Michele Clarke

Calcitonin paracrine signaling controls heart fibrogenesis and arrhythmia

Lucia Moreira, Abhijit Takawale, David A Menassa, Constantinos Psarros, Neelam Mehta, Neil Evans, Marc-Antoine Gillis, Angela Lee, Patrice Naud, Mary Norris, Michele V Clarke, Patricia K Russell, Barbara Casadei, Shoumo Bhattacharya, Jeffrey D Zajac, Rachel A Davey, Martin Sirois, Rana Sayeed, George Krasopoulos, Charles Redwood, et al.

Journal article  |  2022  |  Journal of Molecular and Cellular Cardiology

The AR in bone marrow progenitor cells protects against short-term high-caloric diet-induced weight gain in male mice

Varun S Venkatesh, Patricia K Russell, Barbara Fam White, Michele Clarke, Suzanne Golub, Salvatore Mangiofico, Christian Haralambous, Julie Lokan, Sof Andrikopoulos, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2022  |  JOURNAL OF MOLECULAR ENDOCRINOLOGY

We previously identified a novel pathway of testosterone action via the androgen receptor (AR) in bone marrow mesenchymal precurso..

Functional MRI in assessment of diabetic kidney disease in people with type 1 diabetes

Jas-mine Seah, Elissa Botterill, Richard J MacIsaac, Michele Milne, Elif Ekinci, Ruth P Lim

Journal article  |  2021  |  JOURNAL OF DIABETES AND ITS COMPLICATIONS

AIMS: To compare levels of renal hypoxia measured by Blood Oxygen Level Dependent (BOLD) magnetic resonance imaging (MRI) with mea..

Changes in white adipose tissue gene expression in a randomized control trial of dieting obese men with lowered serum testosterone alone or in combination with testosterone treatment

Mathis Grossmann, Mark Ng Tang Fui, Tian Nie, Rudolf Hoermann, Michele V Clarke, Ada S Cheung, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2021  |  ENDOCRINE

PURPOSE: The aim of this study was to determine early weight loss-associated changes in subcutaneous abdominal white adipose tissu..

The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice

Rachel A Davey, Michele Clarke, Suzanne B Golub, Patricia K Russell, Jeffrey D Zajac

Journal article  |  2021  |  JOURNAL OF ENDOCRINOLOGY

The physiological role of calcitonin, and its receptor, the CTR (or Calcr), has long been debated. We previously provided the firs..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Vitamin D receptor expression in mature osteoclasts reduces bone loss due to low dietary calcium intake in male mice

Yolandi Starczak, Daniel C Reinke, Kate R Barratt, Patricia K Russell, Michelle Clarke, Rachel A Davey, Gerald J Atkins, Paul H Anderson

Journal article  |  2021  |  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mature osteoclasts express the vitamin D receptor (VDR) and are able to respond to active vitamin D (1α, 25-dihydroxyvitamin D3; 1..

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

Lucia M Moreira, Abhijit Takawale, Mohit Hulsurkar, David A Menassa, Agne Antanaviciute, Satadru K Lahiri, Neelam Mehta, Neil Evans, Constantinos Psarros, Paul Robinson, Alexander J Sparrow, Marc-Antoine Gillis, Neil Ashley, Patrice Naud, Javier Barallobre-Barreiro, Konstantinos Theofilatos, Angela Lee, Mary Norris, Michele V Clarke, Patricia K Russell, et al.

Journal article  |  2020  |  NATURE

Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly ..

Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility

Sih Min Tan, Mark Ziemann, Vicki Thallas-Bonke, Matthew Snelson, Vinod Kumar, Adrienne Laskowski, Tuong-Vi Nguyen, Kevin Huynh, Michele V Clarke, Renata Libianto, Scott T Baker, Alison Skene, David A Power, Richard J MacIsaac, Darren C Henstridge, Rick A Wetsel, Assam El-Osta, Peter J Meikle, Scott G Wilson, Josephine M Forbes, et al.

Journal article  |  2020  |  DIABETES

The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediate..

Changes in soluble tumor necrosis factor receptor type 1 levels and early renal function decline in patients with diabetes

Richard J MacIsaac, Matthew Farag, Varuni Obeyesekere, Michele Clarke, Ray Boston, Glenn M Ward, George Jerums, Elif Ekinci

Journal article  |  2019  |  JOURNAL OF DIABETES INVESTIGATION

The relationship between serial changes in soluble tumor necrosis factor receptor type 1 (TNFR1) levels and an early decline in es..