Kong Choo

The Architecture and Evolution of Cancer Neochromosomes

Dale W Garsed, Owen J Marshall, Vincent DA Corbin, Arthur Hsu, Leon Di Stefano, Jan Schroeder, Jason Li, Zhi-Ping Feng, Bo W Kim, Mark Kowarsky, Ben Lansdell, Ross Brookwell, Ola Myklebost, Leonardo Meza-Zepeda, Andrew J Holloway, Florence Pedeutour, KH Andy Choo, Michael A Damore, Andrew J Deans, Anthony T Papenfuss, et al.

Journal article  |  2014  |  CANCER CELL

We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated lip..

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

WC Earnshaw, RC Allshire, BE Black, K Bloom, BR Brinkley, W Brown, IM Cheeseman, KHA Choo, GP Copenhaver, JG DeLuca, A Desai, S Diekmann, S Erhardt, M Fitzgerald-Hayes, D Foltz, T Fukagawa, R Gassmann, DW Gerlich, DM Glover, GJ Gorbsky, et al.

Journal article  |  2013  |  CHROMOSOME RESEARCH

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognise..

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

Fiona TM Chang, James D McGhie, F Lyn Chan, Michelle C Tang, Melissa A Anderson, Jeffrey R Mann, KH Andy Choo, Lee H Wong

Journal article  |  2013  |  NUCLEIC ACIDS RESEARCH

We have previously shown that α-thalassemia mental retardation X-linked (ATRX) and histone H3.3 are key regulators of telomeric ch..

Normal DNA Methylation Dynamics in DICER1-Deficient Mouse Embryonic Stem Cells

Jonathan Ip, Paul Canham, KH Andy Choo, Yoshimi Inaba, Shelley A Jacobs, Paul Kalitsis, Deidre M Mattiske, Jane Ng, Richard Saffery, Nicholas C Wong, Lee H Wong, Jeffrey R Mann

Journal article  |  2012  |  PLOS GENETICS

Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats hav..

The evolutionary life cycle of the resilient centromere

Paul Kalitsis, KH Andy Choo

Journal article  |  2012  |  CHROMOSOMA

The centromere is a chromosomal structure that is essential for the accurate segregation of replicated eukaryotic chromosomes to d..

Putative CENP-B paralogues are not present at mammalian centromeres

Owen J Marshall, KH Andy Choo

Journal article  |  2012  |  CHROMOSOMA

Although centromere protein B (CENP-B) is a highly conserved mammalian centromere protein, its function remains unknown. The prese..

Contrasting roles of condensin I and condensin II in mitotic chromosome formation

Lydia C Green, Paul Kalitsis, Tsz M Chang, Miri Cipetic, Ji Hun Kim, Owen Marshall, Lynne Turnbull, Cynthia B Whitchurch, Paola Vagnarelli, Kumiko Samejima, William C Earnshaw, KH Andy Choo, Damien F Hudson

Journal article  |  2012  |  JOURNAL OF CELL SCIENCE

In vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizi..

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

F Lyn Chan, Owen J Marshall, Richard Saffery, Bo Won Kim, Elizabeth Earle, KH Andy Choo, Lee H Wong

Journal article  |  2012  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription of the centromeric regions has been reported to occur in G1 and S phase in different species. Here, we investigate w..

Epigenetic Changes in Response to Tai Chi Practice: A Pilot Investigation of DNA Methylation Marks

Hua Ren, Veronica Collins, Sandy J Clarke, Jin-Song Han, Paul Lam, Fiona Clay, Laram Williamson, KH Andy Choo

Journal article  |  2012  |  EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

Tai chi exercise has been shown to improve physiological and psychosocial functions, well-being, quality of life, and disease cond..

Shorter Telomere Length in Peripheral Blood Cells Associated With Migraine in Women

Hua Ren, Veronica Collins, Francesca Fernandez, Sharon Quinlan, Lyn Griffiths, KH Andy Choo

Journal article  |  2010  |  HEADACHE

OBJECTIVE: To evaluate relative telomere length of female migraine patients. BACKGROUND: Migraine is a debilitating disorder affec..