Tim Johanson

Survey of activation-induced genome architecture reveals a novel enhancer of Myc

Wing Fuk Chan, Hannah D Coughlan, Michelle Ruhle, Nadia Iannarella, Carolina Alvarado, Joanna R Groom, Christine R Keenan, Andrew J Kueh, Adam K Wheatley, Gordon K Smyth, Rhys S Allan, Timothy M Johanson

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

The transcription factor Myc is critically important in driving cell proliferation, a function that is frequently dysregulated in ..

MiMIC analysis reveals an isoform specific role for Drosophila Musashi in follicle stem cell maintenance and escort cell function

Nicole A Siddall, Franca Casagranda, Timothy M Johanson, Nicole Dominado, James Heaney, Jessie M Sutherland, Eileen A McLaughlin, Gary R Hime

Journal article  |  2022  |  CELL DEATH DISCOVERY

The Drosophila ovary is regenerated from germline and somatic stem cell populations that have provided fundamental conceptual unde..

Activation of stably silenced genes by recruitment of a synthetic de-methylating module

Wing Fuk Chan, Hannah D Coughlan, Yunshun Chen, Christine R Keenan, Gordon K Smyth, Andrew C Perkins, Timothy M Johanson, Rhys S Allan

Journal article  |  2022  |  NATURE COMMUNICATIONS

Stably silenced genes that display a high level of CpG dinucleotide methylation are refractory to the current generation of dCas9-..

In Situ HiC.

Timothy M Johanson, Rhys S Allan

Book Chapter  |  2022  |  Methods in Molecular Biology

In situ HiC uses the relative frequency of DNA-DNA ligation events to reconstruct the three-dimensional architecture of a genome. ..

Parsing the transcription factors governing T cell immunity

Timothy M Johanson, Rhys S Allan

Journal article  |  2021  |  NATURE IMMUNOLOGY

Shedding Structured Light on Molecular Immunity: The Past, Present and Future of Immune Cell Super Resolution Microscopy

Timothy M Johanson, Christine R Keenan, Rhys S Allan

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

In the two decades since the invention of laser-based super resolution microscopy this family of technologies has revolutionised t..

A microRNA expression and regulatory element activity atlas of the mouse immune system

Samuel A Rose, Aleksandra Wroblewska, Maxime Dhainaut, Hideyuki Yoshida, Jonathan M Shaffer, Anela Bektesevic, Benjamin Ben-Zvi, Andrew Rhoads, Edy Y Kim, Bingfei Yu, Yonit Lavin, Miriam Merad, Jason D Buenrostro, Brian D Brown

Journal article  |  2021  |  NATURE IMMUNOLOGY

To better define the control of immune system regulation, we generated an atlas of microRNA (miRNA) expression from 63 mouse immun..

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan, Ramya Raviram, Robert M Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N Huskins, Conor J Kearney, Jennifer R Devlin, Zheng Fan, Jafar S Jabbari, Ben P Martin, Mohamed Fareh, Madison J Kelly, et al.

Journal article  |  2021  |  MOLECULAR CELL

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigen..

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Ricardo Grieshaber-Bouyer, Felix A Radtke, Pierre Cunin, Giuseppina Stifano, Anais Levescot, Brinda Vijaykumar, Nathan Nelson-Maney, Rachel B Blaustein, Paul A Monach, Peter A Nigrovic

Journal article  |  2021  |  NATURE COMMUNICATIONS

Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete ..

Publisher Correction: Gut CD4 T cell phenotypes are a continuum molded by microbes, not by TH archetypes.

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, Kaitavjeet Chowdhary, Hugo Schmutz, Jodie Chandler, Alexandra Schnell, Pratiksha I Thakore, Graham LeGros, Sara Mostafavi, Diane Mathis, Christophe Benoist, undefined Immunological Genome Project Consortium

Journal article  |  2021  |  Nat Immunol

In the version of this article initially published, in the second paragraph of Results section “Teff phenotypes over time,” “Tcra ..