Bruce Wines

Innate and Adaptive Anti-SIV Responses in Macaque Semen: Implications for Infectivity and Risk of Transmission

Karunasinee Suphaphiphat, Sibylle Bernard-Stoecklin, Celine Gommet, Benoit Delache, Nathalie Dereuddre-Bosquet, Stephen J Kent, Bruce D Wines, P Mark Hogarth, Roger Le Grand, Mariangela Cavarelli

Journal article  |  2020  |  Frontiers in Immunology

Epidemic thunderstorm asthma susceptibility from sensitization to ryegrass (Lolium perenne) pollen and major allergen Lol p 5

Mark Hew, Joy Lee, Nirupama Varese, Pei M Aui, Craig I McKenzie, Bruce D Wines, Heather Aumann, Jennifer M Rolland, Phillip Mark Hogarth, Menno C van Zelm, Robyn E O'Hehir

Journal article  |  2020  |  Allergy

Harnessing the immune system via Fc gamma R function in immune therapy: a pathway to next-gen mAbs

Alicia M Chenoweth, Bruce D Wines, Jessica C Anania, P Hogarth

Journal article  |  2020  |  Immunology & Cell Biology

The human fragment crystallizable (Fc)γ receptor (R) interacts with antigen-complexed immunoglobulin (Ig)G ligands to both activat..

Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial.

Liriye Kurtovic, Tanmaya Atre, Gaoqian Feng, Bruce D Wines, Jo-Anne Chan, Michelle J Boyle, Damien R Drew, P Mark Hogarth, Freya JI Fowkes, Elke S Bergmann-Leitner, James G Beeson

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: RTS,S is the leading malaria vaccine candidate, but only confers partial efficacy against malaria in children. RTS,S i..

Fc functional antibody responses to adjuvanted versus unadjuvanted seasonal influenza vaccination in community-dwelling older adults

Hillary A Vanderven, Ian Barr, Arnold Reynaldi, Adam K Wheatley, Bruce D Wines, Miles P Davenport, P Mark Hogarth, Stephen J Kent

Journal article  |  2020  |  Vaccine

BACKGROUND: Seasonal influenza vaccination with a standard trivalent influenza vaccine (TIV) induces a modest, and cross-reactive,..

Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcg Receptors: Implications for Measuring Fc Dependent Antibody Functions

Ester Lopez, Nichollas E Scott, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Stephen J Kent, Amy W Chung

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and aut..

Boosting of Markers of Fc gamma Receptor Function in Anti-HIV Antibodies During Structured Treatment Interruption

Hugh Billings, Bruce D Wines, Wayne B Dyer, Robert J Center, Halina M Trist, Stephen J Kent, P Mark Hogarth

Journal article  |  2019  |  AIDS Research and Human Retroviruses

Anti-HIV envelope antibodies elicit important Fc receptor functions, including FcγRIIIa-mediated NK killing of opsonised infected ..

Plasma levels of the soluble form of the Fc gamma RIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

Jianlin Qiao, Eimear Dunne, Bruce Wines, Dermot Kenny, Geraldine M McCarthy, P Mark Hogarth, Kailin Xu, Robert K Andrews, Elizabeth E Gardiner

Journal article  |  2019  |  Platelets

The Human Fc gamma RII (CD32) Family of Leukocyte FcR in Health and Disease

Jessica C Anania, Alicia M Chenoweth, Bruce D Wines, P Mark Hogarth

Journal article  |  2019  |  Frontiers in Immunology

Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells

Sai Priya Anand, Jeremie Prevost, Sophie Baril, Jonathan Richard, Halima Medjahed, Jean-Philippe Chapleau, William D Tolbert, Sharon Kirk, Amos B Smith, Bruce D Wines, Stephen J Kent, P Mark Hogarth, Matthew S Parsons, Marzena Pazgier, Andres Finzi

Journal article  |  2019  |  Journal of Virology

Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

Matthew S Parsons, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Georges Khoury, Adam K Wheatley, Arnold Reynaldi, Bruce D Wines, P Mark Hogarth, Miles P Davenport, Stephen J Kent

Journal article  |  2019  |  Journal of Clinical Investigation

Dimeric Fc gamma R ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia

BD Wines, CW Tan, E Duncan, S McRae, RI Baker, RK Andrews, S Esparon, EE Gardiner, PM Hogarth

