Yee-Foong Mok

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G Lieu, Yee-Foong Mok, Michael DW Griffin, Naoto Ito, Toyoyuki Ose, Herve Bourhy, Gregory W Moseley, Paul R Gooley

Journal article  |  2019  |  Cell Reports

To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of path..

Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and alpha-ketoglutarate: implications for primary hyperoxaluria type-3

Amadeus Huang, Julia Burke, Richard D Bunker, Yee-Foong Mok, Michael D Griffin, Edward N Baker, Kerry M Loomes

Journal article  |  2019  |  Biochemical Journal

4-hydroxy-2-oxoglutarate aldolase (HOGA1) is a mitochondrial enzyme that plays a gatekeeper role in hydroxyproline metabolism. Its..

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

Ryan D Mills, Lung-Yu Liang, Daisy Sio-Seng Lio, Yee-Foong Mok, Terrence D Mulhern, George Cao, Michael Griffin, Vijaya B Kenche, Janetta G Culvenor, Heung-Chin Cheng

Journal article  |  2018  |  Journal of Neurochemistry

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Daouda AK Traore, Jessica A Wisniewski, Sarena F Flanigan, Paul J Conroy, Santosh Panjikar, Yee-Foong Mok, Carmen Lao, Michael DW Griffin, Vicki Adams, Julian I Rood, James C Whisstock

Journal article  |  2018  |  Nature Communications

Identification of a novel tetrameric structure for human apolipoprotein-D

Claudia S Kielkopf, Jason KK Low, Yee-Foong Mok, Surabhi Bhatia, Tony Palasovski, Aaron J Oakley, Andrew E Whitten, Brett Garner, Simon HJ Brown

Journal article  |  2018  |  Journal of Structural Biology

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

Katherine A Davies, Maria C Tanzer, Michael DW Griffin, Yee Foong Mok, Samuel N Young, Rui Qin, Emma J Petrie, Peter E Czabotar, John Silke, James M Murphy

Journal article  |  2018  |  Cell Death & Differentiation

Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils

Courtney O Zlatic, Yu Mao, Nevena Todorova, Yee-Foong Mok, Geoffrey J Howlett, Irene Yarovsky, Paul R Gooley, Michael DW Griffin

Journal article  |  2018  |  The FEBS Journal

Cryo-EM structure of an essential Plasmodium vivax invasion complex

Jakub Gruszczyk, Rick K Huang, Li-Jin Chan, Sebastien Menant, Chuan Hong, James M Murphy, Yee-Foong Mok, Michael DW Griffin, Richard D Pearson, Wilson Wong, Alan F Cowman, Zhiheng Yu, Tham Wai-Hong

Journal article  |  2018  |  Nature

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

Jakub Gruszczyk, Usheer Kanjee, Li-Jin Chan, Sebastien Menant, Benoit Malleret, Nicholas TY Lim, Christoph Q Schmidt, Yee-Foong Mok, Kai-Min Lin, Richard D Pearson, Gabriel Rangel, Brian J Smith, Melissa J Call, Michael P Weekes, Michael DW Griffin, James M Murphy, Jonathan Abraham, Kanlaya Sriprawat, Maria J Menezes, Marcelo U Ferreira, et al.

Journal article  |  2018  |  Science

Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1

Victor Muleya, Claudius Marondedze, Janet I Wheeler, Ludivine Thomas, Yee-Fong Mok, Michael DW Griffin, David T Manallack, Lusisizwe Kwezi, Kathryn S Lilley, Christoph Gehring, Helen R Irving

Journal article  |  2016  |  Biochemical Journal

Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement

Jakub Gruszczyk, Nicholas TY Lim, Alicia Arnott, Wen-Qiang He, Wang Nguitragool, Wanlapa Roobsoong, Yee-Foong Mok, James M Murphy, Katherine R Smith, Stuart Lee, Melanie Bahlo, Ivo Mueller, Alyssa E Barry, Wai-Hong Tham

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Fluphenazine center dot HCl and Epigallocatechin Gal late Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

Courtney O Zlatic, Yu Mao, Timothy M Ryan, Yee-Foong Mok, Blaine R Roberts, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2015  |  Biochemistry

A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation

Huaying Zhao, Rodolfo Ghirlando, Carlos Alfonso, Fumio Arisaka, Ilan Attali, David L Bain, Marina M Bakhtina, Donald F Becker, Gregory J Bedwell, Ahmet Bekdemir, Tabot MD Besong, Catherine Birck, Chad A Brautigam, William Brennerman, Olwyn Byron, Agnieszka Bzowska, Jonathan B Chaires, Catherine T Chaton, Helmut Coelfen, Keith D Connaghan, et al.

