Neil Young

Genome-wide exploration reveals distinctive northern and southern variants of Clonorchis sinensis in the Far East

Liina Kinkar, Pasi K Korhonen, Urmas Saarma, Tao Wang, Xing-Quan Zhu, Ivon Harliwong, Bicheng Yang, J Lynn Fink, Daxi Wang, Bill CH Chang, Galina N Chelomina, Anson V Koehler, Neil D Young, Robin B Gasser

Journal article  |  2023  |  MOLECULAR ECOLOGY RESOURCES

Clonorchis sinensis is a carcinogenic liver fluke that causes clonorchiasis-a neglected tropical disease (NTD) affecting ~35 milli..

The redlegged earth mite draft genome provides new insights into pesticide resistance evolution and demography in its invasive Australian range

Joshua A Thia, Pasi K Korhonen, Neil D Young, Robin B Gasser, Paul A Umina, Qiong Yang, Owain Edwards, Tom Walsh, Ary A Hoffmann

Journal article  |  2022  |  JOURNAL OF EVOLUTIONARY BIOLOGY

Genomic data provide valuable insights into pest management issues such as resistance evolution, historical patterns of pest invas..

Proteomic analysis of Sarcoptes scabiei reveals that proteins differentially expressed between eggs and female adult stages are involved predominantly in genetic information processing, metabolism and/or host-parasite interactions

Tao A Wang, Robin Gasser, Pasi R Korhonen, Neil D Young, Ching-Seng Ang, Nicholas Williamson, Guangxu Ma, Gangi Samarawickrama, Deepani Fernando, Katja Fischer

Journal article  |  2022  |  PLOS NEGLECTED TROPICAL DISEASES

Presently, there is a dearth of proteomic data for parasitic mites and their relationship with the host animals. Here, using a hig..

Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868

Aya CC Taki, Tao Wang, Nghi NN Nguyen, Ching-Seng Ang, Michael GG Leeming, Shuai Nie, Joseph JJ Byrne, Neil DD Young, Yuanting Zheng, Guangxu Ma, Pasi KK Korhonen, Anson VV Koehler, Nicholas AA Williamson, Andreas Hofmann, Bill CH Chang, Cecile Haeberli, Jennifer Keiser, Abdul Jabbar, Brad EE Sleebs, Robin BB Gasser

Journal article  |  2022  |  FRONTIERS IN PHARMACOLOGY

Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. T..

Evidence that Transcriptional Alterations in Sarcoptes scabiei Are under Tight Post-Transcriptional (microRNA) Control

Pasi K Korhonen, Tao Wang, Neil D Young, Gangi R Samarawickrama, Deepani D Fernando, Guangxu Ma, Robin B Gasser, Katja Fischer

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Here, we explored transcriptomic differences among early egg (Ee), late egg (Le) and adult female (Af) stages of the scabies mite,..

Ubiquitination pathway model for the barber's pole worm - Haemonchus contortus

Yuanting Zheng, Guangxu Ma, Tao Wang, Andreas Hofmann, Jiangning Song, Robin B Gasser, Neil D Young

Journal article  |  2022  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

The ubiquitin-mediated pathway has been comprehensively explored in the free-living nematode Caenorhabditis elegans, but very litt..

Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus.

Jack Adderley, Tao Wang, Guangxu Ma, Yuanting Zheng, Neil D Young, Christian Doerig, Robin B Gasser

Journal article  |  2022  |  Parasit Vectors

BACKGROUND: Gaining insight into molecular signalling pathways of socioeconomically important parasitic nematodes has implications..

Chromosome-level genome assembly defines female-biased genes associated with sex determination and differentiation in the human blood fluke Schistosoma japonicum

Xindong Xu, Yifeng Wang, Changhong Wang, Gangqiang Guo, Xinyu Yu, Yang Dai, Yaobao Liu, Guiying Wei, Xiaohui He, Ge Jin, Ziqiu Zhang, Qingtian Guan, Arnab Pain, Shengyue Wang, Wenbao Zhang, Neil D Young, Robin B Gasser, Donald P McManus, Jun Cao, Qi Zhou, et al.

Journal article  |  2022  |  MOLECULAR ECOLOGY RESOURCES

Schistosomiasis is a neglected tropical disease of humans caused by blood flukes of the genus Schistosoma, the only dioecious para..

NKG7 Enhances CD8 T Cell Synapse Efficiency to Limit Inflammation

Emily J Lelliott, Kelly M Ramsbottom, Mark R Dowling, Carolyn Shembrey, Tahereh Noori, Conor J Kearney, Jessica Michie, Ian A Parish, Margaret A Jordan, Alan G Baxter, Neil D Young, Amelia J Brennan, Jane Oliaro

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer c..

Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1

Daniela Castiblanco, Jesse A Rudd-Schmidt, Tahereh Noori, Vivien R Sutton, Ya Hui Hung, Thijs WH Flinsenberg, Adrian W Hodel, Neil D Young, Nicholas Smith, Drago Bratkovic, Heidi Peters, Mark Walterfang, Joseph A Trapani, Amelia J Brennan, Ilia Voskoboinik

Journal article  |  2022  |  BLOOD

Niemann-Pick disease type C1 (NP-C1) is a rare lysosomal storage disorder resulting from mutations in an endolysosomal cholesterol..