Graeme Joseph O'Keefe

Human biodistribution and internal dosimetry of 4-[F-18]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart

Cameron D Pain, Graeme J O'Keefe, Uwe Ackermann, Vincent Dore, Victor L Villemagne, Christopher C Rowe

Journal article  |  2020  |  EJNMMI Research

BACKGROUND: 4-[18F] fluorobenzyl dexetimide (F-DEX) is the first non-subtype selective fluorine-18 labelled tracer for muscarinic ..

Imaging of neuroinflammation in adult Niemann-Pick type C disease A cross-sectional study

Mark Walterfang, Maria A Di Biase, Vanessa L Cropley, Andrew M Scott, Graeme O'Keefe, Dennis Velakoulis, Kunthi Pathmaraj, Uwe Ackermann, Christos Pantelis

Journal article  |  2020  |  Neurology

OBJECTIVE: To test the hypothesis that neuroinflammation is a key process in adult Niemann-Pick type C (NPC) disease, we undertook..

Spatial and quantitative mapping of glycolysis and hypoxia in glioblastoma as a predictor of radiotherapy response and sites of relapse

Antoine Leimgruber, Kevin Hickson, Sze Ting Lee, Hui K Gan, Lawrence M Cher, John Sachinidis, Graeme J O'Keefe, Andrew M Scott

Journal article  |  2020  |  European Journal of Nuclear Medicine and Molecular Imaging

INTRODUCTION: Tumor hypoxia is a centerpiece of disease progression mechanisms such as neoangiogenesis or aggressive hypoxia-resis..

First clinical study of a pegylated diabody I-124-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers

Andrew M Scott, Timothy Akhurst, Fook-Thean Lee, Marika Ciprotti, Ian D Davis, Andrew J Weickhardt, Hui K Gan, Rodney J Hicks, Sze Ting Lee, Pece Kocovski, Nancy Guo, Maggie Oh, Linda Mileshkin, Scott Williams, Declan Murphy, Kunthi Pathmaraj, Graeme J O'Keefe, Sylvia J Gong, John S Pedersen, Fiona E Scott, et al.

Journal article  |  2020  |  Theranostics

Through protein engineering and a novel pegylation strategy, a diabody specific to tumor-associated glycoprotein 72 (TAG-72) (PEG-..

PRELIMINARY FINDINGS OF A PHASE I SAFETY AND BIOIMAGING TRIAL OF KB004 (IFABOTUZUMAB) IN PATIENTS WITH GLIOBLASTOMA

Hui Gan, Lawrence Cher, Po Inglis, Zarnie Lwin, Eddie Lau, Uwe Ackermann, Nicole Coombs, Kirsten Remen, Nancy Guo, Sze Ting Lee, Sylvia Gong, Jodie Palmer, Kunthi Pathmaraj, Graeme O'Keefe, Fiona Scott, Bryan Day, Andrew Boyd, Paul Thomas, Cameron Durrant, Andrew Scott

Conference Proceedings  |  2019  |  NEURO-ONCOLOGY

Preliminary findings of a Phase I safety and bioimaging trial of KB004 (ifabotuzumab) in patients with glioblastoma

Hui Gan, Lawrence Cher, Po Inglis, Zarnie Lwin, Eddie Lau, Christian Wichmann, Uwe Ackermann, Nicole Coombs, Kirsten Remen, Nancy Guo, Sze Ting Lee, Sylvia Gong, Jodie B Palmer, Kunthi Pathmaraj, Graeme O'Keefe, Fiona Scott, Bryan W Day, Andrew W Boyd, Paul Thomas, Cameron Durrant, et al.

Conference Proceedings  |  2019  |  Clinical Trials

Phantom measurement predicts the impact of image reconstruction on Florbetapir SUVR quantification

Robert Williams, Leigh Johnston, Vincent Dore, Graeme O'Keefe, Jason Callahan, Zhihan Xu, Shuning Zheng, Bradford Moffat, Colin Masters, Christopher Rowe

Conference Proceedings  |  2019  |  JOURNAL OF NUCLEAR MEDICINE

Accuracy of Dose Calibrators for Ga-68 PET Imaging: Unexpected Findings in a Multicenter Clinical Pretrial Assessment

Dale L Bailey, Michael S Hofman, Nicholas J Forwood, Graeme J O'Keefe, Andrew M Scott, Winifred M van Wyngaardt, Bonnie Howe, Olga Kovacev, Roslyn J Francis

Journal article  |  2018  |  Journal of Nuclear Medicine

Molecular imaging of T cell co-regulator factor B7-H3 with Zr-89-DS-5573a

Ingrid Julienne Georgette Burvenich, Sagun Parakh, Fook-Thean Lee, Nancy Guo, Zhanqi Liu, Hui Kong Gan, Angela Rigopoulos, Graeme Joseph O'Keefe, Sylvia Jie Gong, Yit Wooi Goh, Henri Tochon-Danguy, Fiona Elizabeth Scott, Masakatsu Kotsuma, Kenji Hirotani, Giorgio Senaldi, Andrew Mark Scott

Journal article  |  2018  |  THERANOSTICS

Cerebral Blood Flow and A beta-Amyloid Estimates by WARM Analysis of [C-11]PiB Uptake Distinguish among and between Neurodegenerative Disorders and Aging

Anders B Rodell, Graeme O'Keefe, Christopher C Rowe, Victor L Villemagne, Albert Gjedde

Journal article  |  2017  |  Frontiers in Aging Neuroscience