Gregory Steinberg

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia.

Aphrodite T Choumessi, Manuel Johanns, Claire Beaufay, Marie-France Herent, Vincent Stroobant, Didier Vertommen, Cyril Corbet, Roxane Jacobs, Gaëtan Herinckx, Gregory R Steinberg, Olivier Feron, Joëlle Quetin-Leclercq, Mark H Rider

Journal article  |  2019  |  Biochemical Journal

Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK..

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

EA Day, RJ Ford, BK Smith, P Mohammadi-Shemirani, MR Morrow, RM Gutgesell, R Lu, AR Raphenya, M Kabiri, AG McArthur, N McInnes, S Hess, G Paré, HC Gerstein, GR Steinberg

Journal article  |  2019  |  Nature Metabolism

The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.

Dan Zhang, Agata L Gava, Richard Van Krieken, Neel Mehta, Renzhong Li, Bo Gao, Eric M Desjardins, Gregory R Steinberg, Thomas Hawke, Joan C Krepinsky

Journal article  |  2019  |  Kidney International

Glomerular matrix protein accumulation, mediated largely by mesangial cells, is central to the pathogenesis of diabetic kidney dis..

Obesity and muscle-macrophage crosstalk in humans and mice: A systematic review.

Srikesh Rudrapatna, Meha Bhatt, Kuan-Wen Wang, Rachel Bierbrier, Pei-Wen Wang, Laura Banfield, Wagdi Elsheikh, E Danielle Sims, Devin Peterson, Lehana Thabane, Mark A Tarnopolsky, Gregory R Steinberg, M Constantine Samaan

Journal article  |  2019  |  Obesity Reviews

Obesity is associated with the production of inflammatory cytokines that are implicated in insulin resistance (IR), and if not add..

MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold

SM Oreskovich, FJ Ong, BA Ahmed, NB Konyer, DP Blondin, E Gunn, NP Singh, MD Noseworthy, F Haman, AC Carpentier, Z Punthakee, GR Steinberg, KM Morrison

Journal article  |  2019  |  Journal of the Endocrine Society

Abstract Context In rodents, cold exposure induces the activation of brown adi..

The gut microbiome regulates host glucose homeostasis via peripheral serotonin.

Alyce M Martin, Julian M Yabut, Jocelyn M Choo, Amanda J Page, Emily W Sun, Claire F Jessup, Steve L Wesselingh, Waliul I Khan, Geraint B Rogers, Gregory R Steinberg, Damien J Keating

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts ..

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease.

Wouter N Leonhard, Xuewen Song, Anish A Kanhai, Ioan-Andrei Iliuta, Andrea Bozovic, Gregory R Steinberg, Dorien JM Peters, York Pei

Journal article  |  2019  |  EBioMedicine

BACKGROUND: Multiple preclinical studies have highlighted AMP-activated protein kinase (AMPK) as a potential therapeutic target fo..

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.

Julian M Yabut, Justin D Crane, Alexander E Green, Damien J Keating, Waliul I Khan, Gregory R Steinberg

Journal article  |  2019  |  Endocrine Reviews

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in maintaining energy homeostasis for bill..

AMP-activated protein kinase: the current landscape for drug development.

Gregory R Steinberg, David Carling

Journal article  |  2019  |  Nature Reviews Drug Discovery

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights in..

Salicylate enhances the response of prostate cancer to radiotherapy.

Lindsay A Broadfield, Katarina Marcinko, Evangelia Tsakiridis, Panayiotis G Zacharidis, Linda Villani, James SV Lally, Gabe Menjolian, Danitra Maharaj, Tammy Mathurin, Marcia Smoke, Thomas Farrell, Paola Muti, Gregory R Steinberg, Theodoros Tsakiridis

Journal article  |  2019  |  The Prostate

BACKGROUND: Radiotherapy (RT) is a key therapeutic modality for prostate cancer (PrCa), but RT resistance necessitates dose-escala..

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp, Gregori Casals, Gregory R Steinberg, Daniel F Vatner, Kitt F Petersen, Gerald I Shulman

Journal article  |  2019  |  Nature Medicine

In the version of this article originally published, the VPC and VCS flux data shown in Fig. 6e,f were inadvertently duplicated fr..

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.

James SV Lally, Sarani Ghoshal, Danielle K DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P Houde, Alexander E Anagnostopoulos, Alice Wang, Lindsay A Broadfield, Rebecca J Ford, Robert A Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S Ray, et al.

Journal article  |  2019  |  Cell Metabolism

The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the prevalence of obesity and non-alcoholic fatty liv..

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance

Kim Loh, Shanna Tam, Lisa Murray-Segal, Kevin Huynh, Peter J Meikle, John W Scott, Bryce van Denderen, Zhiping Chen, Rohan Steel, Nicholas D LeBlond, Leah A Burkovsky, Conor O'Dwyer, Julia RC Nunes, Gregory R Steinberg, Morgan D Fullerton, Sandra Galic, Bruce E Kemp

Journal article  |  2019  |  Hepatology Communications

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation

Sophie Lepropre, Shakeel Kautbally, Marie Octave, Audrey Ginion, Marie-Blanche Onselaer, Gregory R Steinberg, Bruce E Kemp, Alexandre Hego, Odile Wera, Sanne Brouns, Frauke Swieringa, Martin Giera, Victor M Darley-Usmar, Jerome Ambroise, Bruno Guigas, Johan Heemskerk, Luc Bertrand, Cecile Oury, Christophe Beauloye, Sandrine Horman

Journal article  |  2018  |  Blood

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, Joao-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp, Gregori Casals, Gregory R Steinberg, Daniel F Vatner, Kitt F Petersen, Gerald Shulman

Journal article  |  2018  |  Nature Medicine

Emerging Role of AMPK in Brown and Beige Adipose Tissue (BAT): Implications for Obesity, Insulin Resistance, and Type 2 Diabetes.

Eric M Desjardins, Gregory R Steinberg

Journal article  |  2018  |  Current Diabetes Reports

PURPOSE OF REVIEW: The global prevalence of type 2 diabetes (T2D) is escalating at alarming rates, demanding the development of ad..

Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults.

Chris McGlory, Mark T von Allmen, Tanner Stokes, Robert W Morton, Amy J Hector, Briony A Lago, Amogelang R Raphenya, Brennan K Smith, Andrew G McArthur, Gregory R Steinberg, Steven K Baker, Stuart M Phillips

Journal article  |  2018  |  The Journals of Gerontology: Series A

Background: Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of 2 wk of ac..

The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.

Derek T Hall, Takla Griss, Jennifer F Ma, Brenda Janice Sanchez, Jason Sadek, Anne Marie K Tremblay, Souad Mubaid, Amr Omer, Rebecca J Ford, Nathalie Bedard, Arnim Pause, Simon S Wing, Sergio Di Marco, Gregory R Steinberg, Russell G Jones, Imed-Eddine Gallouzi

Journal article  |  2018  |  EMBO Molecular Medicine

Activation of AMPK has been associated with pro-atrophic signaling in muscle. However, AMPK also has anti-inflammatory effects, su..

The role of AMP-activated protein kinase in the expression of the dystrophin-associated protein complex in skeletal muscle.

Athan G Dial, Paul Rooprai, James S Lally, Adam L Bujak, Gregory R Steinberg, Vladimir Ljubicic

Journal article  |  2018  |  The FASEB Journal

Stimulation of AMPK induces the expression of dystrophin-associated protein complex (DAPC) components in skeletal muscle, whereas ..

Association of Metformin with Breast Cancer Incidence and Mortality in Patients with Type II Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis.

Grace H Tang, Meloja Satkunam, Gregory R Pond, Gregory R Steinberg, Giovanni Blandino, Holger J Schünemann, Paola Muti

Journal article  |  2018  |  Cancer Epidemiology Biomarkers & Prevention

Background: Preclinical data suggest that metformin may reduce breast cancer incidence and improve cancer prognosis. However, the ..

