Gregory Steinberg

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia.

Aphrodite T Choumessi, Manuel Johanns, Claire Beaufay, Marie-France Herent, Vincent Stroobant, Didier Vertommen, Cyril Corbet, Roxane Jacobs, Gaëtan Herinckx, Gregory R Steinberg, Olivier Feron, Joëlle Quetin-Leclercq, Mark H Rider

Journal article  |  2019  |  Biochemical Journal

Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK..

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

EA Day, RJ Ford, BK Smith, P Mohammadi-Shemirani, MR Morrow, RM Gutgesell, R Lu, AR Raphenya, M Kabiri, AG McArthur, N McInnes, S Hess, G Paré, HC Gerstein, GR Steinberg

Journal article  |  2019  |  Nature Metabolism

The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.

Dan Zhang, Agata L Gava, Richard Van Krieken, Neel Mehta, Renzhong Li, Bo Gao, Eric M Desjardins, Gregory R Steinberg, Thomas Hawke, Joan C Krepinsky

Journal article  |  2019  |  Kidney International

Glomerular matrix protein accumulation, mediated largely by mesangial cells, is central to the pathogenesis of diabetic kidney dis..

Obesity and muscle-macrophage crosstalk in humans and mice: A systematic review.

Srikesh Rudrapatna, Meha Bhatt, Kuan-Wen Wang, Rachel Bierbrier, Pei-Wen Wang, Laura Banfield, Wagdi Elsheikh, E Danielle Sims, Devin Peterson, Lehana Thabane, Mark A Tarnopolsky, Gregory R Steinberg, M Constantine Samaan

Journal article  |  2019  |  Obesity Reviews

Obesity is associated with the production of inflammatory cytokines that are implicated in insulin resistance (IR), and if not add..

MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold

SM Oreskovich, FJ Ong, BA Ahmed, NB Konyer, DP Blondin, E Gunn, NP Singh, MD Noseworthy, F Haman, AC Carpentier, Z Punthakee, GR Steinberg, KM Morrison

Journal article  |  2019  |  Journal of the Endocrine Society

Abstract Context In rodents, cold exposure induces the activation of brown adi..

The gut microbiome regulates host glucose homeostasis via peripheral serotonin.

Alyce M Martin, Julian M Yabut, Jocelyn M Choo, Amanda J Page, Emily W Sun, Claire F Jessup, Steve L Wesselingh, Waliul I Khan, Geraint B Rogers, Gregory R Steinberg, Damien J Keating

Journal article  |  2019  |  Proceedings of the National Academy of Sciences of USA

The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts ..

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease.

Wouter N Leonhard, Xuewen Song, Anish A Kanhai, Ioan-Andrei Iliuta, Andrea Bozovic, Gregory R Steinberg, Dorien JM Peters, York Pei

Journal article  |  2019  |  EBioMedicine

BACKGROUND: Multiple preclinical studies have highlighted AMP-activated protein kinase (AMPK) as a potential therapeutic target fo..

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.

Julian M Yabut, Justin D Crane, Alexander E Green, Damien J Keating, Waliul I Khan, Gregory R Steinberg

Journal article  |  2019  |  Endocrine Reviews

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in maintaining energy homeostasis for bill..

AMP-activated protein kinase: the current landscape for drug development.

Gregory R Steinberg, David Carling

Journal article  |  2019  |  Nature Reviews Drug Discovery

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights in..

Salicylate enhances the response of prostate cancer to radiotherapy.

Lindsay A Broadfield, Katarina Marcinko, Evangelia Tsakiridis, Panayiotis G Zacharidis, Linda Villani, James SV Lally, Gabe Menjolian, Danitra Maharaj, Tammy Mathurin, Marcia Smoke, Thomas Farrell, Paola Muti, Gregory R Steinberg, Theodoros Tsakiridis

Journal article  |  2019  |  The Prostate

BACKGROUND: Radiotherapy (RT) is a key therapeutic modality for prostate cancer (PrCa), but RT resistance necessitates dose-escala..