Andreas Strasser

Characterization of a novel human BFL-1-specific monoclonal antibody.

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells.

Charis E Teh, Jia-Nan Gong, David Segal, Tania Tan, Cassandra J Vandenberg, Pasquale L Fedele, Michael SY Low, George Grigoriadis, Simon J Harrison, Andreas Strasser, Andrew W Roberts, David CS Huang, Garry P Nolan, Daniel HD Gray, Melissa E Ko

Journal article  |  2020  |  Cell Death & Differentiation

Multiple myeloma is an incurable and fatal cancer of immunoglobulin-secreting plasma cells. Most conventional therapies aim to ind..

The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system

Daniel HD Gray, David L Vaux, Andreas Strasser

Journal article  |  2019  |  Cell Death & Differentiation

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

Michael Sze Yuan Low, Erica J Brodie, Pasquale L Fedele, Yang Liao, George Grigoriadis, Andreas Strasser, Axel Kallies, Simon N Willis, Julie Tellier, Wei Shi, Sarah Gabriel, Kristy O'Donnell, Catherine Pitt, Stephen L Nutt, David Tarlinton

Journal article  |  2019  |  Cell Reports

The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasm..

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins.

Leah Fitzsimmons, Rachel Cartlidge, Catherine Chang, Nenad Sejic, Laura CA Galbraith, Chathura D Suraweera, Deborah Croom-Carter, Grant Dewson, Rosemary J Tierney, Andrew I Bell, Clare Shannon-Lowe, Marco J Herold, Alan B Rickinson, Peter M Colman, David CS Huang, Andreas Strasser, Marc Kvansakul, Martin Rowe, Gemma L Kelly

Journal article  |  2019  |  Cell Death & Differentiation

Epstein-Barr virus (EBV), which is ubiquitous in the adult population, is causally associated with human malignancies. Like many i..

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells.

Kerstin Brinkmann, Ashley P Ng, Carolyn A de Graaf, Ladina Di Rago, Craig D Hyland, Eugenio Morelli, Jai Rautela, Nicholas D Huntington, Andreas Strasser, Warren S Alexander, Marco J Herold

Journal article  |  2019  |  Cell Death & Differentiation

The miR17~92 cluster plays important roles in haematopoiesis. However, it is not clear at what stage of differentiation and throug..

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

Prerak M Trivedi, Stacey Fynch, Lucy M Kennedy, Jonathan Chee, Balasubramanian Krishnamurthy, Lorraine A O'Reilly, Andreas Strasser, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  Cell Death Discovery

CD8+ T cells play a central role in beta-cell destruction in type 1 diabetes. CD8+ T cells use two main effector pathways to kill ..

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3( ) regulatory T cells

Antonia Polichen, Keisuke Horikawa, Liz Milla, Jennifer Kofler, Philippe Bouillet, Gabrielle T Belz, Lorraine A O'Reilly, Christopher C Goodnow, Andreas Strasser, Daniel HD Gray

Journal article  |  2019  |  Immunology & Cell Biology

FOXP3+ regulatory T (Treg) cells are essential for immunological tolerance and immune homeostasis. Despite a great deal of interes..

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

Ranja Salvamoser, Kerstin Brinkmann, Lorraine A O'Reilly, Lachlan Whitehead, Andreas Strasser, Marco J Herold

Journal article  |  2019  |  Cell Death & Differentiation

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Erinna F Lee, Tiffany J Harris, Sharon Tran, Marco Evangelista, Surein Arulananda, Thomas John, Celeste Ramnac, Chloe Hobbs, Haoran Zhu, Gency Gunasingh, David Segal, Andreas Behren, Jonathan Cebon, Alexander Dobrovic, John M Mariadason, Andreas Strasser, Leona Rohrbeck, Nikolas K Haass, Marco J Herold, W Douglas Fairlie

Journal article  |  2019  |  Cell Death & Disease

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.

Journal article  |  2019  |  Blood

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.

Journal article  |  2019  |  Cell Reports

Discussion of some "knowns' and some "unknowns' about the tumour suppressor p53

Elizabeth Lieschke, Zilu Wang, Gemma L Kelly, Andreas Strasser

Journal article  |  2019  |  Journal of Molecular Cell Biology

Unexpected overlapping roles of multiple caspases and programmed cell death pathways in the response to bacterial infection

Ranja Salvamoser, Paul G Whitney, Marcel Doerflinger, Sammy Bedoui, Andreas Strasser, Clare Bryant, Marco J Herold

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

Physiological role of linear ubiquitination: more to it than meets the eye

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Lucia Taraborrelli, Amanda Fisher, Tobias L Haas, Yutaka Shimizu, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Ciaran Hutchinson, Charlotta Boiers, Michael T Ashworth, Allison Beal, Tariq Enver, John Bertin, et al.

