Alex Boussioutas

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial.

John Burn, Harsh Sheth, Faye Elliott, Lynn Reed, Finlay Macrae, Jukka-Pekka Mecklin, Gabriela Möslein, Fiona E McRonald, Lucio Bertario, D Gareth Evans, Anne-Marie Gerdes, Judy WC Ho, Annika Lindblom, Patrick J Morrison, Jem Rashbass, Raj Ramesar, Toni Seppälä, Huw JW Thomas, Kirsi Pylvänäinen, Gillian M Borthwick, et al.

Journal article  |  2020  |  The Lancet

BACKGROUND: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, espec..

High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer

Minyu Wang, Yu-Kuan Huang, Joseph CH Kong, Yu Sun, Daniela G Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha Di Costanzo, Ian R Gordon, Catherine Mitchell, Laura K Mackay, Rita A Busuttil, Paul J Neeson, Alex Boussioutas

Journal article  |  2020  |  Clinical & Translational Immunology

Objectives: To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive stu..

The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome

Yoon-Jung Kang, James Killen, Michael Caruana, Kate Simms, Natalie Taylor, Ian M Frayling, Tristan Snowsill, Nicola Huxley, Veerle MH Coupe, Suzanne Hughes, Victoria Freeman, Alex Boussioutas, Alison H Trainer, Robyn L Ward, Gillian Mitchell, Finlay A Macrae, Karen Canfell

Journal article  |  2020  |  Medical Journal of Australia

A systematic review of risk-reducing cancer surgery outcomes for hereditary cancer syndromes

Oliver Peacock, Peadar S Waters, Jaime Otero de Pablos, Alex Boussioutas, Anita Skandarajah, Jonathan A Simpson, Satish K Warrier, Alexander G Heriot

Journal article  |  2019  |  European Journal of Surgical Oncology

Cancer predisposition genes are rare mutations that confer a high risk of cancer. For many hereditary cancer syndromes, risk reduc..

Increased and co-localized CD4 FOXP3 and CD8 T cells is a strong independent prognostic indicator in gastric cancer

Minyu Wang, Yu-Kuan Huang, Joe Kong, Yu Sun, Daniela Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha di Costanzo, Ian Gordon, Catherine Mitchell, Laura Mackay, Rita Busuttil, Paul Neeson, Alex Boussioutas

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Premalignant lesions and gastric cancer: Current understanding

Athanasios Koulis, Andrew Buckle, Alex Boussioutas

Journal article  |  2019  |  World Journal of Gastrointestinal Oncology

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A Hamilton, Rita A Busuttil, Alex Boussioutas

Journal article  |  2019  |  Nature Communications

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Moritz F Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D Huntington, Margaret L Hibbs, Alex Boussioutas, Michele A Grimbaldeston, Michael Buchert, Robert JJ O'Donoghue, Frederick Masson, Matthias Ernst

Journal article  |  2019  |  Nature Communications

Dietary Intake of Nutrients Involved in One-Carbon Metabolism and Risk of Gastric Cancer: A Prospective Study

Pierre-Antoine Dugue, Julie K Bassett, Maree T Brinkman, Melissa C Southey, Jihoon E Joo, Ee Ming Wong, Roger L Milne, Dallas R English, Graham G Giles, Alex Boussioutas, Hazel Mitchell, Allison M Hodge

Journal article  |  2019  |  Nutrition and Cancer

Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations

Dustin J Flanagan, Nick Barker, Natasha S Di Costanzo, Elizabeth A Mason, Austin Gurney, Valerie S Meniel, Sarah Koushyar, Chloe R Austin, Matthias Ernst, Helen B Pearson, Alex Boussioutas, Hans Clevers, Toby J Phesse, Elizabeth Vincan

Journal article  |  2019  |  Cancer Research

Safety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients

Wladyslaw Januszewicz, Wei Keith Tan, Katie Lehovsky, Irene Debiram-Beecham, Tara Nuckcheddy, Susan Moist, Sudarshan Kadri, Massimiliano di Pietro, Alex Boussioutas, Nicholas J Shaheen, David A Katzka, Evan S Dellon, Rebecca C Fitzgerald

Journal article  |  2019  |  Clinical Gastroenterology and Hepatology

Current mismatch repair deficiency tumor testing practices and capabilities: A survey of Australian pathology providers

Lyon Mascarenhas, Susan Shanley, Gillian Mitchell, Amanda B Spurdle, Finlay Macrae, Nicholas Pachter, Daniel D Buchanan, Robyn L Ward, Stephen Fox, Elaine Duxbury, Rebecca Driessen, Alex Boussioutas

Journal article  |  2018  |  Asia-Pacific Journal of Clinical Oncology

Revised Australian national guidelines for colorectal cancer screening: family history

Mark A Jenkins, Driss Ait Ouakrim, Alex Boussioutas, John L Hopper, Hooi C Ee, Jon D Emery, Finlay A Macrae, Albert Chetcuti, Laura Wuellner, D James B St John

Journal article  |  2018  |  Medical Journal of Australia

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Yumeng Wang, Xiaoyan Xu, Dejan Maglic, Michael T Dill, Kamalika Mojumdar, Patrick Kwok-Shing Ng, Kang Jin Jeong, Yiu Huen Tsang, Daniela Moreno, Venkata Hemanjani Bhavana, Xinxin Peng, Zhongqi Ge, Hu Chen, Jun Li, Zhongyuan Chen, Huiwen Zhang, Leng Han, Di Du, Chad J Creighton, Gordon B Mills, et al.

