel Y Aboagye, Sarah L Baines, Torsten Seemann, Dieter Bulach, Anders Goncalves da Silva, Ian R Monk, Benjamin P Howden, Gerd Pluschke, Dorothy Yeboah-Manu, Timothy Stinear

Journal article  |  2017  |  PeerJ

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Mycobacterium chimaera Spread from Heating and Cooling Units in Heart Surgery

Deborah Williamson, Benjamin Howden, Timothy Stinear

Journal article  |  2017  |  New England Journal of Medicine

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Correspondence: Spontaneous secondary mutations confound analysis of the essential two-component system WalKR in Staphylococcus aureus

Ian R Monk, Benjamin P Howden, Torsten Seemann, Timothy P Stinear

Journal article  |  2017  |  Nature Communications

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Comment on: Benchmarking of methods for identification of antimicrobial resistance genes in bacterial whole genome data

Jason C Kwong, Mark B Schultz, Deborah A Williamson, Timothy P Stinear, Torsten Seemann, Benjamin P Howden

Journal article  |  2017  |  Journal of Antimicrobial Chemotherapy

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Evolutionary origins of the emergent ST796 clone of vancomycin resistant Enterococcus faecium

Andrew H Buultjens, Margaret MC Lam, Susan Ballard, Ian R Monk, Andrew A Mahony, Elizabeth A Grabsch, M Lindsay Grayson, Stanley Pang, Geoffrey W Coombs, J Owen Robinson, Torsten Seemann, Paul DR Johnson, Benjamin P Howden, Timothy P Stinear

Journal article  |  2017  |  PeerJ

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Genomic insights into a sustained national outbreak of Yersinia pseudotuberculosis.

Deborah A Williamson, Sarah L Baines, Glen Carter, Anders Gonçalves da Silva, Xiaoyun Ren, Jill Sherwood, Muriel Dufour, Mark B Schultz, Nigel P French, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2017  |  Genome Biol Evol

In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across all major cities in New Zealand (N..

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A phylogenomic framework for assessing the global emergence and evolution of clonal complex 398 methicillin-resistant Staphylococcus aureus

Anders Goncalves da Silva, Sarah L Baines, Glen P Carter, Helen Heffernan, Nigel P French, Xiaoyun Ren, Torsten Seemann, Dieter Bulach, Jason Kwong, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson

Journal article  |  2017  |  Microbial Genomics

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Genomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis

Deborah A Williamson, Sarah L Baines, Glen P Carter, Anders Goncalves da silva, Xiaoyun Ren, Jill Sherwood, Muriel Dufour, Mark B Schultz, Nigel P French, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2016  |  Genome Biology and Evolution

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Emergence of endemic MLST non-typeable vancomycin-resistant Enterococcus faecium

Glen P Carter, Andrew H Buultjens, Susan A Ballard, Sarah L Baines, Takehiro Tomita, Janet Strachan, Paul DR Johnson, John K Ferguson, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2016  |  Journal of Antimicrobial Chemotherapy

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Leprosy in red squirrels

Timothy P Stinear, Roland Brosch

Journal article  |  2016  |  Science

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Use of bacterial whole-genome sequencing to understand and improve the management of invasive Staphylococcus aureus infections

Stefano G Giulieri, Natasha E Holmes, Timothy P Stinear, Benjamin P Howden

Journal article  |  2016  |  Expert Review of Anti-infective Therapy

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Evolutionary origins of the emergent ST796 clone of vancomycin resistant Enterococcus faecium

Andrew Buultjens, Margaret Lam, Susan Ballard, Ian Monk, Andrew Mahony, Elizabeth Grabsch, Lindsay Grayson, Stanley Pang, Geoffrey Coombs, Owen Robinson, Torsten Seemann, Paul Johnson, Benjamin Howden, Timothy Stinear

Journal article  |  2016

From early 2012, a novel clone of vancomycin resistant Enterococcus faecium (assigned the multi locus sequence type ST796) was sim..

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A large outbreak of Campylobacter jejuni infection in a university college caused by chicken liver pâté, Australia, 2013

CRM Moffatt, A Greig, M Valcanis, W Gao, T Seemann, BP Howden, MD Kirk

Journal article  |  2016  |  Epidemiology and infection

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Table S1

Tim Stinear, ANDREW BUULTJENS

Dataset  |  2016

Table S1: Genomic regions enriched in S. aureus MRSA ST88

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Sharing Is Caring: International Sharing of Data Enhances Genomic Surveillance of Listeria monocytogenes

Jason C Kwong, Russell Stafford, Errol Strain, Timothy P Stinear, Torsten Seemann, Benjamin P Howden

Journal article  |  2016  |  Clinical Infectious Diseases

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Functional analysis of the first complete genome sequence of a multidrug resistant sequence type 2 Staphylococcus epidermidis

Jean YH Lee, Ian R Monk, Sacha J Pidot, Siddarth Singh, Kyra YL Chua, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2016  |  Microbial Genomics

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Possible healthcare-associated transmission as a cause of secondary infection and population structure of Staphylococcus aureus isolates from two wound treatment centres in Ghana.

G Kpeli, I Darko Otchere, A Lamelas, AL Buultjens, D Bulach, SL Baines, T Seemann, S Giulieri, Z Nakobu, SY Aboagye, E Owusu-Mireku, G Pluschke, TP Stinear, D Yeboah-Manu

Journal article  |  2016  |  New Microbes and New Infections

We have previously shown that secondary infections of Buruli ulcer wounds were frequently caused by Staphylococcus aureus. To gain..

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Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

Eva C Boritsch, Varun Khanna, Alexandre Pawlik, Nadine Honore, Victor H Navas, Laurence Ma, Christiane Bouchier, Torsten Seemann, Philip Supply, Timothy P Stinear, Roland Brosch

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

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Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle

Nicholas J Tobias, Bagdevi Mishra, Deepak K Gupta, Rahul Sharma, Marco Thines, Timothy P Stinear, Helge B Bode

Journal article  |  2016  |  BMC Genomics

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NGMASTER: in silico multi-antigen sequence typing for Neisseria gonorrhoeae

Jason C Kwong, Anders Goncalves da Silva, Kristin Dyet, Deborah A Williamson, Timothy P Stinear, Benjamin P Howden, Torsten Seemann

Journal article  |  2016  |  Microbial Genomics

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In silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages

Danielle J Ingle, Mary Valcanis, Alex Kuzevski, Marija Tauschek, Michael Inouye, Tim Stinear, Myron M Levine, Roy M Robins-Browne, Kathryn E Holt

Journal article  |  2016  |  Microbial Genomics

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Snapshot fecal survey of domestic animals in rural Ghana for Mycobacterium ulcerans

Nicholas J Tobias, Nana Ama Ammisah, Evans K Ahortor, John R Wallace, Anthony Ablordey, Timothy P Stinear

Journal article  |  2016  |  PeerJ

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Supplmentary Table S1

Tim Stinear

Dataset  |  2016

List of publicly available Staphylococcus epidermidis genomes used in this study

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Increasing tolerance of hospital Enterococcus faecium to hand-wash alcohols

Sacha Pidot, Wei Gao, Andrew Buultjens, Ian Monk, Romain Guerillot, Glen Carter, Jean YH Lee, Margaret Lam, Lindsay Grayson, Susan Ballard, Andrew Mahony, Elizabeth Grabsch, Despina Kotsanas, Tony Korman, Geoffrey Coombs, Owen Robinson, Anders Gonçalves da Silva, Torsten Seemann, Benjamin Howden, Paul Johnson, et al.

