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Metformin-induced increases in GDF15 are important for suppressing appetite and promoting ..
The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.
Displaying the most recent project by Gregory Steinberg.
Displaying the 97 most recent scholarly works by Gregory Steinberg.
Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia.
Aphrodite T Choumessi, Manuel Johanns, Claire Beaufay, Marie-France Herent, Vincent Stroobant, Didier Vertommen, Cyril Corbet, Roxane Jacobs, Gaëtan Herinckx, Gregory R Steinberg, Olivier Feron, Joëlle Quetin-Leclercq, Mark H Rider
Journal article | 2019 | Biochemical Journal
Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK..
Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss
EA Day, RJ Ford, BK Smith, P Mohammadi-Shemirani, MR Morrow, RM Gutgesell, R Lu, AR Raphenya, M Kabiri, AG McArthur, N McInnes, S Hess, G Paré, HC Gerstein, GR Steinberg
Journal article | 2019 | Nature Metabolism
The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.
Dan Zhang, Agata L Gava, Richard Van Krieken, Neel Mehta, Renzhong Li, Bo Gao, Eric M Desjardins, Gregory R Steinberg, Thomas Hawke, Joan C Krepinsky
Journal article | 2019 | Kidney International
Glomerular matrix protein accumulation, mediated largely by mesangial cells, is central to the pathogenesis of diabetic kidney dis..
Obesity and muscle-macrophage crosstalk in humans and mice: A systematic review.
Srikesh Rudrapatna, Meha Bhatt, Kuan-Wen Wang, Rachel Bierbrier, Pei-Wen Wang, Laura Banfield, Wagdi Elsheikh, E Danielle Sims, Devin Peterson, Lehana Thabane, Mark A Tarnopolsky, Gregory R Steinberg, M Constantine Samaan
Journal article | 2019 | Obesity Reviews
Obesity is associated with the production of inflammatory cytokines that are implicated in insulin resistance (IR), and if not add..
MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold
SM Oreskovich, FJ Ong, BA Ahmed, NB Konyer, DP Blondin, E Gunn, NP Singh, MD Noseworthy, F Haman, AC Carpentier, Z Punthakee, GR Steinberg, KM Morrison
Journal article | 2019 | Journal of the Endocrine Society
Abstract Context In rodents, cold exposure induces the activation of brown adi..
The gut microbiome regulates host glucose homeostasis via peripheral serotonin.
Alyce M Martin, Julian M Yabut, Jocelyn M Choo, Amanda J Page, Emily W Sun, Claire F Jessup, Steve L Wesselingh, Waliul I Khan, Geraint B Rogers, Gregory R Steinberg, Damien J Keating
Journal article | 2019 | Proceedings of the National Academy of Sciences
The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts ..
Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease.
Wouter N Leonhard, Xuewen Song, Anish A Kanhai, Ioan-Andrei Iliuta, Andrea Bozovic, Gregory R Steinberg, Dorien JM Peters, York Pei
Journal article | 2019 | EBioMedicine
BACKGROUND: Multiple preclinical studies have highlighted AMP-activated protein kinase (AMPK) as a potential therapeutic target fo..
Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.
Julian M Yabut, Justin D Crane, Alexander E Green, Damien J Keating, Waliul I Khan, Gregory R Steinberg
Journal article | 2019 | Endocrine Reviews
Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in maintaining energy homeostasis for bill..
Salicylate enhances the response of prostate cancer to radiotherapy.
Lindsay A Broadfield, Katarina Marcinko, Evangelia Tsakiridis, Panayiotis G Zacharidis, Linda Villani, James SV Lally, Gabe Menjolian, Danitra Maharaj, Tammy Mathurin, Marcia Smoke, Thomas Farrell, Paola Muti, Gregory R Steinberg, Theodoros Tsakiridis
Journal article | 2019 | The Prostate
BACKGROUND: Radiotherapy (RT) is a key therapeutic modality for prostate cancer (PrCa), but RT resistance necessitates dose-escala..
Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp, Gregori Casals, Gregory R Steinberg, Daniel F Vatner, Kitt F Petersen, Gerald I Shulman
Journal article | 2019 | Nature Medicine
In the version of this article originally published, the VPC and VCS flux data shown in Fig. 6e,f were inadvertently duplicated fr..
