Bruce Wines

Systems serology detects functionally distinct coronavirus antibody features in children and elderly.

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul V Licciardi, et al.

Journal article  |  2021  |  Nature Communications

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites

Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson

Journal article  |  2021  |  Nature Communications

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..

Novel Virus-Like Particle Vaccine Encoding the Circumsporozoite Protein of Plasmodium falciparum Is Immunogenic and Induces Functional Antibody Responses in Mice.

Liriye Kurtovic, David Wetzel, Linda Reiling, Damien R Drew, Catherine Palmer, Betty Kouskousis, Eric Hanssen, Bruce D Wines, P Mark Hogarth, Manfred Suckow, Volker Jenzelewski, Michael Piontek, Jo-Anne Chan, James G Beeson

Journal article  |  2021  |  Frontiers in Immunology

RTS,S is the leading malaria vaccine in development, but has demonstrated only moderate protective efficacy in clinical trials. RT..

Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection.

Jo-Anne Chan, Jessica R Loughland, Fabian de Labastida Rivera, Arya SheelaNair, Dean W Andrew, Nicholas L Dooley, Bruce D Wines, Fiona H Amante, Lachlan Webb, P Mark Hogarth, James S McCarthy, James G Beeson, Christian R Engwerda, Michelle J Boyle

Journal article  |  2020  |  Cell Reports Medicine

CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, th..

Innate and Adaptive Anti-SIV Responses in Macaque Semen: Implications for Infectivity and Risk of Transmission

Karunasinee Suphaphiphat, Sibylle Bernard-Stoecklin, Celine Gommet, Benoit Delache, Nathalie Dereuddre-Bosquet, Stephen J Kent, Bruce D Wines, P Mark Hogarth, Roger Le Grand, Mariangela Cavarelli

Journal article  |  2020  |  Frontiers in Immunology

Epidemic thunderstorm asthma susceptibility from sensitization to ryegrass (Lolium perenne) pollen and major allergen Lol p 5

Mark Hew, Joy Lee, Nirupama Varese, Pei M Aui, Craig I McKenzie, Bruce D Wines, Heather Aumann, Jennifer M Rolland, Phillip Mark Hogarth, Menno C van Zelm, Robyn E O'Hehir

Journal article  |  2020  |  Allergy

Harnessing the immune system via Fc gamma R function in immune therapy: a pathway to next-gen mAbs

Alicia M Chenoweth, Bruce D Wines, Jessica C Anania, P Hogarth

Journal article  |  2020  |  Immunology and Cell Biology

The human fragment crystallizable (Fc)γ receptor (R) interacts with antigen-complexed immunoglobulin (Ig)G ligands to both activat..

Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial.

Liriye Kurtovic, Tanmaya Atre, Gaoqian Feng, Bruce D Wines, Jo-Anne Chan, Michelle J Boyle, Damien R Drew, P Mark Hogarth, Freya JI Fowkes, Elke S Bergmann-Leitner, James G Beeson

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: RTS,S is the leading malaria vaccine candidate, but only confers partial efficacy against malaria in children. RTS,S i..

Fc functional antibody responses to adjuvanted versus unadjuvanted seasonal influenza vaccination in community-dwelling older adults

Hillary A Vanderven, Ian Barr, Arnold Reynaldi, Adam K Wheatley, Bruce D Wines, Miles P Davenport, P Mark Hogarth, Stephen J Kent

Journal article  |  2020  |  Vaccine

BACKGROUND: Seasonal influenza vaccination with a standard trivalent influenza vaccine (TIV) induces a modest, and cross-reactive,..

Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcg Receptors: Implications for Measuring Fc Dependent Antibody Functions

Ester Lopez, Nichollas E Scott, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Stephen J Kent, Amy W Chung

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and aut..