Journal article  |  2018  |  Journal of Thrombosis and Haemostasis

Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection

Hillary A Vanderen, Kathleen Wragg, Fernanda Ana-Sosa-Batiz, Anne B Kristensen, Sinthujan Jegaskanda, Adam K Wheatley, Deborah Wentworth, Bruce D Wines, P Mark Hogarth, Steve Rockman, Stephen J Kent

Journal article  |  2018  |  The Journal of Infectious Diseases

The Rare Anaphylaxis-Associated Fc gamma RIIa3 Exhibits Distinct Characteristics From the Canonical Fc gamma RIIa1

Jessica C Anania, Halina M Trist, Catherine S Palmer, Peck Szee Tan, Betty P Kouskousis, Alicia M Chenoweth, Stephen J Kent, Graham A Mackay, Alberta Hoi, Rachel Koelmeyer, Charlotte Slade, Vanessa L Bryant, Philip D Hodgkin, Pei Mun Aui, Menno C van Zelm, Bruce D Wines, P Mark Hogarth

Journal article  |  2018  |  Frontiers in Immunology

Antibody-Dependent Cellular Cytotoxicity Responses to Seasonal Influenza Vaccination in Older Adults

Hillary A Vanderven, Sinthujan Jegaskanda, Bruce D Wines, P Mark Hogarth, Sarina Carmuglia, Steven Rockman, Amy W Chung, Stephen J Kent

Journal article  |  2018  |  The Journal of Infectious Diseases

Antibody-dependent phagocytosis (ADP) responses following trivalent inactivated influenza vaccination of younger and older adults

Fernanda Ana-Sosa-Batiz, Angus PR Johnston, P Mark Hogarth, Bruce D Wines, Ian Barr, Adam K Wheatley, Stephen J Kent

Journal article  |  2017  |  Vaccine

HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV

Vijaya Madhavi, Bruce D Wines, Janaki Amin, Sean Emery, Ester Lopez, Anthony Kelleher, Rob J Center, P Mark Hogarth, Amy W Chung, Stephen J Kent, Ivan Stratov

Journal article  |  2017  |  Journal of Virology

Anti-HIV-1 ADCC Antibodies following Latency Reversal and Treatment Interruption

Wen Shi Lee, Anne B Kristensen, Thomas A Rasmussen, Martin Tolstrup, Lars Ostergaard, Ole S Sogaard, Bruce D Wines, P Mark Hogarth, Arnold Reynaldi, Miles P Davenport, Sean Emery, Janaki Amin, David A Cooper, Virginia L Kan, Julie Fox, Henning Gruell, Matthew S Parsons, Stephen J Kent

Journal article  |  2017  |  JOURNAL OF VIROLOGY

Dimeric Fc gamma Receptor Enzyme-Linked Immunosorbent Assay To Study HIV-Specific Antibodies: A New Look into Breadth of Fc gamma Receptor Antibodies Induced by the RV144 Vaccine Trial

Milla R McLean, Vijaya Madhavi, Bruce D Wines, P Mark Hogarth, Amy W Chung, Stephen J Kent

Journal article  |  2017  |  The Journal of Immunology

Effect of Combination Antiretroviral Therapy on HIV-1-specific Antibody-Dependent Cellular Cytotoxicity Responses in Subtype B- and Subtype C-Infected Cohorts

Vijaya Madhavi, Archana Kulkarni, Ashwini Shete, Wen S Lee, Milla R Mclean, Anne B Kristensen, Manisha Ghate, Bruce D Wines, Phillip M Hogarth, Matthew S Parsons, Anthony Kelleher, David A Cooper, Janaki Amin, Sean Emery, Madhuri Thakar, Stephen J Kent

Journal article  |  2017  |  JAIDS Journal of Acquired Immune Deficiency Syndromes

A Phase 1 Human Immunodeficiency Virus Vaccine Trial for Cross-Profiling the Kinetics of Serum and Mucosal Antibody Responses to CN54gp140 Modulated by Two Homologous Prime-Boost Vaccine Regimens

Sven Kratochvil, Paul F McKay, Jakub T Kopycinski, Cynthia Bishop, Peter John Hayes, Luke Muir, Christopher L Pinder, Deniz Cizmeci, Deborah King, Yoann Aldon, Bruce D Wines, P Mark Hogarth, Amy W Chung, Stephen J Kent, Kathrin Held, Christof Geldmacher, Len Dally, Nelson S Santos, Tom Cole, Jill Gilmour, et al.

