Peter Gibbs

A Phase Ib/II Trial of Combined BRAF and EGFR Inhibition in BRAF V600E Positive Metastatic Colorectal Cancer and Other Cancers: The EVICT (Erlotinib and Vemurafenib In Combination Trial) Study.

Lavinia Tan, Ben Tran, Jeanne Tie, Ben Markman, Sumi Ananda, Niall C Tebbutt, Michael Michael, Emma Link, Stephen Q Wong, Sushma Chandrashekar, Jerick Guinto, David Ritchie, Rachel Koldej, Benjamin J Solomon, Grant A McArthur, Rodney J Hicks, Peter Gibbs, Sarah-Jane Dawson, Jayesh Desai

Journal article  |  2023  |  Clin Cancer Res

PURPOSE: BRAF V600E mutant metastatic colorectal cancer represents a significant clinical problem, with combination approaches bei..

Association between metformin, aspirin and cancer incidence and mortality risk in adults with diabetes.

Suzanne G Orchard, Jessica E Lockery, Jonathan C Broder, Michael E Ernst, Sara Espinoza, Peter Gibbs, Rory Wolfe, Galina Polekhina, Sophia Zoungas, Holli A Loomans-Kropp, Robyn L Woods

Journal article  |  2023  |  JNCI Cancer Spectr

BACKGROUND: Metformin and aspirin are commonly co-prescribed to people with diabetes. Metformin may prevent cancer but, in older p..

Pembrolizumab in Asian patients with microsatellite-instability-high/mismatch-repair-deficient colorectal cancer.

Takayuki Yoshino, Thierry Andre, Tae Won Kim, Wei Peng Yong, Kai-Keen Shiu, Benny Vittrup Jensen, Lars Henrik Jensen, Cornelis JA Punt, Denis Smith, Rocio Garcia-Carbonero, Julia Alcaide-Garcia, Peter Gibbs, Christelle de la Fouchardiere, Fernando Rivera, Elena Elez, Dung T Le, Noriaki Adachi, David Fogelman, Patricia Marinello, Luis A Diaz

Journal article  |  2023  |  Cancer Sci

The phase 3 KEYNOTE-177 study evaluated pembrolizumab versus chemotherapy with or without bevacizumab or cetuximab in patients wit..

S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer.

Ronnie Ren Jie Low, Ka Yee Fung, Hugh Gao, Adele Preaudet, Laura F Dagley, Jumana Yousef, Belinda Lee, Samantha J Emery-Corbin, Paul M Nguyen, Rune H Larsen, Nadia J Kershaw, Antony W Burgess, Peter Gibbs, Frédéric Hollande, Michael DW Griffin, Sean M Grimmond, Tracy L Putoczki

Journal article  |  2023  |  Cell Death Differ

Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT, and mesenchymal states, each of whic..

Conventional and radiomic features to predict pathology in the preoperative assessment of anterior mediastinal masses.

Maria Mayoral, Andrew M Pagano, Jose Arimateia Batista Araujo-Filho, Junting Zheng, Rocio Perez-Johnston, Kay See Tan, Peter Gibbs, Annemarie Fernandes Shepherd, Andreas Rimner, Charles B Simone Ii, Gregory Riely, James Huang, Michelle S Ginsberg

Journal article  |  2023  |  Lung Cancer

OBJECTIVES: The aim of this study was to differentiate benign from malignant tumors in the anterior mediastinum based on computed ..

"Nothing to lose and the possibility of gaining": a qualitative study on the feasibility and acceptability of registry-based randomised controlled trials among cancer patients and clinicians

Khic-Houy Prang, Bill Karanatsios, Angela Zhang, Ebony Verbunt, Hui-li Wong, Vanessa Wong, Lucy Gately, Ben Tran, Peter Gibbs, Margaret Kelaher

Journal article  |  2023  |  TRIALS

BACKGROUND: Randomised controlled trials (RCTs) are considered the "gold standard" for evaluating the effectiveness of interventio..

Prostate-specific membrane antigen positron emission tomography-computed tomography use prior to systemic therapy in metastatic castration-resistant prostate cancer.

Richard Kelly, Andrew Jensen, Nathasha Karunaratna, Shirley Wong, Julia Shapiro, Andrew Weickhardt, Phillip Parente, Arun A Azad, Anthony Uccellini, Javier Torres, Francis Parnis, Jeffrey Goh, Edmond M Kwan, Stephen Brown, Christopher Steer, Mark Warren, Peter Gibbs, Ben Tran, Angelyn Anton

Journal article  |  2023  |  BJU Int

Cancer Treatment Patterns and Factors Affecting Receipt of Treatment in Older Adults: Results from the ASPREE Cancer Treatment Substudy (ACTS)

Jaidyn Muhandiramge, Erica T Warner, John R Zalcberg, Andrew Haydon, Galina Polekhina, Gijsberta J van Londen, Peter Gibbs, Wendy B Bernstein, Jeanne Tie, Jeremy L Millar, Victoria J Mar, John J McNeil, Robyn L Woods, Suzanne G Orchard, Investigator Group ASPREE

Journal article  |  2023  |  CANCERS

INTRODUCTION: Cancer treatment planning in older adults is complex and requires careful balancing of survival, quality of life ben..

Evaluating Multiple Next-Generation Sequencing-Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status.

Romy Walker, Peter Georgeson, Khalid Mahmood, Jihoon E Joo, Enes Makalic, Mark Clendenning, Julia Como, Susan Preston, Sharelle Joseland, Bernard J Pope, Ryan A Hutchinson, Kais Kasem, Michael D Walsh, Finlay A Macrae, Aung K Win, John L Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M Sieber, Dylan E O'Sullivan, et al.

Journal article  |  2023  |  J Mol Diagn

Identifying tumor DNA mismatch repair deficiency (dMMR) is important for precision medicine. Tumor features, individually and in c..

Health economic evidence for adjuvant chemotherapy in stage II and III colon cancer: a systematic review

Yat Hang To, Peter Gibbs, Jeanne Tie, Maarten IJzerman, Koen Degeling

Journal article  |  2023  |  COST EFFECTIVENESS AND RESOURCE ALLOCATION

OBJECTIVE: The aims of this study was to appraise the health economic evidence for adjuvant chemotherapy (AC) strategies in stage ..