Frank Shann

The non-specific and sex-differential effects of vaccines.

Peter Aaby, Christine Stabell Benn, Katie L Flanagan, Sabra L Klein, Tobias R Kollmann, David J Lynn, Frank Shann

Journal article  |  2020  |  Nature Reviews Immunology

The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, ..

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

Byron Brook, Danny J Harbeson, Casey P Shannon, Bing Cai, Daniel He, Rym Ben-Othman, Freddy Francis, Joe Huang, Natallia Varankovich, Aaron Liu, Winnie Bao, Morten Bjerregaard-Andersen, Frederik Schaltz-Buchholzer, Lilica Sanca, Christian N Golding, Kristina Lindberg Larsen, Ofer Levy, Beate Kampmann, Rusung Tan, Adrian Charles, et al.

Journal article  |  2020  |  Science Translational Medicine

Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-..

A live-vaccine-last schedule: saving an extra million lives a year?

Frank Shann

Journal article  |  2020  |  Clinical Infectious Diseases

Licensed Bacille Calmette-Guerin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation

Asimenia Angelidou, Maria-Giulia Conti, Joann Diray-Arce, Christine S Benn, Frank Shann, Mihai G Netea, Mark Liu, Lakshmi Prasad Potluri, Guzman Sanchez-Schmitz, Robert Husson, Al Ozonoff, Beate Kampmann, Simon Daniel van Haren, Ofer Levy

Journal article  |  2020  |  Vaccine

BACKGROUND: Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions ac..

Study protocol for the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a randomised controlled trial to determine the non-specific effects of neonatal BCG vaccination in a low-mortality setting

Nicole L Messina, Kaya Gardiner, Susan Donath, Katie Flanagan, Anne-Louise Ponsonby, Frank Shann, Roy Robins-Browne, Bridget Freyne, Veronica Abruzzo, Clare Morison, Lianne Cox, Susie Germano, Christel Zufferey, Petra Zimmermann, Katie J Allen, Peter Vuillermin, Mike South, Dan Casalaz, Nigel Curtis

Journal article  |  2019  |  BMJ Open

INTRODUCTION: BCG vaccination reduces all-cause infant mortality in high-mortality settings by more than can be attributed to prot..

Biological sex influences antibody responses to routine vaccinations in the first year of life

Petra Zimmermann, Kirsten P Perrett, Nicole Ritz, Katie L Flanagan, Roy Robins-Browne, Fiona RM van der Klis, Nigel Curtis, Veronica Abruzzo, Katie Allen, Rhian Bonnici, Dan Casalaz, Hannah Elborough, Bridget Freyne, Kaya Gardiner, Susie Germano, Tobias Kollmann, Nicole Messina, Clare Morrison, Helder Nakaya, Anne Louise Ponsonby, et al.

Journal article  |  2019  |  Acta Paediatrica

The influence of neonatal Bacille Calmette-Guerin (BCG) immunisation on heterologous vaccine responses in infants

Petra Zimmermann, Susan Donath, Kirsten P Perrett, Nicole L Messina, Nicole Ritz, Mihai G Netea, Katie L Flanagan, Fiona RM van der Klis, Nigel Curtis, Veronica Abruzzo, Katie Allen, Dan Casalaz, Bridget Freyne, Kaya Gardiner, Susie Germano, Care Morrison, Anne Louise Ponsonby, Roy Robins-Browne, Frank Shann, Peter Vuillermin

Journal article  |  2019  |  Vaccine

RACHS-ANZ: A Modified Risk Adjustment in Congenital Heart Surgery Model for Outcome Surveillance in Australia and New Zealand

Brent McSharry, Lahn Straney, Janet Alexander, Tom Gentles, David Winlaw, John Beca, Johnny Millar, Frank Shann, Barry Wilkins, Andrew Numa, Christian Stocker, Simon Erickson, Anthony Slater

Journal article  |  2019  |  Journal of the American Heart Association

Background Outcomes for pediatric cardiac surgery are commonly reported from international databases compiled from voluntary data ..