Journal article  |  2017  |  Frontiers in Immunology

Distinctive expression of interleukin-23 receptor subunits on human Th17 and gamma delta T cells

Bruce D Wines, May L Yap, Maree S Powell, Peck-Szee Tan, K Kerry Ko, Eva Orlowski, P Mark Hogarth

Journal article  |  2017  |  Immunology & Cell Biology

Antibody Functional Assays as Measures of Fc Receptor-Mediated Immunity to HIV - New Technologies and their Impact on the HIV Vaccine Field

Bruce D Wines, Hugh Billings, Milla R Mclean, Stephen J Kent, P Mark Hogarth

Journal article  |  2017  |  Current HIV Research

Partial Efficacy of a Broadly Neutralizing Antibody against Cell-associated SHIV Infection

Matthew Parsons, Sarah Lloyd, Robert Center, Katherine Swiderek, Celia LaBranche, David Montefiori, Brandon Keele, Jeffrey Lifson, Vanessa Venturi, Miles Davenport, Thakshila Amarasena, Stephen Kent

Conference Proceedings  |  2016  |  Science Translational Medicine

Dimeric Fc gamma R Ectodomains as Probes of the Fc Receptor Function of Anti-Influenza Virus IgG

Bruce D Wines, Hillary A Vanderven, Sandra E Esparon, Anne B Kristensen, Stephen J Kent, P Mark Hogarth

Journal article  |  2016  |  The Journal of Immunology

Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

Anne B Kristensen, William N Lay, Fernanda Ana-Sosa-Batiz, Hillary A Vanderven, Vijaya Madhavi, Karen L Laurie, Louise Carolan, Bruce D Wines, Mark Hogarth, Adam K Wheatley, Stephen J Kent

Journal article  |  2016  |  JOURNAL OF VIROLOGY

What Lies Beneath: Antibody Dependent Natural Killer Cell Activation by Antibodies to Internal Influenza Virus Proteins

Hillary A Vanderven, Fernanda Ana-Sosa-Batiz, Sinthujan Jegaskanda, Steven Rockman, Karen Laurie, Ian Barr, Weisan Chen, Bruce Wines, P Mark Hogarth, Teresa Lambe, Sarah C Gilbert, Matthew S Parsons, Stephen J Kent

Journal article  |  2016  |  EBioMedicine

The high-affinity receptor for IgG, FcRI, of humans and non-human primates

Alicia M Chenoweth, Halina M Trist, Peck-Szee Tan, Bruce D Wines, P Mark Hogarth

Journal article  |  2015  |  Immunological Reviews

Polymorphisms and Interspecies Differences of the Activating and Inhibitory Fc gamma RII of Macaca nemestrina Influence the Binding of Human IgG Subclasses

Halina M Trist, Peck Szee Tan, Bruce D Wines, Paul A Ramsland, Eva Orlowski, Janine Stubbs, Elizabeth E Gardiner, Geoffrey A Pietersz, Stephen J Kent, Ivan Stratov, Dennis R Burton, P Mark Hogarth

Journal article  |  2014  |  The Journal of Immunology

The Fc gamma R of Humans and Non-human Primates and Their Interaction with IgG: Implications for Induction of Inflammation, Resistance to Infection and the Use of Therapeutic Monoclonal Antibodies

P Mark Hogarth, Jessica C Anania, Bruce D Wines

Book Chapter  |  2014  |  Current Topics in Microbiology and Immunology

Structural Basis for Fc gamma RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

Paul A Ramsland, William Farrugia, Tessa M Bradford, Caroline Tan Sardjono, Sandra Esparon, Halina M Trist, Maree S Powell, Peck Szee Tan, Angela C Cendron, Bruce D Wines, Andrew M Scott, P Mark Hogarth

Journal article  |  2011  |  Journal of Immunology

Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain.

Deepa Patel, Bruce D Wines, Ries J Langley, John D Fraser

Journal article  |  2010  |  The Journal of Immunology

Staphylococcal superantigen-like protein 10 (SSL10) is a highly conserved member of the SSL family secreted by Staphylococcus aure..

