Matthew Watt

Early intervention exercise training does not delay prostate cancer progression in Pten(-/-) mice

Renea A Taylor, Simon G Farrelly, Ashlee K Clark, Matthew J Watt

Journal article  |  2020  |  The Prostate

BACKGROUND: There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of..

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery

Journal article  |  2020  |  Current Diabetes Reports

PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..

A Neural basis for Octanoic acid regulation of energy balance

Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt

Journal article  |  2020  |  Molecular Metabolism

OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..

The role of Ap2a2 in PPAR alpha-mediated regulation of lipolysis in adipose tissue

Magdalene K Montgomery, Jacqueline Bayliss, Stacey Keenan, Sarah Rhost, Stephen B Ting, Matthew J Watt

Journal article  |  2019  |  The FASEB Journal

Adipose tissue plays a major role in the regulation of systemic metabolic homeostasis, with the AP2 adaptor complex being importan..

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Mercedes Davalos-Salas, Magdalene K Montgomery, Camilla M Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Togel, Angela Rigopoulos, Sylvia J Gong, David S Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert, et al.

Journal article  |  2019  |  Nature Communications

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulati..

The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance

Matthew J Watt, Paula M Miotto, William De Nardo, Magdalene K Montgomery

Journal article  |  2019  |  Endocrine Reviews

The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic gluco..

Unsuspected Protumorigenic Signaling Role for the Oncometabolite GABA in Advanced Prostate Cancer

Renea A Taylor, Matthew J Watt

Journal article  |  2019  |  Cancer Research

Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice[S]

Vanessa R Haynes, Stacey N Keenan, Jackie Bayliss, Erin M Lloyd, Peter Meikle, Miranda D Grounds, Matthew J Watt

Journal article  |  2019  |  Journal of Lipid Research

Exercise serum increases GLUT4 in human adipocytes

Marcelo Flores-Opazo, Arthe Raajendiran, Matthew J Watt, Mark Hargreaves

Journal article  |  2019  |  Experimental Physiology

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues

Arthe Raajendiran, Geraldine Ooi, Jackie Bayliss, Paul E O'Brien, Ralf B Schittenhelm, Ashlee K Clark, Renea A Taylor, Matthew S Rodeheffer, Paul R Burton, Matthew J Watt

Journal article  |  2019  |  Cell Reports

Choline administration attenuates aspects of the dystrophic pathology in mdx mice

FM Alves, MK Caldow, J Trieu, T Naim, MK Montgomery, MJ Watt, GS Lynch, R Koopman

Journal article  |  2019  |  Clinical Nutrition Experimental

An integrative systems genetic analysis of mammalian lipid metabolism

Benjamin L Parker, Anna C Calkin, Marcus M Seldin, Michael F Keating, Elizabeth J Tarling, Pengyi Yang, Sarah C Moody, Yingying Liu, Eser J Zerenturk, Elise J Needham, Matthew L Miller, Bethan L Clifford, Pauline Morand, Matthew J Watt, Ruth CR Meex, Kang-Yu Peng, Richard Lee, Kaushala Jayawardana, Calvin Pan, Natalie A Mellett, et al.

Journal article  |  2019  |  Nature

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

Stacey N Keenan, Ruth C Meex, Jennifer CY Lo, Andrew Ryan, Shuai Nie, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2019  |  Diabetes

Impact of Lipotoxicity on Tissue "Cross Talk" and Metabolic Regulation

Magdalene K Montgomery, William De Nardo, Matthew J Watt

Journal article  |  2019  |  Physiology

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Matthew J Watt, Ashlee K Clark, Luke A Selth, Vanessa R Haynes, Natalie Lister, Richard Rebello, Laura H Porter, Birunthi Niranjan, Sarah T Whitby, Jennifer Lo, Cheng Huang, Ralf B Schittenhelm, Kimberley E Anderson, Luc Furic, Poornima R Wijayaratne, Maria Matzaris, Magdalene K Montgomery, Melissa Papargiris, Sam Norden, Maria Febbraio, et al.

Journal article  |  2019  |  Science Translational Medicine

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A Febbraio, Saskia Reibe, Shabnam Shalapour, Geraldine J Ooi, Matthew J Watt, Michael Karin

Journal article  |  2019  |  Cell Metabolism

Effect of Body Mass Index, Metabolic Health and Adipose Tissue Inflammation on the Severity of Non-alcoholic Fatty Liver Disease in Bariatric Surgical Patients: a Prospective Study

Geraldine J Ooi, Paul R Burton, Jacqueline Bayliss, Arthe Raajendiran, Arul Earnest, Cheryl Laurie, William W Kemp, Catriona A McLean, Stuart K Roberts, Matthew J Watt, Wendy A Brown

Journal article  |  2019  |  Obesity Surgery

The Influence of Aerobic Exercise on Hippocampal Integrity and Function: Preliminary Findings of a Multi-Modal Imaging Analysis.

Lauren Den Ouden, Aaron Kandola, Chao Suo, Joshua Hendrikse, Ricardo JS Costa, Matthew J Watt, Valentina Lorenzetti, Yann Chye, Linden Parkes, Kristina Sabaroedin, Murat Yücel

Journal article  |  2018  |  Brain Plasticity

Aerobic exercise (AE) interventions represent promising therapeutic approaches in disorders that compromise hippocampal integrity,..

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.

David Rotter, Heshan Peiris, D Bennett Grinsfelder, Alyce M Martin, Jana Burchfield, Valentina Parra, Christi Hull, Cyndi R Morales, Claire F Jessup, Dusan Matusica, Brian W Parks, Aldons J Lusis, Ngoc Uyen Nhi Nguyen, Misook Oh, Israel Iyoke, Tanvi Jakkampudi, D Randy McMillan, Hesham A Sadek, Matthew J Watt, Rana K Gupta, et al.

Journal article  |  2018  |  EMBO reports

Increasing non-shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is championed as an ..

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Marcus Grohmann, Florian Wiede, Garron T Dodd, Esteban N Gurzov, Geraldine J Ooi, Tariq Butt, Aliki A Rasmiena, Supreet Kaur, Twishi Gulati, Pei K Goh, Aislinn E Treloar, Stuart Archer, Wendy A Brown, Mathias Muller, Matthew J Watt, Osamu Ohara, Catriona A McLean, Tony Tiganis

Journal article  |  2018  |  Cell

Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury.

Connie PC Ow, Jennifer P Ngo, Md Mahbub Ullah, Giannie Barsha, Ruth C Meex, Matthew J Watt, Lucinda M Hilliard, Maarten P Koeners, Roger G Evans

Journal article  |  2018  |  American Journal of Physiology-Renal Physiology

Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion injury (IRI), particularly during the period ..

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression

Kang-Yu Peng, Matthew J Watt, Sander Rensen, Jan Willem Greve, Kevin Huynh, Kaushala S Jayawardana, Peter J Meikle, Ruth CR Meex

Journal article  |  2018  |  Journal of Lipid Research

Insights into the neurochemical signature of the Innervation of Beige Fat

Aneta Stefanidis, Nicole M Wiedmann, Sonika Tyagi, Andrew M Allen, Matthew J Watt, Brian J Oldfield

Journal article  |  2018  |  Molecular Metabolism

Radical gastric cancer surgery results in widespread upregulation of pro-tumourigenic intraperitoneal cytokines.

Andrew J Long, Paul R Burton, Michael J De Veer, Geraldine J Ooi, Cheryl P Laurie, Peter D Nottle, Matthew J Watt, Wendy A Brown

Journal article  |  2018  |  ANZ Journal of Surgery

BACKGROUND: Radical surgical resection is the mainstay of curative treatment for oesophagogastric malignancy. However, survival an..

Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle

Magdalene K Montgomery, Ruzaidi Mokhtar, Jacqueline Bayliss, Helena C Parkington, Victor M Suturin, Clinton R Bruce, Matthew J Watt

Journal article  |  2018  |  Diabetes

No evidence of white adipocyte browning after endurance exercise training in obese men

T Tsiloulis, AL Carey, J Bayliss, B Canny, RCR Meex, MJ Watt

Journal article  |  2018  |  International Journal of Obesity

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning.

Alex Reichenbach, Romana Stark, Mathieu Mequinion, Raphael RG Denis, Jeferson F Goularte, Rachel E Clarke, Sarah H Lockie, Moyra B Lemus, Greg M Kowalski, Clinton R Bruce, Cheng Huang, Ralf B Schittenhelm, Randall L Mynatt, Brian J Oldfield, Matthew J Watt, Serge Luquet, Zane B Andrews

Journal article  |  2018  |  Cell Reports

AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient r..

Triglyceride metabolism in exercising muscle.

Matthew J Watt, Yunsheng Cheng

Journal article  |  2017  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Triglycerides are stored within lipid droplets in skeletal muscle and can be hydrolyzed to produce fatty acids for energy producti..

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Aowen Zhuang, Felicia Yt Yap, Clinton Bruce, Chris Leung, Manuel R Plan, Mitchell A Sullivan, Chandana Herath, Domenica McCarthy, Karly C Sourris, Phillip Kantharidis, Melinda T Coughlan, Mark A Febbraio, Mark P Hodson, Matthew J Watt, Peter Angus, Benjamin L Schulz, Josephine M Forbes

Journal article  |  2017  |  Scientific Reports

Prevention of the adverse effects of olanzapine on lipid metabolism with the antiepileptic zonisamide.

Aneta Stefanidis, Matthew J Watt, Michael A Cowley, Brian J Oldfield

Journal article  |  2017  |  Neuropharmacology

BACKGROUND: Atypical antipsychotic drugs, particularly olanzapine, represent a mainstay in the treatment of psychoses; however, th..

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance.

Ruth CR Meex, Matthew J Watt

Journal article  |  2017  |  Nature Reviews Endocrinology

Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver dis..

Impact of endurance exercise training on adipocyte microRNA expression in overweight men

Thomas Tsiloulis, Joshua Pike, David Powell, Fernando J Rossello, Benedict J Canny, Ruth CR Meex, Matthew J Watt

Journal article  |  2017  |  The FASEB Journal

Adipose tissue development and the molecular regulation of lipid metabolism.

Arthe Raajendiran, Thomas Tsiloulis, Matthew J Watt

Journal article  |  2016  |  Essays in Biochemistry

The production of new adipocytes is required to maintain adipose tissue mass and involves the proliferation and differentiation of..

RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State

Jennifer Chi Yi Lo, Anne E O'Connor, Zane B Andrews, Camden Lo, Tony Tiganis, Matthew J Watt, Moira K O'Bryan

Journal article  |  2016  |  Endocrinology

alpha-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

Pablo J Enriori, Weiyi Chen, Maria C Garcia-Rudaz, Bernadette E Grayson, Anne E Evans, Sarah M Comstock, Ursel Gebhardt, Hermann L Mueller, Thomas Reinehr, Belinda A Henry, Russell D Brown, Clinton R Bruce, Stephanie E Simonds, Sara A Litwak, Sean L McGee, Serge Luquet, Sarah Martinez, Martin Jastroch, Matthias H Tschoep, Matthew J Watt, et al.

Journal article  |  2016  |  Molecular Metabolism

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Justin L Chen, Kelly L Walton, Hongwei Qian, Timothy D Colgan, Adam Hagg, Matthew J Watt, Craig A Harrison, Paul Gregorevic

Journal article  |  2016  |  Cancer Research

Reduced ATGL-mediated lipolysis attenuates beta-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue

Rebecca EK MacPherson, Steven M Dragos, Sofhia Ramos, Charles Sutton, Scott Frendo-Cumbo, Laura Castellani, Matthew J Watt, Christopher GR Perry, David M Mutch, David C Wright

Journal article  |  2016  |  American Journal of Physiology-Cell Physiology

Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts

Jennifer CY Lo, Ashlee K Clark, Natasha Ascui, Mark Frydenberg, Gail P Risbridger, Renea A Taylor, Matthew J Watt

Journal article  |  2016  |  Oncotarget

Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training

Ruzaidi AM Mohktar, Magda K Montgomery, Robyn M Murphy, Matthew J Watt

Journal article  |  2016  |  American Journal of Physiology-Endocrinology and Metabolism

Fat talks: a new role for adipose tissue in promoting prostate cancer in obesity

Matthew J Watt, Renea A Taylor

Journal article  |  2016  |  Translational Cancer Research

Skeletal muscle action of estrogen receptor a is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Vicent Ribas, Brian G Drew, Zhenqi Zhou, Jennifer Phun, Nareg Y Kalajian, Teo Soleymani, Pedram Daraei, Kevin Widjaja, Jonathan Wanagat, Thomas Q de Aguiar Vallim, Amy H Fluitt, Steven Bensinger, Le Thuc, Caius Radu, Julian P Whitelegge, Simon W Beaven, Peter Tontonoz, Aldons J Lusis, Brian W Parks, Laurent Vergnes, et al.