Journal article  |  2018  |  Cell Reports

Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization..

Gastrointestinal complications of melanoma immunotherapy in a large Australian cohort

A Buckle, R Vaughan, A Weppler, S Sandhu, A Boussioutas

Conference Proceedings  |  2018  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

Andre Kahles, Kjong-Van Lehmann, Nora C Toussaint, Matthias Huser, Stefan G Stark, Timo Sachsenberg, Oliver Stegle, Oliver Kohlbacher, Chris Sander, Gunnar Ratsch

Journal article  |  2018  |  Cancer Cell

Family history-based colorectal cancer screening in Australia: A modelling study of the costs, benefits, and harms of different participation scenarios

Mary Dillon, Louisa Flander, Daniel D Buchanan, Finlay A Macrae, Jon D Emery, Ingrid M Winship, Alex Boussioutas, Graham G Giles, John L Hopper, Mark A Jenkins, Driss Ait Ouakrim

Journal article  |  2018  |  PLOS MEDICINE

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (vol 23, pg 313, 2018)

Christopher J Ricketts, Aguirre A De Cubas, Huihui Fan, Christof C Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A Gibb, Rehan Akbani, Rameen Beroukhim, Donald P Bottaro, Toni K Choueiri, Richard A Gibbs, Andrew K Godwin, Scott Haake, A Ari Hakimi, Elizabeth P Henske, James J Hsieh, Thai H Ho, Rupa S Kanchi, et al.

Journal article  |  2018  |  Cell Reports

'Why don't I need a colonoscopy?' A novel approach to communicating risks and benefits of colorectal cancer screening

Jon D Emery, Marie Pirotta, Finlay Macrae, Jennifer G Walker, Ashleigh Qama, Alex Boussioutas, Mark Jenkins

Journal article  |  2018  |  Australian Journal of General Practice

Differential response to adjuvant chemotherapy based on Lauren subtype affects clinical outcome of gastric cancer: A cohort study and meta-analysis.

Kunning Wang, En Xiao Li, Rita A Busuttil, Joseph C Kong, Sharon Tracy Pattison, Joseph JY Sung, Jun Yu, Emad M El-Omar, Julie A Simpson, Alex Boussioutas

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer

Daniella Brasacchio, Rita A Busuttil, Tahereh Noori, Ricky W Johnstone, Alex Boussioutas, Joseph A Trapani

Journal article  |  2018  |  Cell Death & Disease

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

Yang Liu, Nilay S Sethi, Toshinori Hinoue, Barbara G Schneider, Andrew D Cherniack, Francisco Sanchez-Vega, Jose A Seoane, Farshad Farshidfar, Reanne Bowlby, Mirazul Islam, Jaegil Kim, Walid Chatila, Rehan Akbani, Rupa S Kanchi, Charles S Rabkin, Joseph E Willis, Kenneth K Wang, Shannon J McCall, Lopa Mishra, Akinyemi I Ojesina, et al.

Journal article  |  2018  |  Cancer Cell

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

Alison M Taylor, Juliann Shih, Gavin Ha, Galen F Gao, Xiaoyang Zhang, Ashton C Berger, Steven E Schumacher, Chen Wang, Hai Hu, Jianfang Liu, Alexander J Lazar, Andrew D Cherniack, Rameen Beroukhim, Matthew Meyerson

Journal article  |  2018  |  Cancer Cell

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

Ashton C Berger, Anil Korkut, Rupa S Kanchi, Apurva M Hegde, Walter Lenoir, Wenbin Liu, Yuexin Liu, Huihui Fan, Hui Shen, Visweswaran Ravikumar, Arvind Rao, Andre Schultz, Xubin Li, Pavel Sumazin, Cecilia Williams, Pieter Mestdagh, Preethi H Gunaratne, Christina Yau, Reanne Bowlby, A Gordon Robertson, et al.

Journal article  |  2018  |  Cancer Cell

Comprehensive Characterization of Cancer Driver Genes and Mutations

Matthew H Bailey, Collin Tokheim, Eduard Porta-Pardo, Sohini Sengupta, Denis Bertrand, Amila Weerasinghe, Antonio Colaprico, Michael C Wendl, Jaegil Kim, Brendan Reardon, Patrick Kwok-Shing Ng, Kang Jin Jeong, Song Cao, Zixing Wang, Jianjiong Gao, Qingsong Gao, Fang Wang, Eric Minwei Liu, Loris Mularoni, Carlota Rubio-Perez, et al.

