Paul Ramsland

Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin

Sandip D Kamath, Sandra Scheiblhofer, Christopher M Johnson, Yoan Machado, Thomas McLean, Aya C Taki, Paul A Ramsland, Swati Iyer, Isabella Joubert, Heidi Hofer, Michael Wallner, Josef Thalhamer, Jennifer Rolland, Robyn O'Hehir, Peter Briza, Fatima Ferreira, Richard Weiss, Andreas L Lopata

Journal article  |  2020  |  ALLERGY

Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross‐re..

Molecular and structural basis for Lewis glycan recognition by a cancer-targeting antibody

Caroline Soliman, Andrew J Guy, Jia Xin Chua, Mireille Vankemmelbeke, Richard S McIntosh, Sarah Eastwood, Vi Khanh Truong, Aaron Elbourne, Ian Spendlove, Lindy G Durrant, Paul A Ramsland

Journal article  |  2020  |  BIOCHEMICAL JOURNAL

Immunotherapy has been successful in treating many tumour types. The development of additional tumour-antigen binding monoclonal a..

Editorial overview: Carbohydrates - structural glycobiology catches the wave of rapid progress

Sony Malhotra, Paul A Ramsland

Journal article  |  2020  |  CURRENT OPINION IN STRUCTURAL BIOLOGY

Antibody recognition of bacterial surfaces and extracellular polysaccharides

Caroline Soliman, Gerald B Pier, Paul A Ramsland

Journal article  |  2020  |  CURRENT OPINION IN STRUCTURAL BIOLOGY

Because of the ongoing increase in antibiotic-resistant microbes, new strategies such as therapeutic antibodies and effective vacc..

Identifying glycan motifs using a novel subtree mining approach

Lachlan Coff, Jeffrey Chan, Paul A Ramsland, Andrew J Guy

Journal article  |  2020  |  BMC BIOINFORMATICS

BACKGROUND: Glycans are complex sugar chains, crucial to many biological processes. By participating in binding interactions with ..

The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody

Caroline Soliman, Jia Xin Chua, Mireille Vankemmelbeke, Richard S McIntosh, Andrew J Guy, Ian Spendlove, Lindy G Durrant, Paul A Ramsland

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer remains a leading cause of morbidity and mortality worldwide, requiring ongoing development of targeted therapeutics such a..

The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody

Caroline Soliman, Jia Xin Chua, Mireille Vankemmelbeke, Richard S McIntosh, Andrew J Guy, Ian Spendlove, Lindy G Durrant, Paul A Ramsland

Journal article  |  2020  |  Journal of Biological Chemistry

The membrane effects of melittin on gastric and colorectal cancer

Caroline Soliman, Sarah Eastwood, Khanh Truong Vi, Paul A Ramsland, Aaron Elbourne

Journal article  |  2019  |  PLOS ONE

The cytotoxic effects of melittin, a bee-venom peptide, have been widely studied towards cancer cells. Typically, these studies ha..

Pre-clinical evaluation of a quadrivalent HCV VLP vaccine in pigs following microneedle delivery

D Christiansen, L Earnest-Silveira, B Grubor-Bauk, DK Wijesundara, I Boo, PA Ramsland, E Vincan, HE Drummer, EJ Gowans, J Torresi

Journal article  |  2019  |  SCIENTIFIC REPORTS

The introduction of directly acting antiviral agents (DAAs) has produced significant improvements in the ability to cure chronic h..

Probing and pressing surfaces of hepatitis C virus-like particles

Simon Collett, Joseph Torresi, Linda Earnest-Silveira, Dale Christiansen, Aaron Elbourne, Paul A Ramsland

Journal article  |  2019  |  JOURNAL OF COLLOID AND INTERFACE SCIENCE

Hepatitis C virus-like particles (VLPs) are being developed as a quadrivalent vaccine candidate, eliciting both humoral and cellul..