Journal article  |  2016  |  Science Translational Medicine

Central Administration of the Ciliary Neurotrophic Factor Analogue, Axokine, Does Not Play a Role in Long-Term Energy Homeostasis in Adult Mice

Melissa L Borg, Alex Reichenbach, Moyra Lemus, Brian J Oldfield, Zane B Andrews, Matthew J Watt

Journal article  |  2016  |  Neuroendocrinology

Linking obesogenic dysregulation to prostate cancer progression

Renea A Taylor, Jennifer Lo, Natasha Ascui, Matthew J Watt

Journal article  |  2015  |  Endocrine Connections

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

Ruth C Meex, Andrew J Hoy, Alexander Morris, Russell D Brown, Jennifer CY Lo, Melissa Burke, Robert JA Goode, Bronwyn A Kingwell, Michael J Kraakman, Mark A Febbraio, Jan Willem Greve, Sander S Rensen, Mark P Molloy, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt

Journal article  |  2015  |  Cell Metabolism

Comparative analysis of microRNA expression in mouse and human brown adipose tissue

Isabelle Gueller, Sarah McNaughton, Tamsyn Crowley, Vicente Gilsanz, Shingo Kajimura, Matthew Watt, Aaron P Russell

Journal article  |  2015  |  BMC Genomics

Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice

Stanley MH Chan, Xiao-Yi Zeng, Ruo-Qiong Sun, Eunjung Jo, Xiu Zhou, Hao Wang, Songpei Li, Aimin Xu, Matthew J Watt, Ji-Ming Ye

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

Ruth CR Meex, Andrew J Hoy, Rachael M Mason, Sheree D Martin, Sean L McGee, Clinton R Bruce, Matthew J Watt

Journal article  |  2015  |  American Journal of Physiology-Endocrinology and Metabolism

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity

Ahrathy Selathurai, Greg M Kowalski, Micah L Burch, Patricio Sepulveda, Steve Risis, Robert S Lee-Young, Severine Lamon, Peter J Meikle, Amanda J Genders, Sean L McGee, Matthew J Watt, Aaron P Russell, Matthew Frank, Suzanne Jackowski, Mark A Febbraio, Clinton R Bruce

Journal article  |  2015  |  Cell Metabolism

Erratum to: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase [Diabetologia, 2009, DOI 10.1007/s00125-009-1364-1]

VB Matthews, MB Åström, MHS Chan, CR Bruce, KS Krabbe, O Prelovsek, T Åkerström, C Yfanti, C Broholm, OH Mortensen, M Penkowa, P Hojman, A Zankari, MJ Watt, H Bruunsgaard, BK Pedersen, MA Febbraio

Journal article  |  2015  |  Diabetologia

Unraveling the roles of PLIN5: linking cell biology to physiology

Rachael R Mason, Matthew J Watt

Journal article  |  2015  |  Trends in Endocrinology & Metabolism

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet

Greg M Kowalski, Joachim Kloehn, Micah L Burch, Ahrathy Selathurai, Steven Hamley, Stephanie AM Bayol, Severine Lamon, Matthew J Watt, Robert S Lee-Young, Malcolm J McConville, Clinton R Bruce

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Itsuhiro Takizawa, Mitchell G Lawrence, Preetika Balanathan, Richard Rebello, Helen B Pearson, Elika Garg, John Pedersen, Normand Pouliot, Robert Nadon, Matthew J Watt, Renea A Taylor, Patrick Humbert, Ivan Topisirovic, Ola Larsson, Gail P Risbridger, Luc Furic

Journal article  |  2015  |  Oncotarget

Exercise and the Regulation of Adipose Tissue Metabolism

Thomas Tsiloulis, Matthew J Watt

Book Chapter  |  2015  |  Progress in molecular biology and translational science

Hypothalamic Neurogenesis Is Not Required for the Improved Insulin Sensitivity Following Exercise Training

Melissa L Borg, Moyra Lemus, Alex Reichenbach, Ahrathy Selathurai, Brian J Oldfield, Zane B Andrews, Matthew J Watt

Journal article  |  2014  |  Diabetes

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

Rachael R Mason, Ruzaidi Mokhtar, Maria Matzaris, Ahrathy Selathurai, Greg M Kowalski, Nancy Mokbel, Peter J Meikle, Clinton R Bruce, Matthew J Watt

Journal article  |  2014  |  Molecular Metabolism

Cellular Localization and Associations of the Major Lipolytic Proteins in Human Skeletal Muscle at Rest and during Exercise

Rachael R Mason, Ruth CR Meex, Aaron P Russell, Benedict J Canny, Matthew J Watt

Journal article  |  2014  |  PLoS ONE

Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2

Esteban N Gurzov, Melanie Tran, Manuel A Fernandez-Rojo, Troy L Merry, Xinmei Zhang, Yang Xu, Atsushi Fukushima, Michael J Waters, Matthew J Watt, Sofianos Andrikopoulos, Benjamin G Neel, Tony Tiganis

Journal article  |  2014  |  Cell Metabolism

Augmented expression and secretion of adipose-derived pigment epithelium-derived factor does not alter local angiogenesis or contribute to the development of systemic metabolic derangements

Thomas V Lakeland, Melissa L Borg, Maria Matzaris, Amany Abdelkader, Roger G Evans, Matthew J Watt

Journal article  |  2014  |  American Journal of Physiology-Endocrinology and Metabolism

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

Darren C Henstridge, Clinton R Bruce, Brian G Drew, Kalman Tory, Attila Kolonics, Emma Estevez, Jason Chung, Nadine Watson, Timothy Gardner, Robert S Lee-Young, Timothy Connor, Matthew J Watt, Kevin Carpenter, Mark Hargreaves, Sean L McGee, Andrea L Hevener, Mark A Febbraio

Journal article  |  2014  |  Diabetes

High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage

Troy L Merry, Melanie Tran, Maria Stathopoulos, Florian Wiede, Barbara Christianne Fam, Garron T Dodd, Iain Clarke, Matthew J Watt, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2014  |  Antioxidants & Redox Signaling

Dietary glycotoxins exacerbate progression of experimental fatty liver disease

Christopher Leung, Chandana B Herath, Zhiyuan Jia, Michelle Goodwin, Kai Yan Mak, Matthew J Watt, Josephine M Forbes, Peter W Angus