Two Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guerin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing < 2000 g in India

Kumutha Jayaraman, Bethou Adhisivam, Saravanan Nallasivan, R Gokul Krishnan, Chinnathambi Kamalarathnam, Mangala Bharathi, Brent McSharry, Siva P Namachivayam, Frank Shann, Sasireka I Boopalan, Ponrani David, B Vishnu Bhat

Journal article  |  2019  |  The Pediatric Infectious Disease Journal

LONG-TERM EFFECTS OF SALINE INSTILLED DURING ENDOTRACHEAL SUCTION IN PEDIATRIC INTENSIVE CARE: A RANDOMIZFD TRIAL

Dianne F McKinley, Sharon B Kinney, Beverley Copnell, Frank Shann

Journal article  |  2018  |  American Journal of Critical Care

An opportunity to compare the effects of BCG-Moreau and BCG-Russia in Brazil

Paulo RZ Antas, Mario Flores-Valdez, Frank Shann

Journal article  |  2018  |  The International Journal of Tuberculosis and Lung Disease

Pharmacodynamics of intravenous frusemide bolus in critically ill patients

Frank Shann

Journal article  |  2017  |  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

Heterologous vaccine effects

Mitra Saadatian-Elahi, Peter Aaby, Frank Shann, Mihai G Netea, Ofer Levy, Jacques Louis, Valentina Picot, Michael Greenberg, William Warren

Journal article  |  2016  |  Vaccine

Substantial benefits from finding the most effective BCG strain

Frank Shann

Journal article  |  2016  |  The Lancet Respiratory Medicine

Changing oral vaccine to inactivated polio vaccine might increase mortality

Eleanor N Fish, Kate L Flanagan, David Furman, Sabra L Klein, Tobias R Kollmann, Dorthe L Jeppesen, Ofer Levy, Arnaud Marchant, Siva Namachivayam, Mihai G Netea, Magdalena Plebanski, Sarah L Rowland-Jones, Liisa K Selin, Frank Shann, Hilton C Whittle

Journal article  |  2016  |  The Lancet

RTS,S Malaria Vaccine and Increased Mortality in Girls

Sabra L Klein, Frank Shann, William J Moss, Christine S Benn, Peter Aaby

Journal article  |  2016  |  mBio

Why Has the Number of Child Deaths Halved Since 1990?

Frank Shann

Journal article  |  2015  |  The Pediatric Infectious Disease Journal

Different Strains of Bacillus Calmette-Guerin Vaccine Have Very Different Effects on Tuberculosis and on Unrelated Infections

Frank Shann

Journal article  |  2015  |  Clinical Infectious Diseases

Bubble CPAP for pneumonia: perils of stopping trials early

Frank Shann, Theis Lange

Journal article  |  2015  |  The Lancet

Five-Year Survival of Children With Chronic Critical Illness in Australia and New Zealand

Siva P Namachivayam, Janet Alexander, Anthony Slater, Johnny Millar, Simon Erickson, James Tibballs, Marino Festa, Subodh Ganu, Liz Segedin, Luregn J Schlapbach, Gary Williams, Frank Shann, Warwick Butt

Journal article  |  2015  |  Critical Care Medicine

The heterologous (non-specific) effects of vaccines: implications for policy in high-mortality countries

Frank Shann

Journal article  |  2015  |  Transactions of the Royal Society of Tropical Medicine and Hygiene

ANZROD, COPE 4 and PIM 3: caveat emptor

GJ Duke, DV Pilcher, F Shann, JD Santamaria, F Oberender, MJ Bailey

Journal article  |  2014  |  Critical Care and Resuscitation

A multicentre, randomised, double-blind, placebo-controlled trial of aminophylline for bronchiolitis in infants admitted to intensive care

Alastair Turner, Frank Shann, Carmel Delzoppo, Robert Henning, Anthony Slater, John Beca, Simon Erickson, Warwick Butt

Journal article  |  2014  |  Critical Care and Resuscitation

The Use and Evaluation of Pediatric Index of Mortality and Pediatric Risk of Mortality in Pediatric Intensive Care

Frank Shann

Journal article  |  2014  |  Pediatric Critical Care Medicine

Natural Disasters, Armed Conflict, and Public Health

Frank Shann

Journal article  |  2014  |  The New England journal of medicine

A randomised controlled trial of plasma filtration in severe paediatric sepsis

Elliot J Long, Frank Shann, Gale Pearson, David Buckley, Warwick Butt

Journal article  |  2013  |  Critical Care and Resuscitation

Paediatric Index of Mortality 3: An Updated Model for Predicting Mortality in Pediatric Intensive Care

Lahn Straney, Archie Clements, Roger C Parslow, Gale Pearson, Frank Shann, Jan Alexander, Anthony Slater

Journal article  |  2013  |  Pediatric Critical Care Medicine

Heterologous ("Nonspecific") and Sex-Differential Effects of Vaccines: Epidemiology, Clinical Trials, and Emerging Immunologic Mechanisms

KL Flanagan, R van Crevel, N Curtis, F Shann, O Levy

Journal article  |  2013  |  Clinical Infectious Diseases

Antibiotic-resistant Gram-negative Bacteremia in Pediatric Oncology Patients-Risk Factors and Outcomes