Recent advances in the detection of brown adipose tissue in adult humans: a review.

Frank J Ong, Basma A Ahmed, Stephan M Oreskovich, Denis P Blondin, Tahniyah Haq, Norman B Konyer, Michael D Noseworthy, Francois Haman, Andre C Carpentier, Katherine M Morrison, Gregory R Steinberg

Journal article  |  2018  |  Clinical Science

The activation of brown adipose tissue (BAT) is associated with reductions in circulating lipids and glucose in rodents and contri..

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.

Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K Smith, Emily A Day, Chuong Nguyen, Kieran F Geoghegan, John M Kreeger, Alan Opsahl, Jessica Ward, Amit S Kalgutkar, et al.

Journal article  |  2018  |  EBioMedicine

Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in exc..

Cellular Energy Sensing and Metabolism-Implications for Treating Diabetes: The 2017 Outstanding Scientific Achievement Award Lecture.

Gregory R Steinberg

Journal article  |  2018  |  Diabetes

The Outstanding Scientific Achievement Award recognizes distinguished scientific achievement in the field of diabetes, taking into..

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

Sandra Galic, Kim Loh, Lisa Murray-Segal, Gregory R Steinberg, Zane B Andrews, Bruce E Kemp

Journal article  |  2018  |  ELIFE

Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders.

Stephen L Pinkosky, Pieter HE Groot, Narendra D Lalwani, Gregory R Steinberg

Journal article  |  2017  |  Trends in Molecular Medicine

Chronic overnutrition and a sedentary lifestyle promote imbalances in metabolism, often manifesting as risk factors for life-threa..

Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants.

Kristen E Boyle, Zachary W Patinkin, Allison LB Shapiro, Carly Bader, Lauren Vanderlinden, Katerina Kechris, Rachel C Janssen, Rebecca J Ford, Brennan K Smith, Gregory R Steinberg, Elizabeth J Davidson, Ivana V Yang, Dana Dabelea, Jacob E Friedman

Journal article  |  2017  |  Molecular Metabolism

OBJECTIVE: Infants born to mothers with obesity have greater adiposity, ectopic fat storage, and are at increased risk for childho..

Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats.

Jamie Whitfield, Sabina Paglialunga, Brennan K Smith, Paula M Miotto, Genevieve Simnett, Holly L Robson, Swati S Jain, Eric AF Herbst, Eric M Desjardins, David J Dyck, Lawrence L Spriet, Gregory R Steinberg, Graham P Holloway

Journal article  |  2017  |  Journal of Biological Chemistry

TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been ..

Optimizing the methodology for measuring supraclavicular skin temperature using infrared thermography; implications for measuring brown adipose tissue activity in humans.

Tahniyah Haq, Justin D Crane, Sarah Kanji, Elizabeth Gunn, Mark A Tarnopolsky, Hertzel C Gerstein, Gregory R Steinberg, Katherine M Morrison

Journal article  |  2017  |  Scientific Reports

The discovery of brown adipose tissue (BAT) in adults has sparked interest in its role as a therapeutic target in metabolic disord..

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

Toby A Dite, Naomi XY Ling, John W Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L Parker, Kevin RW Ngoei, Christopher G Langendorf, Matthew T O'Brien, Mondira Kundu, Benoit Viollet, Gregory R Steinberg, Kei Sakamoto, Bruce E Kemp, Jonathan S Oakhill

Journal article  |  2017  |  Nature Communications

AMPK beta 1 reduces tumor progression and improves survival in p53 null mice

Vanessa P Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A Hammill, Jonathan L Bramson, Robert A Foster, Theodoros Tsakiridis, Bruce E Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R Steinberg

Journal article  |  2017  |  Molecular Oncology

AMPK as a Therapeutic Target for Treating Metabolic Diseases.

Emily A Day, Rebecca J Ford, Gregory R Steinberg

Journal article  |  2017  |  Trends in Endocrinology & Metabolism

The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic pathways and may have therapeutic importance ..

Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities

C Pulito, F Mori, A Sacconi, F Goeman, M Ferraiuolo, P Pasanisi, C Campagnoli, F Berrino, M Fanciulli, RJ Ford, M Levrero, N Pediconi, L Ciuffreda, M Milella, GR Steinberg, M Cioce, P Muti, S Strano, G Blandino

Journal article  |  2017  |  Cell Discovery

Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

Vidhi Gaur, Timothy Connor, Kylie Venardos, Darren C Henstridge, Sheree D Martin, Courtney Swinton, Shona Morrison, Kathryn Aston-Mourney, Stefan M Gehrig, Roelof van Ewijk, Gordon S Lynch, Mark A Febbraio, Gregory R Steinberg, Mark Hargreaves, Ken R Walder, Sean L McGee

Journal article  |  2017  |  Diabetes, Obesity and Metabolism

AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity.

Brennan K Smith, Gregory R Steinberg

Journal article  |  2017  |  Current Opinion in Clinical Nutrition and Metabolic Care

PURPOSE OF REVIEW: Insulin resistance is an important risk factor for metabolic diseases such as type 2 diabetes, cardiovascular d..

Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise.

Lykke Sylow, Lisbeth LV Møller, Maximilian Kleinert, Gommaar D'Hulst, Estelle De Groote, Peter Schjerling, Gregory R Steinberg, Thomas E Jensen, Erik A Richter

Journal article  |  2017  |  Diabetes

Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle and therefore represents an important alternati..

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.

Emilio P Mottillo, Eric M Desjardins, Andreas M Fritzen, Vito Z Zou, Justin D Crane, Julian M Yabut, Bente Kiens, Derek M Erion, Adhiraj Lanba, James G Granneman, Saswata Talukdar, Gregory R Steinberg

Journal article  |  2017  |  Molecular Metabolism

OBJECTIVE: Fibroblast growth factor 21 (FGF21) shows great potential for the treatment of obesity and type 2 diabetes, as its long..

Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice

Michelle Van Sinderen, Gregory Steinberg, Sebastian B Jorgensen, Jane Honeyman, Jenny DY Chow, Evan R Simpson, Margaret EE Jones, Wah Chin Boon

Journal article  |  2017  |  The Journal of Steroid Biochemistry and Molecular Biology

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4.

Joseph F Cavallari, Morgan D Fullerton, Brittany M Duggan, Kevin P Foley, Emmanuel Denou, Brennan K Smith, Eric M Desjardins, Brandyn D Henriksbo, Kalvin J Kim, Brian R Tuinema, Jennifer C Stearns, David Prescott, Philip Rosenstiel, Brian K Coombes, Gregory R Steinberg, Jonathan D Schertzer

Journal article  |  2017  |  Cell Metabolism

Intestinal dysbiosis contributes to obesity and insulin resistance, but intervening with antibiotics, prebiotics, or probiotics ca..

Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?

Rebecca J Ford, Eric M Desjardins, Gregory R Steinberg

Journal article  |  2017  |  EBioMedicine

Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.

Paula M Miotto, Gregory R Steinberg, Graham P Holloway

Journal article  |  2017  |  Biochemical Journal

The obligatory role of carnitine palmitoyltransferase-I (CPT-I) in mediating mitochondrial lipid transport is well established, a ..

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin.

Hertzel C Gerstein, Guillaume Pare, Sibylle Hess, Rebecca J Ford, Jennifer Sjaarda, Kripa Raman, Matthew McQueen, ShunFu Lee, Heinz Haenel, Gregory R Steinberg, undefined ORIGIN Investigators

Journal article  |  2017  |  Diabetes Care

OBJECTIVE: Metformin is a commonly used glucose-lowering drug. However, apart from glycemic measures, no biomarker for its presenc..

Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: Translational biology and rationale for current clinical trials

M Troncone, SM Cargnelli, LA Villani, N Isfahanian, LA Broadfield, L Zychla, J Wright, G Pond, GR Steinberg, T Tsakiridis

Journal article  |  2017  |  Oncotarget

AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism

Miranda M Sung, Beshay N Zordoky, Adam L Bujak, James SV Lally, David Fung, Martin E Young, Sandrine Horman, Edward J Miller, Peter E Light, Bruce E Kemp, Gregory R Steinberg, Jason RB Dyck

Journal article  |  2015  |  Cardiovascular Research

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

Adam L Bujak, Justin D Crane, James S Lally, Rebecca J Ford, Sally J Kang, Irena A Rebalka, Alex E Green, Bruce E Kemp, Thomas J Hawke, Jonathan D Schertzer, Gregory R Steinberg

Journal article  |  2015  |  Cell Metabolism

Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression

James SV Lally, Rebecca J Ford, Jasper Johar, Justin D Crane, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2015  |  Physiological Reports

AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation

Beshay NM Zordoky, Jeevan Nagendran, Thomas Pulinilkunnil, Petra C Kienesberger, Grant Masson, Terri J Waller, Bruce E Kemp, Gregory R Steinberg, Jason RB Dyck

Journal article  |  2014  |  Circulation Research

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice

Hayley M O'Neill, James S Lally, Sandra Galic, Melissa Thomas, Paymon D Azizi, Morgan D Fullerton, Brennan K Smith, Thomas Pulinilkunnil, Zhiping Chen, M Constantine Samaan, Sebastian B Jorgensen, Jason RB Dyck, Graham P Holloway, Thomas J Hawke, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2014  |  Diabetologia

Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress

Sean L McGee, Courtney Swinton, Shona Morrison, Vidhi Gaur, Duncan E Campbell, Sebastian B Jorgensen, Bruce E Kemp, Keith Baar, Gregory R Steinberg, M Hargreaves

Journal article  |  2014  |  The FASEB Journal

Mechanism of Action of Compound-13: An alpha 1-Selective Small Molecule Activator of AMPK

Roger W Hunter, Marc Foretz, Laurent Bultot, Morgan D Fullerton, Maria Deak, Fiona A Ross, Simon A Hawley, Natalia Shpiro, Benoit Viollet, Denis Barron, Bruce E Kemp, Gregory R Steinberg, D Grahame Hardie, Kei Sakamoto

Journal article  |  2014  |  Chemistry & Biology

Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance

Adam L Bujak, Regje ME Bluemer, Katarina Marcinko, Morgan D Fullerton, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2014  |  Journal of Applied Physiology

PPAR delta activation attenuates hepatic steatosis in Ldlr(-/-) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

Lazar A Bojic, Dawn E Telford, Morgan D Fullerton, Rebecca J Ford, Brian G Sutherland, Jane Y Edwards, Cynthia G Sawyez, Robert Gros, Bruce E Kemp, Gregory R Steinberg, Murray W Huff

Journal article  |  2014  |  Journal of Lipid Research

Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling

John W Scott, Naomi Ling, Samah MA Issa, Toby A Dite, Matthew T O'Brien, Zhi-Ping Chen, Sandra Galic, Christopher G Langendorf, Gregory R Steinberg, Bruce E Kemp, Jonathan S Oakhill

Journal article  |  2014  |  Chemistry & Biology

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

Serge Ducommun, Rebecca J Ford, Laurent Bultot, Maria Deak, Luc Bertrand, Bruce E Kemp, Gregory R Steinberg, Kei Sakamoto

Journal article  |  2014  |  American Journal of Physiology-Endocrinology and Metabolism

Evidence for the Role of AMPK in Regulating PGC-1 Alpha Expression and Mitochondrial Proteins in Mouse Epididymal Adipose Tissue

Zhongxiao Wan, Jared Root-Mccaig, Laura Castellani, Bruce E Kemp, Gregory R Steinberg, David C Wright

Journal article  |  2014  |  Obesity

Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse

Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jorgensen, Sarah Q To, Kevin C Knower, Colin D Clyne, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Margaret EE Jones, Evan R Simpson, Wah Chin Boon

Journal article  |  2014  |  PLoS One

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

Sebastian Beck Jorgensen, Hayley M O'Neill, Lykke Sylow, Jane Honeyman, Kimberly A Hewitt, Rengasamy Palanivel, Morgan D Fullerton, Lisa Oberg, Anudharan Balendran, Sandra Galic, Chris van der Poel, Ian A Trounce, Gordon S Lynch, Jonathan D Schertzer, Gregory R Steinberg

Journal article  |  2013  |  Diabetes

Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance

R Palanivel, MD Fullerton, S Galic, J Honeyman, KA Hewitt, SB Jorgensen, GR Steinberg

Journal article  |  2012  |  Diabetologia

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

Simon A Hawley, Morgan D Fullerton, Fiona A Ross, Jonathan D Schertzer, Cyrille Chevtzoff, Katherine J Walker, Mark W Peggie, Darya Zibrova, Kevin A Green, Kirsty J Mustard, Bruce E Kemp, Kei Sakamoto, Gregory R Steinberg, D Grahame Hardie

Journal article  |  2012  |  Science

Hematopoietic AMPK beta 1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

Sandra Galic, Morgan D Fullerton, Jonathan D Schertzer, Sarah Sikkema, Katarina Marcinko, Carl R Walkley, David Izon, Jane Honeyman, Zhi-Ping Chen, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2011  |  Journal of Clinical Investigation

AMP-activated protein kinase (AMPK) beta 1 beta 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

Hayley M O'Neill, Stine J Maarbjerg, Justin D Crane, Jacob Jeppesen, Sebastian B Jorgensen, Jonathan D Schertzer, Olga Shyroka, Bente Kiens, Bryce J van Denderen, Mark A Tarnopolsky, Bruce E Kemp, Erik A Richter, Gregory R Steinberg

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

Nirupa Sachithanandan, Kate L Graham, Sandra Galic, Jane E Honeyman, Stacey L Fynch, Kimberly A Hewitt, Gregory R Steinberg, Thomas W Kay

Journal article  |  2011  |  Diabetes

Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent

J Jeppesen, PH Albers, AJ Rose, JB Birk, P Schjerling, N Dzamko, GR Steinberg, B Kiens

Journal article  |  2011  |  Journal of Lipid Research

Whole Body Deletion of AMP-activated Protein Kinase beta 2 Reduces Muscle AMPK Activity and Exercise Capacity

Gregory R Steinberg, Hayley M O'Neill, Nicolas L Dzamko, Sandra Galic, Tim Naim, Rene Koopman, Sebastian B Jorgensen, Jane Honeyman, Kimberly Hewitt, Zhi-Ping Chen, Jonathan D Schertzer, John W Scott, Frank Koentgen, Gordon S Lynch, Matthew J Watt, Bryce JW van denderen, Duncan J Campbell, Bruce E Kemp

Journal article  |  2010  |  Journal of Biological Chemistry

AMPK beta 1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Nicolas Dzamko, Bryce JW van Denderen, Andrea L Hevener, Sebastian Beck Jorgensen, Jane Honeyman, Sandra Galic, Zhi-Ping Chen, Matthew J Watt, Duncan J Campbell, Gregory R Steinberg, Bruce E Kemp

Journal article  |  2010  |  Journal of Biological Chemistry

Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity

S Beck Jorgensen, HM O'Neill, K Hewitt, BE Kemp, GR Steinberg

Journal article  |  2009  |  Diabetologia

Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation

Sebastian Beck Jorgensen, Jane Honeyman, Jonathan S Oakhill, Daniel Fazakerley, Jacqueline Stoeckli, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2009  |  American Journal of Physiology - Endocrinology and Metabolism

Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women.

Kristy A Brown, Kerry J McInnes, Nicole I Hunger, Jonathan S Oakhill, Gregory R Steinberg, Evan R Simpson

Journal article  |  2009  |  Cancer Research

Epidemiologic evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase plays an im..

Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Dependent Pathway That Is Impaired With Obesity

Gregory R Steinberg, Matthew J Watt, Matthias Ernst, Morris J Birnbaum, Bruce E Kemp, Sebastian Beck Jorgensen

Journal article  |  2009  |  Diabetes

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

Nicolas Dzamko, Jonathan D Schertzer, James G Ryall, Rohan Steel, S Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J Michell, Jonathan S Oakhill, Matthew J Watt, Sebastian Beck Jorgensen, Gordon S Lynch, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2008  |  Journal of Physiology

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase beta 1-Containing Complexes

John W Scott, Bryce JW van Denderen, Sebastian B Jorgensen, Jane E Honeyman, Gregory R Steinberg, Jonathan S Oakhill, Tristan J Iseli, Ann Koay, Paul R Gooley, David Stapleton, Bruce E Kemp

Journal article  |  2008  |  Chemistry & Biology

Regulation and function of triacylglycerol lipases in cellular metabolism

Matthew J Watt, Gregory R Steinberg

Journal article  |  2008  |  Biochemical Journal

Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK

Peter F Mount, Natalie Lane, Sudharsan Venkatesan, Gregory R Steinberg, Scott A Fraser, Bruce E Kemp, David A Power

Journal article  |  2008  |  Atherosclerosis

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPAR alpha and UCP2 expression in rats

Anna G Holmes, Jose L Mesa, Bronwyn A Neill, Jason Chung, Andrew L Carey, Gregory R Steinberg, Bruce E Kemp, Robert J Southgate, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt, Mark A Febbraio

Journal article  |  2008  |  Journal of Endocrinology

Pathways involved in lipid-induced insulin resistance in obesity

Matthew J Watt, Gregory R Steinberg

Journal article  |  2007  |  Future Lipidology

Adipocyte triglyceride lipase expression in human obesity

Gregory R Steinberg, Bruce E Kemp, Matthew J Watt

Journal article  |  2007  |  American Journal of Physiology - Endocrinology and Metabolism

Adiponectin: Starving for attention

Gregory R Steinberg, Bruce E Kemp

Journal article  |  2007  |  Cell Metabolism

The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity.

Gregory R Steinberg, Sebastian Beck Jørgensen

Journal article  |  2007  |  Mini-Reviews in Medicinal Chemistry

Over the past decade, an epidemic of obesity has developed throughout the Western World. In recent years, significant interest has..

Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance.

Gregory R Steinberg

Journal article  |  2007  |  Cell Cycle

Over the past two decades increases in obesity, due to high caloric intakes and immobilizing technologies, has led to a surge in t..

Leptin stimulation of COXIV is impaired in obese skeletal muscle myotubes

AJ McAinch, GR Steinberg, J Mollica, PE O'Brien, JB Dixon, BE Kemp, D Cameron-Smith

Journal article  |  2007  |  Obesity Research & Clinical Practice

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

Gregory R Steinberg, Belinda J Michell, Bryce JW van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Gorgun, David Carling, Gokhan S Hotamisligil, Mark A Febbraio, Thomas W Kay, Bruce E Kemp

Journal article  |  2006  |  Cell Metabolism

Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals

Andrew J McAinch, Gregory R Steinberg, Janelle Mollica, Paul E O'Brien, John B Dixon, S Lance Macaulay, Bruce E Kemp, David Cameron-Smith

Journal article  |  2006  |  Obesity

Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise

Jason L Talanian, Rebecca J Tunstall, Matthew J Watt, Mylinh Duong, Christopher GR Perry, Gregory R Steinberg, Bruce E Kemp, George JF Heigenhauser, Lawrence L Spriet

Journal article  |  2006  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

Andrew L Carey, Gregory R Steinberg, S Lance Macaulay, Walter G Thomas, Anna G Holmes, Georg Ramm, Oja Prelovsek, Cordula Hohnen-Behrens, Matthew J Watt, David E James, Bruce E Kemp, Bente K Pedersen, Mark A Febbraio

Journal article  |  2006  |  Diabetes

The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans

Gregory R Steinberg, Andrew J McAinch, Michael B Chen, Paul E O'Brien, John B Dixon, David Cameron-Smith, Bruce E Kemp

Journal article  |  2006  |  Journal of Clinical Endocrinology & Metabolism

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice

Gregory R Steinberg, Matthew J Watt, Barbara C Fam, Joseph Proietto, Sofianos Andrikopoulos, Andrew M Allen, Mark A Febbraio, Bruce E Kemp

Journal article  |  2006  |  Endocrinology

Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes

Matthew J Watt, Gregory R Steinberg, Zhi-Ping Chen, Bruce E Kemp, Mark A Febbraio

Journal article  |  2006  |  Journal of Physiology

AMP-activated protein kinase - the fat controller of the energy railroad

Gregory R Steinberg, S Lance Macaulay, Mark A Febbraio, Bruce E Kemp

Journal article  |  2006  |  Canadian Journal of Physiology and Pharmacology

Reduced glycogen availability is associated with increased AMPK alpha 2 activity, nuclear AMPK alpha 2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

Gregory R Steinberg, Matthew J Watt, Sean L McGee, Stanley Chan, Mark Hargreaves, Mark A Febbraio, David Stapleton, Bruce E Kemp

Journal article  |  2006  |  Applied Physiology, Nutrition and Metabolism

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

Matthew J Watt, Nicolas Dzamko, Walter G Thomas, Stefan Rose-John, Matthias Ernst, David Carling, Bruce E Kemp, Mark A Febbraio, Gregory R Steinberg

Journal article  |  2006  |  Nature Medicine

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue

MJ Watt, AG Holmes, SK Pinnamaneni, AP Garnham, GR Steinberg, BE Kemp, MA Febbraio

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.

Robert J Southgate, Clinton R Bruce, Andrew L Carey, Gregory R Steinberg, Ken Walder, Robert Monks, Matthew J Watt, John A Hawley, Morris J Birnbaum, Mark A Febbraio

Journal article  |  2005  |  FASEB Journal

There are multiple binding domains on the promoter region of the peroxisome proliferator activator receptor gamma coactivator-1 al..

Socs1 deficiency enhances hepatic insulin signaling

E Jamieson, MMW Chong, GR Steinberg, V Jovanovska, BC Fam, DVR Bullen, Y Chen, BE Kemp, J Proietto, TWH Kay, S Andrikopoulos

Journal article  |  2005  |  Journal of Biological Chemistry

Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics

MB Chen, AJ McAinch, SL Macaulay, LA Castelli, PE O'Brien, JB Dixon, D Cameron-Smith, BE Kemp, GR Steinberg

Journal article  |  2005  |  Journal of Clinical Endocrinology & Metabolism

Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro

EW Petersen, AL Carey, M Sacchetti, GR Steinberg, SL Macaulay, MA Febbraio, BK Pedersen

Journal article  |  2005  |  American Journal of Physiology - Endocrinology and Metabolism

AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females

GR Steinberg, AC Smith, BJW van Denderen, ZP Chen, S Murthy, DJ Campbell, GJF Heigenhauser, DJ Dyck, BE Kemp

Journal article  |  2004  |  Journal of Clinical Endocrinology & Metabolism

Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle

MJ Watt, AG Holmes, GR Steinberg, JL Mesa, BE Kemp, MA Febbraio

Journal article  |  2004  |  American Journal of Physiology - Endocrinology and Metabolism

beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling

MJ Watt, GR Steinberg, S Chan, A Garnham, BE Kemp, MA Febbraio

Journal article  |  2004  |  FASEB Journal