Matthew Watt

Investigating dual inhibition of ACC and CD36 for the treatment of nonalcoholic fatty liver disease in mice.

Camille J Devereux, Jacqueline Bayliss, Stacey N Keenan, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2023  |  Am J Physiol Endocrinol Metab

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation in hepatic lipid metabo..

Metabolic effects of lipectomy and of adipose tissue transplantation.

Sarah Davis, Samantha Hocking, Matthew J Watt, Jenny E Gunton

Journal article  |  2023  |  Obesity (Silver Spring)

OBJECTIVE: The goal of this study was to review the metabolic effects of fat transplantation. METHODS: Fat (adipose tissue [AT]) t..

Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signalling and Glucose Transport in Skeletal Muscle.

Magdalene K Montgomery, Jacqueline Bayliss, Shuai Nie, William de Nardo, Stacey N Keenan, Marziyeh Anari, Amanuiel Z Taddese, Nicholas A Williamson, Geraldine J Ooi, Wendy A Brown, Paul R Burton, Paul Gregorevic, Craig A Goodman, Kevin I Watt, Matthew J Watt

Journal article  |  2022  |  Diabetes

Non-alcoholic fatty liver disease (NAFLD) and impaired glycaemic control are closely linked, however, the pathophysiological mecha..

Multi-substrate metabolic tracing reveals marked heterogeneity and dependency on fatty acid metabolism in human prostate cancer.

Gio Fidelito, David P De Souza, Birunthi Niranjan, William de Nardo, Shivakumar Keerthikumar, Kristin Brown, Renea A Taylor, Matthew J Watt

Journal article  |  2022  |  Mol Cancer Res

Cancer cells undergo metabolic reprogramming to meet increased bioenergetic demands. Studies in cells and mice have highlighted th..

Reply to 'Lactate as a major myokine and exerkine'.

Lisa S Chow, Robert E Gerszten, Joan M Taylor, Bente K Pedersen, Henriette van Praag, Scott Trappe, Mark A Febbraio, Zorina S Galis, Yunling Gao, Jacob M Haus, Ian R Lanza, Carl J Lavie, Chih-Hao Lee, Alejandro Lucia, Cedric Moro, Ambarish Pandey, Jeremy M Robbins, Kristin I Stanford, Alice E Thackray, Saul Villeda, et al.

Journal article  |  2022  |  Nat Rev Endocrinol

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as anAMPK substrate regulating skeletal muscle function

Ronnie Blazev, Christian S Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J Kueh, Paula M Miotto, Vanessa R Haynes, Justin P Hardee, Jin D Chung, James W McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S Oakhill, Marco J Herold, Thomas E Jensen, Leszek Lisowski, Gordon S Lynch, et al.

Journal article  |  2022  |  CELL METABOLISM

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signal..

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

Anne Senabouth, Maciej Daniszewski, Grace E Lidgerwood, Helena H Liang, Damian Hernandez, Mehdi Mirzaei, Stacey N Keenan, Ran Zhang, Xikun Han, Drew Neavin, Louise Rooney, Maria Isabel G Lopez Sanchez, Lerna Gulluyan, Joao A Paulo, Linda Clarke, Lisa S Kearns, Vikkitharan Gnanasambandapillai, Chia-Ling Chan, Uyen Nguyen, Angela M Steinmann, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

There are currently no treatments for geographic atrophy, the advanced form of age-related macular degeneration. Hence, innovative..

Exerkines in health, resilience and disease.

Lisa S Chow, Robert E Gerszten, Joan M Taylor, Bente K Pedersen, Henriette van Praag, Scott Trappe, Mark A Febbraio, Zorina S Galis, Yunling Gao, Jacob M Haus, Ian R Lanza, Carl J Lavie, Chih-Hao Lee, Alejandro Lucia, Cedric Moro, Ambarish Pandey, Jeremy M Robbins, Kristin I Stanford, Alice E Thackray, Saul Villeda, et al.

Journal article  |  2022  |  Nat Rev Endocrinol

The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhan..

Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

William De Nardo, Paula M Miotto, Jacqueline Bayliss, Shuai Nie, Stacey N Keenan, Magdalene K Montgomery, Matthew J Watt

Journal article  |  2022  |  MOLECULAR METABOLISM

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which..

Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

Magdalene K Montgomery, Jacqueline Bayliss, Shuai Nie, William De Nardo, Stacey N Keenan, Paula M Miotto, Hamzeh Karimkhanloo, Cheng Huang, Ralf B Schittenhelm, Anthony S Don, Andrew Ryan, Nicholas A Williamson, Geraldine J Ooi, Wendy A Brown, Paul R Burton, Benjamin L Parker, Matthew J Watt

Journal article  |  2022  |  NATURE COMMUNICATIONS

Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning th..