Christine Keenan

Identification and characterization of the long noncoding RNA Dreg1 as a novel regulator of Gata3

Wing Fuk Chan, Hannah D Coughlan, Nadia Iannarella, Gordon K Smyth, Timothy M Johanson, Christine R Keenan, Rhys S Allan

Journal article  |  2020  |  Immunology & Cell Biology

The eukaryotic genome is three-dimensionally segregated into discrete globules of topologically associating domains (TADs), within..

Chromosomes distribute randomly to, but not within, human neutrophil nuclear lobes

Christine Keenan, Michael Mlodzianoski, Hannah Coughlan, Naiara Bediaga, Gaetano Naselli, Erin Lucas, Qike Wang, Carolyn de Graaf, Douglas Hilton, Leonard Harrison, Gordon Smyth, Kelly Rogers, Thomas Boudier, Rhys Allan, Timothy Johanson

Journal article  |  2020

The proximity pattern and radial distribution of chromosome territories within spherical nuclei are well understood to be random a..

Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription

Christine Keenan, Hannah Coughlan, Nadia Iannarella, Timothy Johanson, Wing Fuk Chan, Alexandra Garnham, Gordon Smyth, Rhys Allan

Journal article  |  2020

Summary H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key ro..

EZH2 function in immune cell development

Stephen L Nutt, Christine Keenan, Michael Chopin, Rhys S Allan

Journal article  |  2020  |  Biological Chemistry

The polycomb repressive complex 2 (PRC2) consists of three core components EZH2, SUZ12 and EED. EZH2 catalyzes the methylation of ..

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging

Christine R Keenan, Nadia Iannarella, Gaetano Naselli, Naiara G Bediaga, Timothy M Johanson, Leonard C Harrison, Rhys S Allan

Journal article  |  2020  |  Blood

Abstract Loss of heterochromatin has been proposed as a universal mechanism of aging across different species and c..

Genome reconfiguration prior to mitosis shapes the generation of adaptive immunity

Wing Fuk Chan, Hannah Coughlan, Jie HS Zhou, Christine Keenan, Naiara Bediaga, Phillip Hodgkin, Gordon Smyth, Timothy Johanson, Rhys Allan

Journal article  |  2019

Abstract During cellular differentiation chromosome conformation is altered to support the lineage-specific transcriptional progra..

Genome organization in immune cells: unique challenges

Timothy M Johanson, Wing Fuk Chan, Christine R Keenan, Rhys S Allan

Journal article  |  2019  |  Nature Reviews Immunology

Polycomb repressive complex 2 is a critics mediator of allergic inflammation

Christine R Keenan, Nadia Iannarella, Alexandra L Garnham, Alexandra C Brown, Richard Y Kim, Jay C Horvat, Philip M Hansbro, Stephen L Nutt, Rhys S Allan

Journal article  |  2019  |  JCI Insight

A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-beta 1 in Steroid-Resistant Airway Diseases

Meina Li, Christine R Keenan, Guillermo Lopez-Campos, Jonathan E Mangum, Qianyu Chen, Danica Prodanovic, Yuxiu C Xia, Shenna Y Langenbach, Trudi Harris, Vinzenz Hofferek, Gavin E Reid, Alastair G Stewart

Journal article  |  2019  |  iScience

Epigenomic drivers of immune dysfunction in aging

Christine R Keenan, Rhys S Allan

Journal article  |  2019  |  Aging Cell