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
James SV Lally, Sarani Ghoshal, Danielle K DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P Houde, Alexander E Anagnostopoulos, Alice Wang, Lindsay A Broadfield, Rebecca J Ford, Robert A Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S Ray, et al.
Journal article | 2019 | Cell Metabolism
The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the prevalence of obesity and non-alcoholic fatty liv..
Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance
Kim Loh, Shanna Tam, Lisa Murray-Segal, Kevin Huynh, Peter J Meikle, John W Scott, Bryce van Denderen, Zhiping Chen, Rohan Steel, Nicholas D LeBlond, Leah A Burkovsky, Conor O'Dwyer, Julia RC Nunes, Gregory R Steinberg, Morgan D Fullerton, Sandra Galic, Bruce E Kemp
Journal article | 2019 | Hepatology Communications
AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation
Sophie Lepropre, Shakeel Kautbally, Marie Octave, Audrey Ginion, Marie-Blanche Onselaer, Gregory R Steinberg, Bruce E Kemp, Alexandre Hego, Odile Wera, Sanne Brouns, Frauke Swieringa, Martin Giera, Victor M Darley-Usmar, Jerome Ambroise, Bruno Guigas, Johan Heemskerk, Luc Bertrand, Cecile Oury, Christophe Beauloye, Sandrine Horman
Journal article | 2018 | Blood
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, Joao-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp, Gregori Casals, Gregory R Steinberg, Daniel F Vatner, Kitt F Petersen, Gerald Shulman
Journal article | 2018 | Nature Medicine
Emerging Role of AMPK in Brown and Beige Adipose Tissue (BAT): Implications for Obesity, Insulin Resistance, and Type 2 Diabetes.
Eric M Desjardins, Gregory R Steinberg
Journal article | 2018 | Current Diabetes Reports
PURPOSE OF REVIEW: The global prevalence of type 2 diabetes (T2D) is escalating at alarming rates, demanding the development of ad..
Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults.
Chris McGlory, Mark T von Allmen, Tanner Stokes, Robert W Morton, Amy J Hector, Briony A Lago, Amogelang R Raphenya, Brennan K Smith, Andrew G McArthur, Gregory R Steinberg, Steven K Baker, Stuart M Phillips
Journal article | 2018 | The Journals of Gerontology: Series A
Background: Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of 2 wk of ac..
The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.
Derek T Hall, Takla Griss, Jennifer F Ma, Brenda Janice Sanchez, Jason Sadek, Anne Marie K Tremblay, Souad Mubaid, Amr Omer, Rebecca J Ford, Nathalie Bedard, Arnim Pause, Simon S Wing, Sergio Di Marco, Gregory R Steinberg, Russell G Jones, Imed-Eddine Gallouzi
Journal article | 2018 | EMBO Molecular Medicine
Activation of AMPK has been associated with pro-atrophic signaling in muscle. However, AMPK also has anti-inflammatory effects, su..
Association of Metformin with Breast Cancer Incidence and Mortality in Patients with Type II Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis.
Grace H Tang, Meloja Satkunam, Gregory R Pond, Gregory R Steinberg, Giovanni Blandino, Holger J Schünemann, Paola Muti
Journal article | 2018 | Cancer Epidemiology Biomarkers & Prevention
Background: Preclinical data suggest that metformin may reduce breast cancer incidence and improve cancer prognosis. However, the ..
The role of AMP-activated protein kinase in the expression of the dystrophin-associated protein complex in skeletal muscle.
Athan G Dial, Paul Rooprai, James S Lally, Adam L Bujak, Gregory R Steinberg, Vladimir Ljubicic
Journal article | 2018 | The FASEB Journal
Stimulation of AMPK induces the expression of dystrophin-associated protein complex (DAPC) components in skeletal muscle, whereas ..
Recent advances in the detection of brown adipose tissue in adult humans: a review.
Frank J Ong, Basma A Ahmed, Stephan M Oreskovich, Denis P Blondin, Tahniyah Haq, Norman B Konyer, Michael D Noseworthy, Francois Haman, Andre C Carpentier, Katherine M Morrison, Gregory R Steinberg
Journal article | 2018 | Clinical Science
The activation of brown adipose tissue (BAT) is associated with reductions in circulating lipids and glucose in rodents and contri..
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K Smith, Emily A Day, Chuong Nguyen, Kieran F Geoghegan, John M Kreeger, Alan Opsahl, Jessica Ward, Amit S Kalgutkar, et al.
