Freya Sheeran

Adaptations in Protein Expression and Regulated Activity Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure

Freya L Sheeran, Julie Angerosa, Norman Y Liaw, Michael M Cheung, Salvatore Pepe

Journal article  |  2019  |  OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

Pyruvate dehydrogenase (PDH) complex, a multienzyme complex at the nexus of glycolytic and Krebs cycles, provides acetyl-CoA to th..

Mitochondrial Bioenergetics and Dysfunction in Failing Heart

Freya L Sheeran, Salvatore Pepe

Book Chapter  |  2017  |  Advances in Experimental Medicine and Biology

Energy insufficiency has been recognized as a key feature of systolic heart failure. Although mitochondria have long been known to..

Posttranslational modifications and dysfunction of mitochondrial enzymes in human heart failure

Freya L Sheeran, Salvatore Pepe

Journal article  |  2016  |  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deficiency of energy supply is a major complication contributing to the syndrome of heart failure (HF). Because the concurrent act..

Molecular markers of programmed cell death in donor hearts before transplantation

Silvana F Marasco, Freya L Sheeran, Krishanu Chaudhuri, Matthew Vale, Michael Bailey, Salvatore Pepe

Journal article  |  2014  |  JOURNAL OF HEART AND LUNG TRANSPLANTATION

BACKGROUND: In this study we investigate whether pro-apoptotic, pro-inflammatory and other early signaling markers indicative of i..

Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: A randomized controlled trial

Bryn O Jones, Salvatore Pepe, Freya L Sheeran, Susan Donath, Pollyanna Hardy, Lara Shekerdemian, Daniel J Penny, Ian McKenzie, Stephen Horton, Christian P Brizard, Yves d'Udekem, Igor E Konstantinov, Michael MH Cheung

Journal article  |  2013  |  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

OBJECTIVE: The myocardial protective effect of remote ischemic preconditioning has been demonstrated in heterogeneous groups of pa..

Postnatal shifts in ischemic tolerance and cell survival signaling in murine myocardium

Norman Y Liaw, Louise See Hoe, Freya L Sheeran, Jason N Peart, John P Headrick, Michael MH Cheung, Salvatore Pepe

Journal article  |  2013  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The immature heart is known to be resistant to ischemia-reperfusion (I/R) injury; however, key proteins engaged in phospho-depende..

Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.

Jiro Ikeda, Toshihiro Ichiki, Hirohide Matsuura, Eriko Inoue, Junji Kishimoto, Aya Watanabe, Chikahiro Sankoda, Shiro Kitamoto, Tomotake Tokunou, Kotaro Takeda, Guo-Hua Fong, Kenji Sunagawa

Journal article  |  2013  |  J Am Heart Assoc

BACKGROUND: Hypertension induces cardiovascular hypertrophy and fibrosis. Infiltrated macrophages are critically involved in this ..

Effect of Remote Ischemic Preconditioning on Phosphorylated Protein Signaling in Children Undergoing Tetralogy of Fallot Repair: A Randomized Controlled Trial

Salvatore Pepe, Norman Y Liaw, Michele Hepponstall, Freya L Sheeran, Matthew S Yong, Yves d'Udekem, Michael M Cheung, Igor E Konstantinov

Journal article  |  2013  |  JOURNAL OF THE AMERICAN HEART ASSOCIATION

BACKGROUND: Our previous randomized controlled trial demonstrated cardiorespiratory protection by remote ischemic preconditioning ..

Oxidation of Myofibrillar Proteins in Human Heart Failure

Marcella Canton, Sara Menazza, Freya L Sheeran, Patrizia Polverino de laureto, Fabio Di Lisa, Salvatore Pepe

Journal article  |  2011  |  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

OBJECTIVES: We investigated the incidence and contribution of the oxidation/nitrosylation of tropomyosin and actin to the contract..

Mitochondrial dysfunction in CD4 lymphocytes from stavudine-treated HIV patients

Lloyd Einsiedel, Catherine L Cherry, Freya L Sheeran, Anna Friedhuber, Steve L Wesselingh, Salvatore Pepe

Journal article  |  2010  |  MITOCHONDRION

HIV therapy with nucleoside analogue reverse transcriptase inhibitors (NRTI) such as stavudine remains in widespread use in resour..