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Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial-Astro..
Displaying the 3 most recent projects by Wah Chin Boon.
Internal Research Grant
Displaying the 56 most recent scholarly works by Wah Chin Boon.
Androgen receptor antagonism accelerates disease onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis
Victoria M McLeod, Chew L Lau, Mathew DF Chiam, Thusitha W Rupasinghe, Ute Roessner, Elvan Djouma, Wah C Boon, Bradley J Turner
Journal article | 2019 | British Journal of Pharmacology
Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?
Gabriel B Bernasochi, Wah Chin Boon, Claire L Curl, Upasna Varma, Salvatore Pepe, Marianne Tare, Laura J Parry, Evdokia Dimitriadis, Stephen B Harrap, Chrishan J Nalliah, Jonathan M Kalman, Lea MD Delbridge, James R Bell
Journal article | 2017 | Journal of Molecular and Cellular Cardiology
Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice
Michelle Van Sinderen, Gregory Steinberg, Sebastian B Jorgensen, Jane Honeyman, Jenny DY Chow, Evan R Simpson, Margaret EE Jones, Wah Chin Boon
Journal article | 2017 | The Journal of Steroid Biochemistry and Molecular Biology
SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24( ) CD49f(hi) Mammary Stem Cell-Enriched Compartment
Genevieve V Dall, Jessica L Vieusseux, Kenneth S Korach, Yukitomo Arao, Sylvia C Hewitt, Katherine J Hamilton, Elaine Dzierzak, Wah Chin Boon, Evan R Simpson, Robert G Ramsay, Torsten Stein, Joanne S Morris, Robin L Anderson, Gail P Risbridger, Kara L Britt
Journal article | 2017 | Stem Cell Reports
Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice
Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jorgensen, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Amy L Winship, Evdokia Dimitriadis, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
Journal article | 2015 | PLOS ONE
Myocardial and Cardiomyocyte Stress Resilience Is Enhanced in Aromatase-Deficient Female Mouse Hearts Through CaMKII delta Activation
James R Bell, Gabriel B Bernasochi, Amanda C Wollermann, Antonia JA Raaijmakers, Wah Chin Boon, Evan R Simpson, Claire L Curl, Kimberley M Mellor, Lea MD Delbridge
Journal article | 2015 | Endocrinology
Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice
James R Bell, Gabriel B Bernasochi, Upasna Varma, Wah Chin Boon, Stuart J Ellem, Gail P Risbridger, Lea MD Delbridge
Journal article | 2014 | American Journal of Physiology - Heart and Circulatory Physiology
Characterization of Aromatase Expression in the Adult Male and Female Mouse Brain. I. Coexistence with Oestrogen Receptors alpha and beta, and Androgen Receptors
Davor Stanic, Sydney Dubois, Hui Kheng Chua, Bruce Tonge, Nicole Rinehart, Malcolm K Horne, Wah Chin Boon
Journal article | 2014 | PLOS ONE
Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jorgensen, Sarah Q To, Kevin C Knower, Colin D Clyne, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
Journal article | 2014 | PLoS One
The Aromatase Gene CYP19A1: Several Genetic and Functional Lines of Evidence Supporting a Role in Reading, Speech and Language
Heidi Anthoni, Lara E Sucheston, Barbara A Lewis, Isabel Tapia-Paez, Xiaotang Fan, Marco Zucchelli, Mikko Taipale, Catherine M Stein, Marie-Estelle Hokkanen, Eero Castren, Bruce F Pennington, Shelley D Smith, Richard K Olson, J Bruce Tomblin, Gerd Schulte-Koerne, Markus Noethen, Johannes Schumacher, Bertram Mueller-Myhsok, Per Hoffmann, Jeffrey W Gilger, et al.
