Jie Lin

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Michael NT Souter, Wael Awad, Shihan Li, Troi Pediongco, Bronwyn S Meehan, Lucy J Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T Praveena, Jacinta Wubben, Jie Lin, Lucy C Sullivan, George Lovrecz, Jeffrey YW Mak, Ligong Liu, Lyudmila Kostenko, et al.

Journal article  |  2022  |  Journal of Experimental Medicine

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by t..

Natural killer cell receptors regulate responses of HLA-E-restricted T cells

Lucy C Sullivan, Thi HO Nguyen, Christopher M Harpur, Sanda Stankovic, Abbie R Kanagarajah, Marios Koutsakos, Philippa M Saunders, Zhangying Cai, James A Gray, Jacqueline ML Widjaja, Jie Lin, Gabriella Pietra, Maria Cristina Mingari, Lorenzo Moretta, Jerome Samir, Fabio Luciani, Glen P Westall, Karl J Malmberg, Katherine Kedzierska, Andrew G Brooks

Journal article  |  2021  |  SCIENCE IMMUNOLOGY

Human cytomegalovirus (CMV) infection can stimulate robust human leukocyte antigen (HLA)-E-restricted CD8+ T cell responses. These..

The Structure of the Cytomegalovirus-Encoded m04 Glycoprotein, a Prototypical Member of the m02 Family of Immunoevasins

Richard Berry, Julian P Vivian, Felix A Deuss, Gautham R Balaji, Philippa M Saunders, Jie Lin, Dene R Littler, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2014  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The ability of CMVs to evade the immune system of the host is dependent on the expression of a wide array of glycoproteins, many o..

Targeting of a natural killer cell receptor family by a viral immunoevasin

Richard Berry, Natasha Ng, Philippa M Saunders, Julian P Vivian, Jie Lin, Felix A Deuss, Alexandra J Corbett, Catherine A Forbes, Jacqueline M Widjaja, Lucy C Sullivan, Adrian D McAlister, Matthew A Perugini, Melissa J Call, Anthony A Scalzo, Mariapia A Degli-Esposti, Jerome D Coudert, Travis Beddoe, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2013  |  NATURE IMMUNOLOGY

Activating and inhibitory receptors on natural killer (NK) cells have a crucial role in innate immunity, although the basis of the..

Polymorphism in Human Cytomegalovirus UL40 Impacts on Recognition of Human Leukocyte Antigen-E (HLA-E) by Natural Killer Cells

Susan L Heatley, Gabriella Pietra, Jie Lin, Jacqueline ML Widjaja, Christopher M Harpur, Sue Lester, Jamie Rossjohn, Jeff Szer, Anthony Schwarer, Kenneth Bradstock, Peter G Bardy, Maria Cristina Mingari, Lorenzo Moretta, Lucy C Sullivan, Andrew G Brooks

Journal article  |  2013  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Natural killer (NK) cell recognition of the nonclassical human leukocyte antigen (HLA) molecule HLA-E is dependent on the presenta..

Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells

Daniel M Andrews, Lucy C Sullivan, Nikola Baschuk, Christopher J Chan, Richard Berry, Claire L Cotterell, Jie Lin, Heloise Halse, Sally V Watt, Jennifer Poursine-Laurent, Chyung-Ru Wang, Anthony A Scalzo, Wayne M Yokoyama, Jamie Rossjohn, Andrew G Brooks, Mark J Smyth

Journal article  |  2012  |  NATURE IMMUNOLOGY

The development and function of natural killer (NK) cells is regulated by the interaction of inhibitory receptors of the Ly49 fami..

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

Julian P Vivian, Renee C Duncan, Richard Berry, Geraldine M O'Connor, Hugh H Reid, Travis Beddoe, Stephanie Gras, Philippa M Saunders, Maya A Olshina, Jacqueline ML Widjaja, Christopher M Harpur, Jie Lin, Sebastien M Maloveste, David A Price, Bernard AP Lafont, Daniel W McVicar, Craig S Clements, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2011  |  NATURE

Members of the killer cell immunoglobulin-like receptor (KIR) family, a large group of polymorphic receptors expressed on natural ..

RECOGNITION OF HLA-E BY NATURAL KILLER CELLS IS IMPACTED BY VARIATION IN CYTOMEGALOVIRUS UL40 SEQUENCES IN HAEMOPOIETIC STEM CELL TRANSPLANTATION

Susan Heatley, Lucy Sullivan, Gabriella Pietra, Jie Lin, Jason Jordan, Maria Cristina Mingari, Lorenzo Moretta, Andrew Brooks

Conference Proceedings  |  2009  |  HUMAN IMMUNOLOGY

Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs

Erik Rollman, Rosemarie D Mason, Jie Lin, Andrew G Brooks, Stephen J Kent

Journal article  |  2008  |  JOURNAL OF MEDICAL PRIMATOLOGY

BACKGROUND: Live attenuated SIV vaccines are highly efficacious, but how they mediate protection is poorly understood. A feature o..

Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors

Hilary L Hoare, Lucy C Sullivan, Craig S Clements, Lauren K Ely, Travis Beddoe, Kate N Henderson, Jie Lin, Hugh H Reid, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2008  |  JOURNAL OF MOLECULAR BIOLOGY

Human leukocyte antigen (HLA)-E is a non-classical major histocompatibility complex class I molecule that binds peptides derived f..