Journal article  |  2018  |  Cell

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

Han Chen, Chunyan Li, Xinxin Peng, Zhicheng Zhou, John N Weinstein, Han Liang

Journal article  |  2018  |  Cell

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

Jianfang Liu, Tara Lichtenberg, Katherine A Hoadley, Laila M Poisson, Alexander J Lazar, Andrew D Cherniack, Albert J Kovatich, Christopher C Benz, Douglas A Levine, Adrian V Lee, Larsson Omberg, Denise M Wolf, Craig D Shriver, Vesteinn Thorsson, Hai Hu

Journal article  |  2018  |  Cell

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Francisco Sanchez-Vega, Marco Mina, Joshua Armenia, Walid K Chatila, Augustin Luna, Konnor C La, Sofia Dimitriadoy, David L Liu, Havish S Kantheti, Sadegh Saghafinia, Debyani Chakravarty, Foysal Daian, Qingsong Gao, Matthew H Bailey, Wen-Wei Liang, Steven M Foltz, Ilya Shmulevich, Li Ding, Zachary Heins, Angelica Ochoa, et al.

Journal article  |  2018  |  Cell

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Katherine A Hoadley, Christina Yau, Toshinori Hinoue, Denise M Wolf, Alexander J Lazar, Esther Drill, Ronglai Shen, Alison M Taylor, Andrew D Cherniack, Vesteinn Thorsson, Rehan Akbani, Reanne Bowlby, Christopher K Wong, Maciej Wiznerowicz, Francisco Sanchez-Vega, A Gordon Robertson, Barbara G Schneider, Michael S Lawrence, Houtan Noushmehr, Tathiane M Malta, et al.

Journal article  |  2018  |  Cell

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Hua-Sheng Chiu, Sonal Somvanshi, Ektaben Patel, Ting-Wen Chen, Vivek P Singh, Barry Zorman, Sagar L Patil, Yinghong Pan, Sujash S Chatterjee, Anil K Sood, Preethi H Gunaratne, Pavel Sumazin

Journal article  |  2018  |  Cell Reports

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

Qingsong Gao, Wen-Wei Liang, Steven M Foltz, Gnanavel Mutharasu, Reyka G Jayasinghe, Song Cao, Wen-Wei Liao, Sheila M Reynolds, Matthew A Wyczalkowski, Lijun Yao, Lihua Yu, Sam Q Sun, Ken Chen, Alexander J Lazar, Ryan C Fields, Michael C Wendl, Brian A Van Tine, Ravi Vij, Feng Chen, Matti Nykter, et al.

Journal article  |  2018  |  Cell Reports

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

Theo A Knijnenburg, Linghua Wang, Michael T Zimmermann, Nyasha Chambwe, Galen F Gao, Andrew D Cherniack, Huihui Fan, Hui Shen, Gregory P Way, Casey S Greene, Yuexin Liu, Rehan Akbani, Bin Feng, Lawrence A Donehower, Chase Miller, Yang Shen, Mostafa Karimi, Haoran Chen, Pora Kim, Peilin Jia, et al.

Journal article  |  2018  |  Cell Reports

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

Joshua D Campbell, Christina Yau, Reanne Bowlby, Yuexin Liu, Kevin Brennan, Huihui Fan, Alison M Taylor, Chen Wang, Vonn Walter, Rehan Akbani, Lauren Averett Byers, Chad J Creighton, Cristian Coarfa, Juliann Shih, Andrew D Cherniack, Olivier Gevaert, Marcos Prunello, Hui Shen, Pavana Anur, Jianhong Chen, et al.

Journal article  |  2018  |  Cell Reports

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Michael Seiler, Shouyong Peng, Anant A Agrawal, James Palacino, Teng Teng, Ping Zhu, Peter G Smith, Silvia Buonamici, Lihua Yu

Journal article  |  2018  |  Cell Reports

The conundrum of quality in colonoscopy

Timothy J Chittleborough, Andrew Luck, Alex Boussioutas, Satish Warrier, Alexander G Heriot

Journal article  |  2018  |  ANZ Journal of Surgery

An orthotopic mouse model of gastric cancer invasion and metastasis

Rita A Busuttil, David S Liu, Natasha Di Costanzo, Jan Schroder, Catherine Mitchell, Alex Boussioutas

Journal article  |  2018  |  Scientific Reports

Colonoscopic surveillance: quality, guidelines and effectiveness

Timothy J Chittleborough, Joseph C Kong, Glen R Guerra, Robert Ramsay, Alexander G Heriot

Journal article  |  2018  |  ANZ Journal of Surgery

Early relapses after adjuvant chemotherapy suggests primary chemoresistance in diffuse gastric cancer

Sharon Pattison, Catherine Mitchell, Stephen Lade, Trevor Leong, Rita A Busuttil, Alex Boussioutas

Journal article  |  2017  |  PLOS ONE

TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG

Trevor Leong, B Mark Smithers, Karin Haustermans, Michael Michael, Val Gebski, Danielle Miller, John Zalcberg, Alex Boussioutas, Michael Findlay, Rachel L O'Connell, Jaclyn Verghis, David Willis, Tomas Kron, Melissa Crain, William K Murray, Florian Lordick, Carol Swallow, Gail Darling, John Simes, Rebecca Wong

Journal article  |  2017  |  Annals of Surgical Oncology

Tumor testing to identify lynch syndrome in two Australian colorectal cancer cohorts

Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Stine V Eriksen, Michael D Walsh, Rhiannon J Walters, Stephen N Thibodeau, Jenna Stewart, Susan Preston, Aung Ko Win, Louisa Flander, Driss Ait Ouakrim, Finlay A Macrae, Alex Boussioutas, Ingrid M Winship, Graham G Giles, John L Hopper, Melissa C Southey, Dallas English, Mark A Jenkins

Journal article  |  2017  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Integrated genomic characterization of oesophageal carcinoma

Jihun Kim, Reanne Bowlby, Andrew J Mungall, A Gordon Robertson, Robert D Odze, Andrew D Cherniack, Juliann Shih, Chandra Sekhar Pedamallu, Carrie Cibulskis, Andrew Dunford, Samuel R Meier, Jaegil Kim, Benjamin J Raphael, Hsin-Ta Wu, Alexandra M Wong, Joseph E Willis, Adam J Bass, Sarah Derks, Katherine Garman, Shannon J McCall, et al.

