Jennifer Stone

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L Hopper, Melissa C Southey, Tu Nguyen-Dumont, Tuong L Nguyen, Peter A Fasching, Annika Behrens, Gemma Cadby, et al.

Journal article  |  2022  |  BREAST CANCER RESEARCH

BACKGROUND: Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dens..

Assessment of repeated reference measurements to inform the validity of optical breast spectroscopy

Rachel Lloyd, Jane Walter, Sarah Pirikahu, Gemma Cadby, Martha Hickey, David D Sampson, Karol Karnowski, Michael J Hackmann, Christobel Saunders, Lothar Lilge, Jennifer Stone

Journal article  |  2022  |  REVIEW OF SCIENTIFIC INSTRUMENTS

Mammographic breast density is a strong breast cancer risk factor, and its routine clinical measurement could potentially be used ..

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Anna Morra, Maria Escala-Garcia, Jonathan Beesley, Renske Keeman, Sander Canisius, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Paul L Auer, Annelie Augustinsson, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Stig E Bojesen, Manjeet K Bolla, Hermann Brenner, Thomas Bruening, Saundra S Buys, et al.

Journal article  |  2021  |  BREAST CANCER RESEARCH

BACKGROUND: Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival t..

Is Mammographic Breast Density an Endophenotype for Breast Cancer?

Ellie Darcey, Nina McCarthy, Eric K Moses, Christobel Saunders, Gemma Cadby, Jennifer Stone

Journal article  |  2021  |  CANCERS

Mammographic breast density (MBD) is a strong and highly heritable predictor of breast cancer risk and a biomarker for the disease..

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Joseph S Baxter, Nichola Johnson, Katarzyna Tomczyk, Andrea Gillespie, Sarah Maguire, Rachel Brough, Laura Fachal, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, et al.

Journal article  |  2021  |  AMERICAN JOURNAL OF HUMAN GENETICS

A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine..

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (vol 12, 1078, 2021)

Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, Muriel A Adank, Simona Agata, Thomas Ahearn, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Norbert Arnold, Kristan J Aronson, Banu K Arun, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants hav..

Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk

Pooja Middha Kapoor, Nasim Mavaddat, Parichoy Pal Choudhury, Amber N Wilcox, Sara Lindstrom, Sabine Behrens, Kyriaki Michailidou, Joe Dennis, Manjeet K Bolla, Qin Wang, Audrey Jung, Zomoroda Abu-Ful, Thomas Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Laura E Beane Freeman, Heiko Becher, et al.

Journal article  |  2021  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for ..

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson, Sarah Maguire, Anna Morra, Pooja Middha Kapoor, Katarzyna Tomczyk, Michael E Jones, Minouk J Schoemaker, Clare Gilham, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Caroline Baynes, Laura E Beane Freeman, et al.

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cance..

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  AMERICAN JOURNAL OF HUMAN GENETICS

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

Post-mammographic screening behaviour: A survey investigating what women do after being told they have dense breasts

Ellie Darcey, Emma Jane Hunt, Louise Keogh, Kirsty McLean, Christobel Saunders, Sandra Thompson, Catherine Woulfe, Elizabeth Wylie, Jennifer Stone

Journal article  |  2020  |  HEALTH PROMOTION JOURNAL OF AUSTRALIA

ISSUE ADDRESSED: Despite widespread calls for women undergoing mammographic screening to be informed of their breast density, conc..