Jessica Porter

Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Nocardia Isolate

Marion Herisse, Keishi Ishida, Jessica L Porter, Ben Howden, Christian Hertweck, Timothy P Stinear, Sacha J Pidot

Journal article  |  2020  |  ACS Chemical Biology

The genus Nocardia contains >50 human pathogenic species that cause a range of illnesses from skin and soft tissue infections to l..

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model

Kirstie M Mangas, Andrew H Buultjens, Jessica L Porter, Sarah L Baines, Estelle Marion, Laurent Marsollier, Nicholas J Tobias, Sacha J Pidot, Kylie M Quinn, David J Price, Katherine Kedzierska, Weiguang Zeng, David C Jackson, Brendon Y Chua, Timothy P Stineara

Journal article  |  2020  |  Infection and Immunity

The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no ef..

Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie International Edition

Biosynthesis and Ether‐Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie

Abstract: The nargenicin family of antibiotics are macrolides containing a rare ether‐bridged cis‐decalin motif. Several of these ..

In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model

Till F Omansen, Renee A Marcsisin, Brendon Y Chua, Weiguang Zeng, David C Jackson, Jessica L Porter, Ymkje Stienstra, Tjip S van der Werf, Timothy P Stinear

Journal article  |  2019  |  The American Journal of Tropical Medicine and Hygiene

Buruli ulcer (BU) is a neglected tropical disease caused by infection with Mycobacterium ulcerans. Unclear transmission, no availa..

The Phi BT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia

Marion Herisse, Jessica L Porter, Romain Guerillot, Takehiro Tomita, Anders Goncalves Da Silva, Torsten Seemann, Benjamin P Howden, Timothy P Stinear, Sacha J Pidot

Journal article  |  2018  |  PEERJ

Comparative Genomics Shows That Mycobacterium ulcerans Migration and Expansion Preceded the Rise of Buruli Ulcer in Southeastern Australia

Andrew H Buultjens, Koen Vandelannoote, Conor J Meehan, Miriam Eddyani, Bouke C de Jong, Janet AM Fyfe, Maria Globan, Nicholas J Tobias, Jessica L Porter, Takehiro Tomita, Ee Laine Tay, Torsten Seemann, Benjamin P Howden, Paul DR Johnson, Timothy P Stinear

Journal article  |  2018  |  Applied and Environmental Microbiology

Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant &ITStaphylococcus aureus&IT

Romain Guerillot, Anders Goncalves da Silva, Ian Monk, Stefano Giulieri, Takehiro Tomita, Eloise Alison, Jessica Porter, Sacha Pidot, Wei Gao, Anton Y Peleg, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  MSPHERE

Target-Specific Assay for Rapid and Quantitative Detection of Mycobacterium chimaera DNA

Enrique Zozaya-Valdes, Jessica L Porter, John Coventry, Janet AM Fyfe, Glen P Carter, Anders Goncalves da Silva, Mark B Schultz, Torsten Seemann, Paul DR Johnson, Andrew J Stewardson, Ivan Bastian, Sally A Roberts, Benjamin P Howden, Deborah A Williamson, Timothy P Stinear

Journal article  |  2017  |  Journal of Clinical Microbiology

Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer

John R Wallace, Kirstie M Mangas, Jessica L Porter, Renee Marcsisin, Sacha J Pidot, Brian Howden, Till F Omansen, Weiguang Zeng, Jason K Axford, Paul DR Johnson, Timothy P Stinear

Journal article  |  2017  |  PLOS NEGLECTED TROPICAL DISEASES

A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer

Miriam Eddyani, Koen Vandelannoote, Conor J Meehan, Sabin Bhuju, Jessica L Porter, Julia Aguiar, Torsten Seemann, Michael Jarek, Mahavir Singh, Francoise Portaels, Timothy P Stinear, Bouke C de Jong

Journal article  |  2015  |  PLoS Negl Trop Dis

Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient

Ella M Meumann, Maria Globan, Janet AM Fyfe, David Leslie, Jessica L Porter, Torsten Seemann, Justin Denholm, Timothy P Stinear

Journal article  |  2015  |  MICROBIAL GENOMICS

Whole Genome Comparisons Suggest Random Distribution of Mycobacterium ulcerans Genotypes in a Buruli Ulcer Endemic Region of Ghana

Anthony S Ablordey, Koen Vandelannoote, Isaac A Frimpong, Evans K Ahortor, Nana Ama Amissah, Miriam Eddyani, Lies Durnez, Francoise Portaels, Bouke C de Jong, Herwig Leirs, Jessica L Porter, Kirstie M Mangas, Margaret MC Lam, Andrew Buultjens, Torsten Seemann, Nicholas J Tobias, Timothy P Stinear

Journal article  |  2015  |  PLoS Negl Trop Dis

In-vitro Activity of Avermectins against Mycobacterium ulcerans

Till F Omansen, Jessica L Porter, Paul DR Johnson, Tjip S van der Werf, Ymkje Stienstra, Timothy P Stinear

Journal article  |  2015  |  PLOS Neglected Tropical Diseases

Hyperexpression of alpha-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus

Kyra YL Chua, Ian R Monk, Ya-Hsun Lin, Torsten Seemann, Kellie L Tuck, Jessica L Porter, Justin Stepnell, Geoffrey W Coombs, John K Davies, Timothy P Stinear, Benjamin P Howden