Journal article  |  2017  |  Nature

Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study

Harindra Jayasekara, Jeanette C Reece, Daniel D Buchanan, Christophe Rosty, S Ghazaleh Dashti, Driss Ait Ouakrim, Ingrid M Winship, Finlay A Macrae, Alex Boussioutas, Graham G Giles, Dennis J Ahnen, Jan Lowery, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, Noralane M Lindor, John L Hopper, Susan Parry, et al.

Journal article  |  2016  |  INTERNATIONAL JOURNAL OF CANCER

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

A Marcell Szasz, Andrs Lanczky, Adm Nagy, Susann Foerster, Kim Hark, Jeffrey E Green, Alex Boussioutas, Rita Busuttil, Andras Szabo, Balazs Gyorffy

Journal article  |  2016  |  ONCOTARGET

Immunological battlefield in gastric cancer and role of immunotherapies

Minyu Wang, Rita A Busuttil, Sharon Pattison, Paul J Neeson, Alex Boussioutas

Journal article  |  2016  |  World Journal of Gastroenterology

Multivitamin, calcium and folic acid supplements and the risk of colorectal cancer in Lynch syndrome

Rowena Chau, Seyedeh Ghazaleh Dashti, Driss Ait Ouakrim, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Joanne P Young, Graham G Giles, Finlay A Macrae, Alex Boussioutas, Susan Parry, Jane C Figueiredo, A Joan Levine, Dennis J Ahnen, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Stephen N Thibodeau, et al.

Journal article  |  2016  |  International Journal of Epidemiology

Predictors of outcome after surgery for gastric cancer in a Western cohort

Sharon Pattison, G Bruce Mann, Gary Crosthwaite, Stephen Lade, Catherine Mitchell, Trevor Leong, Rita A Busuttil, Alex Boussioutas

Journal article  |  2016  |  ANZ Journal of Surgery

Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant

Jun Li, Susan L Woods, Sue Healey, Jonathan Beesley, Xiaoqing Chen, Jason S Lee, Haran Sivakumaran, Nicci Wayte, Katia Nones, Joshua J Waterfall, John Pearson, Anne-Marie Patch, Janine Senz, Manuel A Ferreira, Pardeep Kaurah, Robertson Mackenzie, Alireza Heravi-Moussavi, Samantha Hansford, Tamsin RM Lannagan, Amanda B Spurdle, et al.

Journal article  |  2016  |  The American Journal of Human Genetics

Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the Colon Cancer Family Registry Cohort

Christophe Rosty, Mark Clendenning, Michael D Walsh, Stine V Eriksen, Melissa C Southey, Ingrid M Winship, Finlay A Macrae, Alex Boussioutas, Nicola K Poplawski, Susan Parry, Julie Arnold, Joanne P Young, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, John D Potter, Melissa DeRycke, Noralane M Lindor, et al.

Journal article  |  2016  |  BMJ OPEN

Colorectal cancer

Alex Boussioutas, Stephen Fox, Iris Nagtegaal, Alexander Heriot, Jonathan Knowles, Michael Michael, Sam Ngan, Kathryn Field, John Zalcberg

Book Chapter  |  2016

This chapter covers colorectal cancer, and includes information on epidemiology, risk factors (chronic inflammation/inflammatory b..

Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas

Suling J Lin, Johann A Gagnon-Bartsch, Iain Beehuat Tan, Sophie Earle, Louise Ruff, Katherine Pettinger, Bauke Ylstra, Nicole van Grieken, Sun Young Rha, Hyun Cheol Chung, Ju-Seog Lee, Jae Ho Cheong, Sung Hoon Noh, Toru Aoyama, Yohei Miyagi, Akira Tsuburaya, Takaki Yoshikawa, Jaffer A Ajani, Alex Boussioutas, Khay Guan Yeoh, et al.

Journal article  |  2015  |  GUT

Defective macrophage handling of Escherichia coli in Crohn's disease

TR Elliott, BN Hudspith, NB Rayment, NJ Prescott, L Petrovska, J Hermon-Taylor, J Brostoff, A Boussioutas, CG Mathew, JD Sanderson

Journal article  |  2015  |  Journal of Gastroenterology and Hepatology

TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG)

Trevor Leong, B Mark Smithers, Michael Michael, Val Gebski, Alex Boussioutas, Danielle Miller, John Simes, John Zalcberg, Karin Haustermans, Florian Lordick, Christoph Schuhmacher, Carol Swallow, Gail Darling, Rebecca Wong

Journal article  |  2015  |  BMC CANCER

Lamina propria macrophage phenotypes in relation to Escherichia coli in Crohn's disease

Timothy R Elliott, Neil B Rayment, Barry N Hudspith, Rebecca E Hands, Kirstin Taylor, Gareth C Parkes, Natalie J Prescott, Liljana Petrovska, John Hermon-Taylor, Jonathan Brostoff, Alex Boussioutas, Christopher G Mathew, Stephen A Bustin, Jeremy D Sanderson

Journal article  |  2015  |  BMC GASTROENTEROLOGY

Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers

Rachel S van der Post, Ingrid P Vogelaar, Fatima Carneiro, Parry Guilford, David Huntsman, Nicoline Hoogerbrugge, Carlos Caldas, Karen E Chelcun Schreiber, Richard H Hardwick, Margreet GEM Ausems, Linda Bardram, Patrick R Benusiglio, Tanya M Bisseling, Vanessa Blair, Eveline Bleiker, Alex Boussioutas, Annemieke Cats, Daniel Coit, Lynn DeGregorio, Joana Figueiredo, et al.

Journal article  |  2015  |  Journal of Medical Genetics

Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives

Aung Ko Win, Daniel D Buchanan, Christophe Rosty, Robert J MacInnis, James G Dowty, Gillian S Dite, Graham G Giles, Melissa C Southey, Joanne P Young, Mark Clendenning, Michael D Walsh, Rhiannon J Walters, Alex Boussioutas, Thomas C Smyrk, Stephen N Thibodeau, John A Baron, John D Potter, Polly A Newcomb, Loic Le Marchand, Robert W Haile, et al.

Journal article  |  2015  |  GUT

Pathophysiology of hereditary diffuse gastric cancer

S Pattison, A Boussioutas

Book Chapter  |  2015

Role of p53 in the progression of gastric cancer

Rita A Busuttil, Giada V Zapparoli, Sue Haupt, Christina Fennell, Stephen Q Wong, Jia-Min B Pang, Elena A Takeno, Catherine Mitchell, Natasha Di Costanzo, Stephen Fox, Ygal Haupt, Alexander Dobrovic, Alex Boussioutas

Journal article  |  2014  |  ONCOTARGET

Comprehensive molecular characterization of gastric adenocarcinoma

Adam J Bass, Vesteinn Thorsson, Ilya Shmulevich, Sheila M Reynolds, Michael Miller, Brady Bernard, Toshinori Hinoue, Peter W Laird, Christina Curtis, Hui Shen, Daniel J Weisenberger, Nikolaus Schultz, Ronglai Shen, Nils Weinhold, David P Keiser, Reanne Bowlby, Payal Sipahimalani, Andrew D Cherniack, Gad Getz, Yingchun Liu, et al.

Journal article  |  2014  |  Nature

Spot Diagnosis

Zornitza Stark, Lynda J Campbell, Catherine Mitchell, Paul A James, John A Heath, Alex Boussioutas, Craig Lynch, Alison H Trainer

Journal article  |  2014  |  New England Journal of Medicine

A Signature Predicting Poor Prognosis in Gastric and Ovarian Cancer Represents a Coordinated Macrophage and Stromal Response

Rita A Busuttil, Joshy George, Richard W Tothill, Kylie Ioculano, Adam Kowalczyk, Catherine Mitchell, Stephen Lade, Patrick Tan, Izhak Haviv, Alex Boussioutas

Journal article  |  2014  |  Clinical Cancer Research

Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer

Julia M Humphries, Megan AS Penno, Florian Weiland, Manuela Klingler-Hoffmann, Agnieszka Zuber, Alex Boussioutas, Matthias Ernst, Peter Hoffmann

Journal article  |  2014  |  Biochimica et Biophysica Acta-Proteins and Proteomics

Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer

Aung Ko Win, James G Dowty, Sean P Cleary, Hyeja Kim, Daniel D Buchanan, Joanne P Young, Mark Clendenning, Christophe Rosty, Robert J MacInnis, Graham G Giles, Alex Boussioutas, Finlay A Macrae, Susan Parry, Jack Goldblatt, John A Baron, Terrilea Burnett, Loic Le Marchand, Polly A Newcomb, Robert W Haile, John L Hopper, et al.

Journal article  |  2014  |  GASTROENTEROLOGY

Cost-effectiveness of family history-based colorectal cancer screening in Australia

Driss A Ouakrim, Alex Boussioutas, Trevor Lockett, John L Hopper, Mark A Jenkins

Journal article  |  2014  |  BMC CANCER

Processed pseudogenes acquired somatically during cancer development

Susanna L Cooke, Adam Shlien, John Marshall, Christodoulos P Pipinikas, Inigo Martincorena, Jose MC Tubio, Yilong Li, Andrew Menzies, Laura Mudie, Manasa Ramakrishna, Lucy Yates, Helen Davies, Niccolo Bolli, Graham R Bignell, Patrick S Tarpey, Sam Behjati, Serena Nik-Zainal, Elli Papaemmanuil, Vitor H Teixeira, Keiran Raine, et al.

