Matthew Watt

Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes

Jacqueline Bayliss, Geraldine J Ooi, William De Nardo, Yazmin Johari Halim Shah, Magdalene K Montgomery, Catriona McLean, William Kemp, Stuart K Roberts, Wendy A Brown, Paul R Burton, Matthew J Watt

Journal article  |  2021  |  Frontiers in Endocrinology

Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of obese mice ..

GIP receptor deletion in mice confers resistance to HFD-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism.

Geke Aline Boer, Stacey N Keenan, Paula M Miotto, Jens J Holst, Matthew J Watt

Journal article  |  2021  |  AJP Endocrinology and Metabolism

Glucose-dependent insulinotropic polypeptide (GIP) is best known as an incretin hormone that is secreted from K-cells of the proxi..

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity.

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  Molecular Metabolism

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

Circulating cathepsin S improves glycaemic control in mice.

Hamzeh Karimkhanloo, Stacey N Keenan, Emily W Sun, David A Wattchow, Damien J Keating, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2021  |  Journal of Endocrinology

Cathepsin S (CTSS) is a cysteine protease that regulates many physiological processes and is increased in obesity and type 2 diabe..

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control.

Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt

Journal article  |  2021  |  The Journal of Lipid Research

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..

Long Chain Fatty Acids Differentially Regulate Sub-populations of Arcuate POMC and NPY Neurons

Natalie J Michael, Matthew J Watt

Journal article  |  2020  |  Neuroscience

Long chain fatty acids (LCFAs) have been suggested to influence the activity of hypothalamic neurons, however, limited studies hav..

Importance of myofibre-type specific differences in disease manifestation for muscular dystrophies: focus on dysferlinopathy

E Lloyd, G Pinniger, R Murphy, M Watt, M Grounds

Conference Proceedings  |  2020  |  Neuromuscular Disorders

Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality

Chrishan J Nalliah, James R Bell, Antonia JA Raaijmakers, Helen M Waddell, Simon P Wells, Gabriel B Bernasochi, Magdalene K Montgomery, Simon Binny, Troy Watts, Subodh B Joshi, Elaine Lui, Choon Boon Sim, Marco Larobina, Michael O'Keefe, John Goldblatt, Alistair Royse, Geoffrey Lee, Enzo R Porrello, Matthew J Watt, Peter M Kistler, et al.

Journal article  |  2020  |  Journal of the American College of Cardiology

BACKGROUND: Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of a..

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt

Journal article  |  2020  |  Science Translational Medicine

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..

Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity

Thomas Tsiloulis, Arthe Raajendiran, Stacey N Keenan, Geraldine Ooi, Renea A Taylor, Paul Burton, Matthew J Watt

Journal article  |  2020  |  AJP Endocrinology and Metabolism

Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. W..