Gregory Steinberg

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

Correction: Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.

Nusrat Hussain, Sheng-Ju Chuang, Manuel Johanns, Didier Vertommen, Gregory R Steinberg, Bruce E Kemp, Mark H Rider

Journal article  |  2020  |  Biochem J

During the production process the Western blots for pThr246 PRAS40 in Figure 6B were accidentally duplicated in Figure 6C pThr649 ..

Current and emerging roles of adipose tissue in health and disease.

Emilio P Mottillo, Gregory R Steinberg

Journal article  |  2020  |  Biochem J

The mega-importance of de novo lipogenesis in platelet production.

Ishac Nazy, Donald M Arnold, Gregory R Steinberg

Journal article  |  2020  |  Nat Metab

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt

Journal article  |  2020  |  SCIENCE TRANSLATIONAL MEDICINE

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi XY Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin RW Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Journal article  |  2020  |  NATURE METABOLISM

Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and s..

Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease.

Xuewen Song, Evelyn Tsakiridis, Gregory R Steinberg, York Pei

Journal article  |  2020  |  Cell Signal

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic kidney disease worldwide and an important caus..

Impact of pesticide exposure on adipose tissue development and function.

Robert M Gutgesell, Evangelia E Tsakiridis, Shanza Jamshed, Gregory R Steinberg, Alison C Holloway

Journal article  |  2020  |  Biochem J

Obesity is a leading cause of morbidity, mortality and health care expenditure whose incidence is rapidly rising across the globe...

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice.

Emily A Day, Rebecca J Ford, Jessie H Lu, Rachel Lu, Lucie Lundenberg, Eric M Desjardins, Alex E Green, James SV Lally, Jonathan D Schertzer, Gregory R Steinberg

Journal article  |  2020  |  Biochem J

Sodium-glucose cotransporter 2 inhibitors such as canagliflozin lower blood glucose and reduce cardiovascular events in people wit..

Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue

Nusrat Hussain, Sheng-Ju Chuang, Manuel Johanns, Didier Vertommen, Gregory R Steinberg, Bruce E Kemp, Mark H Rider

Journal article  |  2020  |  BIOCHEMICAL JOURNAL

We investigated acute effects of two allosteric protein kinase B (PKB) inhibitors, MK-2206 and Akti-1/2, on insulin-stimulated lip..