Yee-Foong Mok

Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.

Ashish Sethi, Shoni Bruell, Tim Ryan, Fei Yan, Mohammad Hossein Tanipour, Yee-Foong Mok, Chris Draper-Joyce, Yogesh Khandokar, Riley D Metcalfe, Michael DW Griffin, Daniel J Scott, Mohammad Akhter Hossain, Emma J Petrie, Ross AD Bathgate, Paul R Gooley

Journal article  |  2021  |  J Mol Biol

Our poor understanding of the mechanism by which the peptide-hormone H2 relaxin activates its G protein coupled receptor, RXFP1 an..

SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization

Alexandra D Gurzau, Christopher R Horne, Yee-Foong Mok, Megan Iminitoff, Tracy A Willson, Samuel N Young, Marnie E Blewitt, James M Murphy

Journal article  |  2021  |  BIOCHEMICAL JOURNAL

Structural maintenance of chromosomes flexible hinge domain-containing 1 (SMCHD1) is an epigenetic regulator that mediates gene ex..

N- and C-terminal regions of ?B-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

Emily E Selig, Courtney O Zlatic, Dezerae Cox, Yee-Foong Mok, Paul R Gooley, Heath Ecroyd, Michael DW Griffin

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Small heat-shock proteins (sHSPs) are ubiquitously expressed molecular chaperones that inhibit amyloid fibril formation; however, ..

The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

Sunyuan Zhang, Nicholas A Williamson, Lisa Duvick, Alexander Lee, Harry T Orr, Austin Korlin-Downs, Praseuth Yang, Yee-Foong Mok, David A Jans, Marie A Bogoyevitch

Journal article  |  2020  |  Nature Communications

The expanded polyglutamine (polyQ) tract form of ataxin-1 drives disease progression in spinocerebellar ataxia type 1 (SCA1). Alth..

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G Lieu, Yee-Foong Mok, Michael DW Griffin, Naoto Ito, Toyoyuki Ose, Herve Bourhy, Gregory W Moseley, Paul R Gooley

Journal article  |  2019  |  CELL REPORTS

To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of path..

Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and alpha-ketoglutarate: implications for primary hyperoxaluria type-3

Amadeus Huang, Julia Burke, Richard D Bunker, Yee-Foong Mok, Michael D Griffin, Edward N Baker, Kerry M Loomes

Journal article  |  2019  |  BIOCHEMICAL JOURNAL

4-hydroxy-2-oxoglutarate aldolase (HOGA1) is a mitochondrial enzyme that plays a gatekeeper role in hydroxyproline metabolism. Its..

Structural elucidation of viral antagonism of innate immunity: the STAT1 interface

Gregory W Moseley, Alamgir Hossain, Florence Larrous, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Stephen M Rawlinson, Kim G Lieu, Yee-Foong Mok, Michael DW Griffin, Naoto Ito, Toyoyuki Ose, Hervé Bourhy, Paul R Gooley

Journal article  |  2019  |  Access Microbiology

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

Ryan D Mills, Lung-Yu Liang, Daisy Sio-Seng Lio, Yee-Foong Mok, Terrence D Mulhern, George Cao, Michael Griffin, Vijaya B Kenche, Janetta G Culvenor, Heung-Chin Cheng

Journal article  |  2018  |  JOURNAL OF NEUROCHEMISTRY

The Parkinson's disease (PD)-causative leucine-rich repeat kinase 2 (LRRK2) belongs to the Roco family of G-proteins comprising a ..

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Daouda AK Traore, Jessica A Wisniewski, Sarena F Flanigan, Paul J Conroy, Santosh Panjikar, Yee-Foong Mok, Carmen Lao, Michael DW Griffin, Vicki Adams, Julian I Rood, James C Whisstock

Journal article  |  2018  |  NATURE COMMUNICATIONS

Conjugation is fundamental for the acquisition of new genetic traits and the development of antibiotic resistance in pathogenic or..

Identification of a novel tetrameric structure for human apolipoprotein-D

Claudia S Kielkopf, Jason KK Low, Yee-Foong Mok, Surabhi Bhatia, Tony Palasovski, Aaron J Oakley, Andrew E Whitten, Brett Garner, Simon HJ Brown

Journal article  |  2018  |  JOURNAL OF STRUCTURAL BIOLOGY

Apolipoprotein-D is a 25 kDa glycosylated member of the lipocalin family that folds into an eight-stranded β-barrel with a single ..