Gabrielle M Haeusler, Francoise Mechinaud, Andrew J Daley, Mike Starr, Frank Shann, Thomas G Connell, Penelope A Bryant, Susan Donath, Nigel Curtis

Journal article  |  2013  |  Pediatric Infectious Disease Journal

Nonspecific Effects of Vaccines and the Reduction of Mortality in Children

Frank Shann

Journal article  |  2013  |  Clinical Therapeutics

Pertussis prophylaxis

Frank Shann

Journal article  |  2012  |  Australian Prescriber

Australia, immunisation, GAVI, and the non-specific effects of vaccines

Frank Shann

Journal article  |  2012  |  Australian and New Zealand Journal of Public Health

Hemodynamic Index for Risk Stratification After Neonatal Total Anomalous Pulmonary Venous Drainage Repair

Matthew S Yong, Frank Shann, Yves d'Udekem, Michael HH Cheung, Robert G Weintraub, Christian P Brizard, Igor E Konstantinov

Journal article  |  2012  |  Annals of Thoracic Surgery

Transposition with intact septum diagnosed at nine months: arterial switch?

Yves d'Udekem, Michael Cheung, Warwick Butt, Frank Shann, Christian P Brizard

Journal article  |  2012  |  Asian Cardiovascular & Thoracic Annals

A 9-month-old infant presented with transposition of the great arteries and intact ventricular septum. His left ventricle was thin..

COMMENTARY: BCG VACCINATION HALVES NEONATAL MORTALITY

Frank Shann

Journal article  |  2012  |  Pediatric Infectious Disease Journal

No Evidence of Bias in Trial Showing BCG Reduces Neonatal Mortality Reply

Frank Shann

Journal article  |  2012  |  Journal of Infectious Diseases

The new decade of vaccines

Frank Shann

Journal article  |  2012  |  The Lancet

Neonatal herpes virus infection: Duration of extracorporeal support and the dose of acyclovir

Frank Shann, Roberto Chiletti

Journal article  |  2011  |  Pediatric Critical Care Medicine

The Nonspecific Effects of Vaccines and the Expanded Program on Immunization

Frank Shann

Journal article  |  2011  |  Journal of Infectious Diseases

Outcomes of Surgery for Simple Total Anomalous Pulmonary Venous Drainage in Neonates

Matthew S Yong, Yves d'Udekem, Terry Robertson, Stephen Horton, Mithilesh Dronavalli, Christian Brizard, Robert Weintraub, Frank Shann, Michael Cheung, Igor E Konstantinov

Journal article  |  2011  |  Annals of Thoracic Surgery

Insulin infused at 0.05 versus 0.1 units/kg/hr in children admitted to intensive care with diabetic ketoacidosis

Said Al Hanshi, Frank Shann

Journal article  |  2011  |  Pediatric Critical Care Medicine

Rotating inotrope therapy in a pediatric population with decompensated heart failure

Lindsay M Ryerson, Peta MA Alexander, Warwick W Butt, Frank A Shann, Daniel J Penny, Lara S Shekerdemian

Journal article  |  2011  |  Pediatric Critical Care Medicine

Pneumonia in Children in Developing Countries

Frank Shann

Book Chapter  |  2011  |  Advances in Experimental Medicine and Biology

The non-specific effects of vaccines in low income countries

Frank Shann

Journal article  |  2011  |  Archives of Disease in Childhood: Education and Practice Edition

Role of intensive care in countries with a high child mortality rate

Frank Shann

Journal article  |  2011  |  Pediatric Critical Care Medicine

The non-specific effects of vaccines

Frank Shann

Journal article  |  2010  |  Archives of Disease in Childhood: Education and Practice Edition

Three decades of pediatric intensive care: Who was admitted, what happened in intensive care, and what happened afterward

Poongundran Namachivayam, Frank Shann, Lara Shekerdemian, Anna Taylor, Irene van Sloten, Carmel Delzoppo, Claire Daffey, Warwick Butt

Journal article  |  2010  |  Pediatric Critical Care Medicine

Antibiotic prophylaxis for cardiac surgery - are we getting it right?

Frank A Shann

Journal article  |  2010  |  Medical Journal of Australia

Warfare and children

Frank Shann

Journal article  |  2010  |  Journal of Paediatrics and Child Health

The motor response to stimulation predicts outcome as well as the full Glasgow Coma Scale in children with severe head injury

Peter-Marc Fortune, Frank Shann

Journal article  |  2010  |  Pediatric Critical Care Medicine

Extracorporeal membrane oxygenation via sternotomy for circulatory shock

Stephen Horton, Yves d'Udekem, Frank Shann, Warwick Butt, Martin Bennett, Derek Best, Christian Brizard

Journal article  |  2010  |  Journal of Thoracic and Cardiovascular Surgery

Twenty-three thousand unnecessary deaths every day: What are you doing about it?

Frank Shann, Trevor Duke

Journal article  |  2009  |  Pediatric Critical Care Medicine

Procalcitonin versus C-reactive protein and immature-to-total neutrophil ratio as markers of infection after cardiopulmonary bypass in children

Paddy McMaster, Dong Young Park, Frank Shann, Andrew Cochrane, Kevin Morris, James Gray, Serena Cottrell, John Belcher

Journal article  |  2009  |  Pediatric Critical Care Medicine

Sepsis in babies: should we stimulate the phagocytes?

Frank Shann

Journal article  |  2009  |  The Lancet

Liposomal amphotericin B trial marred by conclusions

Joshua Wolf, Jim Buttery, Andrew J Daley, Sarah Hanieh, Frank Shann, Mike Starr, Nigel Curtis

Journal article  |  2007  |  CLINICAL INFECTIOUS DISEASES

Warfare and the state of the world's children

Frank Shann

Book Chapter  |  2006  |  Advances in Experimental Medicine and Biology

Outcome-based clinical indicators for intensive care medicine

G Duke, J Santamaria, F Shann, R Stow

Journal article  |  2005  |  Anaesthesia and Intensive Care

Non-specific effects of vaccination - Vaccines have non-specific (heterologous) effects

F Shann

Journal article  |  2005  |  British Medical Journal

A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants

M English, S Mohammed, A Ross, S Ndirangu, G Kokwaro, F Shann, K Marsh

Journal article  |  2004  |  Archives of Disease in Childhood: Education and Practice Edition

Heterologous immunity and the nonspecific effects of vaccines - A major medical advance?

F Shann

Journal article  |  2004  |  Pediatric Infectious Disease Journal

Antibiotic treatment for bacterial meningitis in children in developing countries

DG Fuller, T Duke, F Shann, N Curtis

Journal article  |  2003  |  Annals of Tropical Paediatrics

Fluid and electrolyte therapy

FA SHANN

Book Chapter  |  2003

Evidence on the use of paracetamol in febrile children

FM Russell, F Shann, N Curtis, K Mulholland

Journal article  |  2003  |  Bulletin of the World Health Organization

Paediatrics for doctors in Papua New Guinea. A guide for doctors providing health services for children.

FA SHANN, J BIDDULPH, J VINCE

Book  |  2003

Paediatric Intensive Care Guidelines

FA SHANN, R HENNING

Book  |  2003

Bacterial meningitis in developing countries

RN CURTIS, TD DUKE, DG FULLER, FA SHANN

Journal article  |  2003  |  The Lancet

Paediatric Intensive Care Guidelines

FA SHANN, R HENNING

Book  |  2003

Drug Doses

FA SHANN

Book  |  2003

Systematic review of rheumatic heart disease prevalence in children in developing countries: The role of environmental factors

AC Steer, JR Carapetis, TM Nolan, F Shann

Journal article  |  2002  |  Journal of Paediatrics and Child Health

Drugs used in paediatrics

FA SHANN

Book Chapter  |  2002

Few rich countries attain UN's aid target for poor countries

F Shann

Journal article  |  2001  |  British Medical Journal

Nasopharyngeal oxygen therapy produces positive end-expiratory pressure in infants

B Frey, PJ McQuillan, F Shann, N Freezer

Journal article  |  2001  |  European Journal of Pediatrics

Bacterial pneumonia: commoner than perceived

F Shann

Journal article  |  2001  |  The Lancet

Uses of error: the wrong research costs lives.

F Shann

Journal article  |  2001  |  The Lancet

Effect of reusing suction catheters on the occurrence of pneumonia in children

MK Scoble, B Copnell, A Taylor, S Kinney, F Shann

Journal article  |  2001  |  Heart & Lung

A randomized trial of very early decompressive craniectomy in children with traumatic brain injury and sustained intracranial hypertension

A Taylor, W Butt, J Rosenfeld, F Shann, M Ditchfield, E Lewis, G Klug, D Wallace, R Henning, J Tibballs

Journal article  |  2001  |  Childs Nervous System

Calibration of the paediatric index of mortality in UK paediatric intensive care units

GA Pearson, J Stickley, F Shann

Journal article  |  2001  |  Archives of Disease in Childhood: Education and Practice Edition

Drug Doses

FA SHANN

Book  |  2001