Rebecca Ritchie

Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

Cheng Peng, Alastair G Stewart, Owen L Woodman, Rebecca H Ritchie, Cheng Xue Qin

Journal article  |  2020  |  FRONTIERS IN PHARMACOLOGY

Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the populat..

Gene therapy targeting cardiac phosphoinositide 3-kinase (p110 alpha) attenuates cardiac remodeling in type 2 diabetes

Darnel Prakoso, Miles J De Blasio, Mitchel Tate, Helen Kiriazis, Daniel G Donner, Hongwei Qian, David Nash, Minh Deo, Kate L Weeks, Laura J Parry, Paul Gregorevic, Julie R McMullen, Rebecca Helen Ritchie

Journal article  |  2020  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diabetic cardiomyopathy is a distinct form of heart disease that represents a major cause of death and disability in diabetic pati..

Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice

Maria Jelinic, Nicola Kahlberg, Chen Huei Leo, Hooi Hooi Ng, Sarah Rosli, Minh Deo, Mandy Li, Siobhan Finlayson, Jesse Walsh, Laura J Parry, Rebecca H Ritchie, Cheng Xue Qin

Journal article  |  2020  |  British Journal of Pharmacology

Background and purpose Arterial stiffness, a characteristic feature of diabetes, increases the risk of cardiovascular complication..

The Novel Small-molecule Annexin-A1 Mimetic, Compound 17b, Elicits Vasoprotective Actions in Streptozotocin-induced Diabetic Mice.

Sarah A Marshall, Cheng Xue Qin, Maria Jelinic, Kelly O'Sullivan, Minh Deo, Jesse Walsh, Mandy Li, Laura J Parry, Rebecca H Ritchie, Chen Huei Leo

Journal article  |  2020  |  International Journal of Molecular Sciences

The formyl peptide receptor (FPR) family are a group of G-protein coupled receptors that play an important role in the regulation ..

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl.

Cheng Xue Qin, Jarryd Anthonisz, Chen Huei Leo, Nicola Kahlberg, Anida Velagic, Mandy Li, Edwina Jap, Owen L Woodman, Laura J Parry, John D Horowitz, Barbara K Kemp-Harper, Rebecca H Ritchie

Journal article  |  2020  |  Antioxidants and Redox Signaling

Aim: Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO•), known as NO• resistance, occurs in many c..

Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights

Chen Huei Leo, Hooi Hooi Ng, Sarah A Marshall, Maria Jelinic, Thusitha Rupasinghe, Chengxue Qin, Ute Roessner, Rebecca H Ritchie, Marianne Tare, Laura J Parry

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Endothelium-derived vasoconstriction is a hallmark of vascular dysfunction in hypertension. In some cases,..

Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Girdhar Singh Deora, Cheng Xue Qin, Elizabeth A Vecchio, Aaron J Debono, Daniel L Priebbenow, Ryan M Brady, Julia Beveridge, Silvia C Teguh, Deo Minh, Lauren T May, Guy Krippner, Rebecca H Ritchie, Jonathan B Baell

Journal article  |  2019  |  JOURNAL OF MEDICINAL CHEMISTRY

Herein we describe the development of a focused series of functionalized pyridazin-3(2 H)-one-based formyl peptide receptor (FPR) ..

Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges

Bianca C Bernardo, Paul Gregorevic, Rebecca H Ritchie, Julie R McMullen

Journal article  |  2018  |  FRONTIERS IN PHARMACOLOGY

Heart failure (HF) is a debilitating and deadly chronic disease, with almost 50% of patients with HF dying within 5 years of diagn..

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications

Arpeeta Sharma, Mitchel Tate, Geetha Mathew, James E Vince, Rebecca H Ritchie, Judy B de Haan

Journal article  |  2018  |  FRONTIERS IN PHYSIOLOGY

It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that steri..

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

Chanchal Chandramouli, Melissa E Reichelt, Claire L Curl, Upasna Varma, Laura A Bienvenu, Parisa Koutsifeli, Antonia JA Raaijmakers, Miles J De Blasio, Cheng Xue Qin, Alicia J Jenkins, Rebecca H Ritchie, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2018  |  SCIENTIFIC REPORTS

Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascula..