Geoffrey McFadden

A candidate transporter allowing symbiotic dinoflagellates to feed their coral hosts.

Keren Maor-Landaw, Marion Eisenhut, Giada Tortorelli, Allison van de Meene, Samantha Kurz, Gabriela Segal, Madeleine JH van Oppen, Andreas PM Weber, Geoffrey I McFadden

Journal article  |  2023  |  ISME Commun

The symbiotic partnership between corals and dinoflagellate algae is crucial to coral reefs. Corals provide their algal symbionts ..

Targeting malaria parasites with novel derivatives of azithromycin

Amy L Burns, Brad E Sleebs, Maria Gancheva, Kimberley T McLean, Ghizal Siddiqui, Henrietta Venter, James G Beeson, Ryan O'Handley, Darren J Creek, Shutao Ma, Sonja Froelich, Christopher D Goodman, Geoffrey McFadden, Danny W Wilson

Journal article  |  2022  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

INTRODUCTION: The spread of artemisinin resistant Plasmodium falciparum parasites is of global concern and highlights the need to ..

Roles of the apicoplast across the life cycles of rodent and human malaria parasites

Hayley D Buchanan, Christopher D Goodman, Geoffrey I McFadden

Journal article  |  2022  |  JOURNAL OF EUKARYOTIC MICROBIOLOGY

Malaria parasites are diheteroxenous, requiring two hosts—a vertebrate and a mosquito—to complete their life cycle. ..

6 ''-Modifed alpha-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria

Michael A Meijlink, Yu Cheng Chua, Susanna TS Chan, Regan J Anderson, Matthew W Rosenberg, Anton Cozijnsen, Vanessa Mollard, Geoffrey McFadden, Sarah L Draper, Lauren E Holz, Ian F Hermans, William R Heath, Gavin F Painter, Benjamin J Compton

Journal article  |  2022  |  RSC CHEMICAL BIOLOGY

Self-adjuvanting vaccines consisting of peptide epitopes conjugated to immune adjuvants are a powerful way of generating antigen-s..

The cell wall polysaccharides of a photosynthetic relative of apicomplexans, Chromera velia

Giada Tortorelli, Filomena Pettolino, De-Hua Lai, Ales Tomcala, Antony Bacic, Miroslav Obornik, Julius Lukes, Geoffrey McFadden

Journal article  |  2021  |  JOURNAL OF PHYCOLOGY

Chromerids are a group of alveolates, found in corals, that show peculiar morphological and genomic features. These organisms are ..

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Brodie L Bailey, William Nguyen, Anna Ngo, Christopher D Goodman, Maria R Gancheva, Paola Favuzza, Laura M Sanz, Francisco-Javier Gamo, Kym N Lowes, Geoffrey I McFadden, Danny W Wilson, Benoit Laleu, Stephen Brand, Paul F Jackson, Alan F Cowman, Brad E Sleebs

Journal article  |  2021  |  BIOORGANIC CHEMISTRY

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported..

Cell wall proteomic analysis of the cnidarian photosymbionts Breviolum minutum and Cladocopium goreaui

Giada Tortorelli, Clinton A Oakley, Simon K Davy, Madeleine JH van Oppen, Geoffrey McFadden

Journal article  |  2021  |  JOURNAL OF EUKARYOTIC MICROBIOLOGY

The algal cell wall is an important cellular component that functions in defense, nutrient utilization, signaling, adhesion, and c..

Cell surface carbohydrates of symbiotic dinoflagellates and their role in the establishment of cnidarian-dinoflagellate symbiosis

Giada Tortorelli, Carsten Rautengarten, Antony Bacic, Gabriela Segal, Berit Ebert, Simon K Davy, Madeleine JH van Oppen, Geoffrey McFadden

Journal article  |  2021  |  ISME JOURNAL

Symbiodiniaceae algae are often photosymbionts of reef-building corals. The establishment of their symbiosis resembles a microbial..

Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes

Marco Biddau, TR Santha Kumar, Philipp Henrich, Larissa M Laine, Gavin J Blackburn, Achuthanunni Chokkathukalam, Tao Li, Kim Lee Sim, Lewis King, Stephen L Hoffman, Michael P Barrett, Graham H Coombs, Geoffrey I McFadden, David A Fidock, Sylke Mueller, Lilach Sheiner

Journal article  |  2021  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Malaria is still one of the most important global infectious diseases. Emergence of drug resistance and a shortage of new efficien..

Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites

Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson

Journal article  |  2021  |  NATURE COMMUNICATIONS

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..