Alex Boussioutas

DOP10 Persistent sonographic Inflammation as a predictor of clinical complications in patients with Crohn’s Disease

R Vaughan, D Tjandra, A Patwardhan, N Mingos, R Gibson, A Boussioutas, B Christensen

Journal article  |  2021  |  Journal of Crohn's and Colitis

Abstract Background Transmural healing has emerged as a new treatment target a..

Rapid Resistance of FGFR-driven Gastric Cancers to Regorafenib and Targeted FGFR Inhibitors can be Overcome by Parallel Inhibition of MEK

David K Lau, Ian Y Luk, Laura J Jenkins, Andrew Martin, David S Williams, Kael L Schoffer, Fiona Chionh, Michael Buchert, Katrin Sjoquist, Alex Boussioutas, Sarah A Hayes, Matthias Ernst, Andrew J Weickhardt, Nick Pavlakis, Niall C Tebbutt, John M Mariadason

Journal article  |  2021  |  MOLECULAR CANCER THERAPEUTICS

Amplification or overexpression of the FGFR family of receptor tyrosine kinases occurs in a significant proportion of gastric canc..

DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case-control Study

James A Chamberlain, Pierre-Antoine Dugue, Julie K Bassett, Roger L Milne, Jihoon E Joo, Ee Ming Wong, Maree T Brinkman, Geoffrey W Stuart, Alex Boussioutas, Melissa C Southey, Graham G Giles, Hazel Mitchell, Dallas R English, Allison M Hodge

Journal article  |  2021  |  CANCER PREVENTION RESEARCH

DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We co..

Diet and risk of gastro-oesophageal reflux disease in the Melbourne Collaborative Cohort Study.

Sabrina E Wang, Allison M Hodge, S Ghazaleh Dashti, Suzanne C Dixon-Suen, Hazel Mitchell, Robert Js Thomas, Elizabeth M Williamson, Enes Makalic, Alex Boussioutas, Andrew M Haydon, Graham G Giles, Roger L Milne, Bradley J Kendall, Dallas R English

Journal article  |  2021  |  Public Health Nutr

OBJECTIVE: To examine associations between diet and risk of developing gastro-oesophageal reflux disease (GERD). DESIGN: Prospecti..

SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence

Rita A Busuttil, Joshy George, Colin M House, Stephen Lade, Catherine Mitchell, Natasha S Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, Alex Boussioutas

Journal article  |  2020  |  GASTRIC CANCER

OBJECTIVE: Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined ..

Hereditary diffuse gastric cancer: updated clinical practice guidelines

Vanessa R Blair, Maybelle McLeod, Fatima Carneiro, Daniel G Coit, Johanna L D'Addario, Jolanda M van Dieren, Kirsty L Harris, Nicoline Hoogerbrugge, Carla Oliveira, Rachel S van der Post, Julie Arnold, Patrick R Benusiglio, Tanya M Bisseling, Alex Boussioutas, Annemieke Cats, Amanda Charlton, Karen E Chelcun Schreiber, Jeremy L Davis, Massimiliano di Pietro, Rebecca C Fitzgerald, et al.

Journal article  |  2020  |  LANCET ONCOLOGY

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of di..

A cohort study and meta-analysis of the evidence for consideration of Lauren subtype when prescribing adjuvant or palliative chemotherapy for gastric cancer

Kunning Wang, Enxiao Li, Rita A Busuttil, Joseph C Kong, Sharon Pattison, Joseph JY Sung, Jun Yu, Emad M El-Omar, Julie A Simpson, Alex Boussioutas

Journal article  |  2020  |  THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY

Background: The association between the survival or efficacy of chemotherapy and the Lauren subtype of gastric cancer (GC) remains..

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

John Burn, Harsh Sheth, Faye Elliott, Lynn Reed, Finlay Macrae, Jukka-Pekka Mecklin, Gabriela Moeslein, Fiona E McRonald, Lucio Bertario, D Gareth Evans, Anne-Marie Gerdes, Judy WC Ho, Annika Lindblom, Patrick J Morrison, Jem Rashbass, Raj Ramesar, Toni Seppala, Huw JW Thomas, Kirsi Pylvanainen, Gillian M Borthwick, et al.

Journal article  |  2020  |  LANCET

BACKGROUND: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, espec..

High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer

Minyu Wang, Yu-Kuan Huang, Joseph CH Kong, Yu Sun, Daniela G Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha Di Costanzo, Ian R Gordon, Catherine Mitchell, Laura K Mackay, Rita A Busuttil, Paul J Neeson, Alex Boussioutas

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive stu..

Molecular heterogeneity of gastric cancer explained by methylation-driven key regulators.

Seungyeul Yoo, Quan Chen, Li Wang, Wenhui Wang, Ankur Chakravarthy, Rita Busuttil, Alex Boussioutas, Tim R Fenton, Jiangwen Zhang, Xiaodan Fan, Seut-Yi Leung, Jun Zhu

Conference Proceedings  |  2020  |  CANCER IMMUNOLOGY RESEARCH