Journal article  |  2016

Abstract Alcohol-based hand rubs are international pillars of hospital infection control, restricting transmission of pathogens su..

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Rapid Emergence and Evolution of Staphylococcus aureus Clones Harboring fusC-Containing Staphylococcal Cassette Chromosome Elements

Sarah L Baines, Benjamin P Howden, Helen Heffernan, Timothy P Stinear, Glen P Carter, Torsten Seemann, Jason C Kwong, Stephen R Ritchie, Deborah A Williamson

Journal article  |  2016  |  Antimicrobial agents and chemotherapy

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Complete Bypass of Restriction Systems for Major Staphylococcus aureus Lineages (vol 6, e00308, 2015)

Ian R Monk, Jai J Tree, Benjamin P Howden, Timothy P Stinear, Timothy J Foster

Journal article  |  2016  |  mBio

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Application of microbial genomics in outbreaks and infection control.

Tim Stinear, Benjamin Howden

Journal article  |  2016  |  Pathology

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Prospective Whole-Genome Sequencing Enhances National Surveillance of Listeria monocytogenes

Jason C Kwong, Karolina Mercoulia, Takehiro Tomita, Marion Easton, Hua Y Li, Dieter M Bulach, Timothy P Stinear, Torsten Seemann, Benjamin P Howden

Journal article  |  2016  |  Journal of Clinical Microbiology

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pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

Eva C Boritsch, Wafa Frigui, Alessandro Cascioferro, Wladimir Malaga, Gilles Etienne, Francoise Laval, Alexandre Pawlik, Fabien Le Chevalier, Mickael Orgeur, Laurence Ma, Christiane Bouchier, Timothy P Stinear, Philip Supply, Laleh Majlessi, Mamadou Daffe, Christophe Guilhot, Roland Brosch

Journal article  |  2016  |  Nature Microbiology

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Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease

Fatoumata Niang, Fred S Sarfo, Michael Frimpong, Laure Guenin-Mace, Mark Wansbrough-Jones, Timothy Stinear, Richard O Phillips, Caroline Demangel

Journal article  |  2015  |  Scientific Reports

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A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer

Miriam Eddyani, Koen Vandelannoote, Conor J Meehan, Sabin Bhuju, Jessica L Porter, Julia Aguiar, Torsten Seemann, Michael Jarek, Mahavir Singh, Francoise Portaels, Timothy P Stinear, Bouke C de Jong

Journal article  |  2015  |  PLoS Negl Trop Dis

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Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient

Ella M Meumann, Maria Globan, Janet AM Fyfe, David Leslie, Jessica L Porter, Torsten Seemann, Justin Denholm, Timothy P Stinear

Journal article  |  2015  |  Microbial Genomics

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Changes in protein abundance are observed in bacterial isolates from a natural host

Megan A Rees, Timothy P Stinear, Robert JA Goode, Ross L Coppel, Alexander I Smith, Oded Kleifeld

Journal article  |  2015  |  Frontiers in Cellular and Infection Microbiology

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Supplementary Table S1

Tim Stinear

Dataset  |  2015

This table is a summary of the whole genome SNPs and indels detected over among  8 serial Mycobacterium tuberculosis isolates betw..

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Large tandem chromosome expansions facilitate niche adaptation during persistent infection with drug-resistant Staphylococcus aureus

Wei Gao, Ian R Monk, Nicholas J Tobias, Simon L Gladman, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2015  |  Microbial Genomics

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Complete Bypass of Restriction Systems for Major Staphylococcus aureus Lineages

Ian R Monk, Jai J Tree, Benjamin P Howden, Timothy P Stinear, Timothy J Foster

Journal article  |  2015  |  mBio

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Supplementary Table S4

Tim Stinear

Dataset  |  2015

Summary of mutations

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Optical map Staphylococcus aureus JKD6210

Tim Stinear

Dataset  |  2015

optical map image

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Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant Staphylococcus aureus

Sarah L Baines, Kathryn E Holt, Mark B Schultz, Torsten Seemann, Brian O Howden, Slade O Jensen, Sebastiaan J van Hal, Geoffrey W Coombs, Neville Firth, David R Powell, Timothy P Stinear, Benjamin P Howden

Journal article  |  2015  |  mBio

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Whole Genome Comparisons Suggest Random Distribution of Mycobacterium ulcerans Genotypes in a Buruli Ulcer Endemic Region of Ghana

Anthony S Ablordey, Koen Vandelannoote, Isaac A Frimpong, Evans K Ahortor, Nana Ama Amissah, Miriam Eddyani, Lies Durnez, Francoise Portaels, Bouke C de Jong, Herwig Leirs, Jessica L Porter, Kirstie M Mangas, Margaret MC Lam, Andrew Buultjens, Torsten Seemann, Nicholas J Tobias, Timothy P Stinear

Journal article  |  2015  |  PLoS Negl Trop Dis

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In-vitro Activity of Avermectins against Mycobacterium ulcerans

Till F Omansen, Jessica L Porter, Paul DR Johnson, Tjip S van der Werf, Ymkje Stienstra, Timothy P Stinear

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

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Identification of the Mycobacterium ulcerans Protein MUL_3720 as a Promising Target for the Development of a Diagnostic Test for Buruli Ulcer

Anita Dreyer, Katharina Roeltgen, Jean Pierre Dangy, Marie Therese Ruf, Nicole Scherr, Miriam Bolz, Nicholas Jay Tobias, Charles Moes, Andrea Vettiger, Timothy Paul Stinear, Gerd Pluschke

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

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Proteomic Characterization of a Natural Host Pathogen Interaction: Repertoire of in Vivo Expressed Bacterial and Host Surface-Associated Proteins

Megan A Rees, Oded Kleifeld, Paul K Crellin, Bosco Ho, Timothy P Stinear, A Ian Smith, Ross L Coppel

Journal article  |  2015  |  Journal of Proteome Research

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Enterobacteriaceae Sepsis Outcome Programme annual report, 2013.

John D Turnidge, Thomas Gottlieb, David H Mitchell, Geoffrey W Coombs, Denise A Daly, Jan M Bell, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2014  |  Communicable diseases intelligence quarterly report

The Australian Group on Antimicrobial Resistance performs regular period-prevalence studies to monitor changes in antimicrobial re..

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Australian Enterococcal Sepsis Outcome Programme annual report, 2013.

Geoffrey W Coombs, Julie C Pearson, Denise A Daly, Tam T Le, James O Robinson, Thomas Gottlieb, Benjamin P Howden, Paul DR Johnson, Catherine M Bennett, Timothy P Stinear, John D Turnidge, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2014  |  Communicable diseases intelligence quarterly report

From 1 January to 31 December 2013, 26 institutions around Australia participated in the Australian Enterococcal Sepsis Outcome Pr..

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Australian Staphylococcus aureus Sepsis Outcome Programme annual report, 2013.

Geoffrey W Coombs, Graeme R Nimmo, Denise A Daly, Tam T Le, Julie C Pearson, Hui-Leen Tan, James O Robinson, Peter J Collignon, Mary-Louise McLaws, John D Turnidge, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2014  |  Communicable diseases intelligence quarterly report

From 1 January to 31 December 2013, around Australia 26 institutions around Australia participated in the Australian Staphylococca..

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A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent (vol 93, pg 835, 2014)

Eva C Boritsch, Philip Supply, Nadine Honore, Torsten Seeman, Timothy P Stinear, Roland Brosch

Journal article  |  2014  |  Molecular Microbiology

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What do infectious diseases physicians do? A 2-week snapshot of inpatient consultative activities across Australia, New Zealand and Singapore

PR Ingram, AC Cheng, RJ Murray, CC Blyth, T Walls, DA Fisher, JS Davis

Journal article  |  2014  |  Clinical Microbiology and Infection

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Australian Enterococcal Sepsis Outcome Progamme, 2011.

Geoffrey W Coombs, Julie C Pearson, Tam Le, Denise A Daly, James O Robinson, Thomas Gottlieb, Benjamin P Howden, Paul DR Johnson, Catherine M Bennett, Timothy P Stinear, John D Turnidge, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2014  |  Communicable diseases intelligence quarterly report

From 1 January to 31 December 2011, 29 institutions around Australia participated in the Australian Enterococcal Sepsis Outcome Pr..

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Australian Enterococcal Sepsis Outcome Progamme, 2011

GW Coombs, JC Pearson, T Le, DA Daly, JO Robinson, T Gottlieb, BP Howden, PDR Johnson, CM Bennett, TP Stinear, JD Turnidge

Journal article  |  2014  |  Communicable diseases intelligence quarterly report

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A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent

Eva C Boritsch, Philip Supply, Nadine Honore, Torsten Seeman, Timothy P Stinear, Roland Brosch

Journal article  |  2014  |  Molecular Microbiology

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Investigating the Role of Free-living Amoebae as a Reservoir for Mycobacterium ulcerans

Nana Ama Amissah, Sophie Gryseels, Nicholas J Tobias, Bahram Ravadgar, Mitsuko Suzuki, Koen Vandelannoote, Lies Durnez, Herwig Leirs, Timothy P Stinear, Francoise Portaels, Anthony Ablordey, Miriam Eddyani

Journal article  |  2014  |  PLoS Neglected Tropical Diseases

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Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

Estelle Marion, Ok-Ryul Song, Thierry Christophe, Jeremie Babonneau, Denis Fenistein, Joel Eyer, Frank Letournel, Daniel Henrion, Nicolas Clere, Vincent Paille, Nathalie C Guerineau, Jean-Paul Saint Andre, Philipp Gersbach, Karl-Heinz Altmann, Timothy Paul Stinear, Yannick Comoglio, Guillaume Sandoz, Laurence Preisser, Yves Delneste, Edouard Yeramian, et al.

Journal article  |  2014  |  Cell

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Emergence of a Ribotype 244 Strain of Clostridium difficile Associated With Severe Disease and Related to the Epidemic Ribotype 027 Strain

Sze K Lim, Rhonda L Stuart, Kate E Mackin, Glen P Carter, Despina Kotsanas, Michelle J Francis, Marion Easton, Karolina Dimovski, Briony Elliott, Thomas V Riley, Geoff Hogg, Eldho Paul, Tony M Korman, Torsten Seemann, Timothy P Stinear, Dena Lyras, Grant A Jenkin

Journal article  |  2014  |  Clinical Infectious Diseases

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Community-onset Staphylococcus aureus Surveillance Programme annual report, 2012.

Geoffrey W Coombs, Denise A Daly, Julie C Pearson, Graeme R Nimmo, Peter J Collignon, Mary-Louise McLaws, James O Robinson, John D Turnidge, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2014  |  Communicable diseases intelligence quarterly report

In 2012, the Australian Group on Antimicrobial Resistance (AGAR) conducted a community-onset period-prevalence survey of clinical ..

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Hospital-onset Gram-negative Surveillance Program annual report, 2011.

John D Turnidge, Thomas Gottlieb, David H Mitchell, Geoffrey W Coombs, Julie C Pearson, Jan M Bell, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2014  |  Communicable diseases intelligence quarterly report

The Australian Group on Antimicrobial Resistance performs regular period-prevalence studies to monitor changes in antimicrobial re..

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Community-onset Gram-negative Surveillance Program annual report, 2012.

John D Turnidge, Thomas Gottlieb, David H Mitchell, Geoffrey W Coombs, Denise A Daly, Jan M Bell, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2014  |  Communicable diseases intelligence quarterly report

The Australian Group on Antimicrobial Resistance performs regular period-prevalence studies to monitor changes in antimicrobial re..

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Molecular Epidemiology of Enterococcal Bacteremia in Australia

Geoffrey W Coombs, Julie C Pearson, Denise A Daley, Tam Le, Owen J Robinson, Thomas Gottlieb, Benjamin P Howden, Paul DR Johnson, Catherine M Bennett, Timothy P Stinear, John D Turnidge

Journal article  |  2014  |  Journal of Clinical Microbiology

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Hyperexpression of alpha-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus

Kyra YL Chua, Ian R Monk, Ya-Hsun Lin, Torsten Seemann, Kellie L Tuck, Jessica L Porter, Justin Stepnell, Geoffrey W Coombs, John K Davies, Timothy P Stinear, Benjamin P Howden

Journal article  |  2014  |  BMC microbiology

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Mycobacterial Pathogenomics and Evolution.

Daria Bottai, Timothy P Stinear, Philip Supply, Roland Brosch

Journal article  |  2014  |  Microbiology Spectrum

Most mycobacterial species are harmless saprophytes, often found in aquatic environments. A few species seem to have evolved from ..

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Population genetics and the evolution of virulence in Staphylococcus aureus

Kyra YL Chua, Benjamin P Howden, Jhih-Hang Jiang, Timothy Stinear, Anton Y Peleg

Journal article  |  2014  |  Infection Genetics and Evolution

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Adaptive Change Inferred from Genomic Population Analysis of the ST93 Epidemic Clone of Community-Associated Methicillin-Resistant Staphylococcus aureus

Timothy P Stinear, Kathryn E Holt, Kyra Chua, Justin Stepnell, Kellie L Tuck, Geoffrey Coombs, Paul Francis Harrison, Torsten Seemann, Benjamin P Howden

Journal article  |  2014  |  Genome Biology & Evolution

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The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA

Benjamin P Howden, Anton Y Peleg, Timothy P Stinear

Journal article  |  2014  |  Infection Genetics and Evolution

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Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice

Virginie Roupie, Sacha J Pidot, Tobba Einarsdottir, Christophe Van den Poel, Fabienne Jurion, Timothy P Stinear, Kris Huygen

Journal article  |  2014  |  PLoS Neglected Tropical Diseases

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Mycobacterium ulcerans, causative agent of Buruli ulcer

T Stinear

Journal article  |  2014  |  Microbiology Today

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Hyperexpression of alpha-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus

KYL Chua, IR Monk, YH Lin, T Seemann, KL Tuck, JL Porter, J STEPNELL, GW Coombs, JK Davies, TP Stinear, BP Howden, TP Stinear

Journal article  |  2014  |  BMC Microbiology

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Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source

Caroline Deshayes, Shiva Kumar Angala, Estelle Marion, Irene Brandli, Jeremie Babonneau, Laurent Preisser, Sara Eyangoh, Yves Delneste, Pierre Legras, Chantal De Chastellier, Timothy P Stinear, Mary Jackson, Laurent Marsollier

Journal article  |  2013  |  PLoS Neglected Tropical Diseases

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Australian Group on Antimicrobial Resistance Hospital-onset Staphylococcus aureus Surveillance Programme annual report, 2011.

Geoffrey W Coombs, Graeme R Nimmo, Julie C Pearson, Peter J Collignon, Jan M Bell, Mary-Louise McLaws, Keryn J Christiansen, John D Turnidge, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2013  |  Communicable diseases intelligence quarterly report

In 2011, the Australian Group on Antimicrobial Resistance (AGAR) conducted a period-prevalence survey of clinical Staphylococcus a..

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Australian Group on Antimicrobial Resistance Enterococcus Surveillance Programme annual report, 2010.

Geoffrey W Coombs, Julie C Pearson, Keryn Christiansen, Thomas Gottlieb, Jan M Bell, Narelle George, John D Turnidge, undefined Australian Group on Antimicrobial Resistance

Journal article  |  2013  |  Communicable diseases intelligence quarterly report

In 2010, 15 institutions around Australia conducted a period prevalence study of key resistances in isolates of Enterococcus speci..

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Genomic analysis of teicoplanin resistance emerging during treatment of vanB vancomycin-resistant Enterococcus faecium infections in solid organ transplant recipients including donor-derived cases

Natasha E Holmes, Susan A Ballard, Margaret MC Lam, Paul DR Johnson, M Lindsay Grayson, Timothy P Stinear, Benjamin P Howden

Journal article  |  2013  |  Journal of Antimicrobial Chemotherapy

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Reply to "Internet-Based Solutions for Analysis of Next-Generation Sequence Data"

Norelle L Sherry, Timothy P Stinear, Benjamin P Howden

Journal article  |  2013  |  Journal of Clinical Microbiology

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Comparative analysis of the complete genome of an epidemic hospital sequence type 203 clone of vancomycin-resistant Enterococcus faecium

Margaret MC Lam, Torsten Seemann, Nicholas J Tobias, Honglei Chen, Volker Haring, Robert J Moore, Susan Ballard, Lindsay M Grayson, Paul DR Johnson, Benjamin P Howden, Timothy P Stinear

Journal article  |  2013  |  BMC Genomics

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Analysis of the Small RNA Transcriptional Response in Multidrug-Resistant Staphylococcus aureus after Antimicrobial Exposure

Benjamin P Howden, Marie Beaume, Paul F Harrison, David Hernandez, Jacques Schrenzel, Torsten Seemann, Patrice Francois, Timothy P Stinear

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

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The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis

Jessica L Porter, Nicholas J Tobias, Sacha J Pidot, Steffen Falgner, Kellie L Tuck, Andrea Vettiger, Hui Hong, Peter F Leadlay, Timothy P Stinear

Journal article  |  2013  |  PLoS One

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Functional genomics of Staphylococcus aureus

Kyra YL Chua, Timothy P Stinear, Benjamin P Howden

Journal article  |  2013  |  Briefings in Functional Genomics

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Decreased Vancomycin Susceptibility in Staphylococcus aureus Caused by IS256 Tempering of WalKR Expression

Christopher RE McEvoy, Brian Tsuji, Wei Gao, Torsten Seemann, Jessica L Porter, Kenneth Doig, Dung Ngo, Benjamin P Howden, Timothy P Stineara

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

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Genomic Insights to Control the Emergence of Vancomycin-Resistant Enterococci

Benjamin P Howden, Kathryn E Holt, Margaret MC Lam, Torsten Seemann, Susan Ballard, Geoffrey W Coombs, Steven YC Tong, M Lindsay Grayson, Paul DR Johnson, Timothy P Stinear

Journal article  |  2013  |  MBIO

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Outbreak Investigation Using High-Throughput Genome Sequencing within a Diagnostic Microbiology Laboratory

Norelle L Sherry, Jessica L Porter, Torsten Seemann, Andrew Watkins, Timothy P Stinear, Benjamin P Howden

Journal article  |  2013  |  Journal of Clinical Microbiology

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Determining research priorities for clinician-initiated trials in infectious diseases

David L Paterson

Journal article  |  2013  |  Medical Journal of Australia

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The RpoB H148Y Rifampicin Resistance Mutation and an Active Stringent Response Reduce Virulence and Increase Resistance to Innate Immune Responses in Staphylococcus aureus

Wei Gao, David R Cameron, John K Davies, Xenia Kostoulias, Justin Stepnell, Kellie L Tuck, Michael R Yeaman, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden

Journal article  |  2013  |  Journal of Infectious Diseases

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Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

Philip Supply, Michael Marceau, Sophie Mangenot, David Roche, Carine Rouanet, Varun Khanna, Laleh Majlessi, Alexis Criscuolo, Julien Tap, Alexandre Pawlik, Laurence Fiette, Mickael Orgeur, Michel Fabre, Cecile Parmentier, Wafa Frigui, Roxane Simeone, Eva C Boritsch, Anne-Sophie Debrie, Eve Willery, Danielle Walker, et al.

Journal article  |  2013  |  Nature Genetics

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Complete Genome Sequence of the Frog Pathogen Mycobacterium ulcerans Ecovar Liflandii

Nicholas J Tobias, Kenneth D Doig, Marnix H Medema, Honglei Chen, Volker Haring, Robert Moore, Torsten Seemann, Timothy P Stinear

Journal article  |  2013  |  Journal of Bacteriology

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The Lipoprotein LpqW Is Essential for the Mannosylation of Periplasmic Glycolipids in Corynebacteria

Arek K Rainczuk, Yoshiki Yamaryo-Botte, Rajini Brammananth, Timothy P Stinear, Torsten Seemann, Ross L Coppel, Malcolm J McConville, Paul K Crellin

Journal article  |  2012  |  Journal of Biological Chemistry

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The Molecular Epidemiology of the Highly Virulent ST93 Australian Community Staphylococcus aureus Strain

Geoffrey W Coombs, Richard V Goering, Kyra YL Chua, Stefan Monecke, Benjamin P Howden, Timothy P Stinear, Ralf Ehricht, Frances G O'Brien, Keryn J Christiansen

Journal article  |  2012  |  PLoS One

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On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer

Kenneth D Doig, Kathryn E Holt, Janet AM Fyfe, Caroline J Lavender, Miriam Eddyani, Francoise Portaels, Dorothy Yeboah-Manu, Gerd Pluschke, Torsten Seemann, Timothy P Stinear

Journal article  |  2012  |  BMC Genomics

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Rapid and Sensitive Detection of Mycobacterium ulcerans by Use of a Loop-Mediated Isothermal Amplification Test

Zablon K Njiru, Dorothy Yeboah-Manu, Timothy P Stinear, Janet AM Fyfe

Journal article  |  2012  |  Journal of Clinical Microbiology

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Comparative Analysis of the First Complete Enterococcus faecium Genome

Margaret MC Lam, Torsten Seemann, Dieter M Bulach, Simon L Gladman, Honglei Chen, Volker Haring, Robert J Moore, Susan Ballard, M Lindsay Grayson, Paul DR Johnson, Benjamin P Howden, Timothy P Stinear

Journal article  |  2012  |  Journal of Bacteriology

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The genome, evolution and diversity of Mycobacterium ulcerans

Katharina Roeltgen, Timothy P Stinear, Gerd Pluschke

Journal article  |  2012  |  Infection Genetics and Evolution

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Reply to gould

NE Holmes, JD Turnidge, PDR Johnson, BP Howden

Journal article  |  2012  |  Journal of Infectious Diseases

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Evolution of Multidrug Resistance during Staphylococcus aureus Infection Involves Mutation of the Essential Two Component Regulator WalKR

Benjamin P Howden, Christopher RE McEvoy, David L Allen, Kyra Chua, Wei Gao, Paul F Harrison, Jan Bell, Geoffrey Coombs, Vicki Bennett-Wood, Jessica L Porter, Roy Robins-Browne, John K Davies, Torsten Seemann, Timothy P Stinear

Journal article  |  2011  |  PLoS Pathogens

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The Dominant Australian Community-Acquired Methicillin-Resistant Staphylococcus aureus Clone ST93-IV [2B] Is Highly Virulent and Genetically Distinct

Kyra YL Chua, Torsten Seemann, Paul F Harrison, Shaun Monagle, Tony M Korman, Paul DR Johnson, Geoffrey W Coombs, Brian O Howden, John K Davies, Benjamin P Howden, Timothy P Stinear

Journal article  |  2011  |  PLoS One

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Mycobacterium ulcerans DNA Not Detected in Faecal Samples from Buruli Ulcer Patients: Results of a Pilot Study

Fred S Sarfo, Caroline J Lavender, Janet AM Fyfe, Paul DR Johnson, Timothy P Stinear, Richard O Phillips

Journal article  |  2011  |  PLoS One

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Precision Medicine: Dawn of Supercomputing in ‘omics Research

M Reumann, KE Holt, M Inouye, T Stinear, B Goudey, G Abraham, Q WANG, F Shi, A Kowalczyk, A Pearce, A Isaac, BJ Pope, H Butzkueven, J Wagner, S Moore, M Downton, PC Church, SJ Turner, J Field, M Southey, et al.

Conference Proceedings  |  2011

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Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation

Sacha J Pidot, Jessica L Porter, Nicholas J Tobias, Jeffrey Anderson, Deanne Catmull, Torsten Seemann, Stephen Kidd, John K Davies, Eric Reynolds, Stuart Dashper, Timothy P Stinear

Journal article  |  2010  |  Molecular Microbiology

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Serological Evaluation of Mycobacterium ulcerans Antigens Identified by Comparative Genomics

Sacha J Pidot, Jessica L Porter, Laurent Marsollier, Annick Chauty, Florence Migot-Nabias, Cyril Badaut, Angele Benard, Marie-Therese Ruf, Torsten Seemann, Paul DR Johnson, John K Davies, Grant A Jenkin, Gerd Pluschke, Timothy P Stinear

Journal article  |  2010  |  PLoS Neglected Tropical Diseases

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Complete Genome Sequence of Staphylococcus aureus Strain JKD6008, an ST239 Clone of Methicillin-Resistant Staphylococcus aureus with Intermediate-Level Vancomycin Resistance

Benjamin P Howden, Torsten Seemann, Paul F Harrison, Chris R McEvoy, Jo-Ann L Stanton, Christy J Rand, Chris W Mason, Slade O Jensen, Neville Firth, John K Davies, Paul DR Johnson, Timothy P Stinear

Journal article  |  2010  |  Journal of Bacteriology

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A Sustained Hospital Outbreak of Vancomycin-Resistant Enterococcus faecium Bacteremia due to Emergence of vanB E. faecium Sequence Type 203

Paul DR Johnson, Susan A Ballard, Elizabeth A Grabsch, Timothy P Stinear, Torsten Seemann, Heather L Young, M Lindsay Grayson, Benjamin P Howden

Journal article  |  2010  |  Journal of Infectious Diseases

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Complete Genome Sequence of Staphylococcus aureus Strain JKD6159, a Unique Australian Clone of ST93-IV Community Methicillin-Resistant Staphylococcus aureus

Kyra Chua, Torsten Seemann, Paul F Harrison, John K Davies, Scott J Coutts, Honglei Chen, Volker Haring, Robert Moore, Benjamin P Howden, Timothy P Stinear

Journal article  |  2010  |  Journal of Bacteriology

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A Major Role for Mammals in the Ecology of Mycobacterium ulcerans

Janet AM Fyfe, Caroline J Lavender, Kathrine A Handasyde, Alistair R Legione, Carolyn R O'Brien, Timothy P Stinear, Sacha J Pidot, Torsten Seemann, M Eric Benbow, John R Wallace, Christina McCowan, Paul DR Johnson

Journal article  |  2010  |  PLoS Neglected Tropical Diseases

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Mycobacterium ulcerans and Other Mycolactone-Producing Mycobacteria Should Be Considered a Single Species

Sacha J Pidot, Kingsley Asiedu, Michael Kaeser, Janet AM Fyfe, Timothy P Stinear

Journal article  |  2010  |  PLoS Neglected Tropical Diseases

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Single Nucleotide Polymorphism Typing of Mycobacterium ulcerans Reveals Focal Transmission of Buruli Ulcer in a Highly Endemic Region of Ghana

Katharina Roeltgen, Weihong Qi, Marie-Therese Ruf, Ernestina Mensah-Quainoo, Sacha J Pidot, Torsten Seemann, Timothy P Stinear, Michael Kaeser, Dorothy Yeboah-Manu, Gerd Pluschke

Journal article  |  2010  |  PLoS Negl Trop Dis

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Two Novel Point Mutations in Clinical Staphylococcus aureus Reduce Linezolid Susceptibility and Switch on the Stringent Response to Promote Persistent Infection

Wei Gao, Kyra Chua, John K Davies, Hayley J Newton, Torsten Seemann, Paul F Harrison, Natasha E Holmes, Hyun-Woo Rhee, Jong-In Hong, Elizabeth L Hartland, Timothy P Stinear, Benjamin P Howden

Journal article  |  2010  |  PLoS Pathogens

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A diagnostic PCR assay for the detection of an Australian epidemic strain of Pseudomonas aeruginosa

Heidi L Williams, Lynne Turnbull, Susan J Thomas, Anna Murphy, Tim Stinear, David S Armstrong, Cynthia B Whitchurch

Journal article  |  2010  |  Annals of Clinical Microbiology and Antimicrobials

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Understanding Buruli Ulcer (Mycobacterium ulcerans Disease)

PDR Johnson, C Demangel, TP Stinear, ME Benbow, JA Fyfe

Book Chapter  |  2010  |  Emerging Infections

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Reduced Vancomycin Susceptibility in Staphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

Benjamin P Howden, John K Davies, Paul DR Johnson, Timothy P Stinear, M Lindsay Grayson

Journal article  |  2010  |  Clinical Microbiology Reviews

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Lack of Insertional-Deletional Polymorphism in a Collection of Mycobacterium ulcerans Isolates from Ghanaian Buruli Ulcer Patients

Michael Kaeser, Oliver Gutmann, Julia Hauser, Tim Stinear, Stewart Cole, Dorothy Yeboah-Manu, Gregor Dernick, Ulrich Certa, Gerd Pluschke

Journal article  |  2009  |  Journal of Clinical Microbiology

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Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer

Nicholas J Tobias, Torsten Seemann, Sacha J Pidot, Jessica L Porter, Laurent Marsollier, Estelle Marion, Franck Letournel, Tasnim Zakir, Joseph Azuolas, John R Wallace, Hui Hong, John K Davies, Benjamin P Howden, Paul DR Johnson, Grant A Jenkin, Timothy P Stinear

Journal article  |  2009  |  PLoS Neglected Tropical Diseases

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Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum

Jessica L Porter, Nicholas J Tobias, Hui Hong, Kellie L Tuck, Grant A Jenkin, Timothy P Stinear

Journal article  |  2009  |  Microbiology

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Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

Stephen V Gordon, Daria Bottai, Roxane Simeone, Timothy P Stinear, Roland Brosch

Journal article  |  2009  |  BioEssays

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Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

Caroline Demangel, Timothy P Stinear, Stewart T Cole

Journal article  |  2009  |  Nature Reviews Microbiology

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Effect of nebulised acetylcysteine on sputum quality and diagnostic yield

DMD Taylor, S Taylor, J Ho, M Cabalag, R Hijazi, BP Howden, PGP Charles

Journal article  |  2009  |  J. Pharm. Pract. Res.

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Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones

Sacha J Pidot, Hui Hong, Torsten Seemann, Jessica L Porter, Marcus J Yip, Artem Men, Matthew Johnson, Peter Wilson, John K Davies, Peter F Leadlay, Timothy P Stinear

Journal article  |  2008  |  BMC genomics

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Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis (vol 18, pg 729, 2008)

Timothy P Stinear, Torsten Seemann, Paul F Harrison, Grant A Jenkin, John K Davies, Paul DR Johnson, Zahra Abdellah, Claire Arrowsmith, Tracey Chillingworth, Carol Churcher, Kay Clarke, Ann Cronin, Paul Davis, Ian Goodhead, Nancy Holroyd, Kay Jagels, Angela Lord, Sharon Moule, Karen Mungall, Halina Norbertczak, et al.

Journal article  |  2008  |  Genome Research

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Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus

Benjamin P Howden, Timothy P Stinear, David L Allen, Paul DR Johnson, Peter B Ward, John K Davies

Journal article  |  2008  |  Antimicrob. Agents Chemother.

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Evaluation of VNTR typing for the identification of Mycobacterium ulcerans in environmental samples from Victoria, Australia

Caroline J Lavender, Timothy P Stinear, Paul DR Johnson, Joseph Azuolas, Mark Eric Benbow, John R Wallace, Janet AM Fyfe

Journal article  |  2008  |  FEMS Microbiology Letters

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First report of a mycolactone-producing Mycobacterium infection in fish agriculture in Belgium

Pieter Stragier, Katleen Hermans, Tim Stinear, Francoise Portaels

Journal article  |  2008  |  FEMS Microbiology Letters

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Comprehensive proteome analysis of Mycobacterium ulcerans and quantitative comparison of mycolactone biosynthesis

Petra Tafelmeyer, Christine Laurent, Pascal Lenormand, Jean-Claude Rousselle, Laurent Marsollier, Gilles Reysset, Runxuan Zhang, Albert Sickmann, Timothy P Stinear, Abdelkader Namane, Stewart T Cole

Journal article  |  2008  |  PROTEOMICS

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Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

Timothy P Stinear, Torsten Seemann, Paul F Harrison, Grant A Jenkin, John K Davies, Paul DR Johnson, Zahra Abdellah, Claire Arrowsmith, Tracey Chillingworth, Carol Churcher, Kay Clarke, Ann Cronin, Paul Davis, Ian Goodhead, Nancy Holroyd, Kay Jagels, Angela Lord, Sharon Moule, Karen Mungall, Halina Norbertczak, et al.

Journal article  |  2008  |  Genome research

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First Isolation of Mycobacterium ulcerans from an Aquatic Environment: The End of a 60-Year Search?

Tim Stinear, Paul DR Johnson

Journal article  |  2008  |  PLoS Neglected Tropical Diseases

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Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia

Benjamin P Howden, Danielle J Smith, Ashley Mansell, Paul DR Johnson, Peter B Ward, Timothy P Stinear, John K Davies

Journal article  |  2008  |  BMC Microbiol.

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Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Hui Hong, Caroline Demangel, Sacha J Pidot, Peter F Leadlay, Tim Stinear

Journal article  |  2008  |  Natural Product Reports

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The Mycolactones: Biologically Active Polyketides Produced by Mycobacterium ulcerans and Related Aquatic Mycobacteria

Timothy P Stinear, Pamela LC Small

Book Chapter  |  2008

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A novel mycolactone toxin obtained by biosynthetic engineering

Hui Hong, Tim Stinear, Jessica Porter, Caroline Demangel, Peter F Leadlay

Journal article  |  2007  |  ChemBioChem

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Mycobacterium ulcerans in mosquitoes captured during outbreak of buruli ulcer, Southeastern Australia

Paul DR Johnson, Joseph Azuolas, Caroline J Lavender, Elwyn Wishart, Timothy P Stinear, John A Hayman, Lynne Brown, Grant A Jenkin, Janet AM Fyfe

Journal article  |  2007  |  Emerging Infectious Diseases

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Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans

Michael Kaeser, Simona Rondini, Martin Naegeli, Tim Stinear, Francoise Portaels, Ulrich Certa, Gerd Pluschke

Journal article  |  2007  |  BMC Evolutionary Biology

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Development and application of two multiplex real-time PCR assays for the detection of Mycobacterium ulcerans in clinical and environmental samples

Janet AM Fyfe, Caroline J Lavender, Paul DR Johnson, Maria Globan, Aina Sievers, Joseph Azuolas, Timothy P Stinear

Journal article  |  2007  |  Applied and Environmental Microbiology

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Ongoing genome reductions in Mycobacterium ulcerans

Simona Rondini, Michael Kaser, Timothy Stinear, Michel Tessier, Cyrill Mangold, Gregor Dernick, Martin Naegeli, Francoise Portaels, Ulrich Certa, Gerd Pluschke

Journal article  |  2007  |  Emerging Infectious Diseases

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Analysis of the Mycobacterium ulcerans genome sequence reveals new loci for variable number tandem repeats (VNTR) typing

Markus Hilty, Michael Kaeser, Jakob Zinsstag, Tim Stinear, Gerd Pluschke

Journal article  |  2007  |  Microbiology

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Evolution of Mycobacterium ulcerans and other mycolactone-producing mycobacteria from a common Mycobacterium marinum progenitor

Marcus J Yip, Jessica L Porter, Janet AM Fyfe, Caroline J Lavender, Francoise Portaels, Martha Rhodes, Howard Kator, Angelo Colorni, Grant A Jenkin, Tim Stinear

Journal article  |  2007  |  Journal of Bacteriology

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Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

Timothy P Stinear, Torsten Seemann, Sacha Pidot, Wafa Frigui, Gilles Reysset, Thierry Garnier, Guillaume Meurice, David Simon, Christiane Bouchier, Laurence Ma, Magali Tichit, Jessica L Porter, Janine Ryan, Paul DR Johnson, John K Davies, Grant A Jenkin, Pamela LC Small, Louis M Jones, Fredj Tekaia, Francoise Laval, et al.

Journal article  |  2007  |  Genome research

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First case of Mycobacterium ulcerans disease (Bairnsdale or Buruli ulcer) acquired in New South Wales

Caroline J Lavender, Sanjaya N Senanayake, Janet AM Fyfe, John A Buntine, Maria Globan, Timothy P Stinear, John A Hayman, Paul DR Johnson

Journal article  |  2007  |  Medical Journal of Australia

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From marinum to ulcerans: A mycobacterial human pathogen emerges

T Stinear, PDR Johnson

Journal article  |  2007  |  Microbe Magazine

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THE MYCOBACTERIA: A POSTGENOMIC VIEW

Marien I de Jonge, Timothy P Stinear, Stewart T Cole, Roland Brosch

Book Chapter  |  2007

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Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacterernia

Benjamin P Howden, Paul DR Johnson, Peter B Ward, Timothy P Stinear, John K Davies

Journal article  |  2006  |  Antimicrob. Agents Chemother.

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Erratum: Buruli ulcer (M. ulcerans infection): New insights, new hope for disease control (PLoS Medicine 2:4 DOI: 10.1371/journal.pmed.0020108)

PDR Johnson, T Stinear, PLC Small, G Pluschke, RW Merritt, F Portaels, K Huygen, JA Hayman, K Asiedu

Journal article  |  2005  |  PLoS Medicine

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Buruli ulcer (M-ulcerans infection): New insights, new hope for disease control (vol 2, pg 282, 2005)

PDR Johnson, T Stinear, PLC Small, G Pluschke, RW Merritt, F Portaels, K Huygen, JA Hayman, K Asiedu

Journal article  |  2005  |  PLoS Medicine

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A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase

H Hong, JB Spencer, JL Porter, PF Leadlay, T Stinear

Journal article  |  2005  |  ChemBioChem

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Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans

TP Stinear, MJ Pryor, JL Porter, ST Cole

Journal article  |  2005  |  Microbiology

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Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans

TP Stinear, H Hong, W Frigui, MJ Pryor, R Brosch, T Garnier, PF Leadlay, ST Cole

Journal article  |  2005  |  Journal of Bacteriology

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Chronic falciparum malaria causing massive splenomegaly 9 years after leaving an endemic area

BP Howden, G Vaddadi, J Manitta, ML Grayson

Journal article  |  2005  |  Medical Journal of Australia

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Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry

H Hong, T Stinear, P Skelton, JB Spencer, PF Leadlay

Journal article  |  2005  |  Chemical Communications

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Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

TP Stinear, A Mve-Obiang, PLC Small, W Frigui, MJ Pryor, R Brosch, GA Jenkin, PDR Johnson, JK Davies, RE Lee, S Adusumilli, T Garnier, SF Haydock, PF Leadlay, ST Cole

Journal article  |  2004  |  Proceedings of the National Academy of Sciences

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Aquatic plants stimulate the growth of and biofilm formation by Mycobacterium ulcerans in axenic culture and harbor these bacteria in the environment

L Marsollier, T Stinear, J Aubry, JP Saint Andre, R Robert, P Legras, AL Manceau, C Audrain, S Bourdon, H Kouakou, B Carbonnelle

Journal article  |  2004  |  Applied and Environmental Microbiology

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Subtractive hybridization reveals a type I polyketide synthase locus specific to Mycobacterium ulcerans

GA Jenkin, TP Stinear, PDR Johnson, JK Davies

Journal article  |  2003  |  Journal of Bacteriology

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Mycolactones and Mycobacterium ulcerans disease

TS van der Werf, T Stinear, Y Stienstra, WTA van der Graaf, PL Small

Journal article  |  2003  |  The Lancet

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Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

H Hong, PJ Gates, J Staunton, T Stinear, ST Cole, PF Leadlay, JB Spencer

Journal article  |  2003  |  Chemical Communications

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Enterococcal vanB resistance locus in anaerobic bacteria in human faeces

TP Stinear, DC Olden, PDR Johnson, JK Davies, ML Grayson

Journal article  |  2001  |  The Lancet

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Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence

TP Stinear, GA Jenkin, PDR Johnson, JK Davies

Journal article  |  2000  |  Journal of Bacteriology

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Identification of Mycobacterium ulcerans in the environment from regions in southeast Australia in which it is endemic with sequence capture-PCR

T Stinear, JK Davies, GA Jenkin, JA Hayman, F Oppedisano, PDR Johnson

Journal article  |  2000  |  Applied and Environmental Microbiology

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A simple PCR method for rapid genotype analysis of Mycobacterium ulcerans

T Stinear, JK Davies, GA Jenkin, F Portaels, BC Ross, F Oppedisano, M Purcell, JA Hayman, PDR Johnson

Journal article  |  2000  |  Journal of Clinical Microbiology

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Mycobacterium ulcerans - a mini-review

PDR Johnson, TP Stinear, JA Hayman

Journal article  |  1999  |  Journal of Medical Microbiology

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Identification and characterization of IS2404 and IS2606: Two distinct repeated sequences for detection of Mycobacterium ulcerans by PCR

T Stinear, BC Ross, JK Davies, L Marino, RM Robins-Browne, F Oppedisano, A Sievers, PDR Johnson

Journal article  |  1999  |  Journal of Clinical Microbiology

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Sensitive and rapid detection of viable Giardia cysts and Cryptosporidium parvum oocysts in large-volume water samples with wound fiberglass cartridge filters and reverse transcription PCR (vol 64, pg 1743, 1998)

C Kaucner, T Stinear

Journal article  |  1998  |  Applied and environmental microbiology

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Sensitive and rapid detection of viable giardia cysts and Cryptosporidium parvum oocysts in large-volume water samples with wound fiberglass cartridge filters and reverse transcription-PCR

C Kaucner, T Stinear

Journal article  |  1998  |  Applied and Environmental Microbiology

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Erratum: Sensitive and rapid detection of viable Giardia cysts and Cryptosporidium parvum oocysts in large-volume water samples with wound fiberglass cartridge filters and reverse transcription-PCR (Applied and Environmental Microbiology (1998) 64:5 (1743-1749))

C Kaucner, T Stinear

Journal article  |  1998  |  Applied and Environmental Microbiology

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Detection of Mycobacterium ulcerans in environmental samples during an outbreak of ulcerative disease

BC Ross, PDR Johnson, F Oppedisano, L Marino, A Sievers, T Stinear, JA Hayman, MGK Veitch, RM RobinsBrowne

Journal article  |  1997  |  Applied and environmental microbiology

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Detection of a single viable Cryptosporidium parvum oocyst in environmental water concentrates by reverse transcription-PCR (vol 62, pg 3386, 1996)

T Stinear, A Matusan, K Hines, M Sandery

Journal article  |  1997  |  Applied and environmental microbiology

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Erratum: Detection of a single viable Cryptosporidium parvum oocyst in environmental water concentrates by reverse transcription-PCR (Applied and Environmental Microbiology 62:9 (3386))

T Stinear, A Matusan, K Hines, M Sandery

Journal article  |  1997  |  Applied and Environmental Microbiology

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Detection of a single viable Cryptosporidium parvum oocyst in environmental water concentrates by reverse transcription-PCR

T Stinear, A Matusan, K Hines, M Sandery

Journal article  |  1996  |  Applied and environmental microbiology

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Detection of pathogenic Yersinia enterocolitica in environmental waters by PCR

M Sandery, T Stinear, C Kaucner

Journal article  |  1996  |  Journal of Applied Bacteriology

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Complete microbial genomes for public health in Australia and Southwest Pacific

Sarah L Baines, Anders Gonçalves da Silva, Glen Carter, Amy V Jennison, Irani Rathnayake, Rikki M Graham, Vitali Sintchenko, Qinning Wang, Rebecca J Rockett, Verlaine J Timms, Elena Martinez, Susan Ballard, Takehiro Tomita, Nicole Isles, Kristy A Horan, William Pitchers, Timothy P Stinear, Deborah A Williamson, Benjamin P Howden, Torsten Seemann

Journal article

AbstractComplete genomes of microbial pathogens are essential for the phylogenomic analyses that increasingly underpin core public..

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Evolutionary origins of the emergent ST796 clone of vancomycin resistant Enterococcus faecium

Andrew H Buultjens, Margaret MC Lam, Susan Ballard, Ian R Monk, Andrew A Mahony, Elizabeth A Grabsch, M Lindsay Grayson, Stanley Pang, Geoffrey W Coombs, J Owen Robinson, Torsten Seemann, Paul DR Johnson, Benjamin P Howden, Timothy P Stinear

Journal article

From early 2012, a novel clone of vancomycin resistant Enterococcus faecium (assigned the multi locus sequence type ST796) was sim..

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Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)
Microbiology
Clinical Sciences
Medical Microbiology
Public Health (excl. Specific Population Health)
Expanding Knowledge
Genetics
Biochemistry and Cell Biology
Immunology
Public Health and Health Services

News

Displaying the 2 most recent news articles by Tim Stinear.

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Is this the end for alcohol handwash in hospitals?

Tim Stinear

August 1, 2018
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The science behind Victoria’s “flesh-eating bacteria”

Tim Stinear

September 22, 2017

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News Articles

Honours, Awards and Fellowships

2005

Dean's Award, Research Excellence

Monash University
2001

CSL Award, Outstanding PhD Student

Monash University
1995

Prof. Ed Westaway Award, Outstanding Honours Student

Monash University
2017

FASM - Fellow of the Australian Society of Microbiology

4

Awards

Credentials

Positions

Professorial Fellow

Microbiology And Immunology

International Member

American Society for Microbiology

Associate

Australian Society for Microbiology

Education

GRADUATE CERTIFICATE OF UNIVERSITY TEACHING

University of Melbourne

DOCTORATE OF MICROBIOLOGY

Monash University

BACHELORS OF SCIENCE HONOURS

Monash University

BACHELORS OF SCIENCE

Monash University

Links