Journal article  |  2015  |  PLOS ONE

The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II

Timothy M Ryan, Yee-Foong Mok, Geoffrey J Howlett, Michael DW Griffin

Book Chapter  |  2015  |  Advances in Experimental Medicine and Biology

Sedimentation Velocity Analysis of the Size Distribution of Amyloid Oligomers and Fibrils

Yee-Foong Mok, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2015  |  Methods in Enzymology

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

Saskia Polling, Yee-Foong Mok, Yasmin M Ramdzan, Bradley J Turner, Justin J Yerbury, Andrew F Hill, Danny M Hatters

Journal article  |  2014  |  JOURNAL OF BIOLOGICAL CHEMISTRY

A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70

Angelique R Ormsby, Yasmin M Ramdzan, Yee-Foong Mok, Kristijan D Jovanoski, Danny M Hatters

Journal article  |  2013  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging the Morphology and Structure of Apolipoprotein Amyloid Fibrils

YF Mok, CL Teoh, GJ Howlett, MDW Griffin

Book Chapter  |  2013

Simultaneous Binding of the Anti-Cancer IgM Monoclonal Antibody PAT-SM6 to Low Density Lipoproteins and GRP78

Zachary Rosenes, Yee-Foong Mok, Shuo Yang, Michael DW Griffin, Terrence D Mulhern, Danny M Hatters, Frank Hensel, Geoffrey J Howlett

Journal article  |  2013  |  PLOS ONE

The Allosteric Mechanism Induced by Protein Kinase A (PKA) Phosphorylation of Dematin (Band 4.9)

Lin Chen, Jeffrey W Brown, Yee-Foong Mok, Danny M Hatters, C James McKnight

Journal article  |  2013  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Size analysis of polyglutamine protein aggregates using fluorescence detection in an analytical ultracentrifuge.

Saskia Polling, Danny M Hatters, Yee-Foong Mok

Journal article  |  2013  |  Methods Mol Biol

Defining the aggregation process of proteins formed by poly-amino acid repeats in cells remains a challenging task due to a lack o..

The Anti-Cancer IgM Monoclonal Antibody PAT-SM6 Binds with High Avidity to the Unfolded Protein Response Regulator GRP78

Zachary Rosenes, Terrence D Mulhern, Danny M Hatters, Leodevico L Ilag, Barbara E Power, Chris Hosking, Frank Hensel, Geoffrey J Howlett, Yee-Foong Mok

Journal article  |  2012  |  PLOS ONE

A Cyclic Peptide Inhibitor of ApoC-II Peptide Fibril Formation: Mechanistic Insight from NMR and Molecular Dynamics Analysis

Michael DW Griffin, Levi Yeung, Andrew Hung, Nevena Todorova, Yee-Foong Mok, John A Karas, Paul R Gooley, Irene Yarovsky, Geoffrey J Howlett

Journal article  |  2012  |  JOURNAL OF MOLECULAR BIOLOGY

AMP-Activated Protein Kinase beta-Subunit Requires Internal Motion for Optimal Carbohydrate Binding

Michael Bieri, Jesse I Mobbs, Ann Koay, Gavin Louey, Yee-Foong Mok, Danny M Hatters, Jong-Tae Park, Kwan-Hwa Park, Dietbert Neumann, David Stapleton, Paul R Gooley

Journal article  |  2012  |  BIOPHYSICAL JOURNAL

Sedimentation velocity analysis of amyloid oligomers and fibrils using fluorescence detection

Yee-Foong Mok, Timothy M Ryan, Shuo Yang, Danny M Hatters, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2011  |  METHODS

Sedimentation Velocity Analysis of Amyloid Fibrils

Le Lan Pham Chi, Yee-Foong Mok, Geoffrey J Howlett

Book Chapter  |  2011  |  Methods in Molecular Biology

Two molecules of lobophorolide cooperate to stabilize an actin dimer using both their "ring" and "tail" region.