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

Delphine Merino, Gemma L Kelly, Guillaume Lessene, Andrew H Wei, Andrew W Roberts, Andreas Strasser

Journal article  |  2018  |  Cancer Cell

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

Brandon J Aubrey, Ana Janic, Yunshun Chen, Catherine Chang, Elizabeth C Lieschke, Sarah T Diepstraten, Andrew J Kueh, Jonathan P Bernardini, Grant Dewson, Lorraine A O'Reilly, Lachlan Whitehead, Anne K Voss, Gordon K Smyth, Andreas Strasser, Gemma L Kelly

Journal article  |  2018  |  Genes & Development

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Margs S Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas Strasser, Grant Dewson, Gemma L Kelly, Marco J Herold

Journal article  |  2018  |  Blood

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak

Journal article  |  2018  |  Nature Communications

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Stephanie Grabow, Andrew J Kueh, Francine Ke, Hannah K Vanyai, Bilal N Sheikh, Michael A Dengler, William Chiang, Samantha Eccles, Ian M Smyth, Lynelle K Jones, Frederic J de Sauvage, Mark Scott, Lachlan Whitehead, Anne K Voss, Andreas Strasser

Journal article  |  2018  |  Cell Reports

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B Baell, David J Leaver, Stefan J Hermans, Gemma L Kelly, Margs S Brennan, Natalie L Downer, Nghi Nguyen, Johannes Wichmann, Helen M Mcrae, Yuqing Yang, Ben Cleary, H Rachel Lagiakos, Stephen Mieruszynski, Guido Pacini, Hannah K Vanyai, Maria I Bergamasco, Rose E May, Bethany K Davey, Kimberly J Morgan, Andrew J Sealey, et al.

Journal article  |  2018  |  Nature

DNA repair processes are critical mediators of p53-dependent tumor suppression

Ana Janic, Liz J Valente, Matthew J Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J Vandenberg, Andrew J Kueh, Shinsuke Mizutani, Margs S Brennan, Robyn L Schenk, Lisa M Lindqvist, Anthony T Papenfuss, Liam O'Connor, Andreas Strasser, Marco J Herold

Journal article  |  2018  |  Nature Medicine

miR17~92 is essential for the survival of hematopoietic stem and progenitor cells by restraining pro-apoptotic BIM

Kerstin Brinkmann, Craig Hyland, Carolyn de Graaf, Andreas Strasser, Warren Alexander, Marco Herold

Journal article  |  2018

Summary The micro RNA cluster miR17~92 , also known as oncomiR-1, impacts diverse cellular processes, such as cell survival and pr..

Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use

Margs Brennan, Catherine Chang, Grant Dewson, Lin Tai, Guillaume Lessene, Andreas Strasser, Gemma Kelly, Marco Herold

Journal article  |  2018

SUMMARY MCL-1 is a pro-survival BCL-2 protein required for the sustained growth of many cancers. Recently a highly specific MCL-1-..

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Nguyen Quynh-Nhu, Nadeen Zerafa, Seng H Liew, F Hamish Morgan, Andreas Strasser, Clare L Scott, Jock K Findlay, Martha Hickey, Karla J Hutt

Journal article  |  2018  |  Cell Death & Disease

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

Francine FS Ke, Hannah K Vanyai, Angus D Cowan, Alex RD Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E Czabotar, Anne K Voss, Andreas Strasser

Journal article  |  2018  |  Cell

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L Haas, Yutaka Shimizu, Charlotta Boiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T Ashworth, Allison Beal, et al.

Journal article  |  2018  |  Nature

How do thymic epithelial cells die?

Reema Jain, Justine D Mintern, Iris Tan, Grant Dewson, Andreas Strasser, Daniel HD Gray

Journal article  |  2018  |  Cell Death & Differentiation

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

Rui Liu, Ashleigh King, Philippe Bouillet, David M Tarlinton, Andreas Strasser, Jorg Heierhorst

Journal article  |  2018  |  Frontiers in Immunology

Loss of NF-kappa B1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

Lorraine A O'Reilly, Tracy L Putoczki, Lisa A Mielke, Jun T Low, Ann Lin, Adele Preaudet, Marco J Herold, Kelvin Yaprianto, Lin Tai, Andrew Kueh, Guido Pacini, Richard L Ferrero, Raffi Gugasyan, Yifang Hu, Michael Christie, Stephen Wilcox, Raelene Grumont, Michael DW Griffin, Liam O'Connor, Gordon K Smyth, et al.

Journal article  |  2018  |  Immunity

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews, Margherita Annicchiarico-Petruzzelli, Alexey V Antonov, Eli Arama, Eric H Baehrecke, Nickolai A Barlev, Nicolas G Bazan, Francesca Bernassola, Mathieu JM Bertrand, Katiuscia Bianchi, Mikhail V Blagosklonny, et al.

Journal article  |  2018  |  Cell Death & Differentiation

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

Leah Fitzsimmons, Andrew J Boyce, Wenbin Wei, Catherine Chang, Deborah Croom-Carter, Rosemary J Tierney, Marco J Herold, Andrew I Bell, Andreas Strasser, Gemma L Kelly, Martin Rowe

Journal article  |  2018  |  Cell Death & Differentiation

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Brandon J Aubrey, Gemma L Kelly, Ana Janic, Marco J Herold, Andreas Strasser

Journal article  |  2018  |  Cell death and differentiation

The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also p..

Viewing BCL2 and cell death control from an evolutionary perspective

Andreas Strasser, David L Vaux

Journal article  |  2018  |  Cell Death & Differentiation

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Brandon J Aubrey, Gemma L Kelly, Ana Janic, Marco J Herold, Andreas Strasser

Journal article  |  2018  |  Cell Death & Differentiation

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

Reema Jain, Julie M Sheridan, Antonia Policheni, Melanie Heinlein, Luke C Gandolfo, Grant Dewson, Gordon K Smyth, Stephen N Sansom, Nai Yang Fu, Jane E Visvader, Georg A Hollander, Andreas Strasser, Daniel HD Gray

Journal article  |  2017  |  Blood

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice

Kerstin Brinkmann, Stephanie Grabow, Craig D Hyland, Charis E Teh, Warren S Alexander, Marco J Herold, Andreas Strasser

Journal article  |  2017  |  Cell Death & Differentiation

Loss of BIM augments resistance of ATM-deficient thymocytes to DNA damage-induced apoptosis but does not accelerate lymphoma development

Alex RD Delbridge, Stephanie Grabow, Andreas Strasser

Journal article  |  2017  |  Cell Death & Differentiation

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser, Andreas Villunger

Journal article  |  2017  |  Nature Communications

Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms

Ashleigh King, Lingli Li, David M Wong, Rui Liu, Rebecca Bamford, Andreas Strasser, David M Tarlinton, Jorg Heierhorst

Journal article  |  2017  |  PLOS Genetics

Mcl-1 is a key anti-apoptotic protein in human and rodent pancreatic beta cells

N Violato, K Meyerovich, M Fukaya, N Pachera, P Marchetti, L Marselli, A Strasser, D Eizirik, A Cardozo

Conference Proceedings  |  2017  |  DIABETOLOGIA

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic beta-Cells

Kira Meyerovich, Natalia M Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L Eizirik, Alessandra K Cardozo

Journal article  |  2017  |  Diabetes

PTPN2 regulates T cell lineage commitment and alpha beta versus gamma delta specification

Florian Wiede, Jarrod A Dudakov, Kun-Hui Lu, Garron T Dodd, Tariq Butt, Dale I Godfrey, Andreas Strasser, Richard L Boyd, Tony Tiganis

Journal article  |  2017  |  The Journal of Experimental Medicine

The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF

Seng H Liew, Quynh-Nhu Nguyen, Andreas Strasser, Jock K Findlay, Karla J Hutt

Journal article  |  2017  |  Cell Death & Disease

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

Alex RD Delbridge, Brandon J Aubrey, Craig Hyland, Jonathan P Bernardini, Ladina Di Rago, Jean-Marc Garnier, Guillaume Lessene, Andreas Strasser, Warren S Alexander, Stephanie Grabow

Journal article  |  2017  |  Cell Death & Disease

Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature

Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, Christine M Sorenson

Journal article  |  2017  |  PLOS ONE

Cell death and thymic tolerance

Stephen R Daley, Charis Teh, Daniel Y Hu, Andreas Strasser, Daniel HD Gray

Journal article  |  2017  |  Immunological Reviews

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew

Journal article  |  2017  |  Cell Death & Differentiation

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment

Robyn L Schenk, Selma Tuzlak, Emma M Carrington, Yifan Zhan, Susanne Heinzel, Charis E Teh, Daniel H Gray, Lin Tai, Andrew M Lew, Andreas Villunger, Andreas Strasser, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection

Selma Tuzlak, Robyn L Schenk, Ajithkumar Vasanthakumar, Simon P Preston, Manuel D Haschka, Dimitra Zotos, Axel Kallies, Andreas Strasser, Andreas Villunger, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

Charlotte Viant, Sophie Guia, Robert J Hennessy, Jai Rautela, Kim Pham, Claire Bernat, Wilford Goh, Yuhao Jiao, Rebecca Delconte, Michael Roger, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Stephanie Grabow, Gabrielle T Belz, Benjamin T Kile, Andreas Strasser, Daniel Gray, Phillip D Hodgkin, Bruce Beutler, Eric Vivier, et al.

