Christine Nguyen

Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy.

Da Zhao, Paulo Pinares-Garcia, Chaseley E McKenzie, Lauren E Bleakley, Ian C Forster, Vickie HY Wong, Christine TO Nguyen, Ingrid E Scheffer, Christopher A Reid, Bang V Bui

Journal article  |  2023  |  J Neurosci

Pathogenic variants in HCN1 are associated with a range of epilepsy syndromes including a developmental and epileptic encephalopat..

Characterization of retinal function and structure in the MPTP murine model of Parkinson's disease

Katie KN Tran, Vickie HY Wong, Jeremiah KH Lim, Ali Shahandeh, Hoang Anh, David Finkelstein, Bang Bui, Christine TO Nguyen

Journal article  |  2022  |  SCIENTIFIC REPORTS

In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Par..

White matter tract conductivity is resistant to wide variations in paranodal structure and myelin thickness accompanying the loss of Tyro3: an experimental and simulated analysis

Farrah Blades, Jordan D Chambers, Timothy D Aumann, Christine TO Nguyen, Vickie HY Wong, Andrea Aprico, Eze C Nwoke, Bang Bui, David B Grayden, Trevor J Kilpatrick, Michele D Binder

Journal article  |  2022  |  BRAIN STRUCTURE & FUNCTION

Myelination within the central nervous system (CNS) is crucial for the conduction of action potentials by neurons. Variation in co..

Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders

Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen

Journal article  |  2022  |  FRONTIERS IN NEUROSCIENCE

Iron plays an important role in a wide range of metabolic pathways that are important for neuronal health. Excessive levels of iro..

Progressive impairments in executive function in the APP/PS1 model of Alzheimer's disease as measured by translatable touchscreen testing

Amy Shepherd, Jeremiah KH Lim, Vicky HY Wong, Ariel M Zeleznikow-Johnston, Leonid Churilov, Christine TO Nguyen, Bang V. Bui, Anthony J Hannan, Emma L Burrows

Journal article  |  2021  |  NEUROBIOLOGY OF AGING

Executive function deficits in Alzheimer's disease (AD) occur early in disease progression and may be predictive of cognitive decl..

Editorial: Seeing Beyond the Eye: The Brain Connection

Christine TO Nguyen, Monica L Acosta, Silvia Di Angelantonio, Thomas E Salt

Journal article  |  2021  |  FRONTIERS IN NEUROSCIENCE

Retinal hyperspectral imaging in the 5xFAD mouse model of Alzheimer's disease

Jeremiah KH Lim, Qiao-Xin Li, Tim Ryan, Phillip Bedggood, Andrew Metha, Algis J Vingrys, Bang Bui, Christine TO Nguyen

Journal article  |  2021  |  SCIENTIFIC REPORTS

Hyperspectral imaging of the retina has recently been posited as a potentially useful form of spectroscopy of amyloid-beta (Aβ) pr..

Increased episcleral venous pressure in a mouse model of circumlimbal suture induced ocular hypertension

Vickie HY Wong, Da Zhao, Bang Bui, Cameron J Millar, Christine TO Nguyen

Journal article  |  2021  |  EXPERIMENTAL EYE RESEARCH

PURPOSE: To investigate changes in aqueous humor dynamics during intraocular pressure (IOP) elevation induced by circumlimbal sutu..

Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina

Ali Shahandeh, Bang V Bui, David I Finkelstein, Christine TO Nguyen

Journal article  |  2020  |  JOURNAL OF NEUROSCIENCE RESEARCH

Iron is essential for normal cellular function, however, excessive accumulation of iron in neural tissue has been implicated in bo..

Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina

Farrah Blades, Vickie HY Wong, Christine TO Nguyen, Bang V Bui, Trevor J Kilpatrick, Michele D Binder

Journal article  |  2020  |  FRONTIERS IN NEUROSCIENCE

Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons..