Andreas Strasser

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser

Journal article  |  2020  |  The EMBO Journal

Studies of gene-targeted mice identified the roles of the different pro-survival BCL-2 proteins during embryogenesis. However, lit..

Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

Silvia Alvarez-Diaz, Adele Preaudet, Andre L Samson, Paul M Nguyen, Ka Yee Fung, Alexandra L Garnham, Warren S Alexander, Andreas Strasser, Matthias Ernst, Tracy L Putoczki, James M Murphy

Journal article  |  2020  |  Cell Death & Differentiation

Chronic inflammation of the large intestine is associated with an increased risk of developing colorectal cancer (CRC), the second..

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

Sarah A Best, Cassandra J Vandenberg, Etna Abad, Lachlan Whitehead, Laia Guiu, Sheryl Ding, Margs S Brennan, Andreas Strasser, Marco J Herold, Kate D Sutherland, Ana Janic

Journal article  |  2020  |  Cell Death and Disease

TP53 is a critical tumor suppressor that is mutated in approximately 50% of human cancers. Unveiling the downstream target genes o..

BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma

Nenad Sejic, Lindsay C George, Rosemary J Tierney, Catherine Chang, Olga Kondrashova, Ruth N MacKinnon, Ping Lan, Andrew Bell, Guillaume Lessene, Heather M Long, Andreas Strasser, Claire Shannon-Lowe, Gemma L Kelly

Journal article  |  2020  |  Blood Advances

Epstein-Barr virus (EBV)-associated T- and natural killer (NK)-cell malignancies, such as extranodal NK-/T-cell lymphoma (ENKTL), ..

Loss of NFKB1 Results in Expression of Tumor Necrosis Factor and Activation of Signal Transducer and Activator of Transcription 1 to Promote Gastric Tumorigenesis in Mice

Jun T Low, Michael Christie, Matthias Ernst, Laure Dumoutier, Adele Preaudet, Yanhong Ni, Michael DW Griffin, Lisa A Mielke, Andreas Strasser, Tracy L Putoczki, Lorraine A O'Reilly

Journal article  |  2020  |  Gastroenterology

BACKGROUND & AIMS: Activity of nuclear factor κB transcription factors and signaling via signal transducer and activator of transc..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.

Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina SP Poh, Xin Wang, Stefan Fröhling, et al.

Journal article  |  2020  |  Nature Communications

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mec..

Emerging connectivity of programmed cell death pathways and its physiological implications

Sammy Bedoui, Marco J Herold, Andreas Strasser

Journal article  |  2020  |  Nature Reviews Molecular Cell Biology

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathway..

MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3( )regulatory T cells

Charis E Teh, Alissa K Robbins, Darren C Henstridge, Grant Dewson, Sarah T Diepstraten, Gemma Kelly, Mark A Febbraio, Sarah S Gabriel, Lorraine A O'Reilly, Andreas Strasser, Daniel HD Gray

Journal article  |  2020  |  Cell Death and Differentiation

FOXP3+ regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related d..

Cell Death in the Origin and Treatment of Cancer

Andreas Strasser, David L Vaux

Journal article  |  2020  |  Molecular Cell