Journal article | 2018 | EBioMedicine
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in exc..
Cellular Energy Sensing and Metabolism-Implications for Treating Diabetes: The 2017 Outstanding Scientific Achievement Award Lecture.
Gregory R Steinberg
Journal article | 2018 | Diabetes
The Outstanding Scientific Achievement Award recognizes distinguished scientific achievement in the field of diabetes, taking into..
Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders.
Stephen L Pinkosky, Pieter HE Groot, Narendra D Lalwani, Gregory R Steinberg
Journal article | 2017 | Trends in Molecular Medicine
Chronic overnutrition and a sedentary lifestyle promote imbalances in metabolism, often manifesting as risk factors for life-threa..
Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants.
Kristen E Boyle, Zachary W Patinkin, Allison LB Shapiro, Carly Bader, Lauren Vanderlinden, Katerina Kechris, Rachel C Janssen, Rebecca J Ford, Brennan K Smith, Gregory R Steinberg, Elizabeth J Davidson, Ivana V Yang, Dana Dabelea, Jacob E Friedman
Journal article | 2017 | Molecular Metabolism
OBJECTIVE: Infants born to mothers with obesity have greater adiposity, ectopic fat storage, and are at increased risk for childho..
Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats.
Jamie Whitfield, Sabina Paglialunga, Brennan K Smith, Paula M Miotto, Genevieve Simnett, Holly L Robson, Swati S Jain, Eric AF Herbst, Eric M Desjardins, David J Dyck, Lawrence L Spriet, Gregory R Steinberg, Graham P Holloway
Journal article | 2017 | Journal of Biological Chemistry
TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been ..
Optimizing the methodology for measuring supraclavicular skin temperature using infrared thermography; implications for measuring brown adipose tissue activity in humans.
Tahniyah Haq, Justin D Crane, Sarah Kanji, Elizabeth Gunn, Mark A Tarnopolsky, Hertzel C Gerstein, Gregory R Steinberg, Katherine M Morrison
Journal article | 2017 | Scientific Reports
The discovery of brown adipose tissue (BAT) in adults has sparked interest in its role as a therapeutic target in metabolic disord..
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Toby A Dite, Naomi XY Ling, John W Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L Parker, Kevin RW Ngoei, Christopher G Langendorf, Matthew T O'Brien, Mondira Kundu, Benoit Viollet, Gregory R Steinberg, Kei Sakamoto, Bruce E Kemp, Jonathan S Oakhill
Journal article | 2017 | Nature Communications
AMPK beta 1 reduces tumor progression and improves survival in p53 null mice
Vanessa P Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A Hammill, Jonathan L Bramson, Robert A Foster, Theodoros Tsakiridis, Bruce E Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R Steinberg
Journal article | 2017 | Molecular Oncology
AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Emily A Day, Rebecca J Ford, Gregory R Steinberg
Journal article | 2017 | Trends in Endocrinology & Metabolism
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic pathways and may have therapeutic importance ..
Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities
C Pulito, F Mori, A Sacconi, F Goeman, M Ferraiuolo, P Pasanisi, C Campagnoli, F Berrino, M Fanciulli, RJ Ford, M Levrero, N Pediconi, L Ciuffreda, M Milella, GR Steinberg, M Cioce, P Muti, S Strano, G Blandino
Journal article | 2017 | Cell Discovery
Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice
Vidhi Gaur, Timothy Connor, Kylie Venardos, Darren C Henstridge, Sheree D Martin, Courtney Swinton, Shona Morrison, Kathryn Aston-Mourney, Stefan M Gehrig, Roelof van Ewijk, Gordon S Lynch, Mark A Febbraio, Gregory R Steinberg, Mark Hargreaves, Ken R Walder, Sean L McGee
Journal article | 2017 | Diabetes, Obesity and Metabolism
AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity.
Brennan K Smith, Gregory R Steinberg
Journal article | 2017 | Current Opinion in Clinical Nutrition and Metabolic Care
PURPOSE OF REVIEW: Insulin resistance is an important risk factor for metabolic diseases such as type 2 diabetes, cardiovascular d..
FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.
Emilio P Mottillo, Eric M Desjardins, Andreas M Fritzen, Vito Z Zou, Justin D Crane, Julian M Yabut, Bente Kiens, Derek M Erion, Adhiraj Lanba, James G Granneman, Saswata Talukdar, Gregory R Steinberg
Journal article | 2017 | Molecular Metabolism
OBJECTIVE: Fibroblast growth factor 21 (FGF21) shows great potential for the treatment of obesity and type 2 diabetes, as its long..
Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise.
Lykke Sylow, Lisbeth LV Møller, Maximilian Kleinert, Gommaar D'Hulst, Estelle De Groote, Peter Schjerling, Gregory R Steinberg, Thomas E Jensen, Erik A Richter
Journal article | 2017 | Diabetes
Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle and therefore represents an important alternati..
Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice
Michelle Van Sinderen, Gregory Steinberg, Sebastian B Jorgensen, Jane Honeyman, Jenny DY Chow, Evan R Simpson, Margaret EE Jones, Wah Chin Boon
Journal article | 2017 | The Journal of Steroid Biochemistry and Molecular Biology
Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4.
Joseph F Cavallari, Morgan D Fullerton, Brittany M Duggan, Kevin P Foley, Emmanuel Denou, Brennan K Smith, Eric M Desjardins, Brandyn D Henriksbo, Kalvin J Kim, Brian R Tuinema, Jennifer C Stearns, David Prescott, Philip Rosenstiel, Brian K Coombes, Gregory R Steinberg, Jonathan D Schertzer
Journal article | 2017 | Cell Metabolism
Intestinal dysbiosis contributes to obesity and insulin resistance, but intervening with antibiotics, prebiotics, or probiotics ca..
Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.
Paula M Miotto, Gregory R Steinberg, Graham P Holloway
Journal article | 2017 | Biochemical Journal
The obligatory role of carnitine palmitoyltransferase-I (CPT-I) in mediating mitochondrial lipid transport is well established, a ..
Growth Differentiation Factor 15 as a Novel Biomarker for Metformin.
Hertzel C Gerstein, Guillaume Pare, Sibylle Hess, Rebecca J Ford, Jennifer Sjaarda, Kripa Raman, Matthew McQueen, ShunFu Lee, Heinz Haenel, Gregory R Steinberg, undefined ORIGIN Investigators
Journal article | 2017 | Diabetes Care
OBJECTIVE: Metformin is a commonly used glucose-lowering drug. However, apart from glycemic measures, no biomarker for its presenc..
Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: Translational biology and rationale for current clinical trials
M Troncone, SM Cargnelli, LA Villani, N Isfahanian, LA Broadfield, L Zychla, J Wright, G Pond, GR Steinberg, T Tsakiridis
Journal article | 2017 | Oncotarget
AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism
Miranda M Sung, Beshay N Zordoky, Adam L Bujak, James SV Lally, David Fung, Martin E Young, Sandrine Horman, Edward J Miller, Peter E Light, Bruce E Kemp, Gregory R Steinberg, Jason RB Dyck
Journal article | 2015 | Cardiovascular Research
AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging
Adam L Bujak, Justin D Crane, James S Lally, Rebecca J Ford, Sally J Kang, Irena A Rebalka, Alex E Green, Bruce E Kemp, Thomas J Hawke, Jonathan D Schertzer, Gregory R Steinberg
Journal article | 2015 | Cell Metabolism
AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation
Beshay NM Zordoky, Jeevan Nagendran, Thomas Pulinilkunnil, Petra C Kienesberger, Grant Masson, Terri J Waller, Bruce E Kemp, Gregory R Steinberg, Jason RB Dyck
Journal article | 2014 | Circulation Research
AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
Hayley M O'Neill, James S Lally, Sandra Galic, Melissa Thomas, Paymon D Azizi, Morgan D Fullerton, Brennan K Smith, Thomas Pulinilkunnil, Zhiping Chen, M Constantine Samaan, Sebastian B Jorgensen, Jason RB Dyck, Graham P Holloway, Thomas J Hawke, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg
Journal article | 2014 | Diabetologia
Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress
Sean L McGee, Courtney Swinton, Shona Morrison, Vidhi Gaur, Duncan E Campbell, Sebastian B Jorgensen, Bruce E Kemp, Keith Baar, Gregory R Steinberg, M Hargreaves
Journal article | 2014 | The FASEB Journal
Mechanism of Action of Compound-13: An alpha 1-Selective Small Molecule Activator of AMPK
Roger W Hunter, Marc Foretz, Laurent Bultot, Morgan D Fullerton, Maria Deak, Fiona A Ross, Simon A Hawley, Natalia Shpiro, Benoit Viollet, Denis Barron, Bruce E Kemp, Gregory R Steinberg, D Grahame Hardie, Kei Sakamoto
Journal article | 2014 | Chemistry & Biology
PPAR delta activation attenuates hepatic steatosis in Ldlr(-/-) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
Lazar A Bojic, Dawn E Telford, Morgan D Fullerton, Rebecca J Ford, Brian G Sutherland, Jane Y Edwards, Cynthia G Sawyez, Robert Gros, Bruce E Kemp, Gregory R Steinberg, Murray W Huff
Journal article | 2014 | Journal of Lipid Research
Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
John W Scott, Naomi Ling, Samah MA Issa, Toby A Dite, Matthew T O'Brien, Zhi-Ping Chen, Sandra Galic, Christopher G Langendorf, Gregory R Steinberg, Bruce E Kemp, Jonathan S Oakhill
Journal article | 2014 | Chemistry & Biology
Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jorgensen, Sarah Q To, Kevin C Knower, Colin D Clyne, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
Journal article | 2014 | PLoS One
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
Sebastian Beck Jorgensen, Hayley M O'Neill, Lykke Sylow, Jane Honeyman, Kimberly A Hewitt, Rengasamy Palanivel, Morgan D Fullerton, Lisa Oberg, Anudharan Balendran, Sandra Galic, Chris van der Poel, Ian A Trounce, Gordon S Lynch, Jonathan D Schertzer, Gregory R Steinberg
Journal article | 2013 | Diabetes
The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
Simon A Hawley, Morgan D Fullerton, Fiona A Ross, Jonathan D Schertzer, Cyrille Chevtzoff, Katherine J Walker, Mark W Peggie, Darya Zibrova, Kevin A Green, Kirsty J Mustard, Bruce E Kemp, Kei Sakamoto, Gregory R Steinberg, D Grahame Hardie
Journal article | 2012 | Science
Hematopoietic AMPK beta 1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
Sandra Galic, Morgan D Fullerton, Jonathan D Schertzer, Sarah Sikkema, Katarina Marcinko, Carl R Walkley, David Izon, Jane Honeyman, Zhi-Ping Chen, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg
Journal article | 2011 | Journal of Clinical Investigation
AMP-activated protein kinase (AMPK) beta 1 beta 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
Hayley M O'Neill, Stine J Maarbjerg, Justin D Crane, Jacob Jeppesen, Sebastian B Jorgensen, Jonathan D Schertzer, Olga Shyroka, Bente Kiens, Bryce J van Denderen, Mark A Tarnopolsky, Bruce E Kemp, Erik A Richter, Gregory R Steinberg
Journal article | 2011 | Proceedings of the National Academy of Sciences of the United States of America
Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance
Nirupa Sachithanandan, Kate L Graham, Sandra Galic, Jane E Honeyman, Stacey L Fynch, Kimberly A Hewitt, Gregory R Steinberg, Thomas W Kay
Journal article | 2011 | Diabetes
Whole Body Deletion of AMP-activated Protein Kinase beta 2 Reduces Muscle AMPK Activity and Exercise Capacity
Gregory R Steinberg, Hayley M O'Neill, Nicolas L Dzamko, Sandra Galic, Tim Naim, Rene Koopman, Sebastian B Jorgensen, Jane Honeyman, Kimberly Hewitt, Zhi-Ping Chen, Jonathan D Schertzer, John W Scott, Frank Koentgen, Gordon S Lynch, Matthew J Watt, Bryce JW van denderen, Duncan J Campbell, Bruce E Kemp
Journal article | 2010 | Journal of Biological Chemistry
AMPK beta 1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance
Nicolas Dzamko, Bryce JW van Denderen, Andrea L Hevener, Sebastian Beck Jorgensen, Jane Honeyman, Sandra Galic, Zhi-Ping Chen, Matthew J Watt, Duncan J Campbell, Gregory R Steinberg, Bruce E Kemp
Journal article | 2010 | Journal of Biological Chemistry
Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation
Sebastian Beck Jorgensen, Jane Honeyman, Jonathan S Oakhill, Daniel Fazakerley, Jacqueline Stoeckli, Bruce E Kemp, Gregory R Steinberg
Journal article | 2009 | American Journal of Physiology - Endocrinology and Metabolism
Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women.