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

Nick S Laursen, Natasha Gordon, Stefan Hermans, Natalie Lorenz, Nicola Jackson, Bruce Wines, Edzard Spillner, Jesper B Christensen, Morten Jensen, Folmer Fredslund, Mette Bjerre, Lars Sottrup-Jensen, John D Fraser, Gregers R Andersen

Journal article  |  2010  |  Proceedings of the National Academy of Sciences

An Fc gamma RIIa-binding peptide that mimics the interaction between Fc gamma RIIa and IgG

Angela C Cendron, Bruce D Wines, Robert TC Brownlee, Paul A Ramsland, Geoffrey A Pietersz, P Mark Hogarth

Journal article  |  2008  |  Molecular Immunology

The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition (vol 66, pg 1342, 2007)

Matthew C Chung, Bruce D Wines, Heather Baker, Ries J Langley, Edward N Baker, John D Fraser

Journal article  |  2008  |  Molecular Microbiology

The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition

Matthew C Chung, Bruce D Wines, Heather Baker, Ries J Langley, Edward N Baker, John D Fraser

Journal article  |  2007  |  Molecular Microbiology

Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1

Paul A Ramsland, Natasha Willoughby, Halina M Trist, William Farrugia, P Mark Hogarth, John D Fraser, Bruce D Wines

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

The mechanism underlying defective Fc gamma receptor-mediated phagocytosis by HIV-1-infected human monocyte-derived macrophages

Edwin Leeansyah, Bruce D Wines, Suzanne M Crowe, Anthony Jaworowski

Journal article  |  2007  |  Journal of Immunology

IgA receptors in health and disease

Bruce D Wines, P Mark Hogarth

Journal article  |  2006  |  Tissue Antigens

A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors Fc alpha RI and Fc epsilon RI

Bruce D Wines, Halina M Trist, Paul A Ramsland, P Mark Hogarth

Journal article  |  2006  |  Journal of Biological Chemistry

Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding

Maree S Powell, Nadine C Barnes, Tessa M Bradford, Ian F Musgrave, Bruce D Wines, John C Cambier, P Mark Hogarth

Journal article  |  2006  |  Journal of Immunology

Raft localisation of Fc gamma RIIa and efficient signaling are dependent on palmitoylation of cysteine 208

NC Barnes, MS Powell, HM Trist, AL Gavin, BD Wines, PM Hogarth

Conference Proceedings  |  2006  |  Immunology Letters

A competitive mechanism for staphylococcal toxin SSL7 inhibiting the leukocyte IgA receptor, Fc alpha RI, is revealed by SSL7 binding at the C alpha 2/C alpha 3 interface of IgA

BD Wines, N Willoughby, JD Fraser, PM Hogarth

Journal article  |  2006  |  Journal of Biological Chemistry

The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteria

R Langley, B Wines, N Willoughby, I Basu, T Proft, JD Fraser

Journal article  |  2005  |  Journal of Immunology

Fc receptor gamma chain residues at the interface of the cytoplasmic and transmembrane domains affect association with Fc alpha RI, surface expression, and function

BD Wines, HM Trist, RC Monteiro, C van Kooten, PM Hogarth

Journal article  |  2004  |  Journal of Biological Chemistry

IgG purification.

Maree S Powell, Bruce D Wines

Book Chapter  |  2004  |  Methods in Molecular Biology

Soluble Fc gamma RIIa inhibits rheumatoid factor binding to immune complexes

BD Wines, A Gavin, MS Powell, M Steinitz, RRC Buchanan, PM Hogarth

Journal article  |  2003  |  Immunology

The interaction of Fc alpha RI with IgA and its implications for ligand binding by immunoreceptors of the leukocyte receptor cluster

BD Wines, CT Sardjono, HM Trist, CS Lay, PM Hogarth

Journal article  |  2001  |  Journal of Immunology

The IgG Fc contains distinct Fc receptor (FcR) binding sites: The leukocyte receptors Fc gamma RI and Fc gamma RIIa bind to a region in the Fc distinct from that recognized by neonatal FcR and protein A

BD Wines, MS Powell, PWHI Parren, N Barnes, PM Hogarth

Journal article  |  2000  |  The Journal of Immunology

Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG

MS Powell, PA Barton, D Emmanouilidis, BD Wines, GM Neumann, GA Peitersz, KF Maxwell, TPJ Garrett, PM Hogarth

Conference Proceedings  |  1999  |  Immunology Letters

Identification of residues in the first domain of human Fc alpha receptor essential for interaction with IgA

BD Wines, MD Hulett, GP Jamieson, HM Trist, JM Spratt, PM Hogarth

Journal article  |  1999  |  Journal of Immunology

The 3-D structure of FcgammaRII and identification of the binding sites of related receptors combined with gene inactivation studies identify new perspectives on the role of Fc receptors in immunity