Journal article  |  2017  |  The Journal of Experimental Medicine

BCL-2: Long and winding path from discovery to therapeutic target

Robyn L Schenk, Andreas Strasser, Grant Dewson

Journal article  |  2017  |  Biochemical and Biophysical Research Communications

TNF-induced chronic inflammation does not affect tumorigenesis driven by p53 loss

Derek Lacey, Andreas Strasser, Philippe Bouillet

Journal article  |  2017  |  Cell Death & Disease

Mutant p53 Enhances the Development and Sustained Growth of MYC-Driven Lymphoma and Exerts a Dominant Negative Effect Preferentially Deregulating Pathways for Metabolism and DNA Repair

Brandon J Aubrey, Ana Janic, Yunshun Chen, Gordon K Smyth, Andrew J Kueh, Stephen Wilcox, Margs S Brennan, Lin Tai, Daniel HD Gray, Charis Teh, Ann Lin, Catherine Chang, Lorraine A O'Reilly, Marco J Herold, Andreas Strasser, Gemma L Kelly

Conference Proceedings  |  2016  |  Blood

RIPK1 inhibits ZBP1-driven necroptosis during development

Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Andreas Strasser, Victoria C Pham, Jennie R Lill, Merone Roose-Girma, Soren Warming, Margaret Solon, Hai Ngu, Joshua D Webster, Vishva M Dixit

Journal article  |  2016  |  Nature

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM

Leona Rohrbeck, Jia-Nan Gong, Erinna F Lee, Andrew J Kueh, Andreas Behren, Lin Tai, Guillaume Lessene, David CS Huang, Walter D Fairlie, Andreas Strasser, Marco J Herold

Journal article  |  2016  |  Cell Death & Differentiation

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, et al.

Journal article  |  2016  |  Nature Communications

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy, Zoltan Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaetane Le Toumelin-Braizat, Maia Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Marton C Sekei, Attila Paczal, Zoltan B Szabo, Szabolcs Sipos, Gabor Radics, Agnes Proszenyak, Balazs Balint, Levente Ondi, Gabor Blasko, et al.

Journal article  |  2016  |  Nature

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser

Journal article  |  2016  |  Immunity

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

Alex RD Delbridge, Swee Heng Milon Pang, Cassandra J Vandenberg, Stephanie Grabow, Brandon J Aubrey, Lin Tai, Marco J Herold, Andreas Strasser

Journal article  |  2016  |  The Journal of Experimental Medicine

Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1)

Alex RD Delbridge, Stephane Chappaz, Matthew E Ritchie, Benjamin T Kile, Andreas Strasser, Stephanie Grabow

Journal article  |  2016  |  British Journal of Haematology

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL

Ingela B Vikstrom, Anne Slomp, Emma M Carrington, Laura M Moesbergen, Catherine Chang, Gemma L Kelly, Stefan P Glaser, JH Marco Jansen, Jeanette HW Leusen, Andreas Strasser, David CS Huang, Andrew M Lew, Victor Peperzak, David M Tarlinton

Journal article  |  2016  |  Cell Death & Disease

NF kappa B1 suppresses intestinal-type gastric cancer development by preventing chronic inflammation in the stomach

LA O'Reilly, TP Putoczki, L Mielke, A Lin, A Preaudet, JT Low, MJ Herold, L Tai, R Ferrero, Y Hu, R Grumont, G Smyth, M Ernst, P Waring, S Gerondakis, A Strasser

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells

Z Xu, PP Sharp, Y Yao, D Segal, CH Ang, SL Khaw, BJ Aubrey, J Gong, GL Kelly, MJ Herold, A Strasser, AW Roberts, WS Alexander, CJ Burns, DCS Huang, SP Glaser

Journal article  |  2016  |  Leukemia

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance

S Spinner, G Crispatzu, J-H Yi, E Munkhbaatar, P Mayer, U Hoeckendorf, N Mueller, Z Li, T Schader, H Bendz, S Hartmann, M Yabal, K Pechloff, M Heikenwalder, GL Kelly, A Strasser, C Peschel, M-L Hansmann, J Ruland, U Keller, et al.