Journal article  |  2014  |  BMC MICROBIOLOGY

The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis

Jessica L Porter, Nicholas J Tobias, Sacha J Pidot, Steffen Falgner, Kellie L Tuck, Andrea Vettiger, Hui Hong, Peter F Leadlay, Timothy P Stinear

Journal article  |  2013  |  PLOS ONE

Decreased Vancomycin Susceptibility in Staphylococcus aureus Caused by IS256 Tempering of WalKR Expression

Christopher RE McEvoy, Brian Tsuji, Wei Gao, Torsten Seemann, Jessica L Porter, Kenneth Doig, Dung Ngo, Benjamin P Howden, Timothy P Stineara

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

Outbreak Investigation Using High-Throughput Genome Sequencing within a Diagnostic Microbiology Laboratory

Norelle L Sherry, Jessica L Porter, Torsten Seemann, Andrew Watkins, Timothy P Stinear, Benjamin P Howden

Journal article  |  2013  |  Journal of Clinical Microbiology

Lack of upward creep of glycopeptide MICs for methicillin-resistant Staphylococcus aureus (MRSA) isolated in the UK and Ireland 2001-07.

R Reynolds, R Hope, M Warner, AP MacGowan, DM Livermore, MJ Ellington, undefined BSAC Extended Working Party on Resistance Surveillance

Journal article  |  2012  |  Journal of Antimicrobial Chemotherapy

OBJECTIVES: There have been several reports of upward creep in vancomycin MICs for Staphylococcus aureus [predominantly methicilli..

Evolution of Multidrug Resistance during Staphylococcus aureus Infection Involves Mutation of the Essential Two Component Regulator WalKR

Benjamin P Howden, Christopher RE McEvoy, David L Allen, Kyra Chua, Wei Gao, Paul F Harrison, Jan Bell, Geoffrey Coombs, Vicki Bennett-Wood, Jessica L Porter, Roy Robins-Browne, John K Davies, Torsten Seemann, Timothy P Stinear

Journal article  |  2011  |  PLoS Pathogens

Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation

Sacha J Pidot, Jessica L Porter, Nicholas J Tobias, Jeffrey Anderson, Deanne Catmull, Torsten Seemann, Stephen Kidd, John K Davies, Eric Reynolds, Stuart Dashper, Timothy P Stinear

Journal article  |  2010  |  Molecular Microbiology

Serological Evaluation of Mycobacterium ulcerans Antigens Identified by Comparative Genomics

Sacha J Pidot, Jessica L Porter, Laurent Marsollier, Annick Chauty, Florence Migot-Nabias, Cyril Badaut, Angele Benard, Marie-Therese Ruf, Torsten Seemann, Paul DR Johnson, John K Davies, Grant A Jenkin, Gerd Pluschke, Timothy P Stinear

Journal article  |  2010  |  PLOS NEGLECTED TROPICAL DISEASES

Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer

Nicholas J Tobias, Torsten Seemann, Sacha J Pidot, Jessica L Porter, Laurent Marsollier, Estelle Marion, Franck Letournel, Tasnim Zakir, Joseph Azuolas, John R Wallace, Hui Hong, John K Davies, Benjamin P Howden, Paul DR Johnson, Grant A Jenkin, Timothy P Stinear

Journal article  |  2009  |  PLOS NEGLECTED TROPICAL DISEASES

Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum

Jessica L Porter, Nicholas J Tobias, Hui Hong, Kellie L Tuck, Grant A Jenkin, Timothy P Stinear

Journal article  |  2009  |  Microbiology

Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones

Sacha J Pidot, Hui Hong, Torsten Seemann, Jessica L Porter, Marcus J Yip, Artem Men, Matthew Johnson, Peter Wilson, John K Davies, Peter F Leadlay, Timothy P Stinear

Journal article  |  2008  |  BMC GENOMICS

A novel mycolactone toxin obtained by biosynthetic engineering

Hui Hong, Tim Stinear, Jessica Porter, Caroline Demangel, Peter F Leadlay

Journal article  |  2007  |  ChemBioChem

Evolution of Mycobacterium ulcerans and other mycolactone-producing mycobacteria from a common Mycobacterium marinum progenitor

Marcus J Yip, Jessica L Porter, Janet AM Fyfe, Caroline J Lavender, Francoise Portaels, Martha Rhodes, Howard Kator, Angelo Colorni, Grant A Jenkin, Tim Stinear

Journal article  |  2007  |  Journal of Bacteriology

Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

Timothy P Stinear, Torsten Seemann, Sacha Pidot, Wafa Frigui, Gilles Reysset, Thierry Garnier, Guillaume Meurice, David Simon, Christiane Bouchier, Laurence Ma, Magali Tichit, Jessica L Porter, Janine Ryan, Paul DR Johnson, John K Davies, Grant A Jenkin, Pamela LC Small, Louis M Jones, Fredj Tekaia, Francoise Laval, et al.

Journal article  |  2007  |  GENOME RESEARCH

A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase

H Hong, JB Spencer, JL Porter, PF Leadlay, T Stinear

Journal article  |  2005  |  ChemBioChem

Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans

TP Stinear, MJ Pryor, JL Porter, ST Cole

Journal article  |  2005  |  Microbiology