Matthew Watt

Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality.

Chrishan J Nalliah, James R Bell, Antonia JA Raaijmakers, Helen M Waddell, Simon P Wells, Gabriel B Bernasochi, Magdalene K Montgomery, Simon Binny, Troy Watts, Subodh B Joshi, Elaine Lui, Choon Boon Sim, Marco Larobina, Michael O'Keefe, John Goldblatt, Alistair Royse, Geoffrey Lee, Enzo R Porrello, Matthew J Watt, Peter M Kistler, et al.

Journal article  |  2020  |  Journal of the American College of Cardiology

BACKGROUND: Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of a..

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt

Journal article  |  2020  |  Science Translational Medicine

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..

Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity

Thomas Tsiloulis, Arthe Raajendiran, Stacey N Keenan, Geraldine Ooi, Renea A Taylor, Paul Burton, Matthew J Watt

Journal article  |  2020  |  American Journal of Physiology-Endocrinology and Metabolism

Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. W..

Metabolic communication during exercise

Robyn M Murphy, Matthew J Watt, Mark A Febbraio

Journal article  |  2020  |  Nature Metabolism

The coordination of nutrient sensing, delivery, uptake and utilization is essential for maintaining cellular, tissue and whole-bod..

Molecular regulators of lipid metabolism in the intestine - Underestimated therapeutic targets for obesity?

Mercedes Davalos-Salas, John M Mariadason, Matthew J Watt, Magdalene K Montgomery

Journal article  |  2020  |  Biochemical Pharmacology

The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic..

Early intervention exercise training does not delay prostate cancer progression in Pten(-/-) mice

Renea A Taylor, Simon G Farrelly, Ashlee K Clark, Matthew J Watt

Journal article  |  2020  |  The Prostate

BACKGROUND: There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of..

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery

Journal article  |  2020  |  Current Diabetes Reports

PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..

A Neural basis for Octanoic acid regulation of energy balance

Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt

Journal article  |  2020  |  Molecular Metabolism

OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..

The role of Ap2a2 in PPAR alpha-mediated regulation of lipolysis in adipose tissue

Magdalene K Montgomery, Jacqueline Bayliss, Stacey Keenan, Sarah Rhost, Stephen B Ting, Matthew J Watt

Journal article  |  2019  |  The FASEB Journal

Adipose tissue plays a major role in the regulation of systemic metabolic homeostasis, with the AP2 adaptor complex being importan..

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Mercedes Davalos-Salas, Magdalene K Montgomery, Camilla M Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Togel, Angela Rigopoulos, Sylvia J Gong, David S Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert, et al.

Journal article  |  2019  |  Nature Communications

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulati..