Kyra Chua

Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication.

Claire L Gordon, Olivia C Smibert, Natasha E Holmes, Kyra YL Chua, Morgan Rose, George Drewett, Fiona James, Effie Mouhtouris, Thi HO Nguyen, Wuji Zhang, Lukasz Kedzierski, Louise C Rowntree, Brendon Y Chua, Leon Caly, Mike G Catton, Julian Druce, Michelle Sait, Torsten Seemann, Norelle L Sherry, Benjamin P Howden, et al.

Journal article  |  2021  |  Open Forum Infect Dis

We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and ..

The Penicillin Allergy Delabeling Program: A Multicenter Whole-of-Hospital Health Services Intervention and Comparative Effectiveness Study.

Kyra YL Chua, Sara Vogrin, Susan Bury, Abby Douglas, Natasha E Holmes, Nixon Tan, Natasha K Brusco, Rebecca Hall, Belinda Lambros, Jacinta Lean, Wendy Stevenson, Misha Devchand, Kent Garrett, Karin Thursky, M Lindsay Grayson, Monica A Slavin, Elizabeth J Phillips, Jason A Trubiano

Journal article  |  2021  |  Clin Infect Dis

BACKGROUND: Penicillin allergies are associated with inferior patient and antimicrobial stewardship outcomes. We implemented a who..

Staff to staff transmission as a driver of healthcare worker infections with COVID-19.

Claire L Gordon, Jason A Trubiano, Natasha E Holmes, Kyra YL Chua, Jeff Feldman, Greg Young, Norelle L Sherry, M Lindsay Grayson, Jason C Kwong

Journal article  |  2021  |  Infect Dis Health

BACKGROUND: High rates of healthcare worker (HCW) infections due to COVID-19 have been attributed to several factors, including in..

The Role of In Vivo and Ex Vivo Diagnostic Tools in Severe Delayed Immune-Mediated Adverse Antibiotic Drug Reactions

Ana Copaescu, Effie Mouhtouris, Sara Vogrin, Fiona James, Kyra YL Chua, Natasha E Holmes, Abby Douglas, Monica A Slavin, Heather Cleland, Celia Zubrinich, Ar Kar Aung, Michelle SY Goh, Elizabeth J Phillips, Jason A Trubiano

Journal article  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

BACKGROUND: The use of in vivo and ex vivo diagnostic tools for delayed immune-mediated adverse drug reactions is currently ill de..

The Long-term Impact of Beta-lactam Antibiotic Allergy Testing - A Matched Case-control Study

Jason Trubiano, Nada Marhoon, Sara Vogrin, Kyra Chua, Natasha Holmes

Conference Proceedings  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A*32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype

Nontaya Nakkam, Andrew Gibson, Effie Mouhtouris, Katherine C Konvinse, Natasha E Holmes, Kyra Y Chua, Pooja Deshpande, Danmeng Li, David A Ostrov, Jason Trubiano, Elizabeth J Phillips

Journal article  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CAPSULE SUMMARY: All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to d..

COVID-MATCH65-A prospectively derived clinical decision rule for severe acute respiratory syndrome coronavirus 2

Jason A Trubiano, Sara Vogrin, Olivia C Smibert, Nada Marhoon, Adrian A Alexander, Kyra YL Chua, Fiona L James, Nicholas RL Jones, Sam E Grigg, Cecilia LH Xu, Nasreen Moini, Sam R Stanley, Michael T Birrell, Morgan T Rose, Claire L Gordon, Jason C Kwong, Natasha E Holmes

Journal article  |  2020  |  PLOS ONE

OBJECTIVES: We report on the key clinical predictors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and..

Clinical evaluation of four commercial immunoassays for the detection of antibodies against established SARS-CoV-2 infection

Kyra YL Chua, Sara Vogrin, Intissar Bittar, Jennifer H Horvath, Hari Wimaleswaran, Jason A Trubiano, Natasha E Holmes, Que Lam

Journal article  |  2020  |  PATHOLOGY

A comparison of the clinical performance of the Elecsys Anti-SARS-CoV-2, Liaison SARS-CoV-2 S1/S2 IgG, Access SARS-CoV-2 IgG and V..

Matched Case-Control Study of the Long-Term Impact of Beta-Lactam Antibiotic Allergy Testing

Jason A Trubiano, Nada Marhoon, Sara Vogrin, Kyra YL Chua, Natasha E Holmes

Journal article  |  2020  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Whereas the short-term impacts of antibiotic allergy testing on delabeling and antibiotic usage have been demonstrated, the long-t..

PEN-FAST: A validated penicillin allergy clinical decision rule - Implications for prescribing

J Trubiano, S Vogrin, K Chua, J Bourke, J Yun, A Douglas, C Stone, N Holmes, E Phillips

Conference Proceedings  |  2020  |  INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES