Tim Stinear

From cloning to mutant in 5 days: rapid allelic exchange in Staphylococcus aureus

Ian R Monk, Timothy P Stinear

Journal article  |  2021  |  Access Microbiology

In the last 10 years, the barriers preventing the uptake of foreign DNA by clinical ..

Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus.

Stefano G Giulieri, Romain Guérillot, Jason C Kwong, Ian R Monk, Ashleigh S Hayes, Diane Daniel, Sarah Baines, Norelle L Sherry, Natasha E Holmes, Peter Ward, Wei Gao, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2020  |  mBio

Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of invasive methicillin-susceptible Stap..

Complete microbial genomes for public health in Australia and the Southwest Pacific.

Sarah L Baines, Anders Gonçalves da Silva, Glen P Carter, Amy Jennison, Irani Rathnayake, Rikki M Graham, Vitali Sintchenko, Qinning Wang, Rebecca J Rockett, Verlaine J Timms, Elena Martinez, Susan Ballard, Takehiro Tomita, Nicole Isles, Kristy A Horan, William Pitchers, Timothy P Stinear, Deborah A Williamson, Benjamin P Howden, Torsten Seemann, et al.

Journal article  |  2020  |  Microbial Genomics

Complete genomes of microbial pathogens are essential for the phylogenomic analyses that increasingly underpin core public health ..

Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA

Nick Neubacher, Nicholas J Tobias, Michaela Huber, Xiaofeng Cai, Timo Glatter, Sacha J Pidot, Timothy P Stinear, Anna Lena Luetticke, Kai Papenfort, Helge B Bode

Journal article  |  2020  |  Nature Microbiology

Photorhabdus and Xenorhabdus species have mutualistic associations with nematodes and an entomopathogenic stage1,2 in their life c..

Global analysis of adenylate-forming enzymes reveals beta-lactone biosynthesis pathway in pathogenic Nocardia

Serina L Robinson, Barbara R Terlouw, Megan D Smith, Sacha J Pidot, Timothy P Stinear, Marnix H Medema, Lawrence P Wackett

Journal article  |  2020  |  Journal of Biological Chemistry

Enzymes that cleave ATP to activate carboxylic acids play essential roles in primary and secondary metabolism in all domains of li..

Systematic analysis of key parameters for genomics-based real-time detection and tracking of multidrug-resistant bacteria

Claire Gorrie, Anders Goncalves Da Silva, Danielle Ingle, Charlie Higgs, Torsten Seemann, Timothy Stinear, Deborah Williamson, Jason Kwong, Lindsay Grayson, Norelle Sherry, Benjamin Howden

Journal article  |  2020

ABSTRACT Background Pairwise single nucleotide polymorphisms (SNPs) are a cornerstone for genomic approaches to multidrug-resistan..

Oak-Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins

Keishi Ishida, Gulimila Shabuer, Sebastian Schieferdecker, Sacha J Pidot, Timothy P Stinear, Uwe Knuepfer, Michael Cyrulies, Christian Hertweck

Journal article  |  2020  |  Chemistry – A European Journal

Anaerobic bacteria have only recently been recognized as a source of antibiotics; yet, the metabolic potential of Negativicutes (G..

Tracking the COVID-19 pandemic in Australia using genomics

Torsten Seemann, Courtney R Lane, Norelle L Sherry, Sebastian Duchene, Anders Goncalves da Silva, Leon Caly, Michelle Sait, Susan A Ballard, Kristy Horan, Mark B Schultz, Tuyet Hoang, Marion Easton, Sally Dougall, Timothy P Stinear, Julian Druce, Mike Catton, Brett Sutton, Annaliese van Diemen, Charles Alpren, Deborah A Williamson, et al.

Journal article  |  2020  |  Nature Communications

Genomic sequencing has significant potential to inform public health management for SARS-CoV-2. Here we report high-throughput gen..

Introduction of Mycobacterium ulcerans disease in the Bankim Health District of Cameroon follows damming of the Mape River

Koen Vandelannoote, Gerd Pluschke, Miriam Bolz, Martin W Bratschi, Sarah Kerber, Timothy P Stinear, Bouke C de Jong

Journal article  |  2020  |  PLoS Neglected Tropical Diseases

Buruli ulcer (BU) is an emerging ulcerative skin disease caused by infection with Mycobacterium ulcerans. Efforts to control its s..

Small RNA directs symbiosis, virulence, and natural products biosynthesis in entomopathogenic bacteria

Nick Neubacher, Nicholas Tobias, Michaela Huber, Xiaofeng Cai, Timo Glatter, Sacha Pidot, Timothy Stinear, Anna Lena Lütticke, Kai Papenfort, Helge Bode

Journal article  |  2020

Rapid modulation of gene expression is a key feature for the success of bacteria, particularly for those that rapidly have to adap..