J Craig Blain, Yee-Foong Mok, Julia Kubanek, John S Allingham

Journal article  |  2010  |  Chemistry & Biology

Actin filament-disrupting marine macrolides are promising templates from which to design therapeutics against cancer and other dis..

Recognition and Detoxification of the Insecticide DDT by Drosophila melanogaster Glutathione S-Transferase D1

Wai Yee Low, Susanne C Feil, Hooi Ling Ng, Michael A Gorman, Craig J Morton, James Pyke, Malcolm J McConville, Michael Bieri, Yee-Foong Mok, Charles Robin, Paul R Gooley, Michael W Parker, Philip Batterham

Journal article  |  2010  |  Journal of Molecular Biology

Structural basis for the superior activity of the large isoform of snow flea antifreeze protein.

Yee-Foong Mok, Feng-Hsu Lin, Laurie A Graham, Yeliz Celik, Ido Braslavsky, Peter L Davies

Journal article  |  2010  |  Biochemistry

The snow flea (Hypogastrum harveyi) is protected from freezing at sub-zero temperatures by a glycine-rich antifreeze protein (AFP)..

Superheating of ice crystals in antifreeze protein solutions.

Yeliz Celik, Laurie A Graham, Yee-Foong Mok, Maya Bar, Peter L Davies, Ido Braslavsky

Journal article  |  2010  |  Proceedings of the National Academy of Sciences

It has been argued that for antifreeze proteins (AFPs) to stop ice crystal growth, they must irreversibly bind to the ice surface...

Thioflavin T fluorescence in human serum: Correlations with vascular health and cardiovascular risk factors

Michael DW Griffin, Leanne M Wilson, Yee-Foong Mok, Andrzej S Januszewski, Andrew M Wilson, Connie S Karschimkus, Evange Romas, Allan B Lee, Tim Godfrey, Melinda Wong, Laurence Clemens, Alicia J Jenkins, Geoffrey J Howlett

Journal article  |  2010  |  Clinical Biochemistry

Thioflavin T fluorescence in human serum: Correlations with vascular health and cardiovascular risk factors

M GRIFFIN, L WILSON, Y MOK, A JANUSZEWSKI, A WILSON, C KARSCHIMKUS, E ROMAS, A LEE, undefined Godfrey, undefined Wong, undefined Clemens, A JENKINS, G HOWLETT

Journal article  |  2010  |  Clinical Biochemistry

A structural core within apolipoprotein C-II amyloid fibrils identified using hydrogen exchange and proteolysis

Leanne M Wilson, Yee-Foong Mok, Katrina J Binger, Michael DW Griffin, Haydyn DT Mertens, Feng Lin, John D Wade, Paul R Gooley, Geoffrey J Howlett

Journal article  |  2007  |  Journal of Molecular Biology

Sedimentation velocity analysis of amyloid oligomers and fibrils

Yee-Foong Mok, Geoffrey J Howlett

Journal article  |  2006  |  Methods in Enzymology

Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages

CR Stewart, AA Tseng, YF Mok, MK Staples, CH Schiesser, LJ Lawrence, JN Varghese, KJ Moore, GJ Howlett

Journal article  |  2005  |  Biochemistry

Non-fibrillar components of amyloid deposits mediate the self-association and tangling of amyloid fibrils

CA MacRaild, CR Stewart, YF Mok, MJ Gunzburg, MA Perugini, LJ Lawrence, V Tirtaatmadja, JJ Cooper-White, GJ Howlett

Journal article  |  2004  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking

S Akbarzadeh, H Ji, D Frecklington, N Marmy-Conus, YF Mok, L Bowes, L Devereux, M Linsenmeyer, RJ Simpson, DS Dorow

Journal article  |  2002  |  Journal of Biological Chemistry