Andrew Nash

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus

Shereen Oon, Katherine Monaghan, Milica Ng, Alberta Hoi, Eric Morand, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2019  |  Clinical & Translational Immunology

Objectives: Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are majo..

Role of the beta Common (beta c) Family of Cytokines in Health and Disease

Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.

Journal article  |  2018  |  Cold Spring Harbor Perspectives in Biology

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

Ian K Campbell, David Leong, Kirsten M Edwards, Veronika Rayzman, Milica Ng, Gabrielle L Goldberg, Nicholas J Wilson, Karen Scalzo-Inguanti, Charley Mackenzie-Kludas, Kate E Lawlor, Ian P Wicks, Lorena E Brown, Adriana Baz Morelli, Con Panousis, Michael J Wilson, Andrew D Nash, Brent S McKenzie, Arna E Andrews

Journal article  |  2016  |  The Journal of Immunology

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Yan Tan, Gail C Brammar, Katrina A Walsh, William Singleton, Rebecca KH Orth, Nada Slakeski, Keith J Cross, Ivan B Darby, Dorit Becher, Tony Rowe, Adriana Baz Morelli, Andrew Hammet, Andrew Nash, Anna Brown, Bing Ma, Didier Vingadassalom, Jacqueline McCluskey, et al.

Journal article  |  2016  |  NPJ VACCINES

A cytotoxic anti-IL-3R alpha antibody targets key cells and cytokines implicated in systemic lupus erythematosus

Shereen Oon, Huy Huynh, Tsin Yee Tai, Milica Ng, Katherine Monaghan, Mark Biondo, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2016  |  JCI Insight

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors

Con Panousis, Urmi Dhagat, Kirsten M Edwards, Veronika Rayzman, Matthew P Hardy, Hal Braley, Gail M Gauvreau, Timothy R Hercus, Steven Smith, Roma Sehmi, Laura McMillan, Mara Dottore, Barbara J McClure, Louis J Fabri, Gino Vairo, Angel F Lopez, Michael W Parker, Andrew D Nash, Nicholas J Wilson, Michael J Wilson, et al.

Journal article  |  2016  |  MABS

Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC

SJ Busfield, M Biondo, M Wong, HS Ramshaw, EM Lee, S Ghosh, H Braley, C Panousis, AW Roberts, SZ He, D Thomas, L Fabri, G Vairo, RB Lock, AF Lopez, AD Nash

Journal article  |  2014  |  Leukemia

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Sophie E Broughton, Timothy R Hercus, Matthew P Hardy, Barbara J McClure, Tracy L Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F Barry, Winnie L Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J Busfield, Catherine M Owczarek, Andrew D Nash, Nicholas J Wilson, Michael W Parker, Angel F Lopez

Journal article  |  2014  |  Cell Reports

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Urmi Dhagat, Catherine M Owczarek, Matthew P Hardy, Louis J Fabri, Pierre D Scotney, Andrew D Nash, Nicholas J Wilson, Angel F Lopez, Michael W Parker

Journal article  |  2014  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk

Magnus Larsson, Veronika Rayzman, Marc W Nolte, Katrin F Nickel, Jenny Bjorkqvist, Anne Jamsa, Matthew P Hardy, Marion Fries, Stefan Schmidbauer, Patricia Hedenqvist, Michael Broome, Ingo Pragst, Gerhard Dickneite, Michael J Wilson, Andrew D Nash, Con Panousis, Thomas Renne

Journal article  |  2014  |  Science Translational Medicine