Journal article  |  2016  |  Leukemia

Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection

Camilla Margaroli, Susanne Oberle, Christine Lavanchy, Stefanie Scherer, Muriel Rosa, Andreas Strasser, Marc Pellegrini, Dietmar Zehn, Hans Acha-Orbea, Driss Ehirchiou

Journal article  |  2016  |  European Journal of Immunology

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

AA Guirguis, CI Slape, LM Failla, J Saw, CS Tremblay, DR Powell, F Rossello, A Wei, A Strasser, DJ Curtis

Journal article  |  2016  |  Cell Death & Differentiation

Tumor-Suppressor Functions of the TP53 Pathway

Brandon J Aubrey, Andreas Strasser, Gemma L Kelly

Journal article  |  2016  |  Cold Spring Harbor Perspectives in Medicine

BCL2-modifying factor promotes germ cell loss during murine oogenesis

Kavitha Vaithiyanathan, Seng H Liew, Nadeen Zerafa, Thilini Gamage, Michele Cook, Lorraine A O'Reilly, Philippe Bouillet, Clare L Scott, Andreas Strasser, Jock K Findlay, Karla J Hutt

Journal article  |  2016  |  Reproduction

NF kappa B1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

Elisha de Valle, George Grigoriadis, Lorraine A O'Reilly, Simon N Willis, Mhairi J Maxwell, Lynn M Corcoran, Evelyn Tsantikos, Jasper KS Cornish, Kirsten A Fairfax, Ajithkumar Vasanthakumar, Mark A Febbraio, Margaret L Hibbs, Marc Pellegrini, Ashish Banerjee, Philip D Hodgkin, Axel Kallies, Fabienne Mackay, Andreas Strasser, Steve Gerondakis, Raffi Gugasyan

Journal article  |  2016  |  The Journal of Experimental Medicine

p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.

Sara A Litwak, Kim Loh, William J Stanley, Evan G Pappas, Jibran A Wali, Claudia Selck, Andreas Strasser, Helen E Thomas, Esteban N Gurzov

Journal article  |  2016  |  Scientific Reports

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

Stephanie Grabow, Alex RD Delbridge, Brandon J Aubrey, Cassandra J Vandenberg, Andreas Strasser

Journal article  |  2016  |  Cell Reports

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

S Grabow, GL Kelly, ARD Delbridge, PN Kelly, P Bouillet, JM Adams, A Strasser

Journal article  |  2016  |  Cell Death & Disease

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David CS Huang, Lyubomir T Vassilev, Andreas Strasser

Journal article  |  2016  |  Cell Reports

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

Mary Speir, Kate E Lawlor, Stefan P Glaser, Gilu Abraham, Seong Chow, Adam Vogrin, Keith E Schulze, Ralf Schuelein, Lorraine A O'Reilly, Kylie Mason, Elizabeth L Hartland, Trevor Lithgow, Andreas Strasser, Guillaume Lessene, David CS Huang, James E Vince, Thomas Naderer

Journal article  |  2016  |  Nature Microbiology

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

David M Wong, Lingli Li, Sabine Jurado, Ashleigh King, Rebecca Bamford, Meaghan Wall, Mannu K Walia, Gemma L Kelly, Carl R Walkley, David M Tarlinton, Andreas Strasser, Joerg Heierhorst

Journal article  |  2016  |  Cell Reports

Is BOK required for apoptosis induced by endoplasmic reticulum stress?

Yuniel Fernandez-Marrero, Francine Ke, Nohemy Echeverry, Philippe Bouillet, Daniel Bachmann, Andreas Strasser, Thomas Kaufmann

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma

MJ Carter, KL Cox, SJ Blakemore, YD Bogdanov, L Happo, CL Scott, A Strasser, GK Packham, MS Cragg

Journal article  |  2016  |  Cell Death & Differentiation

Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

Alex RD Delbridge, Stephanie Grabow, Andreas Strasser, David L Vaux

Journal article  |  2016  |  Nature Reviews Cancer

Control of Cell Survival and Apoptosis

Daniel Gray, Andreas Strasser

Book Chapter  |  2016

Impact of loss of NF-kappa B1, NF-kappa B2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr)/(lpr) mutant mice

JT Low, P Hughes, A Lin, U Siebenlist, R Jain, K Yaprianto, DHD Gray, S Gerondakis, A Strasser, LA O'Reilly

Journal article  |  2016  |  Immunology and Cell Biology

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK

F Ke, S Grabow, GL Kelly, A Lin, LA O'Reilly, A Strasser

Journal article  |  2015  |  Cell Death & Disease

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N Gurzov, Thomas C Brodnicki, Kate L Graham, Jibran A Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E Thomas, Thomas WH Kay