PM Hogarth, M Powell, N Barnes, B Wines, A Gavin, K Maxwell, T Garrett, P Colman, IFC McKenzie

Journal article  |  1998  |  FASEB Journal

Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea

JC Reeder, KH Rieckmann, B Genton, K Lorry, B Wines, AF Cowman

Journal article  |  1996  |  The American Journal of Tropical Medicine and Hygiene

Recombinant soluble Fc gamma RII inhibits immune complex precipitation

AL Gavin, BD Wines, MS Powell, PM Hogarth

Journal article  |  1995  |  Clinical & Experimental Immunology

RESISTANCE OF MELANOMA CELL-LINES TO INTERFERONS CORRELATES WITH REDUCTION OF IFN-INDUCED TYROSINE PHOSPHORYLATION - INDUCTION OF THE ANTIVIRAL STATE BY IFN IS PREVENTED BY TYROSINE KINASE INHIBITORS

SJ RALPH, BD WINES, MJ PAYNE, D GRUBB, I HATZINISIRIOU, AW LINNANE, RJ DEVENISH

Journal article  |  1995  |  Journal of Immunology

ANTIBODIES TO THE COLLAGEN-LIKE REGION OF C1Q AND TYPE-II COLLAGEN ARE INDEPENDENT NON-CROSS-REACTIVE POPULATIONS IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND RHEUMATOID-ARTHRITIS

AD COOK, MJ ROWLEY, BD WINES, IR MACKAY

Journal article  |  1994  |  Journal of Autoimmunity

COLOURIMETRIC DYE ASSAY TO DETECT ANTIVIRAL ACTIVITY OF INTERFERONS - SENSITIVITY FOR MEASURING CELLULAR RESPONSIVENESS TO INTERFERONS

BD WINES, CC CHOE, I HATZINISIRIOU, RJ DEVENISH, AW LINNANE, SJ RALPH

Journal article  |  1993  |  Biochemistry and Molecular Biology International

The MA (p15) and p12 regions of the gag gene are sufficient for the pathogenicity of the murine AIDS virus.

JM Pozsgay, MW Beilharz, BD Wines, AD Hess, PM Pitha

Journal article  |  1993  |  Journal of Virology

Inoculation of the replication-defective retrovirus DEF27 (BM5d), packaged as an amphotropic virus pseudotype, into C57BL/6J mice ..

RHP is antigenically related to factor H and binds to the globular heads of C1q.

SB Easterbrook-Smith, MR Wilson, BD Wines

Journal article  |  1992  |  Molecular Immunology

RHP was purified from normal serum by sequential euglobin precipitation, ion exchange chromatography on DEAE-Sephacel and gel filt..

IMPROVED PRODUCTION AND PURIFICATION OF INTERFERON-ALPHA-4A USING A T7 RNA-POLYMERASE EXPRESSION SYSTEM

GJ WAINE, BD WINES, LF WANG, GL MCMULLEN

Journal article  |  1992  |  Biochemistry International

NATURAL-KILLER-CELL ACTIVITY AGAINST CULTURED MELANOMA-CELLS - A DYE-REDUCTION TECHNIQUE WITH STUDIES ON AUGMENTED ACTIVITY BY INTERFERON SUBTYPES

C LOSINNO, BD WINES, TG JOHNS, IR MACKAY

Journal article  |  1992  |  Natural Immunity

The Fab/c fragment of IgG produced by cleavage at cyanocysteine residues.

BD Wines, SB Easterbrook-Smith

Journal article  |  1991  |  Molecular Immunology

The intra- and inter-heavy chain disulfides of rabbit IgG were cleaved by mild reduction with either dithiothreitol or sulfite and..

Carbodiimide crosslinking of human C1q and rabbit IgG.

BD Wines, SB Easterbrook-Smith

Journal article  |  1990  |  Molecular Immunology

The water soluble carbodiimide 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide was used to covalently link carboxyl groups on rabbit..

Enhancement of the binding of C1q to immune complexes by polyethylene glycol.

BD Wines, SB Easterbrook-Smith

Journal article  |  1988  |  Molecular Immunology

The binding of 125I-labelled human C1q to insoluble rabbit IgG:ovalbumin immune complexes was enhanced by polyethylene glycol (PEG..