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Understanding COVID-19 in children may provide clues to protect at-risk populations.
Displaying the 14 most recent projects by Phil Sutton.
Internal Research Grant
Displaying the 109 most recent scholarly works by Phil Sutton.
A lack of role for antibodies in regulating Helicobacter pylori colonization and associated gastritis
Umar Arshad, Sohinee Sarkar, Ghazal Alipour Talesh, Philip Sutton
Journal article | 2020 | Helicobacter
BACKGROUND: Helicobacter pylori occupy a unique niche, located within the mucus layer lining the stomach, and attached to the apic..
Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages
Poshmaal Dhar, Sohinee Sarkar, Garrett Z Ng, Paul Kalitsis, Muhammad A Saeed, Michael A McGuckin, Justine A Ellis, Philip Sutton
Journal article | 2019 | Human Immunology
Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infect..
Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations
Jon N Buzzelli, Louise O'Connor, Michelle Scurr, Sharleen Chung Nien Chin, Angelique Catubig, Garrett Z Ng, Masanobu Oshima, Hiroko Oshima, Andrew S Giraud, Philip Sutton, Louise M Judd, Trevelyan R Menheniott
Journal article | 2019 | American Journal of Physiology-Gastrointestinal and Liver Physiology
Reduced PU.1 expression underlies aberrant neutrophil maturation and function in beta-thalassemia mice and patients
Panjaree Siwaponanan, Jurre Ynze Siegers, Razi Ghazali, Thian Ng, Bradley McColl, Garrett Zhen-Wei Ng, Philip Sutton, Nancy Wang, Isabelle Ooi, Chayada Thiengtavor, Suthat Fucharoen, Pornthip Chaichompoo, Saovaros Svasti, Odilia Wijburg, Jim Vadolas
Journal article | 2017 | Blood
MUC13 protects colorectal cancer cells from death by activating the NF-kappa B pathway and is a potential therapeutic target
YH Sheng, Y He, SZ Hasnain, R Wang, H Tong, DT Clarke, R Lourie, I Oancea, KY Wong, JW Lumley, TH Florin, P Sutton, JD Hooper, NA McMillan, MA McGuckin
Journal article | 2017 | Oncogene
The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome
Garrett Z Ng, Trevelyan R Menheniott, Alison L Every, Andrew Stent, Louise M Judd, Yok Teng Chionh, Poshmaal Dhar, Jasper C Komen, Andrew S Giraud, Timothy C Wang, Michael A McGuckin, Philip Sutton
Journal article | 2016 | GUT
Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression
Trevelyan R Menheniott, Louise O'Connor, Yok Teng Chionh, Jan Daebritz, Michelle Scurr, Benjamin N Rollo, Garrett Z Ng, Shelley Jacobs, Angelique Catubig, Bayzar Kurklu, Stephen Mercer, Toshinari Minamoto, David E Ong, Richard L Ferrero, James G Fox, Timothy C Wang, Philip Sutton, Louise M Judd, Andrew S Giraud
Journal article | 2016 | JOURNAL OF CLINICAL INVESTIGATION
Heat shock protein complex vaccines induce antibodies against Neisseria meningitidis via a MyD88-independent mechanism
Jia Xi Han, Garrett Z Ng, Paola Cecchini, Yok Teng Chionh, Muhammad A Saeed, Lisbeth M Naess, Michael Joachim, Lucy E Blandford, Richard A Strugnell, Camilo A Colaco, Philip Sutton
Journal article | 2016 | VACCINE
Heat shock protein complex vaccination induces protection against Helicobacter pylori without exogenous adjuvant
Yok Teng Chionh, Arthi Arulmuruganar, Elena Venditti, Garrett Z Ng, Jia-Xi Han, Claire Entwisle, Ching-Seng Ang, Camilo A Colaco, Shaun McNulty, Philip Sutton
Journal article | 2014 | Vaccine
Genetic polymorphisms involved in the toll-like receptor signaling pathway and Helicobacter pylori-related gastric cancer: a case-control study and meta-analysis
N Castano-Rodriguez, NO Kaakoush, AL Pardo, H-MA Schmidt, DM Ha, K-L Goh, KM Fock, P Sutton, D Forman, HM Mitchell
Conference Proceedings | 2012 | Journal of Gastroenterology and Hepatology
Mouse models of Helicobacter-induced gastric cancer: use of cocarcinogens.
Richard L Ferrero, John E Wilson, Philip Sutton
Book Chapter | 2012 | Methods in Molecular Biology
The human pathogen Helicobacter pylori causes inflammation in the stomach of infected hosts, leading in some cases to the developm..
The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
Yong H Sheng, Rohan Lourie, Sara K Linden, Penny L Jeffery, Deborah Roche, Thu V Tran, Chin W Png, Nigel Waterhouse, Philip Sutton, Timothy HJ Florin, Michael A McGuckin
Journal article | 2011 | Gut
Did transmission of Helicobacter pylori from humans cause a disease outbreak in a colony of Stripe-faced Dunnarts (Sminthopsis macroura)?
Alison L Every, Lynne Selwood, Natalia Castano-Rodriguez, Wei Lu, Helen M Windsor, Janet LK Wee, Agnieszka Swierczak, Barry J Marshall, Nadeem O Kaakoush, Hazel M Mitchell, Philip Sutton
Journal article | 2011 | VETERINARY RESEARCH
Increased Helicobacter felis colonization in male 129/Sv mice fails to suppress gastritis (vol 2, pg 358, 2011)
Garrett Z Ng, Alison L Every, Michael A McGuckin, Philip Sutton
Journal article | 2011 | Gut Microbes
Development of the pathologies associated with Helicobacter pylori infection, most seriously gastric adenocarcinoma, are a consequ..
Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIX (TM) adjuvanted recombinant antigens
Ana Vujanic, Janet LK Wee, Kenneth J Snibson, Stirling Edwards, Martin Pearse, Charles Quinn, Margaret Moloney, Shirley Taylor, Jean-Pierre Y Scheerlinck, Philip Sutton
Journal article | 2010 | Vaccine
Protease-Activated Receptor-1 Down-regulates the Murine Inflammatory and Humoral Response to Helicobacter pylori
Janet LK Wee, Yok-Teng Chionh, Garrett Z Ng, Stacey N Harbour, Cody Allison, Charles N Pagel, Eleanor J Mackie, Hazel M Mitchell, Richard L Ferrero, Philip Sutton
Journal article | 2010 | Gastroenterology
Targeting of whole killed bacteria to gastrointestinal M-cells induces humoral immunity in the female reproductive tract
Yok-Teng Chionh, Philip Sutton
Journal article | 2010 | Gut Microbes
Recently, we demonstrated that oral delivery of whole killed bacteria, when agglutinated by an M-cell targeting lectin, resulted i..
Mucosal immunology down under: Special Interest Group in Mucosal Immunology workshop, Australasian Society for Immunology, Sydney, Australia, 2 December 2007.
Allan W Cripps, Philip Sutton, Ken Beagley, Sarah Robertson, Margaret Dunkley, undefined Mucosal Immunology Special Interest Group of the Australasian Society of Immunology
Conference Proceedings | 2008 | Immunology and Cell Biology
The Mucosal Immunology Special Interest Group (SIG-MI) of the Australasian Society of Immunology was formed 14 years ago and has r..
Essential role of toxin A in C. difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function.
PA Sutton, S Li, J Webb, K Solomon, J Brazier, YR Mahida
Journal article | 2008 | Clinical & Experimental Immunology
Clostridium difficile induces mucosal inflammation via secreted toxins A and B and initial interactions between the toxins and int..
Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis
Michael A Mcguckin, Alison L Every, Caroline D Skene, Sara K Linden, Yok Teng Chionh, Agnieszka Swierczak, Julie Mcauley, Stacey Harbour, Maria Kaparakis, Richard Ferrero, Philip Sutton
Journal article | 2007 | Gastroenterology
Helicobacter‐induced expression of Bcl‐XL in B lymphocytes in the mouse model: A possible step in the development of gastric mucosa‐associated lymphoid tissue (MALT) lymphoma
Andrea Morgner, Phil Sutton, Jani L O'Rourke, Angelina Enno, Michael F Dixon, Adrian Lee
Journal article | 2001 | International Journal of Cancer
The endotoxin of Helicobacter pylori is a modulator of host-dependent gastritis.
T Sakagami, J Vella, MF Dixon, J O'Rourke, F Radcliff, P Sutton, T Shimoyama, K Beagley, A Lee
Journal article | 1997 | Infection and immunity
Atrophic gastritis caused by Helicobacter pylori is the precursor lesion in the development of intestinal-type gastric adenocarcin..
Comparison of the immune response elicited by a free peptide and a lipopeptide construct.
I Ferru, C Rollin, J Estaquier, P Sutton, M Delacre, A Tartar, H Gras-Masse, C Auriault
Journal article | 1996 | Peptide Research
Among the synthetic peptides derived from the 28-kDa Schistosoma mansoni gluthatione-S-transferase (Sm28GST), the C-terminal pepti..
In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi.
P Sutton, NR Newcombe, P Waring, A Müllbacher
Journal article | 1994 | Infection and Immunity
Aspergillosis is a disease caused by the opportunistic pathogen Aspergillus fumigatus and other related fungi. It occurs mainly in..
Paediatrics Royal Children'S Hospital
Scientific Committee Member
European Study Group on Pathogenesis and Immunology in Helicobacter Infections
Doctor of Philosophy
Victoria University of Manchester