Journal article  |  2015  |  Diabetes

The BCL-2 protein family, BH3-mimetics and cancer therapy

ARD Delbridge, A Strasser

Journal article  |  2015  |  Cell Death & Differentiation

Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2

D Merino, SA Best, M-L Asselin-Labat, F Vaillant, B Pal, RA Dickins, RL Anderson, A Strasser, P Bouillet, GJ Lindeman, JE Visvader

Journal article  |  2015  |  Oncogene

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress

Alex RD Delbridge, Joseph T Opferman, Stephanie Grabow, Andreas Strasser

Journal article  |  2015  |  Blood

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production

Danyal Butt, Tyani D Chan, Katherine Bourne, Jana R Hermes, Akira Nguyen, Aaron Statham, Lorraine A O'Reilly, Andreas Strasser, Susan Price, Peter Schofield, Daniel Christ, Antony Basten, Cindy S Ma, Stuart G Tangye, Giang Phan Tri, V Koneti Rao, Robert Brink

Journal article  |  2015  |  Immunity

Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis

ARD Delbridge, S Grabow, P Bouillet, JM Adams, A Strasser

Journal article  |  2015  |  Oncogene

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

Nai Yang Fu, Anne C Rios, Bhupinder Pal, Rina Soetanto, Aaron TL Lun, Kevin Liu, Tamara Beck, Sarah A Best, Francois Vaillant, Philippe Bouillet, Andreas Strasser, Thomas Preiss, Gordon K Smyth, Rey J Lindeman, Jane E Visvader

Journal article  |  2015  |  Nature Cell Biology

Loss of c-REL but not NF-kappa B2 prevents autoimmune disease driven by FasL mutation

LA O'Reilly, P Hughes, A Lin, P Waring, U Siebenlist, R Jain, DHD Gray, S Gerondakis, A Strasser

Journal article  |  2015  |  Cell Death & Differentiation

BCL-2 is dispensable for thrombopoiesis and platelet survival

MA Debrincat, I Pleines, M Lebois, RM Lane, ML Holmes, J Corbin, CJ Vandenberg, WS Alexander, AP Ng, A Strasser, P Bouillet, M Sola-Visner, BT Kile, EC Josefsson

Journal article  |  2015  |  Cell Death & Disease

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Emma M Carrington, Jian-Guo Zhang, Robyn M Sutherland, Ingela B Vikstrom, Jamie L Brady, Priscilla Soo, David Vremec, Cody Allison, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet, Stephanie Grabow, Eleonora Ottina, Marco J Herold, Marc Pellegrini, David CS Huang, David M Tarlinton, Andreas Strasser, Andrew M Lew, Yifan Zhan

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

Bilal N Sheikh, Stanley CW Lee, Farrah El-Saafin, Hannah K Vanyai, Yifang Hu, Swee Heng Milon Pang, Stephanie Grabow, Andreas Strasser, Stephen L Nutt, Warren S Alexander, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2015  |  Blood

An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

Brandon J Aubrey, Gemma L Kelly, Andrew J Kueh, Margs S Brennan, Liam O'Connor, Liz Milla, Stephen Wilcox, Lin Tai, Andreas Strasser, Marco J Herold

Journal article  |  2015  |  Cell Reports

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-alpha Production

Yifan Zhan, Emma M Carrington, Hyun-Ja Ko, Ingela B Vikstrom, Shereen Oon, Jian-Guo Zhang, David Vremec, Jamie L Brady, Philippe Bouillet, Li Wu, David CS Huang, Ian P Wicks, Eric F Morand, Andreas Strasser, Andrew M Lew

Journal article  |  2015  |  Arthritis & Rheumatology

Maintaining dendritic cell viability in culture

David Vremec, Jacinta Hansen, Andreas Strasser, Hans Acha-Orbea, Yifan Zhan, Meredith O'Keeffe, Ken Shortman

Journal article  |  2015  |  Molecular Immunology

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes

Yuxing Zhao, Nicholas A Scott, Stacey Fynch, Lorraine Elkerbout, W Wei-Lynn Wong, Kylie D Mason, Andreas Strasser, David C Huang, Thomas WH Kay, Helen E Thomas

Journal article  |  2015  |  Diabetologia

MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice

Stephanie Grabow, Alex RD Delbridge, Liz J Valente, Andreas Strasser

Journal article  |  2014  |  Blood

Characterisation of a novel A1-specific monoclonal antibody

MJ Lang, MS Brennan, LA O'Reilly, E Ottina, PE Czabotar, E Whitlock, WD Fairlie, L Tai, A Strasser, MJ Herold

Journal article  |  2014  |  Cell Death & Disease

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice

L Gangoda, M Doerflinger, R Srivastava, N Narayan, LE Edgington, J Orian, C Hawkins, LA O'Reilly, H Gu, M Bogyo, P Ekert, A Strasser, H Puthalakath

Journal article  |  2014  |  Cell Death & Differentiation

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3

MN Koenig, E Naik, L Rohrbeck, MJ Herold, E Trounson, P Bouillet, T Thomas, AK Voss, A Strasser, L Coultas

Journal article  |  2014  |  Cell Death & Differentiation

THE PHYSIOLOGICAL RELEVANCE OF DEATH RECEPTOR-MEDIATED APOPTOSIS

Andreas Strasser

Journal article  |  2014  |  Nature Reviews Molecular Cell Biology

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

MJ Herold, R Stuchbery, D Merino, T Willson, A Strasser, D Hildeman, P Bouillet

Journal article  |  2014  |  Cell Death & Disease

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi-Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O'Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, James E Vince

Journal article  |  2014  |  EMBO reports

Plasmacytomagenesis in E mu-v-abl transgenic mice is accelerated when apoptosis is restrained

Cassandra J Vandenberg, Paul Waring, Andreas Strasser, Suzanne Cory

Journal article  |  2014  |  Blood

PUMA regulates germ cell loss and primordial follicle endowment in mice

Michelle Myers, F Hamish Morgan, Seng H Liew, Nadeen Zerafa, Thilini Upeksha Gamage, Mai Sarraj, Michele Cook, Ileana Kapic, Antony Sutherland, Clare L Scott, Andreas Strasser, Jock K Findlay, Jeffrey B Kerr, Karla J Hutt

Journal article  |  2014  |  Reproduction

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

Priyanka Sathe, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Cyril Seillet, Michael Chopin, Cassandra J Vandenberg, Lucille C Rankin, Lisa A Mielke, Ingela Vikstrom, Tatiana B Kolesnik, Sandra E Nicholson, Eric Vivier, Mark J Smyth, Stephen L Nutt, Stefan P Glaser, Andreas Strasser, Gabrielle T Belz, Sebastian Carotta, Nicholas D Huntington

Journal article  |  2014  |  Nature Communications

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA

MJ Herold, LA O'Reilly, A Lin, R Srivastava, M Doerflinger, P Bouillet, A Strasser, H Puthalakath

Journal article  |  2014  |  Cell Death & Disease

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

Monica Yabal, Nicole Mueller, Heiko Adler, Nathalie Knies, Christina J Gross, Rune Busk Damgaard, Hirokazu Kanegane, Marc Ringelhan, Thomas Kaufmann, Mathias Heikenwaelder, Andreas Strasser, Olaf Gross, Juergen Ruland, Christian Peschel, Mads Gyrd-Hansen, Philipp J Jost

Journal article  |  2014  |  Cell Reports

Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf

Verena Labi, Claudia Woess, Selma Tuzlak, Miriam Erlacher, Philippe Bouillet, Andreas Strasser, Alexandar Tzankov, Andreas Villunger

Journal article  |  2014  |  Blood

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner

W Wei-Lynn Wong, James E Vince, Najoua Lalaoui, Kate E Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O'Reilly, Philipp J Jost, James M Murphy, Warren S Alexander, Andreas Strasser, David L Vaux, John Silke

Journal article  |  2014  |  Blood

Loss of the Proapoptotic BH3-Only Protein BCL-2 Modifying Factor Prolongs the Fertile Life Span in Female Mice1

Seng H Liew, Kavitha Vaithiyanathan, Michele Cook, Philippe Bouillet, Clare L Scott, JB Kerr, Andreas Strasser, Jock K Findlay, Karla J Hutt

Journal article  |  2014  |  Biology of Reproduction

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

Shoukat Afshar-Sterle, Dimitra Zotos, Nicholas J Bernard, Anna K Scherger, Lisa Roedling, Amber E Alsop, Jennifer Walker, Frederick Masson, Gabrielle T Belz, Lynn M Corcoran, Lorraine A O'Reilly, Andreas Strasser, Mark J Smyth, Ricky Johnstone, David M Tarlinton, Stephen L Nutt, Axel Kallies

Journal article  |  2014  |  Nature Medicine

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

Emma C Josefsson, Deborah L Burnett, Marion Lebois, Marlyse A Debrincat, Michael J White, Katya J Henley, Rachael M Lane, Diane Moujalled, Simon P Preston, Lorraine A O'Reilly, Marc Pellegrini, Donald Metcalf, Andreas Strasser, Benjamin T Kile

Journal article  |  2014  |  Nature Communications

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

JA Wali, D Rondas, MD McKenzie, Y Zhao, L Elkerbout, S Fynch, EN Gurzov, S Akira, C Mathieu, TWH Kay, L Overbergh, A Strasser, HE Thomas

Journal article  |  2014  |  Cell Death & Disease

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis

JJ Sandow, L Dorstyn, LA O'Reilly, M Tailler, S Kumar, A Strasser, PG Ekert

Journal article  |  2014  |  Cell Death & Differentiation

Is SIRT2 required for necroptosis?

