David Goldgar

Women and babies are dying from inertia: a collaborative framework for obstetrical drug development is urgently needed

Lieske H Schrijver, Antonis C Antoniou, Hakan Olsson, Thea M Mooij, Marie-Jose Roos-Blom, Leyla Azarang, Julian Adlard, Munaza Ahmed, Daniel Barrowdale, Rosemarie Davidson, Alan Donaldson, Ros Eeles, D Gareth Evans, Debra Frost, Alex Henderson, Louise Izatt, Kai-Ren Ong, Valerie Bonadona, Isabelle Coupier, Laurence Faivre, et al.

Journal article  |  2021  |  AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

BACKGROUND: Ovarian cancer risk in BRCA1 and BRCA2 mutation carriers has been shown to decrease with longer duration of oral contr..

Comparing 5-Year and Lifetime Risks of Breast Cancer using the Prospective Family Study Cohort

Robert J MacInnis, Julia A Knight, Wendy K Chung, Roger L Milne, Alice S Whittemore, Richard Buchsbaum, Yuyan Liao, Nur Zeinomar, Gillian S Dite, Melissa C Southey, David Goldgar, Graham G Giles, Allison W Kurian, KConFab Investigators, Irene L Andrulis, Esther M John, Mary B Daly, Saundra S Buys, Kelly-Anne Phillips, John L Hopper, et al.

Journal article  |  2021  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: Clinical guidelines often use predicted lifetime risk from birth to define criteria for making decisions regarding bre..

Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Daniel R Barnes, Matti A Rookus, Lesley McGuffog, Goska Leslie, Thea M Mooij, Joe Dennis, Nasim Mavaddat, Julian Adlard, Munaza Ahmed, Kristiina Aittomaki, Nadine Andrieu, Irene L Andrulis, Norbert Arnold, Banu K Arun, Jacopo Azzollini, Judith Balmana, Rosa B Barkardottir, Daniel Barrowdale, Javier Benitez, Pascaline Berthet, et al.

Journal article  |  2020  |  GENETICS IN MEDICINE

PURPOSE: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian c..

Considerations When Using Breast Cancer Risk Models for Women with Negative BRCA1/BRCA2 Mutation Results

Robert J MacInnis, Yuyan Liao, Julia A Knight, Roger L Milne, Alice S Whittemore, Wendy K Chung, Nicole Leoce, Richard Buchsbaum, Nur Zeinomar, Gillian S Dite, Melissa C Southey, David Goldgar, Graham G Giles, Sue-Anne McLachlan, Prue C Weideman, Stephanie Nesci, Michael L Friedlander, Gord Glendon, Irene L Andrulis, Esther M John, et al.

Journal article  |  2020  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

The performance of breast cancer risk models for women with a family history but negative BRCA1 and/or BRCA2 mutation test results..

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Zomoroda Abu-full, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Adalgeir Arason, Volker Arndt, Kristan J Aronson, Banu K Arun, Ella Asseryanis, Paul L Auer, Jacopo Azzollini, Judith Balmana, Rosa B Barkardottir, Daniel R Barnes, et al.

Journal article  |  2020  |  GENETIC EPIDEMIOLOGY

Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expressio..

Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

Vivek L Patel, Evan L Busch, Tara M Friebel, Angel Cronin, Goska Leslie, Lesley McGuffog, Julian Adlard, Simona Agata, Bjarni A Agnarsson, Munaza Ahmed, Kristiina Aittomaki, Elisa Alducci, Irene L Andrulis, Adalgeir Arason, Norbert Arnold, Grazia Artioli, Brita Arver, Bernd Auber, Jacopo Azzollini, Judith Balmana, et al.

Journal article  |  2020  |  CANCER RESEARCH

Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer...

Alcohol Consumption, Cigarette Smoking, and Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Results from The BRCA1 and BRCA2 Cohort Consortium

Hongyan Li, Mary Beth Terry, Antonis C Antoniou, Kelly-Anne Phillips, Karin Kast, Thea M Mooij, Christoph Engel, Catherine Nogues, Dominique Stoppa-Lyonnet, Christine Lasset, Pascaline Berthet, Veronique Mari, Olivier Caron, Daniel Barrowdale, Debra Frost, Carole Brewer, D Gareth Evans, Louise Izatt, Lucy Side, Lisa Walker, et al.

Journal article  |  2020  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effect..

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

Maria Escala-Garcia, Jean Abraham, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L Auer, Paivi Auvinen, Matthias W Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Borresen-Dale, Hiltrud Brauch, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-base..

Two truncating variants in FANCC and breast cancer risk

Thilo Dork, Paolo Peterlongo, Arto Mannermaa, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Laura E Beane Freeman, Matthias W Beckmann, Alicia Beeghly-Fadiel, Sabine Behrens, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E Bojesen, et al.

Journal article  |  2019  |  SCIENTIFIC REPORTS

Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, mono..

10-year performance of four models of breast cancer risk:a validation study

Mary Beth Terry, Yuyan Liao, Alice S Whittemore, Nicole Leoce, Richard Buchsbaum, Nur Zeinotnar, Gillian S Dite, Wendy K Chung, Julia A Knight, Melissa C Southey, Roger L Milne, David Goldgar, Graham G Giles, Sue-Anne McLachlan, Michael L Friedlander, Prue C Weideman, Gord Glendon, Stephanie Nesci, Irene L Andrulis, Esther M John, et al.

Journal article  |  2019  |  LANCET ONCOLOGY

BACKGROUND: Independent validation is essential to justify use of models of breast cancer risk prediction and inform decisions abo..