Alex Boussioutas

Can butyrate prevent colon cancer? The AusFAP study: A randomised, crossover clinical trial.

Julie Clarke, Alex Boussioutas, Brooke Flanders, Trevor Lockett, Karen Harrap, Ian Saunders, Patrick Lynch, Mark Appleyard, Allan Spigelman, Don Cameron, Finlay Macrae

Journal article  |  2023  |  Contemp Clin Trials Commun

Increased colonic butyrate from microbial fermentation of fibre may protect from colorectal cancer (CRC). Dietary butyrylated high..

Targeted liver ultrasound performed by an expert is the pivotal imaging examination for low phospholipid-associated cholelithiasis.

Shu Su, Andrew Trinh, Andrew J Metz, Tony Speer, Paul Simkin, Daniel Buchanan, Alex Boussioutas, Robert Gibson

Journal article  |  2023  |  Eur J Gastroenterol Hepatol

OBJECTIVES: Low phospholipid-associatedcholelithiasis (LPAC) is a clinical syndrome that can be associated with variants in the ad..

Immune-Related Adverse Events of the Gastrointestinal System.

Steven Nicolaides, Alex Boussioutas

Journal article  |  2023  |  Cancers (Basel)

Immune checkpoint inhibitors (ICI) are a form of immunotherapy that have revolutionized the treatment of a number of cancers. Spec..

A comparison of DNA sequencing and gene expression profiling to assist tissue of origin diagnosis in cancer of unknown primary

Atara Posner, Owen Wj Prall, Tharani Sivakumaran, Dariush Etemadamoghadam, Niko Thio, Andrew Pattison, Shiva Balachander, Krista Fisher, Samantha Webb, Colin Wood, Anna DeFazio, Nicholas Wilcken, Bo Gao, Christos S Karapetis, Madhu Singh, Ian M Collins, Gary Richardson, Christopher Steer, Mark Warren, Narayan Karanth, et al.

Journal article  |  2022  |  JOURNAL OF PATHOLOGY

Cancer of unknown primary (CUP) is a syndrome defined by clinical absence of a primary cancer after standardised investigations. G..

International Delphi consensus guidelines for follow-up after prophylactic total gastrectomy: the Life after Prophylactic Total Gastrectomy (LAP-TG) study.

Geoffrey Roberts, Patrick R Benusiglio, Tanya Bisseling, Daniel Coit, Jeremy L Davis, Sam Grimes, Theresa A Guise, Richard Hardwick, Kirsty Harris, Paul Furman Mansfield, Jeremy Rossaak, Karen Chelcun Schreiber, Peter P Stanich, Vivian E Strong, Pardeep Kaurah, undefined LAP-TG Study Group

Journal article  |  2022  |  Gastric Cancer

BACKGROUND: Prophylactic total gastrectomy (PTG) remains the only means of preventing gastric cancer for people with genetic mutat..

Therapeutic Drug Monitoring of Subcutaneous Infliximab in Inflammatory Bowel Disease-Understanding Pharmacokinetics and Exposure Response Relationships in a New Era of Subcutaneous Biologics.

Robert D Little, Mark G Ward, Emily Wright, Asha J Jois, Alex Boussioutas, Georgina L Hold, Peter R Gibson, Miles P Sparrow

Journal article  |  2022  |  J Clin Med

CT-P13 is the first subcutaneous infliximab molecule approved for the management of inflammatory bowel disease (IBD). Compared to ..

The predicted effect and cost-effectiveness of tailoring colonoscopic surveillance according to mismatch repair gene in patients with Lynch syndrome

Yoon-Jung Kang, Michael Caruana, Kirstie McLoughlin, James Killen, Kate Simms, Natalie Taylor, Ian M Frayling, Veerle MH Coupe, Alex Boussioutas, Alison H Trainer, Robyn L Ward, Finlay Macrae, Karen Canfell

Journal article  |  2022  |  GENETICS IN MEDICINE

PURPOSE: Lynch syndrome-related colorectal cancer (CRC) risk substantially varies by mismatch repair (MMR) gene. We evaluated the ..

Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up

John C Mathers, Faye Elliott, Finlay Macrae, Jukka-Pekka Mecklin, Gabriela Moslein, Fiona E McRonald, Lucio Bertario, D Gareth Evans, Anne-Marie Gerdes, Judy WC Ho, Annika Lindblom, Patrick J Morrison, Jem Rashbass, Raj S Ramesar, Toni T Seppala, Huw JW Thomas, Harsh J Sheth, Kirsi Pylvanainen, Lynn Reed, Gillian M Borthwick, et al.

Journal article  |  2022  |  CANCER PREVENTION RESEARCH

ABSTRACT: The CAPP2 trial investigated the long-term effects of aspirin and resistant starch on cancer incidence in patients with ..

Infliximab Trough Levels Are Associated With Transmural Sonographic Healing in Inflammatory Bowel Disease

Rose Vaughan, Elise Murphy, Michelle Nalder, Robert N Gibson, Zaid Ardalan, Alex Boussioutas, Britt Christensen

Journal article  |  2022  |  INFLAMMATORY BOWEL DISEASES

BACKGROUND: Mucosal healing improves clinical outcomes in patients with inflammatory bowel disease (IBD) and is associated with hi..

Mechanisms for the Sex-Specific Effect of H. Pylori on Risk of Gastroesophageal Reflux Disease and Barrett's Esophagus

Sabrina E Wang, S Ghazaleh Dashti, Allison M Hodge, Suzanne C Dixon-Suen, Natalia Castano-Rodriguez, Robert JS Thomas, Graham G Giles, Roger L Milne, Alex Boussioutas, Bradley J Kendall, Dallas R English

Journal article  |  2022  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: Mechanisms for how Helicobacter pylori infection affects risk of gastroesophageal reflux disease (GERD) and Barrett's ..