Journal article  |  2014  |  JOURNAL OF HEPATOLOGY

Exercise Training does not Enhance Hypothalamic Responsiveness to Leptin or Ghrelin in Male Mice

ML Borg, ZB Andrews, MJ Watt

Journal article  |  2014  |  Journal of Neuroendocrinology

integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Eduardo Dominguez, Andrea Galmozzi, Jae Won Chang, Ku-Lung Hsu, Joanna Pawlak, Weiwei Li, Cristina Godio, Jason Thomas, David Partida, Sherry Niessen, Paul E O'Brien, Aaron P Russell, Matthew J Watt, Daniel K Nomura, Benjamin F Cravatt, Enrique Saez

Journal article  |  2014  |  Nature Chemical Biology

Endurance Training Modulates Intramyocellular Lipid Compartmentalization and Morphology in Skeletal Muscle of Lean and Obese Women

Michaela C Devries, Imtiaz A Samjoo, Mazen J Hamadeh, Colin McCready, Sandeep Raha, Matthew J Watt, Gregory R Steinberg, Mark A Tarnopolsky

Journal article  |  2013  |  The Journal of Clinical Endocrinology & Metabolism

Lipid metabolism in contracting muscle - HSL takes a back seat

Matthew J Watt

Journal article  |  2013  |  The Journal of Physiology

Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance

Johan WE Jocken, Gijs H Goossens, Hanneke Boon, Rachael R Mason, Yvonne Essers, Bas Havekes, Matthew J Watt, Luc J van Loon, Ellen E Blaak

Journal article  |  2013  |  Diabetologia

Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic and normal glucose tolerant men

JWE Jocken, GH Goossens, H Boon, RR Mason, Y Essers, B Havekes, MJ Watt, LJ van Loon, EE Blaak

Conference Proceedings  |  2013  |  DIABETOLOGIA

Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

Birgitte Lindegaard, Vance B Matthews, Claus Brandt, Pernille Hojman, Tamara L Allen, Emma Estevez, Matthew J Watt, Clinton R Bruce, Ole H Mortensen, Susanne Syberg, Caroline Rudnicka, Julie Abildgaard, Henriette Pilegaard, Juan Hidalgo, Susanne Ditlevsen, Thomas J Alsted, Andreas N Madsen, Bente K Pedersen, Mark A Febbraio

Journal article  |  2013  |  Diabetes

Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity

Erin J Stephenson, Sarah J Lessard, Donato A Rivas, Matthew J Watt, Ben B Yaspelkis, Lauren G Koch, Steven L Britton, John A Hawley

Journal article  |  2013  |  American Journal of Physiology-Endocrinology and Metabolism

Activation of PPAR alpha Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose-Fed Mice Despite Increased Endoplasmic Reticulum Stress

Stanley MH Chan, Ruo-Qiong Sun, Xiao-Yi Zeng, Zi-Heng Choong, Hao Wang, Matthew J Watt, Ji-Ming Ye

Journal article  |  2013  |  Diabetes

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

James Boon, Andrew J Hoy, Romana Stark, Russell D Brown, Ruth C Meex, Darren C Henstridge, Simon Schenk, Peter J Meikle, Jeffrey F Horowitz, Bronwyn A Kingwell, Clinton R Bruce, Matthew J Watt

Journal article  |  2013  |  Diabetes

Pigment Epithelium-Derived Factor, Insulin Sensitivity, and Adiposity in Polycystic Ovary Syndrome: Impact of Exercise Training

Anju E Joham, Helena J Teede, Samantha K Hutchison, Nigel K Stepto, Cheryce L Harrison, Boyd J Strauss, Eldho Paul, Matthew J Watt

Journal article  |  2012  |  Obesity

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide

MJ Watt, AC Barnett, CR Bruce, S Schenk, JF Horowitz, AJ Hoy

Journal article  |  2012  |  Diabetologia

Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice

Melissa L Borg, Simin Fallah Omran, Jacquelyn Weir, Peter J Meikle, Matthew J Watt

Journal article  |  2012  |  The Journal of Physiology

Identification and Functional Characterization of Protein Kinase A Phosphorylation Sites in the Major Lipolytic Protein, Adipose Triglyceride Lipase

Joanne Pagnon, Maria Matzaris, Romana Stark, Ruth CR Meex, S Lance Macaulay, Wendy Brown, Paul E O'Brien, Tony Tiganis, Matthew J Watt

Journal article  |  2012  |  Endocrinology

Does too much sugar make for lost memories?

A Stefanidis, MJ Watt

Journal article  |  2012  |  The Journal of Physiology

Phosphorylation of adipose triglyceride lipase Ser(404) is not related to 5 '-AMPK activation during moderate-intensity exercise in humans

Rachael R Mason, Ruth CR Meex, Robert Lee-Young, Benedict J Canny, Matthew J Watt

Journal article  |  2012  |  American Journal of Physiology-Endocrinology and Metabolism

Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function

Matthew J Watt, Andrew J Hoy

Journal article  |  2012  |  American Journal of Physiology-Endocrinology and Metabolism

Erratum: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase (Diabetologia DOI: 10.1007/s00125-009-1364-1)

VB Matthews, MB Åström, MHS Chan, CR Bruce, KS Krabbe, O Prelovsek, T Åkerström, C Yfanti, C Broholm, OH Mortensen, M Penkowa, P Hojman, A Zankari, MJ Watt, H Bruunsgaard, BK Pedersen, MA Febbraio

Journal article  |  2012  |  Diabetologia

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice

K Loh, TL Merry, S Galic, BJ Wu, MJ Watt, S Zhang, Z-Y Zhang, BG Neel, T Tiganis

Journal article  |  2012  |  Diabetologia

Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments

Matthew J Watt, Andrew J Hoy, Deborah M Muoio, Rosalind A Coleman

Journal article  |  2012  |  American Journal of Physiology-Endocrinology and Metabolism

Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity

Mara Monetti, Malin C Levin, Matthew J Watt, Brian K Hubbard, Christopher Newgard, Robert V Farese, Andrea L Hevener, Robert V Farese

Journal article  |  2011  |  Proceedings of the National Academy of Sciences

Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle

P Lau, RL Fitzsimmons, MA Pearen, MJ Watt, GEO Muscat

Journal article  |  2011  |  Diabetologia

Pigment Epithelium-Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase

Melissa L Borg, Zane B Andrews, Ella J Duh, Rudolf Zechner, Peter J Meikle, Matthew J Watt

