Douglas Hilton

In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis.

C Biben, TS Weber, KS Potts, J Choi, DC Miles, A Carmagnac, T Sargeant, CA de Graaf, KA Fennell, A Farley, OJ Stonehouse, MA Dawson, DJ Hilton, SH Naik, S Taoudi

Journal article  |  2023  |  Nat Commun

During embryogenesis, haematopoietic and endothelial lineages emerge closely in time and space. It is thought that the first blood..

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Andrew Keniry, Natasha Jansz, Linden J Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M Nefzger, Peter F Hickey, Quentin Gouil, Joy Liu, Kelsey A Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A Kinkel, Phillippa C Taberlay, Tracy Willson, Miha Pakusch, Matthew E Ritchie, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

The process of epigenetic silencing, while fundamentally important, is not yet completely understood. Here we report a replenishab..

2017 – THE MESODERMAL LINEAGES OF THE YOLK SAC ARE SEEDED BY HAEMANGIOBLAST, HAEMATOMESOBLAST, AND MESENCHYMOANGIOBLAST PRECURSORS

Christine Biben, Tom Weber, Kathryn Potts, Jarny Choi, Denise Miles, Amandine Carmagnac, Tobias Sargent, Carolyn de Graaf, Katie Fennell, Alison Farley, Olivia Stonehouse, Mark Dawson, Douglas Hilton, Shalin Naik, Samir Taoudi

Journal article  |  2021  |  Experimental Hematology

Dissecting the molecular control of Interleukin 6 signaling using the M1 cell line

Rhiannon Morris, Douglas J Hilton, Andrew Jarratt, Jeffrey J Babon

Journal article  |  2021  |  CYTOKINE

Interleukin 6 is the classical member of the IL-6 family of cytokines which triggers activation of the JAK/STAT signaling cascade ..

Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9

Jarrod J Sandow, Andrew I Webb, Dina Stockwell, Nadia J Kershaw, Cyrus Tan, Satoshi Ishido, Warren S Alexander, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola

Journal article  |  2021  |  PROTEOMICS

MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface ex..

Chromosomes distribute randomly to, but not within, human neutrophil nuclear lobes

Christine R Keenan, Michael J Mlodzianoski, Hannah D Coughlan, Naiara G Bediaga, Gaetano Naselli, Erin C Lucas, Qike Wang, Carolyn A de Graaf, Douglas J Hilton, Leonard C Harrison, Gordon K Smyth, Kelly L Rogers, Thomas Boudier, Rhys S Allan, Timothy M Johanson

Journal article  |  2021  |  ISCIENCE

The proximity pattern and radial distribution of chromosome territories within spherical nuclei are random and non-random, respect..

Membrane budding is a major mechanism of in vivo platelet biogenesis

Kathryn S Potts, Alison Farley, Caleb A Dawson, Joel Rimes, Christine Biben, Carolyn de Graaf, Margaret A Potts, Olivia J Stonehouse, Amandine Carmagnac, Pradnya Gangatirkar, Emma C Josefsson, Casey Anttila, Daniela Amann-Zalcenstein, Shalin Naik, Warren S Alexander, Douglas J Hilton, Edwin D Hawkins, Samir Taoudi

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

How platelets are produced by megakaryocytes in vivo remains controversial despite more than a century of investigation. Megakaryo..

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6R alpha)

Jeffrey J Babon, Dina Stockwell, Ladina DiRago, Jian-Guo Zhang, Artem Laktyushin, Jose Villadangos, Alan Ching, Satoshi Ishido, Douglas J Hilton, Warren S Alexander, Nicos A Nicola

Journal article  |  2019  |  BIOCHEMICAL JOURNAL

Interleukin 6 (IL6) is a cytokine that regulates a number of important immune and inflammatory pathways. We used the ability of IL..

Phylotranscriptomics resolves phylogeny of the Heliozelidae (Adeloidea: Lepidoptera) and suggests a Late Cretaceous origin in Australia

Liz Milla, Adnan Moussalli, Stephen A Wilcox, Erik J van Nieukerken, David A Young, Mike Halsey, Thomas McConville, Theresa M Jones, Axel Kallies, Douglas J Hilton

Journal article  |  2019  |  SYSTEMATIC ENTOMOLOGY

Heliozelidae are a cosmopolitan family of small, day-flying moths, and include some pest species of commercial crops. Overall, the..

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2019  |  NUCLEIC ACIDS RESEARCH

During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many..