Tim Johanson

Chromosomes distribute randomly to, but not within, human neutrophil nuclear lobes.

Christine R Keenan, Michael J Mlodzianoski, Hannah D Coughlan, Naiara G Bediaga, Gaetano Naselli, Erin C Lucas, Qike Wang, Carolyn A de Graaf, Douglas J Hilton, Leonard C Harrison, Gordon K Smyth, Kelly L Rogers, Thomas Boudier, Rhys S Allan, Timothy M Johanson

Journal article  |  2021  |  iScience

The proximity pattern and radial distribution of chromosome territories within spherical nuclei are random and non-random, respect..

Pre-mitotic genome re-organisation bookends the B cell differentiation process.

Wing Fuk Chan, Hannah D Coughlan, Jie HS Zhou, Christine R Keenan, Naiara G Bediaga, Philip D Hodgkin, Gordon K Smyth, Timothy M Johanson, Rhys S Allan

Journal article  |  2021  |  Nature Communications

During cellular differentiation chromosome conformation is intricately remodelled to support the lineage-specific transcriptional ..

A comparison of alternative mRNA splicing in the CD4 and CD8 T cell lineages.

Xin Liu, Matthew V Andrews, Jarrod P Skinner, Timothy M Johanson, Mark MW Chong

Journal article  |  2021  |  Molecular Immunology

T cells can be subdivided into a number of different subsets that are defined by their distinct functions. While the specializatio..

Gut CD4( ) T cell phenotypes are a continuum molded by microbes, not by T-H archetypes

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, Kaitavjeet Chowdhary, Hugo Schmutz, Jodie Chandler, Alexandra Schnell, Pratiksha I Thakore, Graham LeGros, Sara Mostafavi, Diane Mathis, Christophe Benoist

Journal article  |  2021  |  Nature Immunology

CD4+ effector lymphocytes (Teff) are traditionally classified by the cytokines they produce. To determine the states that Teff cel..

Multi-level remodelling of chromatin underlying activation of human T cells

Naiara G Bediaga, Hannah D Coughlan, Timothy M Johanson, Alexandra L Garnham, Gaetano Naselli, Jan Schroeder, Liam G Fearnley, Esther Bandala-Sanchez, Rhys S Allan, Gordon K Smyth, Leonard C Harrison

Journal article  |  2021  |  Scientific Reports

Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage develop..

Publisher Correction: Gut CD4 T cell phenotypes are a continuum molded by microbes, not by TH archetypes (Nature Immunology, (2021), 22, 2, (216-228), 10.1038/s41590-020-00836-7)

E Kiner, E Willie, B Vijaykumar, K Chowdhary, H Schmutz, J Chandler, A Schnell, PI Thakore, G LeGros, S Mostafavi, D Mathis, C Benoist, O Aguilar, R Allan, J Astarita, KF Austen, N Barrett, A Baysoy, C Benoist, BD Brown, et al.

Journal article  |  2021  |  Nature Immunology

Identification and characterization of the long noncoding RNA Dreg1 as a novel regulator of Gata3

Wing Fuk Chan, Hannah D Coughlan, Nadia Iannarella, Gordon K Smyth, Timothy M Johanson, Christine R Keenan, Rhys S Allan

Journal article  |  2020  |  Immunology and Cell Biology

The eukaryotic genome is three-dimensionally segregated into discrete globules of topologically associating domains (TADs), within..

ImmGen at 15

Stephanie Vargas Aguilar, Oscar Aguilar, Rhys Allan, El Ad David Amir, Veronique Angeli, Maxim N Artyomov, Natasha Asinovski, Jilian Astarita, K Frank Austen, Geetika Bajpai, Nora Barrett, Alev Baysoy, Christophe Benoist, Angelique Bellemare-Pelletier, Brad Berg, Adam Best, Natalie Bezman, David Blair, Julie M Blander, Milena Bogunovic, et al.

Journal article  |  2020  |  Nature Immunology

An Erg-driven transcriptional program controls B cell lymphopoiesis.

Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson, et al.

Journal article  |  2020  |  Nature Communications

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging

Christine R Keenan, Nadia Iannarella, Gaetano Naselli, Naiara G Bediaga, Timothy M Johanson, Leonard C Harrison, Rhys S Allan

Journal article  |  2020  |  Blood

Abstract Loss of heterochromatin has been proposed as a universal mechanism of aging across different species and c..