Andrew Lawrence

Reward Motivation and Cognitive Flexibility in Tau Null-Mutation Mice

Sara Oberrauch, Jeremy A Metha, Maddison L Brian, Samuel A Barnes, Travis J Featherby, Andrew J Lawrence, Daniel Hoyer, Carsten Murawski, Laura H Jacobson

Journal article  |  2021  |  Neurobiology of Aging

The reduction of tau or hyperphosphorylated tau (p-tau) has been proposed as a therapeutic strategy for Alzheimer's disease (AD) a..

It's more than just interoception: The insular cortex involvement in alcohol use disorder.

Erin J Campbell, Andrew J Lawrence

Journal article  |  2021  |  Journal of Neurochemistry

Understanding brain structures and circuits impacted by alcohol use disorder is critical for improving our future prevention techn..

Genetics of methamphetamine use disorder: A systematic review and meta-analyses of gene association studies.

Alexandre A Guerin, Eric J Nestler, Michael Berk, Andrew J Lawrence, Susan L Rossell, Jee Hyun Kim

Journal article  |  2021  |  Neuroscience & Biobehavioral Reviews

Genetic susceptibility to methamphetamine use disorder is poorly understood. No twin or adequately powered genome-wide association..

Acetylcholine Muscarinic M-4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents

Leigh C Walker, Alice E Berizzi, Nicola A Chen, Patricia Rueda, Victoria M Perreau, Katherine Huckstep, Jirawoot Srisontiyakul, Piyarat Govitrapong, Xiaojian Jia, Craig W Lindsley, Carrie K Jones, Darren M Riddy, Arthur Christopoulos, Christopher J Langmead, Andrew J Lawrence

Journal article  |  2020  |  Biological Psychiatry

BACKGROUND: Alcohol use disorder (AUD) is a major socioeconomic burden on society, and current pharmacotherapeutic treatment optio..

Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking

Erin J Campbell, Mitchell KR Hill, Xavier J Maddern, Shubo Jin, Terence Y Pang, Andrew J Lawrence

Journal article  |  2020  |  Journal of Psychopharmacology

BACKGROUND: The lateral hypothalamic orexin (hypocretin) system has a well-established role in the motivation for reward. This has..

Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking

Leigh C Walker, Lexi J Hand, Bethany Letherby, Kate L Huckstep, Erin J Campbell, Andrew J Lawrence

Journal article  |  2020  |  Neuropsychopharmacology

The central nucleus of the amygdala (CeA) is a key hub of the neural circuitry regulating alcohol and stress interactions. However..

Prelimbic Cortical Stimulation Improves Spatial Memory Through Distinct Patterns of Hippocampal Gene Expression in Aged Rats

Shawn Zheng Kai Tan, Joveen Neoh, Andrew John Lawrence, Ed Xuekui Wu, Lee Wei Lim

Journal article  |  2020  |  Neurotherapeutics

Dementia poses major health challenges worldwide, yet current treatments are faced with issues of efficacy and toxicity. Deep brai..

Extinction and drug-induced reinstatement of cocaine seeking following self-administration or conditioned place preference in adolescent and adult rats

Alexandre A Guerin, Isabel C Zbukvic, Sophia J Luikinga, Katherine D Drummond, Andrew J Lawrence, Heather B Madsen, Jee Hyun Kim

Journal article  |  2020  |  Developmental Psychobiology

Adolescence marks a particularly vulnerable period to developing substance use disorders, and people who start using drugs in adol..

Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex

Alec LW Dick, Qiongyi Zhao, Rose Crossin, Danay Baker-Andresen, Xiang Li, Janette Edson, Simone Roeh, Victoria Marshall, Timothy W Bredy, Andrew J Lawrence, Jhodie R Duncan

Journal article  |  2020  |  Addiction Biology

Inhalants containing the volatile solvent toluene are misused to induce euphoria or intoxication. Inhalant abuse is most common du..

MUSCARINIC ACETYLCHOLINE RECEPTORS IN ALCOHOL USE DISORDER

LC Walker, AE Berrizi, NA Chen, P Rueda, VM Perreau, K Huckstep, CW Lidsley, CK Jones, DM Riddy, A Christopoulos, CJ Langmead, AJ Lawrence

Conference Proceedings  |  2020  |  ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH