Andrew Nash

Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue.

Annelie Falkevall, Annika Mehlem, Erika Folestad, Frank Chenfei Ning, Óscar Osorio-Conles, Rosa Radmann, Ana de Hollanda, Samuel D Wright, Pierre Scotney, Andrew Nash, Ulf Eriksson

Journal article  |  2023  |  J Hepatol

BACKGROUND & AIMS: Hepatic steatosis is a hallmark of non-alcoholic fatty liver disease (NAFLD), a common comorbidity in type 2 di..

HDX-MS study on garadacimab binding to activated FXII reveals potential binding interfaces through differential solvent exposure.

Saw Yen Ow, Eugene A Kapp, Vesna Tomasetig, Anton Zalewski, Jason Simmonds, Con Panousis, Michael J Wilson, Andrew D Nash, Matthias Pelzing

Journal article  |  2023  |  MAbs

Hageman factor (FXII) is an essential component in the intrinsic coagulation cascade and a therapeutic target for the prophylactic..

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

Anti-beta(c) mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model

Kwok Ho Yip, Nicholas J Wilson, Harshita Pant, Christopher L Brown, Samantha Busfield, Milica Ng, Monther Alhamdoosh, Naomi Woodman, Mark Schembri, Damon J Tumes, Gino Vairo, Angel F Lopez, Andrew D Nash, Michael J Wilson, Michele A Grimbaldeston, Catherine M Owczarek

Journal article  |  2019  |  ALLERGY

Expression of the interleukin-3/receptor complex by breast cancer cells promotes vascular mimicry via a PI3K-dependent mechanism and is associated with poor outcome

Emma J Thompson, Camille Duluc, Emma F Barry, Gelareh Farshid, Kaylene J Simpson, Phillip A Gregory, Xiaochun Li, Stephen Madden, Cathy M Owczarek, Nick J Wilson, Gino Vairo, Andrew D Nash, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Yeesim Khew-Goodall, Angel F Lopez, Claudine S Bonder

Conference Proceedings  |  2019  |  Oncology Abstracts

A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus

Shereen Oon, Katherine Monaghan, Milica Ng, Alberta Hoi, Eric Morand, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are majo..

Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation

Helen Cao, Mark Biondo, Hadi Lioe, Samantha Busfield, Veronika Rayzman, Bernhard Nieswandt, Konrad Bork, Leonard C Harrison, Priscilla Auyeung, Henriette Farkas, Dorottya Csuka, Matthias Pelzing, Steve Dower, Michael J Wilson, Andrew Nash, Marc W Nolte, Con Panousis

Journal article  |  2018  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of the beta Common (beta c) Family of Cytokines in Health and Disease

Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.

Journal article  |  2018  |  COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL..

A neutralizing anti-G-CSFR antibody blocks G-CSF-induced neutrophilia without inducing neutropenia in nonhuman primates.

Karen Scalzo-Inguanti, Katherine Monaghan, Kirsten Edwards, Eva Herzog, Danijela Mirosa, Matthew Hardy, Vicki Sorto, Huy Huynh, Steven Rakar, Daria Kurtov, Hal Braley, Nick Wilson, Samantha Busfield, Andrew Nash, Arna Andrews

Journal article  |  2017  |  J Leukoc Biol

Neutrophils are the most abundant WBCs and have an essential role in the clearance of pathogens. Tight regulation of neutrophil nu..

An Anti-VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea.

Yazad D Irani, Pierre D Scotney, Sonja Klebe, Lauren A Mortimer, Andrew D Nash, Keryn A Williams

Journal article  |  2017  |  Invest Ophthalmol Vis Sci

PURPOSE: We tested the ability of an antibody fragment with specificity for vascular endothelial growth factor-B (VEGF-B) to regre..