Alex Boussioutas

SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence

Rita A Busuttil, Joshy George, Colin M House, Stephen Lade, Catherine Mitchell, Natasha S Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, Alex Boussioutas

Journal article  |  2020  |  Gastric Cancer

OBJECTIVE: Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined ..

DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case-control Study.

James A Chamberlain, Pierre-Antoine Dugué, Julie K Bassett, Roger L Milne, Jihoon E Joo, Ee Ming Wong, Maree T Brinkman, Geoffrey W Stuart, Alex Boussioutas, Melissa C Southey, Graham G Giles, Hazel Mitchell, Dallas R English, Allison M Hodge

Journal article  |  2020  |  Cancer Prevention Research

DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We co..

Hereditary diffuse gastric cancer: updated clinical practice guidelines

Vanessa R Blair, Maybelle McLeod, Fatima Carneiro, Daniel G Coit, Johanna L D'Addario, Jolanda M van Dieren, Kirsty L Harris, Nicoline Hoogerbrugge, Carla Oliveira, Rachel S van der Post, Julie Arnold, Patrick R Benusiglio, Tanya M Bisseling, Alex Boussioutas, Annemieke Cats, Amanda Charlton, Karen E Chelcun Schreiber, Jeremy L Davis, Massimiliano di Pietro, Rebecca C Fitzgerald, et al.

Journal article  |  2020  |  The Lancet Oncology

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of di..

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

John Burn, Harsh Sheth, Faye Elliott, Lynn Reed, Finlay Macrae, Jukka-Pekka Mecklin, Gabriela Moeslein, Fiona E McRonald, Lucio Bertario, D Gareth Evans, Anne-Marie Gerdes, Judy WC Ho, Annika Lindblom, Patrick J Morrison, Jem Rashbass, Raj Ramesar, Toni Seppala, Huw JW Thomas, Kirsi Pylvanainen, Gillian M Borthwick, et al.

Journal article  |  2020  |  The Lancet

BACKGROUND: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, espec..

High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer

Minyu Wang, Yu-Kuan Huang, Joseph CH Kong, Yu Sun, Daniela G Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha Di Costanzo, Ian R Gordon, Catherine Mitchell, Laura K Mackay, Rita A Busuttil, Paul J Neeson, Alex Boussioutas

Journal article  |  2020  |  Clinical and Translational Immunology

Objectives: To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive stu..

The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome

Yoon-Jung Kang, James Killen, Michael Caruana, Kate Simms, Natalie Taylor, Ian M Frayling, Tristan Snowsill, Nicola Huxley, Veerle MH Coupe, Suzanne Hughes, Victoria Freeman, Alex Boussioutas, Alison H Trainer, Robyn L Ward, Gillian Mitchell, Finlay A Macrae, Karen Canfell

Journal article  |  2020  |  Medical Journal of Australia

A cohort study and meta-analysis of the evidence for consideration of Lauren subtype when prescribing adjuvant or palliative chemotherapy for gastric cancer.

Kunning Wang, Enxiao Li, Rita A Busuttil, Joseph C Kong, Sharon Pattison, Joseph JY Sung, Jun Yu, Emad M El-Omar, Julie A Simpson, Alex Boussioutas

Journal article  |  2020  |  Therapeutic Advances in Medical Oncology

Background: The association between the survival or efficacy of chemotherapy and the Lauren subtype of gastric cancer (GC) remains..

A systematic review of risk-reducing cancer surgery outcomes for hereditary cancer syndromes

Oliver Peacock, Peadar S Waters, Jaime Otero de Pablos, Alex Boussioutas, Anita Skandarajah, Jonathan A Simpson, Satish K Warrier, Alexander G Heriot

Journal article  |  2019  |  European Journal of Surgical Oncology

Cancer predisposition genes are rare mutations that confer a high risk of cancer. For many hereditary cancer syndromes, risk reduc..

Increased and co-localized CD4 FOXP3 and CD8 T cells is a strong independent prognostic indicator in gastric cancer

Minyu Wang, Yu-Kuan Huang, Joe Kong, Yu Sun, Daniela Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha di Costanzo, Ian Gordon, Catherine Mitchell, Laura Mackay, Rita Busuttil, Paul Neeson, Alex Boussioutas

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Premalignant lesions and gastric cancer: Current understanding

Athanasios Koulis, Andrew Buckle, Alex Boussioutas

Journal article  |  2019  |  World Journal of Gastrointestinal Oncology