Wah Chin Boon

Mapping Motor Neuron Vulnerability in the Neuraxis of Male SOD1(G93A) Mice Reveals Widespread Loss of Androgen Receptor Occurring Early in Spinal Motor Neurons

Victoria M McLeod, Mathew DF Chiam, Nirma D Perera, Chew L Lau, Wah Chin Boon, Bradley J Turner

Journal article  |  2022  |  FRONTIERS IN ENDOCRINOLOGY

Sex steroid hormones have been implicated as disease modifiers in the neurodegenerative disorder amyotrophic lateral sclerosis (AL..

Fatty acids and beyond: Age and Alzheimer's disease related changes in lipids reveal the neuro-nutraceutical potential of lipids in cognition

Kei-Lin Murata Ooi, Kristina Vacy, Wah Chin Boon

Journal article  |  2021  |  NEUROCHEMISTRY INTERNATIONAL

Lipids are essential in maintaining brain function, and lipid profiles have been reported to be altered in aged and Alzheimer's di..

Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis

Doris Tomas, Victoria M McLeod, Mathew DF Chiam, Nayomi Wanniarachchillage, Wah C Boon, Bradley J Turner

Journal article  |  2021  |  SCIENTIFIC REPORTS

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder caused by loss of motor neurons. ALS incidence is..

Dysregulation of Steroid Hormone Receptors in Motor Neurons and Glia Associates with Disease Progression in ALS Mice

Victoria M McLeod, Mathew DF Chiam, Chew L Lau, Thusitha W Rupasinghe, Wah C Boon, Bradley J Turner

Journal article  |  2020  |  ENDOCRINOLOGY

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting motor neurons which shows sexual dimorphism in its in..

A novel mass spectrometric methodology facilitates quantification of testosterone and progesterone, but not estrogens in cardiac and adipose tissues

Gabriel B Bernasochi, Thusitha TW Rupasinghe, James R Bell, Ute Roessner, Wah Chin Boon, Lea MD Delbridge

Conference Proceedings  |  2020  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Victoria M McLeod, Chew L Lau, Mathew DF Chiam, Thusitha W Rupasinghe, Ute Roessner, Elvan Djouma, Wah C Boon, Bradley J Turner

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease typically more common in males, i..

Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial-Astrocytic Crosstalk

David PQ Clark, Victoria M Perreau, Sandy R Shultz, Rhys D Brady, Enie Lei, Shilpi Dixit, Juliet M Taylor, Philip M Beart, Wah Chin Boon

Journal article  |  2019  |  NEUROCHEMICAL RESEARCH

Traumatic brain injury triggers neuroinflammation that may contribute to progressive neurodegeneration. We investigated patterns o..

Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots

Gabriel B Bernasochi, James R Bell, Evan R Simpson, Lea MD Delbridge, Wah Chin Boon

Journal article  |  2019  |  COMPREHENSIVE PHYSIOLOGY

As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) ..

The myocardium and sex steroid hormone influences

Gabriel B Bernasochi, Wah Chin Boon, Lea Md Delbridge, James R Bell

Journal article  |  2018  |  CURRENT OPINION IN PHYSIOLOGY

Extensive evidence of sex steroid hormone influence on cardiac function and cardiopathology has been observed in both clinical and..

Synthesis of (E)-10-hydroxy-2-decenoic acid ethyl ester via a one-pot tandem oxidation-Wittig process

Jacob T Heppell, Wah Chin Boon, Jasim MA Al-Rawi

Journal article  |  2018  |  ORGANIC COMMUNICATIONS

The synthesis of (E)-10-hydroxy-2-decenoic acid ethyl ester (10H2DA-EE) (3) was achieved via a one-pot, tandem oxidation-Wittig pr..