Jessica Porter

In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera

Sacha J Pidot, Jessica L Porter, Troy Lister, Timothy P Stinear

Journal article  |  2021  |  PLOS NEGLECTED TROPICAL DISEASES

Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for..

Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii

Tao Luo, Peng Xu, Yangyi Zhang, Jessica L Porter, Marwan Ghanem, Qingyun Liu, Yuan Jiang, Jing Li, Qing Miao, Bijie Hu, Benjamin P Howden, Janet AM Fyfe, Maria Globan, Wencong He, Ping He, Yiting Wang, Houming Liu, Howard E Takiff, Yanlin Zhao, Xinchun Chen, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Mycobacterium kansasii can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous my..

High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL _3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice

Kirstie M Mangas, Nicholas J Tobias, Estelle Marion, Jeremie Babonneau, Laurent Marsollier, Jessica L Porter, Sacha J Pidot, Chinn Yi Wong, David C Jackson, Brendon Y Chua, Timothy P Stinear

Journal article  |  2020  |  PEERJ

Background: Mycobacterium ulcerans is the causative agent of a debilitating skin and soft tissue infection known as Buruli ulcer (..

Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Nocardia Isolate

Marion Herisse, Keishi Ishida, Jessica L Porter, Ben Howden, Christian Hertweck, Timothy P Stinear, Sacha J Pidot

Journal article  |  2020  |  ACS CHEMICAL BIOLOGY

The genus Nocardia contains >50 human pathogenic species that cause a range of illnesses from skin and soft tissue infections to l..

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model

Kirstie M Mangas, Andrew H Buultjens, Jessica L Porter, Sarah L Baines, Estelle Marion, Laurent Marsollier, Nicholas J Tobias, Sacha J Pidot, Kylie M Quinn, David J Price, Katherine Kedzierska, Weiguang Zeng, David C Jackson, Brendon Y Chua, Timothy P Stineara

Journal article  |  2020  |  INFECTION AND IMMUNITY

The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no ef..

Validation of a single-step, single-tube reverse transcription loop-mediated isothermal amplification assay for rapid detection of SARS-CoV-2 RNA

Jean YH Lee, Nickala Best, Julie McAuley, Jessica L Porter, Torsten Seemann, Mark B Schultz, Michelle Sait, Nicole Orlando, Karolina Mercoulia, Susan A Ballard, Julian Druce, Thomas Tran, Mike G Catton, Melinda J Pryor, Huanhuan L Cui, Angela Luttick, Sean McDonald, Arran Greenhalgh, Jason C Kwong, Norelle L Sherry, et al.

Journal article  |  2020  |  JOURNAL OF MEDICAL MICROBIOLOGY

Introduction. The SARS-CoV-2 pandemic of 2020 has resulted in unparalleled requirements for RNA extraction kits and enzymes requir..

Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The nargenicin family of antibiotics are macrolides containing a rare ether-bridged cis-decalin motif. Several of these compounds ..

Biosynthesis and Ether‐Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie

Abstract: The nargenicin family of antibiotics are macrolides containing a rare ether‐bridged cis‐decalin motif. Several of these ..

In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model

Till F Omansen, Renee A Marcsisin, Brendon Y Chua, Weiguang Zeng, David C Jackson, Jessica L Porter, Ymkje Stienstra, Tjip S van der Werf, Timothy P Stinear

Journal article  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Buruli ulcer (BU) is a neglected tropical disease caused by infection with Mycobacterium ulcerans. Unclear transmission, no availa..

Bioluminscent Mycobacterium ulcerans, a tool to study host-pathogen interactions in a murine tail model of Buruli ulcer

Till Omansen, Renee Marcsisin, Brendon Chua, Weiguang Zeng, David Jackson, Jessica Porter, Ymkje Stienstra, Tjip van der Werf, Timothy Stinear

Journal article  |  2018

Buruli ulcer is a neglected tropical disease caused by infection with Mycobacterium ulcerans . In this study we used a previously ..