Journal article  |  2011  |  Diabetes

Hematopoietic Cell-Restricted Deletion of CD36 Reduces High-Fat Diet-Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue

Hayley T Nicholls, Greg Kowalski, David J Kennedy, Steve Risis, Lee A Zaffino, Nadine Watson, Peter Kanellakis, Matthew J Watt, Alex Bobik, Arend Bonen, Maria Febbraio, Graeme I Lancaster, Mark A Febbraio

Journal article  |  2011  |  Diabetes

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

SM Turpin, AJ Hoy, RD Brown, C Garcia Rudaz, J Honeyman, M Matzaris, MJ Watt

Journal article  |  2011  |  Diabetologia

Adipose Triglyceride Lipase-Null Mice Are Resistant to High-Fat Diet-Induced Insulin Resistance Despite Reduced Energy Expenditure and Ectopic Lipid Accumulation

Andrew J Hoy, Clinton R Bruce, Sarah M Turpin, Alexander J Morris, Mark A Febbraio, Matthew J Watt

Journal article  |  2011  |  Endocrinology

Whole Body Deletion of AMP-activated Protein Kinase beta 2 Reduces Muscle AMPK Activity and Exercise Capacity

Gregory R Steinberg, Hayley M O'Neill, Nicolas L Dzamko, Sandra Galic, Tim Naim, Rene Koopman, Sebastian B Jorgensen, Jane Honeyman, Kimberly Hewitt, Zhi-Ping Chen, Jonathan D Schertzer, John W Scott, Frank Koentgen, Gordon S Lynch, Matthew J Watt, Bryce JW van denderen, Duncan J Campbell, Bruce E Kemp

Journal article  |  2010  |  Journal of Biological Chemistry

Liver-Specific Suppressor of Cytokine Signaling-3 Deletion in Mice Enhances Hepatic Insulin Sensitivity and Lipogenesis Resulting in Fatty Liver and Obesity

Nirupa Sachithanandan, Barbara C Fam, Stacey Fynch, Nicolas Dzamko, Matthew J Watt, Sam Wormald, Jane Honeyman, Sandra Galic, Joseph Proietto, Sofianos Andrikopoulos, Andrea L Hevener, Thomas WH Kay, Gregory R Steinberg

Journal article  |  2010  |  Hepatology

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

VB Matthews, TL Allen, S Risis, MHS Chan, DC Henstridge, N Watson, LA Zaffino, JR Babb, J Boon, PJ Meikle, JB Jowett, MJ Watt, J-O Jansson, CR Bruce, MA Febbraio

Journal article  |  2010  |  Diabetologia

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

Atsushi Fukushima, Kim Loh, Sandra Galic, Barbara Fam, Ben Shields, Florian Wiede, Michel L Tremblay, Matthew J Watt, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2010  |  Diabetes

Triacylglycerol lipases and metabolic control: implications for health and disease

Matthew J Watt, Lawrence L Spriet

Journal article  |  2010  |  American Journal of Physiology-Endocrinology and Metabolism

Adipose Triglyceride Lipase Regulation of Skeletal Muscle Lipid Metabolism and Insulin Responsiveness (Retraction of vol 22, pg 1200, 2008)

Matthew J Watt, Bryce JW van Denderen, Laura A Castelli, Clinton R Bruce, Andrew J Hoy, Edward W Kraegen, Lance Macaulay, Bruce E Kemp

Journal article  |  2010  |  Molecular Endocrinology

Impaired oxidative metabolism and inflammation are associated with insulin resistance in ER alpha-deficient mice

Vicent Ribas, MT Audrey Nguyen, Darren C Henstridge, Anh-Khoi Nguyen, Simon W Beaven, Matthew J Watt, Andrea L Hevener

Journal article  |  2010  |  American Journal of Physiology-Endocrinology and Metabolism

AMPK beta 1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Nicolas Dzamko, Bryce JW van Denderen, Andrea L Hevener, Sebastian Beck Jorgensen, Jane Honeyman, Sandra Galic, Zhi-Ping Chen, Matthew J Watt, Duncan J Campbell, Gregory R Steinberg, Bruce E Kemp

Journal article  |  2010  |  Journal of Biological Chemistry

Erratum: Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro (Diabetologia DOI: 10.1007/s00125-006-0427-9)

SK Pinnamaneni, RJ Southgate, MA Febbraio, MJ Watt

Journal article  |  2010  |  Diabetologia

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

Lily C Chao, Kevin Wroblewski, Zidong Zhang, Liming Pei, Laurent Vergnes, Olga R Ilkayeva, Shi Ying Ding, Karen Reue, Matthew J Watt, Christopher B Newgard, Paul F Pilch, Andrea L Hevener, Peter Tontonoz

Conference Proceedings  |  2009  |  Diabetes

Metabolic Remodeling in Adipocytes Promotes Ciliary Neurotrophic Factor-Mediated Fat Loss in Obesity (vol 149, pg 2546, 2008)

Seamus Crowe, Sarah M Turpin, Francine Ke, Bruce E Kemp, Matthew J Watt

Journal article  |  2009  |  Endocrinology

No need to sweat: is dieting enough to alleviate insulin resistance in obesity?

Matthew J Watt, Clinton R Bruce

Journal article  |  2009  |  The Journal of Physiology

Impaired Skeletal Muscle beta-Adrenergic Activation and Lipolysis Are Associated with Whole-Body Insulin Resistance in Rats Bred for Low Intrinsic Exercise Capacity

Sarah J Lessard, Donato A Rivas, Zhi-Ping Chen, Bryce J van denderen, Matthew J Watt, Lauren G Koch, Steven L Britton, Bruce E Kemp, John A Hawley

Journal article  |  2009  |  Endocrinology

Reactive Oxygen Species Enhance Insulin Sensitivity

Kim Loh, Haiyang Deng, Atsushi Fukushima, Xiaochu Cai, Benoit Boivin, Sandra Galic, Clinton Bruce, Benjamin J Shields, Beata Skiba, Lisa M Ooms, Nigel Stepto, Ben Wu, Christina A Mitchell, Nicholas K Tonks, Matthew J Watt, Mark A Febbraio, Peter J Crack, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2009  |  Cell Metabolism

Retraction. PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.

