Tim Johanson

A microRNA expression and regulatory element activity atlas of the mouse immune system

Samuel A Rose, Aleksandra Wroblewska, Maxime Dhainaut, Hideyuki Yoshida, Jonathan M Shaffer, Anela Bektesevic, Benjamin Ben-Zvi, Andrew Rhoads, Edy Y Kim, Bingfei Yu, Yonit Lavin, Miriam Merad, Jason D Buenrostro, Brian D Brown

Journal article  |  2021  |  NATURE IMMUNOLOGY

To better define the control of immune system regulation, we generated an atlas of microRNA (miRNA) expression from 63 mouse immun..

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan, Ramya Raviram, Robert M Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N Huskins, Conor J Kearney, Jennifer R Devlin, Zheng Fan, Jafar S Jabbari, Ben P Martin, Mohamed Fareh, Madison J Kelly, et al.

Journal article  |  2021  |  MOLECULAR CELL

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigen..

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Ricardo Grieshaber-Bouyer, Felix A Radtke, Pierre Cunin, Giuseppina Stifano, Anais Levescot, Brinda Vijaykumar, Nathan Nelson-Maney, Rachel B Blaustein, Paul A Monach, Peter A Nigrovic

Journal article  |  2021  |  NATURE COMMUNICATIONS

Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete ..

Publisher Correction: Gut CD4 T cell phenotypes are a continuum molded by microbes, not by TH archetypes.

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, Kaitavjeet Chowdhary, Hugo Schmutz, Jodie Chandler, Alexandra Schnell, Pratiksha I Thakore, Graham LeGros, Sara Mostafavi, Diane Mathis, Christophe Benoist, undefined Immunological Genome Project Consortium

Journal article  |  2021  |  Nat Immunol

In the version of this article initially published, in the second paragraph of Results section “Teff phenotypes over time,” “Tcra ..

A comparison of alternative mRNA splicing in the CD4 and CD8 T cell lineages

Xin Liu, Matthew Andrews, Jarrod P Skinner, Timothy M Johanson, Mark MW Chong

Journal article  |  2021  |  MOLECULAR IMMUNOLOGY

T cells can be subdivided into a number of different subsets that are defined by their distinct functions. While the specializatio..

Chromosomes distribute randomly to, but not within, human neutrophil nuclear lobes

Christine R Keenan, Michael J Mlodzianoski, Hannah D Coughlan, Naiara G Bediaga, Gaetano Naselli, Erin C Lucas, Qike Wang, Carolyn A de Graaf, Douglas J Hilton, Leonard C Harrison, Gordon K Smyth, Kelly L Rogers, Thomas Boudier, Rhys S Allan, Timothy M Johanson

Journal article  |  2021  |  ISCIENCE

The proximity pattern and radial distribution of chromosome territories within spherical nuclei are random and non-random, respect..

Pre-mitotic genome re-organisation bookends the B cell differentiation process

Wing Fuk Chan, Hannah D Coughlan, Jie HS Zhou, Christine R Keenan, Naiara G Bediaga, Philip D Hodgkin, Gordon K Smyth, Timothy M Johanson, Rhys S Allan

Journal article  |  2021  |  NATURE COMMUNICATIONS

During cellular differentiation chromosome conformation is intricately remodelled to support the lineage-specific transcriptional ..

Gut CD4( ) T cell phenotypes are a continuum molded by microbes, not by T-H archetypes

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, Kaitavjeet Chowdhary, Hugo Schmutz, Jodie Chandler, Alexandra Schnell, Pratiksha I Thakore, Graham LeGros, Sara Mostafavi, Diane Mathis, Christophe Benoist

Journal article  |  2021  |  NATURE IMMUNOLOGY

CD4+ effector lymphocytes (Teff) are traditionally classified by the cytokines they produce. To determine the states that Teff cel..

Multi-level remodelling of chromatin underlying activation of human T cells

Naiara G Bediaga, Hannah D Coughlan, Timothy M Johanson, Alexandra L Garnham, Gaetano Naselli, Jan Schroeder, Liam G Fearnley, Esther Bandala-Sanchez, Rhys S Allan, Gordon K Smyth, Leonard C Harrison

Journal article  |  2021  |  SCIENTIFIC REPORTS

Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage develop..

Identification and characterization of the long noncoding RNA Dreg1 as a novel regulator of Gata3

Wing Fuk Chan, Hannah D Coughlan, Nadia Iannarella, Gordon K Smyth, Timothy M Johanson, Christine R Keenan, Rhys S Allan

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

The eukaryotic genome is three-dimensionally segregated into discrete globules of topologically associating domains (TADs), within..