Christopher MacIsaac

Venous thromboembolism prophylaxis and related outcomes in patients with traumatic brain injury and prolonged intensive care unit stay

Seunga Park, Stefanie Kalfas, Timothy N Fazio, Ary Serpa Neto, Christopher Macisaac, David J Read, Katharine J Drummond, Rinaldo Bellomo

Journal article  |  2021  |  CRITICAL CARE AND RESUSCITATION

Objective: Traumatic brain injury (TBI) patients with prolonged intensive care unit (ICU) stay are at risk of secondary intracrani..

Assessment of muscle mass using ultrasound with minimal versus maximal pressure compared with computed tomography in critically ill adult patients

Kate Fetterplace, Lucy Corlette, Yasmine Ali Abdelhamid, Jeffrey J Presneill, Michael T Paris, Damien Stella, Marina Mourtzakis, Christopher MacIsaac, Adam M Deane

Journal article  |  2021  |  AUSTRALIAN CRITICAL CARE

BACKGROUND: Preserved skeletal muscle mass identified using computed tomography (CT) predicts improved outcomes from critical illn..

A microcosting analysis of ICU expenditure in the interval between brain death and organ donation

Meghan K Bowtell, Melissa J Ankravs, Timothy Fazio, Jeffrey J Presneill, Christopher MacIsaac, Michelle Spence, Linda Bennet, Mark P Plummer, Yasmine Ali Abdelhamid, Adam M Deane

Journal article  |  2021  |  CRITICAL CARE AND RESUSCITATION

Objective: The cost of providing care in an intensive care unit (ICU) after brain death to facilitate organ donation is unknown. T..

Knowledge, attitudes and practices of healthcare workers within an Australian tertiary hospital to managing high-consequence infectious diseases

Jesse J Fryk, Steven Tong, Caroline Marshall, Arjun Rajkhowa, Kirsty Buising, Christopher MacIsaac, Nicola Walsham, Irani Thevarajan

Journal article  |  2021  |  INFECTION DISEASE & HEALTH

BACKGROUND: Adequate preparation and support for healthcare workers (HCWs) managing high-consequence infectious diseases (HCIDs) i..

Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial

Barry Dixon, Roger J Smith, Duncan J Campbell, John L Moran, Gordon S Doig, Thomas Rechnitzer, Christopher M MacIsaac, Nicholas Simpson, Frank MP van Haren, Angajendra N Ghosh, Sachin Gupta, Emma JC Broadfield, Timothy ME Crozier, Craig French, John D Santamaria

Journal article  |  2021  |  LANCET RESPIRATORY MEDICINE

BACKGROUND: Mechanical ventilation in intensive care for 48 h or longer is associated with the acute respiratory distress syndrome..

Urinary and renal oxygenation during dexmedetomidine infusion in critically ill adults with mechanistic insights from an ovine model

Mark P Plummer, Yugeesh R Lankadeva, Mark E Finnis, Anatole Harrois, Charlie Harding, Rachel M Peiris, Nobuki Okazaki, Clive N May, Roger G Evans, Christopher M Macisaac, Deborah Barge, Rinaldo Bellomo, Adam M Deane

Journal article  |  2021  |  JOURNAL OF CRITICAL CARE

PURPOSE: Examine effects of dexmedetomidine on bladder urinary oxygen tension (PuO2) in critically ill patients and delineate mech..

Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial

Yahya Shehabi, Ary Serpa Neto, Belinda D Howe, Rinaldo Bellomo, Yaseen M Arabi, Michael Bailey, Frances E Bass, Suhaini Bin Kadiman, Colin J McArthur, Michael C Reade, Ian M Seppelt, Jukka Takala, Matt P Wise, Steve A Webb

Journal article  |  2021  |  INTENSIVE CARE MEDICINE

PURPOSE: To quantify potential heterogeneity of treatment effect (HTE), of early sedation with dexmedetomidine (DEX) compared with..

A hospital-wide response to multiple outbreaks of COVID-19 in health care workers: lessons learned from the field

Kirsty L Buising, Deborah Williamson, Benjamin C Cowie, Jennifer MacLachlan, Elizabeth Orr, Christopher MacIsaac, Eloise Williams, Katherine Bond, Stephen Muhi, James McCarthy, Andrea B Maier, Louis Irving, Denise Heinjus, Cate Kelly, Caroline Marshall

Journal article  |  2021  |  MEDICAL JOURNAL OF AUSTRALIA

Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience

Thomas J Oxley, Peter E Yoo, Gil S Rind, Stephen M Ronayne, CM Sarah Lee, Christin Bird, Victoria Hampshire, Rahul P Sharma, Andrew Morokoff, Daryl L Williams, Christopher MacIsaac, Mark E Howard, Lou Irving, Ivan Vrljic, Cameron Williams, Sam E John, Frank Weissenborn, Madeleine Dazenko, Anna H Balabanski, David Friedenberg, et al.

Journal article  |  2021  |  JOURNAL OF NEUROINTERVENTIONAL SURGERY

BACKGROUND: Implantable brain-computer interfaces (BCIs), functioning as motor neuroprostheses, have the potential to restore volu..

Time to antimicrobial therapy in septic shock patients treated with an early goal-directed resuscitation protocol: A post-hoc analysis of the ARISE trial

Esther B Bulle, Sandra L Peake, Mark Finnis, Rinaldo Bellomo, Anthony Delaney

Journal article  |  2020  |  EMERGENCY MEDICINE AUSTRALASIA

Objective: Intravenous antimicrobial therapy within 1 h of the diagnosis of septic shock is recommended in international sepsis gu..