Yee-Foong Mok

N- and C-terminal regions of ?B-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

Emily E Selig, Courtney O Zlatic, Dezerae Cox, Yee-Foong Mok, Paul R Gooley, Heath Ecroyd, Michael DW Griffin

Journal article  |  2020  |  Journal of Biological Chemistry

Small heat-shock proteins (sHSPs) are ubiquitously expressed molecular chaperones that inhibit amyloid fibril formation; however, ..

The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

Sunyuan Zhang, Nicholas A Williamson, Lisa Duvick, Alexander Lee, Harry T Orr, Austin Korlin-Downs, Praseuth Yang, Yee-Foong Mok, David A Jans, Marie A Bogoyevitch

Journal article  |  2020  |  Nature Communications

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G Lieu, Yee-Foong Mok, Michael DW Griffin, Naoto Ito, Toyoyuki Ose, Herve Bourhy, Gregory W Moseley, Paul R Gooley

Journal article  |  2019  |  Cell Reports

To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of path..

Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and alpha-ketoglutarate: implications for primary hyperoxaluria type-3

Amadeus Huang, Julia Burke, Richard D Bunker, Yee-Foong Mok, Michael D Griffin, Edward N Baker, Kerry M Loomes

Journal article  |  2019  |  Biochemical Journal

4-hydroxy-2-oxoglutarate aldolase (HOGA1) is a mitochondrial enzyme that plays a gatekeeper role in hydroxyproline metabolism. Its..

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

Ryan D Mills, Lung-Yu Liang, Daisy Sio-Seng Lio, Yee-Foong Mok, Terrence D Mulhern, George Cao, Michael Griffin, Vijaya B Kenche, Janetta G Culvenor, Heung-Chin Cheng

Journal article  |  2018  |  Journal of Neurochemistry

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Daouda AK Traore, Jessica A Wisniewski, Sarena F Flanigan, Paul J Conroy, Santosh Panjikar, Yee-Foong Mok, Carmen Lao, Michael DW Griffin, Vicki Adams, Julian I Rood, James C Whisstock

Journal article  |  2018  |  Nature Communications

Identification of a novel tetrameric structure for human apolipoprotein-D

Claudia S Kielkopf, Jason KK Low, Yee-Foong Mok, Surabhi Bhatia, Tony Palasovski, Aaron J Oakley, Andrew E Whitten, Brett Garner, Simon HJ Brown

Journal article  |  2018  |  Journal of Structural Biology

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

Katherine A Davies, Maria C Tanzer, Michael DW Griffin, Yee Foong Mok, Samuel N Young, Rui Qin, Emma J Petrie, Peter E Czabotar, John Silke, James M Murphy

Journal article  |  2018  |  Cell Death & Differentiation

Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils

Courtney O Zlatic, Yu Mao, Nevena Todorova, Yee-Foong Mok, Geoffrey J Howlett, Irene Yarovsky, Paul R Gooley, Michael DW Griffin

Journal article  |  2018  |  The FEBS Journal

Cryo-EM structure of an essential Plasmodium vivax invasion complex

Jakub Gruszczyk, Rick K Huang, Li-Jin Chan, Sebastien Menant, Chuan Hong, James M Murphy, Yee-Foong Mok, Michael DW Griffin, Richard D Pearson, Wilson Wong, Alan F Cowman, Zhiheng Yu, Tham Wai-Hong

Journal article  |  2018  |  Nature