Frank Shann

A Live-Vaccine-Last Schedule: Saving an Extra Million Lives a Year?

Frank Shann

Journal article  |  2021  |  CLINICAL INFECTIOUS DISEASES

The non-specific and sex-differential effects of vaccines

Peter Aaby, Christine Stabell Benn, Katie L Flanagan, Sabra L Klein, Tobias R Kollmann, David J Lynn, Frank Shann

Journal article  |  2020  |  NATURE REVIEWS IMMUNOLOGY

The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, ..

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

Byron Brook, Danny J Harbeson, Casey P Shannon, Bing Cai, Daniel He, Rym Ben-Othman, Freddy Francis, Joe Huang, Natallia Varankovich, Aaron Liu, Winnie Bao, Morten Bjerregaard-Andersen, Frederik Schaltz-Buchholzer, Lilica Sanca, Christian N Golding, Kristina Lindberg Larsen, Ofer Levy, Beate Kampmann, Rusung Tan, Adrian Charles, et al.

Journal article  |  2020  |  SCIENCE TRANSLATIONAL MEDICINE

Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-..

Licensed Bacille Calmette-Guerin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation

Asimenia Angelidou, Maria-Giulia Conti, Joann Diray-Arce, Christine S Benn, Frank Shann, Mihai G Netea, Mark Liu, Lakshmi Prasad Potluri, Guzman Sanchez-Schmitz, Robert Husson, Al Ozonoff, Beate Kampmann, Simon Daniel van Haren, Ofer Levy

Journal article  |  2020  |  VACCINE

BACKGROUND: Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions ac..

Licensed Bacille Calmette-Guerin (BCG) vaccine formulations differ markedly in viability and cytokine inducing activity

MG Conti, A Angelidou, J Diray-Arce, C Benn, F Shann, LP Potluri, R Husson, A Ozonoff, S Van Haren, O Levy

Conference Proceedings  |  2020  |  PEDIATRIC ALLERGY AND IMMUNOLOGY

Study protocol for the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a randomised controlled trial to determine the non-specific effects of neonatal BCG vaccination in a low-mortality setting

Nicole L Messina, Kaya Gardiner, Susan Donath, Katie Flanagan, Anne-Louise Ponsonby, Frank Shann, Roy Robins-Browne, Bridget Freyne, Veronica Abruzzo, Clare Morison, Lianne Cox, Susie Germano, Christel Zufferey, Petra Zimmermann, Katie J Allen, Peter Vuillermin, Mike South, Dan Casalaz, Nigel Curtis

Journal article  |  2019  |  BMJ OPEN

INTRODUCTION: BCG vaccination reduces all-cause infant mortality in high-mortality settings by more than can be attributed to prot..

Biological sex influences antibody responses to routine vaccinations in the first year of life

Petra Zimmermann, Kirsten P Perrett, Nicole Ritz, Katie L Flanagan, Roy Robins-Browne, Fiona RM van der Klis, Nigel Curtis, Veronica Abruzzo, Katie Allen, Rhian Bonnici, Dan Casalaz, Hannah Elborough, Bridget Freyne, Kaya Gardiner, Susie Germano, Tobias Kollmann, Nicole Messina, Clare Morrison, Helder Nakaya, Anne Louise Ponsonby, et al.

Journal article  |  2019  |  ACTA PAEDIATRICA

AIM: We investigated the effect of early-life factors, namely sex, delivery mode, feeding method and antibiotic exposure, on antib..

The influence of neonatal Bacille Calmette-Guerin (BCG) immunisation on heterologous vaccine responses in infants

Petra Zimmermann, Susan Donath, Kirsten P Perrett, Nicole L Messina, Nicole Ritz, Mihai G Netea, Katie L Flanagan, Fiona RM van der Klis, Nigel Curtis, Veronica Abruzzo, Katie Allen, Dan Casalaz, Bridget Freyne, Kaya Gardiner, Susie Germano, Care Morrison, Anne Louise Ponsonby, Roy Robins-Browne, Frank Shann, Peter Vuillermin

Journal article  |  2019  |  VACCINE

INTRODUCTION: Bacillus Calmette-Guérin vaccine (BCG), one of the most widely used vaccines, does not only provide protection again..

RACHS-ANZ: A Modified Risk Adjustment in Congenital Heart Surgery Model for Outcome Surveillance in Australia and New Zealand

Brent McSharry, Lahn Straney, Janet Alexander, Tom Gentles, David Winlaw, John Beca, Johnny Millar, Frank Shann, Barry Wilkins, Andrew Numa, Christian Stocker, Simon Erickson, Anthony Slater

Journal article  |  2019  |  JOURNAL OF THE AMERICAN HEART ASSOCIATION

Background Outcomes for pediatric cardiac surgery are commonly reported from international databases compiled from voluntary data ..

Two Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guerin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing < 2000 g in India

Kumutha Jayaraman, Bethou Adhisivam, Saravanan Nallasivan, R Gokul Krishnan, Chinnathambi Kamalarathnam, Mangala Bharathi, Brent McSharry, Siva P Namachivayam, Frank Shann, Sasireka I Boopalan, Ponrani David, B Vishnu Bhat

Journal article  |  2019  |  PEDIATRIC INFECTIOUS DISEASE JOURNAL

BACKGROUND: In randomized trials in Guinea-Bissau, the Danish strain of Bacillus Calmette-Guérin (BCG) reduces neonatal mortality,..