Journal article  |  2014  |  Nature Communications

Quantification and Characterization of Mucosa-Associated and Intracellular Escherichia coli in Inflammatory Bowel Disease

Timothy R Elliott, Barry N Hudspith, Guanghui Wu, Michael Cooley, Gareth Parkes, Beatriz Quinones, Luke Randall, Robert E Mandrell, Clifton K Fagerquist, Jonathan Brostoff, Neil B Rayment, Alex Boussioutas, Liljana Petrovska, Jeremy D Sanderson

Journal article  |  2013  |  Inflammatory Bowel Diseases

Screening participation for people at increased risk of colorectal cancer due to family history: a systematic review and meta-analysis

Driss Ait Ouakrim, Trevor Lockett, Alex Boussioutas, John L Hopper, Mark A Jenkins

Journal article  |  2013  |  Familial Cancer

Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil

Zhengdeng Lei, Iain Beehuat Tan, Kakoli Das, Niantao Deng, Hermioni Zouridis, Sharon Pattison, Clarinda Chua, Zhu Feng, Yeoh Khay Guan, Chia Huey Ooi, Tatiana Ivanova, Shenli Zhang, Minghui Lee, Jeanie Wu, Anna Ngo, Sravanthy Manesh, Elisabeth Tan, Bin Tean Teh, Jimmy Bok Yan So, Liang Kee Goh, et al.

Journal article  |  2013  |  GASTROENTEROLOGY

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

Tracy L Putoczki, Stefan Thiem, Andrea Loving, Rita A Busutti, Nicholas J Wilson, Paul K Ziegler, Paul M Nguyen, Adele Preaudet, Ryan Farid, Kirsten M Edwards, Yeliz Boglev, Rodney B Luwor, Andrew Jarnicki, David Horst, Alex Boussioutas, Joan K Heath, Oliver M Sieber, Irina Pleines, Benjamin T Kile, Andrew Nash, et al.

Journal article  |  2013  |  Cancer Cell

Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer

Yonghui Wu, Heike Grabsch, Tatiana Ivanova, Iain Beehuat Tan, Jacinta Murray, Chia Huey Ooi, Alexander Ian Wright, Nicholas P West, Gordon GA Hutchins, Jeanie Wu, Minghui Lee, Julian Lee, Jun Hao Koo, Khay Guan Yeoh, Nicole van Grieken, Bauke Ylstra, Sun Young Rha, Jaffer A Ajani, Jae Ho Cheong, Sung Hoon Noh, et al.

Journal article  |  2013  |  Gut

Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population.

Torukiri I Ibiebele, Maria Celia Hughes, Christina M Nagle, Christopher J Bain, David C Whiteman, Penelope M Webb, undefined Study of Digestive Health and Australian Cancer Study

Journal article  |  2013  |  International Journal of Cancer

While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on die..

Risk of Metachronous Colon Cancer Following Surgery for Rectal Cancer in Mismatch Repair Gene Mutation Carriers

Aung Ko Win, Susan Parry, Bryan Parry, Matthew F Kalady, Finlay A Macrae, Dennis J Ahnen, Graeme P Young, Lara Lipton, Ingrid Winship, Alex Boussioutas, Joanne P Young, Daniel D Buchanan, Julie Arnold, Loic Le Marchand, Polly A Newcomb, Robert W Haile, Noralane M Lindor, Steven Gallinger, John L Hopper, Mark A Jenkins

Journal article  |  2013  |  ANNALS OF SURGICAL ONCOLOGY

Screening Participation Predictors for People at Familial Risk of Colorectal Cancer A Systematic Review

Driss Ait Ouakrim, Trevor Lockett, Alex Boussioutas, Louise Keogh, Louisa B Flander, John L Hopper, Mark A Jenkins

Journal article  |  2013  |  American Journal of Preventive Medicine

Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?

Aung Ko Win, John L Hopper, Daniel D Buchanan, Joanne P Young, Albert Tenesa, James G Dowty, Graham G Giles, Jack Goldblatt, Ingrid Winship, Alex Boussioutas, Graeme P Young, Susan Parry, John A Baron, David Duggan, Steven Gallinger, Polly A Newcomb, Robert W Haile, Loic Le Marchand, Noralane M Lindor, Mark A Jenkins

Journal article  |  2013  |  EUROPEAN JOURNAL OF CANCER

Cancer Risks for MLH1 and MSH2 Mutation Carriers

James G Dowty, Aung K Win, Daniel D Buchanan, Noralane M Lindor, Finlay A Macrae, Mark Clendenning, Yoland C Antill, Stephen N Thibodeau, Graham Casey, Steve Gallinger, Loic Le Marchand, Polly A Newcomb, Robert W Haile, Graeme P Young, Paul A James, Graham G Giles, Shanaka R Gunawardena, Barbara A Leggett, Michael Gattas, Alex Boussioutas, et al.

Journal article  |  2013  |  Human Mutation

Determining epithelial contribution to in vivo mesenchymal tumour expression signature using species-specific microarray profiling analysis of xenografts

E Purdom, C Restall, RA Busuttil, H Schluter, A Boussioutas, EW Thompson, RL Anderson, TP Speed, I Haviv

Journal article  |  2013  |  Genetics Research

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

Stefan Thiem, Thomas P Pierce, Michelle Palmieri, Tracy L Putoczki, Michael Buchert, Adele Preaudet, Ryan O Farid, Chris Love, Bruno Catimel, Zhengdeng Lei, Steve Rozen, Veena Gopalakrishnan, Fred Schaper, Michael Hallek, Alex Boussioutas, Patrick Tan, Andrew Jarnicki, Matthias Ernst

Journal article  |  2013  |  Journal of Clinical Investigation

Screening participation predictors for people at familial risk of colorectal cancer: a systematic review

D Ait Ouakrim, undefined Lockett, A Boussioutas, LA Keogh, LB Flander, JL Hopper, MA Jenkins

Journal article  |  2013  |  American Journal of Preventive Medicine

The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner

Mhairi Baird, Pei Woon Ang, Ian Clark, Danial Bishop, Masanobu Oshima, Matthew C Cook, Christine Hemmings, Shigeo Takeishi, Dan Worthley, Alex Boussioutas, Timothy C Wang, Doug Taupin

Journal article  |  2013  |  Laboratory Investigation

2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer

Megan AS Penno, Manuela Klingler-Hoffmann, Julie A Brazzatti, Alex Boussioutas, Tracy Putoczki, Matthias Ernst, Peter Hoffmann

Journal article  |  2012  |  JOURNAL OF PROTEOMICS

Screening practices of Australian men and women categorized as "at or slightly above average risk" of colorectal cancer

Driss Ait Ouakrim, Trevor Lockett, Alex Boussioutas, Louise Keogh, Louisa B Flander, Ingrid Winship, Graham G Giles, John L Hopper, Mark A Jenkins

Journal article  |  2012  |  CANCER CAUSES & CONTROL

GASTROINTESTINAL ABNORMALITIES IDENTIFIED BY FLUORESCENCE ENDOMICROSCOPY

Hongchun Bao, Alex Boussioutas, Mcgearey Aleixandria, Rita Busuttil, Min Gu

Journal article  |  2012  |  Journal of Innovative Optical Health Sciences

Prevalence and determinants of frequent gastroesophageal reflux symptoms in the Australian community

N Pandeya, AC Green, DC Whiteman

Journal article  |  2012  |  Diseases of the Esophagus

The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival

Aaron P Thrift, Christina M Nagle, Paul P Fahey, Anne Russell, Bernard M Smithers, David I Watson, David C Whiteman

Journal article  |  2012  |  International Journal of Cancer

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

Niantao Deng, Liang Kee Goh, Hannah Wang, Kakoli Das, Jiong Tao, Iain Beehuat Tan, Shenli Zhang, Minghui Lee, Jeanie Wu, Kiat Hon Lim, Zhengdeng Lei, Glenn Goh, Qing-Yan Lim, Angie Lay-Keng Tan, Dianne Yu Sin Poh, Sudep Riahi, Sandra Bell, Michael M Shi, Ronald Linnartz, Feng Zhu, et al.

Journal article  |  2012  |  GUT

Screening Practices of Unaffected People at Familial Risk of Colorectal Cancer

Driss Ait Ouakrim, Alex Boussioutas, Trevor Lockett, Ingrid Winship, Graham G Giles, Louisa B Flander, Louise Keogh, John L Hopper, Mark A Jenkins

Journal article  |  2012  |  CANCER PREVENTION RESEARCH

Preoperative Diagnosis of Lynch Syndrome With DNA Mismatch Repair Immunohistochemistry on a Diagnostic Biopsy

SK Warrier, AH Trainer, AC Lynch, C Mitchell, R Hiscock, S Sawyer, A Boussioutas, AG Heriot

Journal article  |  2011  |  Diseases of the Colon and Rectum

Gastrointestinal: Tuberculosis of the sigmoid colon-a cautionary tale

HL Philpott, A Boussioutas, I Kronborg, S Zanatti, C Dow

Journal article  |  2011  |  Journal of Gastroenterology and Hepatology

Education and imaging. Gastrointestinal: Tuberculosis of the sigmoid colon--a cautionary tale.

Journal article  |  2011  |  Journal of Gastroenterology and Hepatology

Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy

Iain Beehuat Tan, Tatiana Ivanova, Kiat Hon Lim, Chee Wee Ong, Niantao Deng, Julian Lee, Sze Huey Tan, Jeanie Wu, Ming Hui Lee, Chia Huey Ooi, Sun Young Rha, Wai Keong Wong, Alex Boussioutas, Khay Guan Yeoh, Jimmy So, Wei Peng Yong, Akira Tsuburaya, Heike Grabsch, Han Chong Toh, Steven Rozen, et al.

Journal article  |  2011  |  Gastroenterology

Contribution of the -Omics Era to Our Understanding of Preinvasive Disease and Progression to Cancer

Rita A Busuttil, Alex Boussioutas

Book Chapter  |  2011

Acceptability and accuracy of a non-endoscopic screening test for Barrett's oesophagus in primary care: cohort study

Sudarshan R Kadri, Pierre Lao-Sirieix, Maria O'Donovan, Irene Debiram, Madhumita Das, Jane M Blazeby, Jon Emery, Alex Boussioutas, Helen Morris, Fiona M Walter, Paul Pharoah, Richard H Hardwick, Rebecca C Fitzgerald

Journal article  |  2010  |  British Medical Journal

Second harmonic generation imaging via nonlinear endomicroscopy

Hongchun Bao, Alex Boussioutas, Reynolds Jeremy, Sarah Russell, Min Gu

Journal article  |  2010  |  Optics Express

Genomic and proteomic advances in gastric cancer

A Boussioutas, P Tan

Journal article  |  2009

Nonlinear imaging by an endoscope probe incorporating a tip-tilt-piston microelectromechanical system mirror

D Morrish, L Wu, H Xie, J Reynolds, A Boussioutas, M Gu

Conference Proceedings  |  2009  |  Optics InfoBase Conference Papers

Non-endoscopic screening biomarkers for Barrett's oesophagus: from microarray analysis to the clinic

P Lao-Sirieix, A Boussioutas, SR Kadri, M O'Donovan, I Debiram, M Das, L Harihar, RC Fitzgerald

Journal article  |  2009  |  Gut

Imaging of goblet cells as a marker for intestinal metaplasia of the stomach by one-photon and two-photon fluorescence endomicroscopy

Hongchun Bao, Alex Boussioutas, Jeremy Reynolds, Sarah Russell, Min Gu

Journal article  |  2009  |  Journal of Biomedical Optics

Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

Chia Huey Ooi, Tatiana Ivanova, Jeanie Wu, Minghui Lee, Iain Beehuat Tan, Jiong Tao, Lindsay Ward, Jun Hao Koo, Veena Gopalakrishnan, Yansong Zhu, Lai Ling Cheng, Julian Lee, Sun Young Rha, Hyun Cheol Chung, Kumaresan Ganesan, Jimmy So, Khee Chee Soo, Dennis Lim, Weng Hoong Chan, Wai Keong Wong, et al.

Journal article  |  2009  |  PLoS Genetics

The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development

Meegan Howlett, Andrew S Giraud, Helen Lescesen, Cameron B Jackson, Anastasia Kalantzis, Ian R Van Driel, Lorraine Robb, Mark Van der Hoek, Matthias Ernst, Toshinari Minamoto, Alex Boussioutas, Hiroko Oshima, Masanobu Oshima, Louise M Judd

Journal article  |  2009  |  Gastroenterology

Intestinal metaplasia: A premalignant lesion involved in gastric carcinogenesis

Rita A Busuttil, Alex Boussioutas

Journal article  |  2009  |  Journal of Gastroenterology and Hepatology

Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression

CB Jackson, LM Judd, TR Menheniott, I Kronborg, C Dow, ND Yeomans, A Boussioutas, L Robb, AS Giraud

Journal article  |  2007  |  Journal of Pathology

Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer

MB Loughrey, PM Waring, A Tan, M Trivett, S Kovalenko, V Beshay, M-A Young, G McArthur, A Boussioutas, A Dobrovic

Journal article  |  2007  |  Familial Cancer

Gastric involvement of plasmacytoma associated with t(4 : 14) and chromosome 13 deletion

Heather Robinson, Matthew Damasiewicz, Dirk Honemann, Stephen Lade, Alex Boussioutas, H Miles Prince

Journal article  |  2006  |  Leukemia and Lymphoma

The challenges of gene expression microarrays for the study of human cancer

Anna V Tinker, Alex Boussioutas, David DL Bowtell

Journal article  |  2006  |  Cancer Cell

Topological and functional discovery in a gene coexpression meta-network of gastric cancer

A Aggarwal, DL Guo, Y Hoshida, ST Yuen, KM Chu, S So, A Boussioutas, X Chen, D Bowtell, H Aburatani, SY Leung, P Tan

Journal article  |  2006  |  Cancer Research

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling

BJ Jenkins, D Grail, T Nheu, M Najdovska, B Wang, P Waring, M Inglese, RM McLoughlin, SA Jones, N Topley, H Baumann, LM Judd, AS Giraud, A Boussioutas, HJ Zhu, M Ernst

Journal article  |  2005  |  Nature Medicine

An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin

RW Tothill, A Kowalczyk, D Rischin, A Bousioutas, I Haviv, RK van Laar, PM Waring, J Zalcberg, R Ward, AV Biankin, RL Sutherland, SM Henshall, K Fong, JR Pollack, DDL Bowtell, AJ Holloway

Journal article  |  2005  |  Cancer Research

Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization

KL Gorringe, A Boussioutas, DDL Bowtell

Journal article  |  2005  |  Genes, Chromosomes & Cancer

Current and potential uses for DNA microarrays in transplantation medicine: lessons from other disciplines

A Boussioutas, I Haviv

Journal article  |  2003  |  Tissue Antigens

Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer

A Boussioutas, H Li, J Liu, P Waring, S Lade, AJ Holloway, D Taupin, K Gorringe, I Haviv, PV Desmond, DDL Bowtell

Journal article  |  2003  |  Cancer Research

Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B

P Marcellin, T Chang, SG Lim, MJ Tong, W Sievert, ML Shiffman, L Jeffers, Z Goodman, MS Wulfsohn, S Xiong, J Fry, CL Brosgart, N Afdhal, C O'Conner, P Andreone, C Cursaro, P Angus, R Vaughan, V Bain, K Gutfreund, et al.

Journal article  |  2003  |  New England Journal of Medicine

Towards a molecular approach to gastric cancer management

A Boussioutas, D Taupin

Journal article  |  2001  |  Internal Medicine Journal