Journal article  |  2009  |  The FASEB Journal

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice

Elisabeth Huijsman, Caro van de Par, Catherine Economou, Chris van der Poel, Gordon S Lynch, Gabriele Schoiswohl, Gunter Haemmerle, Rudolf Zechner, Matthew J Watt

Journal article  |  2009  |  American Journal of Physiology - Endocrinology and Metabolism

Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity

Seamus Crowe, Lindsay E Wu, Catherine Economou, Sarah M Turpin, Maria Matzaris, Kyle L Hoehn, Andrea L Hevener, David E James, Elia J Duh, Matthew J Watt

Journal article  |  2009  |  Cell Metabolism

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

Andrew J Hoy, Amanda E Brandon, Nigel Turner, Matthew J Watt, Clinton R Bruce, Gregory J Cooney, Edward W Kraegen

Journal article  |  2009  |  American Journal of Physiology-Endocrinology and Metabolism

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

VB Matthews, M-B Astrom, MHS Chan, CR Bruce, KS Krabbe, O Prelovsek, T Akerstrom, C Yfanti, C Broholm, OH Mortensen, M Penkowa, P Hojman, A Zankari, MJ Watt, H Bruunsgaard, BK Pedersen, MA Febbraio

Journal article  |  2009  |  Diabetologia

Triglyceride lipases alter fuel metabolism and mitochondrial gene expression

Matthew J Watt

Conference Proceedings  |  2009  |  Applied Physiology, Nutrition, and Metabolism

Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice

SM Turpin, JG Ryall, R Southgate, I Darby, AL Hevener, MA Febbraio, BE Kemp, GS Lynch, MJ Watt

Journal article  |  2009  |  Journal of Physiology

Adipose tissue-skeletal muscle crosstalk: are endocannabinoids an unwanted caller?

MJ Watt

Journal article  |  2009  |  Diabetologia

Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Dependent Pathway That Is Impaired With Obesity

Gregory R Steinberg, Matthew J Watt, Matthias Ernst, Morris J Birnbaum, Bruce E Kemp, Sebastian Beck Jorgensen

Journal article  |  2009  |  Diabetes

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance

Clinton R Bruce, Andrew J Hoy, Nigel Turner, Matthew J Watt, Tamara L Allen, Kevin Carpenter, Gregory J Cooney, Mark A Febbraio, Edward W Kraegen

Journal article  |  2009  |  Diabetes

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue (American Journal of Physiology - Endocrinology and Metabolism (E500-E508))

MJ Watt, AG Holmes, SK Pinnamaneni, AP Garnham, GR Steinberg, BE Kemp, MA Febbraio

Journal article  |  2009  |  American Journal of Physiology-Endocrinology and Metabolism

Fat Partitioning and Insulin Sensitivity Robbing Peter to Pay Paul?

Matthew J Watt, Edward W Kraegen

Journal article  |  2009  |  Diabetes

Cytokine regulation of AMPK signalling

Gregory R Steinberg, Matthew J Watt, Mark A Febbraio

Journal article  |  2009  |  Frontiers in Bioscience

STORING UP TROUBLE: DOES ACCUMULATION OF INTRAMYOCELLULAR TRIGLYCERIDE PROTECT SKELETAL MUSCLE FROM INSULIN RESISTANCE?

Matthew J Watt

Journal article  |  2009  |  Clinical and Experimental Pharmacology and Physiology

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

Nicolas Dzamko, Jonathan D Schertzer, James G Ryall, Rohan Steel, S Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J Michell, Jonathan S Oakhill, Matthew J Watt, Sebastian Beck Jorgensen, Gordon S Lynch, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2008  |  Journal of Physiology

Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver

Sherley Visinoni, Barbara C Fam, Amy Blair, Christian Rantzau, Benjamin J Lamont, Russell Bouwman, Matthew J Watt, Joseph Proietto, Jenny M Favaloro, Sofianos Andrikopoulos

Journal article  |  2008  |  American Journal of Physiology - Endocrinology and Metabolism

Regulation and function of triacylglycerol lipases in cellular metabolism

Matthew J Watt, Gregory R Steinberg

Journal article  |  2008  |  Biochemical Journal

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPAR alpha and UCP2 expression in rats

Anna G Holmes, Jose L Mesa, Bronwyn A Neill, Jason Chung, Andrew L Carey, Gregory R Steinberg, Bruce E Kemp, Robert J Southgate, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt, Mark A Febbraio

Journal article  |  2008  |  Journal of Endocrinology

High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine

David J Pedersen, Sarah J Lessard, Vernon G Coffey, Emmanuel G Churchley, Andrew M Wootton, They Ng, Matthew J Watt, John A Hawley

Journal article  |  2008  |  Journal of Applied Physiology

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness (Retracted article. See vol. 24, pg. 1308, 2010)

Matthew J Watt, Bryce JW van Denderen, Laura A Castelli, Clinton R Bruce, Andrew J Hoy, Edward W Kraegen, Lance Macaulay, Bruce E Kemp

Journal article  |  2008  |  Molecular Endocrinology

Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity

Seamus Crowe, Sarah M Turpin, Francine Ke, Bruce E Kemp, Matthew J Watt

Journal article  |  2008  |  Endocrinology

High Rates Of Muscle Glycogen Resynthesis After Exhaustive Exercise When Carbohydrate Is Co-ingested With Caffeine

John A Hawley, David J Pedersen, Sarah J Lessard, Vernon G Coffey, Emmanuel G Churchley, Andrew M Wootton, Hg They, Matthew J Watt

Conference Proceedings  |  2008  |  Medicine & Science in Sports & Exercise

Transcriptional suppression of lipid-induced apoptosis in skeletal muscle in vivo

Sarah Maggie Turpin, JG Ryall, RJ Southgate, I Darby, MA Febbraio, BE Kemp, GS Lynch, MJ Watt

Journal article  |  2008  |  FASEB JOURNAL

HSP72 protects against obesity-induced insulin resistance

Jason Chung, Anh-Khoi Nguyen, Darren C Henstridge, Anna G Holmes, MH Stanley Chan, Jose L Mesa, Graeme I Lancaster, Robert J Southgate, Clinton R Bruce, Stephen J Duffy, Ibolya Horvath, Ruben Mestril, Matthew J Watt, Philip L Hooper, Bronwyn A Kingwell, Laszlo Vigh, Andrea Hevener, Mark A Febbraio