Kristy A Brown, Kerry J McInnes, Nicole I Hunger, Jonathan S Oakhill, Gregory R Steinberg, Evan R Simpson
Journal article | 2009 | Cancer Research
Epidemiologic evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase plays an im..
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation
Nicolas Dzamko, Jonathan D Schertzer, James G Ryall, Rohan Steel, S Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J Michell, Jonathan S Oakhill, Matthew J Watt, Sebastian Beck Jorgensen, Gordon S Lynch, Bruce E Kemp, Gregory R Steinberg
Journal article | 2008 | Journal of Physiology
Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase beta 1-Containing Complexes
John W Scott, Bryce JW van Denderen, Sebastian B Jorgensen, Jane E Honeyman, Gregory R Steinberg, Jonathan S Oakhill, Tristan J Iseli, Ann Koay, Paul R Gooley, David Stapleton, Bruce E Kemp
Journal article | 2008 | Chemistry & Biology
Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPAR alpha and UCP2 expression in rats
Anna G Holmes, Jose L Mesa, Bronwyn A Neill, Jason Chung, Andrew L Carey, Gregory R Steinberg, Bruce E Kemp, Robert J Southgate, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt, Mark A Febbraio
Journal article | 2008 | Journal of Endocrinology
The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity.
Gregory R Steinberg, Sebastian Beck Jørgensen
Journal article | 2007 | Mini-Reviews in Medicinal Chemistry
Over the past decade, an epidemic of obesity has developed throughout the Western World. In recent years, significant interest has..
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
Gregory R Steinberg, Belinda J Michell, Bryce JW van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Gorgun, David Carling, Gokhan S Hotamisligil, Mark A Febbraio, Thomas W Kay, Bruce E Kemp
Journal article | 2006 | Cell Metabolism
Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals
Andrew J McAinch, Gregory R Steinberg, Janelle Mollica, Paul E O'Brien, John B Dixon, S Lance Macaulay, Bruce E Kemp, David Cameron-Smith
Journal article | 2006 | Obesity
Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise
Jason L Talanian, Rebecca J Tunstall, Matthew J Watt, Mylinh Duong, Christopher GR Perry, Gregory R Steinberg, Bruce E Kemp, George JF Heigenhauser, Lawrence L Spriet
Journal article | 2006 | American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
Andrew L Carey, Gregory R Steinberg, S Lance Macaulay, Walter G Thomas, Anna G Holmes, Georg Ramm, Oja Prelovsek, Cordula Hohnen-Behrens, Matthew J Watt, David E James, Bruce E Kemp, Bente K Pedersen, Mark A Febbraio
Journal article | 2006 | Diabetes
The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans
Gregory R Steinberg, Andrew J McAinch, Michael B Chen, Paul E O'Brien, John B Dixon, David Cameron-Smith, Bruce E Kemp
Journal article | 2006 | Journal of Clinical Endocrinology & Metabolism
Reduced glycogen availability is associated with increased AMPK alpha 2 activity, nuclear AMPK alpha 2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle
Gregory R Steinberg, Matthew J Watt, Sean L McGee, Stanley Chan, Mark Hargreaves, Mark A Febbraio, David Stapleton, Bruce E Kemp
Journal article | 2006 | Applied Physiology, Nutrition and Metabolism
PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.
Robert J Southgate, Clinton R Bruce, Andrew L Carey, Gregory R Steinberg, Ken Walder, Robert Monks, Matthew J Watt, John A Hawley, Morris J Birnbaum, Mark A Febbraio
Journal article | 2005 | FASEB Journal
There are multiple binding domains on the promoter region of the peroxisome proliferator activator receptor gamma coactivator-1 al..
Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics
MB Chen, AJ McAinch, SL Macaulay, LA Castelli, PE O'Brien, JB Dixon, D Cameron-Smith, BE Kemp, GR Steinberg
Journal article | 2005 | Journal of Clinical Endocrinology & Metabolism
Honours, Awards and Fellowships
APS Endocrinol.& Metab. Young Investigator Award
Post Graduate Scholarship
Medicine - St Vincent'S Hospital
Doctor of Philosophy
University of Guelph
Bachelor of Science
University of Guelph