Journal article | 2012 | Behavior Genetics
Relaxin and Castration in Male Mice Protect from, but Testosterone Exacerbates, Age-Related Cardiac and Renal Fibrosis, Whereas Estrogens Are an Independent Determinant of Organ Size
Tim D Hewitson, Chongxin Zhao, Belinda Wigg, Sin Wai Lee, Evan R Simpson, Wah Chin Boon, Chrishan S Samuel
Journal article | 2012 | Endocrinology
Increasing cDNA Yields from Single-cell Quantities of mRNA in Standard Laboratory Reverse Transcriptase Reactions using Acoustic Microstreaming
Wah Chin Boon, Karolina Petkovic-Duran, Yonggang Zhu, Richard Manasseh, Malcolm K Horne, Tim D Aumann
Journal article | 2011 | Journal of Visualized Experiments
Acoustic microstreaming increases the efficiency of reverse transcription reactions comprising single-cell quantities of RNA
Wah Chin Boon, Karolina Petkovic-Duran, Kylie White, Elena Tucker, Anthony Albiston, Richard Manasseh, Malcolm Kenneth Horne, Tim Douglas Aumann
Journal article | 2011 | Biotechniques
Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons
Tim D Aumann, Kate Egan, Jamie Lim, Wah C Boon, Chris R Bye, Hui K Chua, Natalija Baban, Clare L Parish, Larisa Bobrovskaya, Phillip Dickson, Malcolm K Horne
Journal article | 2011 | Journal of Neurochemistry
Alternative 5'-untranslated first exons of the mouse Cyp19A1 (aromatase) gene.
Jenny DY Chow, Evan R Simpson, Wah Chin Boon
Journal article | 2009 | The Journal of Steroid Biochemistry and Molecular Biology
The human aromatase gene (CYP19A1) has eleven tissue-specific untranslated first exons, while only three have been described in th..
Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively
Rachel A Hill, Jenny Chow, Karlheinrich Fritzemeier, Evan R Simpson, Wah Chin Boon
Journal article | 2007 | MOLECULAR AND CELLULAR NEUROSCIENCE
Differential expression of factors involved in fat metabolism with age and the menopause transition.
Marie L Misso, Christina Jang, Jennifer Adams, Jane Tran, Yoko Murata, Robin Bell, Wah Chin Boon, Evan R Simpson, Susan R Davis
Journal article | 2005 | Maturitas
OBJECTIVES: Changes in the hormonal milieu at the menopause are associated with an increase in total adiposity and a more android ..
Cholesterol feeding prevents adiposity in the obese female aromatase knockout (ArKO) mouse.
ML Misso, KN Hewitt, WC Boon, Y Murata, MEE Jones, ER Simpson
Journal article | 2005 | Hormone and Metabolic Research
The aromatase (ArKO) knockout mouse develops obesity marked by increased gonadal fat depots. This obesity is characterized by pron..
The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis.
Kylie N Hewitt, Wah Chin Boon, Yoko Murata, Margaret EE Jones, Evan R Simpson
Journal article | 2003 | Endocrinology
The aromatase knockout (ArKO) mouse cannot synthesize endogenous estrogens due to disruption of the Cyp19 gene. We have shown prev..
Orexin-A augments voltage-gated Ca2 currents and synergistically increases growth hormone (GH) secretion with GH-releasing hormone in primary cultured ovine somatotropes.
Ruwei Xu, Qinling Wang, Ming Yan, Maria Hernandez, Changhong Gong, Wah Chin Boon, Yoko Murata, Yoichi Ueta, Chen Chen
Journal article | 2002 | Endocrinology
Orexins are recently discovered neuropeptides that play an important role in the regulation of hormone secretion, and their recept..
Aldosterone secretion by the mid-gestation ovine fetus: role of the AT2 receptor.
KM Moritz, WC Boon, EM Wintour
Journal article | 1999 | Molecular and Cellular Endocrinology
This study shows a short-term (3 h) infusion of ACTH but not angiotensin II (Ang II) stimulates aldosterone production in the mid-..
Hypothesis: aldosterone is synthesized by an alternative pathway during severe sodium depletion. 'A new wine in an old bottle'.
WC Boon, JG McDougall, JP Coghlan
Journal article | 1998 | Clinical and Experimental Pharmacology and Physiology
1. The last three steps of aldosterone biosynthesis, 11 beta-hydroxylation, 18-hydroxylation and 18-oxidation, have been demonstra..
Functional and expression analysis of ovine steroid 11 beta-hydroxylase (cytochrome P450 11 beta).
WC Boon, PJ Roche, A Butkus, JG McDougall, K Jeyaseelan, JP Coghlan
Journal article | 1997 | Endocrine Research
In this study, the ovine steroid 11 beta-hydroxylase (P450(11 beta) or CYP11B) cDNA previously reported by us (1) was transfected ..
Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep.
WC Boon, PJ Roche, VE Hammond, K Jeyaseelan, RJ Crawford, JP Coghlan
Journal article | 1995 | Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
A full length ovine steroid 11 beta-hydroxylase (cytochrome P-450(11 beta)) cDNA clone from a sheep adrenal cortex cDNA library wa..
Florey Department Of Neuroscience And Mental Health
National University of Singapore