Journal article  |  2008  |  Proceedings of the National Academy of Sciences

Fluxing the mitochondria to insulin resistance

Matthew J Watt, Andrea L Hevener

Journal article  |  2008  |  Cell Metabolism

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle

Malin C Levin, Mara Monetti, Matthew J Watt, Mini P Sajan, Robert D Stevens, James R Bain, Christopher B Newgard, Robert V Farese, Robert V Farese

Journal article  |  2007  |  American Journal of Physiology-Endocrinology and Metabolism

Pathways involved in lipid-induced insulin resistance in obesity

Matthew J Watt, Gregory R Steinberg

Journal article  |  2007  |  Future Lipidology

Adipocyte triglyceride lipase expression in human obesity

Gregory R Steinberg, Bruce E Kemp, Matthew J Watt

Journal article  |  2007  |  American Journal of Physiology - Endocrinology and Metabolism

Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver

Mara Monetti, Malin C Levin, Matthew J Watt, Mini P Sajan, Stephen Marmor, Brian K Hubbard, Robert D Stevens, James R Bain, Christopher B Newgard, Robert V Farese, Andrea L Hevener, Robert V Farese

Journal article  |  2007  |  Cell Metabolism

Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity (Retracted article. see vol 293, E1845, 2007)

Fiona J Spargo, Sean L McGee, Nick Dzamko, Matthew J Watt, Bruce E Kemp, Steven L Britton, Lauren G Koch, Mark Hargreaves, John A Hawley

Journal article  |  2007  |  American Journal of Physiology-Endocrinology and Metabolism

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

Andrea L Hevener, Jerrold M Olefsky, Donna Reichart, MT Audrey Nguyen, Gautarn Bandyopadyhay, Ho-Yin Leung, Matthew J Watt, Chris Benner, Mark A Febbraio, Anh-Khoi Nguyen, Brian Folian, Shankar Subramaniam, Frank J Gonzalez, Christopher K Glass, Mercedes Ricote

Journal article  |  2007  |  Journal of Clinical Investigation

Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance

Mark K Todd, Matthew J Watt, Jamie Le, Andrea L Hevener, Lorraine P Turcotte

Journal article  |  2007  |  American Journal of Physiology - Endocrinology and Metabolism

Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance

Sarah M Turpin, Graeme I Lancaster, Ian Darby, Mark A Febbraio, Matthew J Watt

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

Gregory R Steinberg, Belinda J Michell, Bryce JW van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Gorgun, David Carling, Gokhan S Hotamisligil, Mark A Febbraio, Thomas W Kay, Bruce E Kemp

Journal article  |  2006  |  Cell Metabolism

Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro

SK Pinnamaneni, RJ Southgate, MA Febbraio, MJ Watt

Journal article  |  2006  |  Diabetologia

Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise

Jason L Talanian, Rebecca J Tunstall, Matthew J Watt, Mylinh Duong, Christopher GR Perry, Gregory R Steinberg, Bruce E Kemp, George JF Heigenhauser, Lawrence L Spriet

Journal article  |  2006  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

Andrew L Carey, Gregory R Steinberg, S Lance Macaulay, Walter G Thomas, Anna G Holmes, Georg Ramm, Oja Prelovsek, Cordula Hohnen-Behrens, Matthew J Watt, David E James, Bruce E Kemp, Bente K Pedersen, Mark A Febbraio

Journal article  |  2006  |  Diabetes

Acyl CoA: diacylglycerol acyltransferase 2 (DGAT2)-mediated triacylglycerol accumulation in glycolytic muscle promotes insulin resistance

MC Levin, M Monetti, MP Sajan, MJ Watt, RV Farese, RV Farese

Conference Proceedings  |  2006  |  DIABETOLOGIA

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice

Gregory R Steinberg, Matthew J Watt, Barbara C Fam, Joseph Proietto, Sofianos Andrikopoulos, Andrew M Allen, Mark A Febbraio, Bruce E Kemp

Journal article  |  2006  |  Endocrinology

Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes

Matthew J Watt, Gregory R Steinberg, Zhi-Ping Chen, Bruce E Kemp, Mark A Febbraio

Journal article  |  2006  |  Journal of Physiology

Reduced glycogen availability is associated with increased AMPK alpha 2 activity, nuclear AMPK alpha 2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

Gregory R Steinberg, Matthew J Watt, Sean L McGee, Stanley Chan, Mark Hargreaves, Mark A Febbraio, David Stapleton, Bruce E Kemp

Journal article  |  2006  |  Applied Physiology, Nutrition and Metabolism

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

Matthew J Watt, Nicolas Dzamko, Walter G Thomas, Stefan Rose-John, Matthias Ernst, David Carling, Bruce E Kemp, Mark A Febbraio, Gregory R Steinberg

Journal article  |  2006  |  Nature Medicine

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites

JS Lee, SK Pinnamaneni, SJ Eo, IH Cho, JH Pyo, CK Kim, AJ Sinclair, MA Febbraio, MJ Watt

Journal article  |  2006  |  Journal of Applied Physiology

Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues

MJ Watt, A Hevener, GI Lancaster, MA Febbraio

Journal article  |  2006  |  Endocrinology

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue

MJ Watt, AG Holmes, SK Pinnamaneni, AP Garnham, GR Steinberg, BE Kemp, MA Febbraio

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration

T Stellingwerff, LL Spriet, MJ Watt, NE Kimber, M Hargreaves, JA Hawley, LM Burke

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Chronic rosiglitazone treatment restores AMPK alpha 2 activity in insulin-resistant rat skeletal muscle

SJ Lessard, ZP Chen, MJ Watt, M Hashem, JJ Reid, MA Febbraio, BE Kemp, JA Hawley

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.

Robert J Southgate, Clinton R Bruce, Andrew L Carey, Gregory R Steinberg, Ken Walder, Robert Monks, Matthew J Watt, John A Hawley, Morris J Birnbaum, Mark A Febbraio

Journal article  |  2005  |  FASEB Journal

There are multiple binding domains on the promoter region of the peroxisome proliferator activator receptor gamma coactivator-1 al..

Effects of hyperoxia on skeletal muscle carbohydrate metabolism during transient and steady-state exercise

T Stellingwerff, L Glazier, MJ Watt, PJ LeBlanc, GJF Heigenhauser, LL Spriet

Journal article  |  2005  |  Journal of Applied Physiology

Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion

MJ Watt, AL Carey, E Wolsk-Petersen, FB Kraemer, BK Pedersen, MA Febbraio

Journal article  |  2005  |  Diabetologia

Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle

SJ Lessard, SL Lo Giudice, W Lau, JJ Reid, N Turner, MA Febbraio, JA Hawley, MJ Watt

Journal article  |  2004  |  Endocrinology

Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise

M O'Neill, MJ Watt, GJF Heigenhauser, LL Spriet

Journal article  |  2004  |  Journal of Applied Physiology

Ionomycin, but not physiologic doses of epinephrine, stimulates skeletal muscle interleukin-6 mRNA expression and protein release

AG Holmes, MJ Watt, AL Carey, MA Febbraio

Journal article  |  2004  |  Metabolism

Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1 alpha in human skeletal muscle, but not lipid regulatory genes

MJ Watt, RJ Southgate, AG Holmes, MA Febbraio

Journal article  |  2004  |  Journal of Molecular Endocrinology

Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise

MJ Watt, GJF Heigenhauser, PJ LeBlanc, JG Inglis, LL Spriet, SJ Peters

Journal article  |  2004  |  Journal of Applied Physiology

Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction

MHS Chan, SL McGee, MJ Watt, M Hargreaves, MA Febbraio

Journal article  |  2004  |  FASEB Journal

Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability

MHS Chan, AL Carey, MJ Watt, MA Febbraio

Journal article  |  2004  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Suppressing lipolysis increases interleukin-6 at rest and during prolonged moderate-intensity exercise in humans

AG Holmes, MJ Watt, MA Febbraio

Journal article  |  2004  |  Journal of Applied Physiology

Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle

MJ Watt, AG Holmes, GR Steinberg, JL Mesa, BE Kemp, MA Febbraio

Journal article  |  2004  |  American Journal of Physiology - Endocrinology and Metabolism

beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling

MJ Watt, GR Steinberg, S Chan, A Garnham, BE Kemp, MA Febbraio

Journal article  |  2004  |  FASEB Journal

Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting

LL Spriet, RJ Tunstall, MJ Watt, KA Mehan, M Hargreaves, D Cameron-Smith

Journal article  |  2004  |  Journal of Applied Physiology

Regulation and role of hormone-sensitive lipase activity in human skeletal muscle

MJ Watt, LL Spriet

Conference Proceedings  |  2004  |  Proceedings of the Nutrition Society

Muscle fat utilization during exercise: controversial only methodologically - Reply

MJ Watt, GGF Heigenhauser, LL Spriet

Journal article  |  2004  |  Journal of Applied Physiology

Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscle.

Matthew J Watt, Peter Krustrup, Niels H Secher, Bengt Saltin, Bente K Pedersen, Mark A Febbraio

Journal article  |  2004  |  American Journal of Physiology - Endocrinology and Metabolism

To examine the effect of attenuated epinephrine and elevated insulin on intramuscular hormone sensitivity lipase activity (HSLa) d..

Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscle

MJ Watt, P Krustrup, NH Secher, B Saltin, BK Pedersen, MA Febbraio

Journal article  |  2004  |  American Journal of Physiology-Endocrinology and Metabolism

Regulation of glucose kinetics during intense exercise in humans: Effects of alpha- and beta-adrenergic blockade

KF Howlett, MJ Watt, M Hargreaves, MA Febbraio

Journal article  |  2003  |  Metabolism

Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid

MJ Watt, GR Steinberg, GJF Heigenhauser, LL Spriet, DJ Dyck

Journal article  |  2003  |  American Journal of Physiology-Endocrinology and Metabolism

Regulatory mechanisms in the interaction between carbohydrate and lipid oxidation during exercise

LL Spriet, MJ Watt

Conference Proceedings  |  2003  |  Acta Physiologica Scandinavica

Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle

MJ Watt, T Stellingwerff, GJF Heigenhauser, LL Spriet

Journal article  |  2003  |  The Journal of Physiology

Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise

MJ Watt, GJF Heigenhauser, M O'Neill, LL Spriet

Journal article  |  2003  |  Journal of Applied Physiology

Effects of hyperoxia on skeletal muscle PDH activation during the onset and steady state of aerobic exercise

T Stellingwerff, L Glazier, MJ Watt, P LeBlanc, GJF Heigenhauser, LL Spriet

Conference Proceedings  |  2003  |  FASEB JOURNAL

Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise. Pyruvate dehydrogenase.

Trent Stellingwerff, Matthew J Watt, GJF Heigenhauser, Lawrence L Spriet

Journal article  |  2003  |  American Journal of Physiology - Endocrinology and Metabolism

This study investigated the effect of reduced free fatty acid (FFA) availability on pyruvate dehydrogenase activation (PDHa) and c..

Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise

T Stellingwerff, MJ Watt, GJF Heigenhauser, LL Spriet

Journal article  |  2003  |  American Journal of Physiology-Endocrinology and Metabolism

Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle

MJ Watt, GJF Heigenhauser, LL Spriet

Journal article  |  2003  |  The Journal of Physiology

Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man

MJ Watt, GJF Heigenhauser, T Stellingwerff, M Hargreaves, LL Spriet

Journal article  |  2002  |  Journal of Physiology

Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?

MJ Watt, GJF Heigenhauser, LL Spriet

Journal article  |  2002  |  Journal of Applied Physiology

Effect of epinephrine on glucose disposal during exercise in humans: role of muscle glycogen

MJ Watt, M Hargreaves

Journal article  |  2002  |  American Journal of Physiology - Endocrinology and Metabolism

Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man

MJ Watt, GJF Heigenhauser, DJ Dyck, LL Spriet

Journal article  |  2002  |  The Journal of Physiology

Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans

MJ Watt, KF Howlett, MA Febbraio, LL Spriet, M Hargreaves

Journal article  |  2001  |  Journal of Physiology

No effect of mild heat stress on the regulation of carbohydrate metabolism at the onset of exercise

PU Saunders, MJ Watt, AP Garnham, LL Spriet, M Hargreaves, MA Febbraio

Journal article  |  2001  |  Journal of Applied Physiology

Effect of acute plasma volume expansion on thermoregulation and exercise performance in the heat

MJ Watt, AP Garnham, MA Febbraio, M Hargreaves

Journal article  |  2000  |  Medicine & Science in Sports & Exercise

Acute plasma volume expansion: effect on metabolism during submaximal exercise

MJ Watt, MA Febbraio, AP Garnham, M Hargreaves

Journal article  |  1999  |  Journal of Applied Physiology