Kim Newton, Joanne M Hildebrand, Zhirong Shen, Diego Rodriguez, Silvia Alvarez-Diaz, Sean Petersen, Saumil Shah, Debra L Dugger, Chunzi Huang, Johan Auwerx, Peter Vandenabeele, Douglas R Green, Avi Ashkenazi, Vishva M Dixit, William J Kaiser, Andreas Strasser, Alexei Degterev, John Silke

Journal article  |  2014  |  Nature

It's not over until the FAT lady sings

Marco J Herold, Andreas Strasser

Journal article  |  2014  |  EMBO Journal

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis

Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Megumi Takiguchi, Andreas Strasser, Philippe Bouillet, Jerry M Adams, David CS Huang

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

Gemma L Kelly, Stephanie Grabow, Stefan P Glaser, Leah Fitzsimmons, Brandon J Aubrey, Toru Okamoto, Liz J Valente, Mikara Robati, Lin Tai, W Douglas Fairlie, Erinna F Lee, Mikael S Lindstrom, Klas G Wiman, David CS Huang, Philippe Bouillet, Martin Rowe, Alan B Rickinson, Marco J Herold, Andreas Strasser

Journal article  |  2014  |  Genes & Development

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Peter E Czabotar, Guillaume Lessene, Andreas Strasser, Jerry M Adams

Journal article  |  2014  |  Nature Reviews Molecular Cell Biology

Stimulating p53 down-under: a report from the 1st Australian p53 Workshop

PM Neilsen, AW Braithwaite, C Gamell, S Haupt, A Janic, A Strasser, K Wolyniec, Y Haupt

Journal article  |  2013  |  Cell Death & Differentiation

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

Marco J Herold, Leona Rohrbeck, Mathias J Lang, Raelene Grumont, Steve Gerondakis, Lin Tai, Philippe Bouillet, Thomas Kaufmann, Andreas Strasser

Journal article  |  2013  |  EMBO Reports

MCl-1 is critically required for T-lymphocyte non-Hodgkin lymphoma cell survival

S Spinner, G Kelly, M Herold, K Pechloff, G Crispatzu, A Strasser, J Ruland, M Herling, C Peschel, P Jost

Conference Proceedings  |  2013  |  ONKOLOGIE

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, et al.

Journal article  |  2013  |  Immunity

The TACI Receptor Regulates T-Cell-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death

William A Figgett, Kirsten Fairfax, Fabien B Vincent, Melanie A Le Page, Indzi Katik, Devy Deliyanti, Shie Quah Pin, Pali Verma, Raelene Grumont, Steve Gerondakis, Paul Hertzog, Lorraine A O'Reilly, Andreas Strasser, Fabienne Mackay

Journal article  |  2013  |  Immunity

A type III effector antagonizes death receptor signalling during bacterial gut infection

Jaclyn S Pearson, Cristina Giogha, Sze Ying Ong, Catherine L Kennedy, Michelle Kelly, Keith S Robinson, Tania Wong Fok Lung, Ashley Mansell, Patrice Riedmaier, Clare VL Oates, Ali Zaid, Sabrina Muehlen, Valerie F Crepin, Olivier Marches, Ching-Seng Ang, Nicholas A Williamson, Lorraine A O'Reilly, Aleksandra Bankovacki, Ueli Nachbur, Giuseppe Infusini, et al.

Journal article  |  2013  |  Nature

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3( ) regulatory T cells

Wim Pierson, Benedicte Cauwe, Antonia Policheni, Susan M Schlenner, Dean Franckaert, Julien Berges, Stephanie Humblet-Baron, Susann Schonefeldt, Marco J Herold, David Hildeman, Andreas Strasser, Philippe Bouillet, Li-Fan Lu, Patrick Matthys, Antonio A Freitas, Rita J Luther, Casey T Weaver, James Dooley, Daniel HD Gray, Adrian Liston

Journal article  |  2013  |  Nature Immunology

How to best preserve oocytes in female cancer patients exposed to DNA damage inducing therapeutics

K Hutt, JB Kerr, CL Scott, JK Findlay, A Strasser

Journal article  |  2013  |  Cell Death & Differentiation

Consequences of the combined loss of BOK and BAK or BOK and BAX

F Ke, P Bouillet, T Kaufmann, A Strasser, J Kerr, AK Voss

Journal article  |  2013  |  Cell Death & Disease

Intracellular localization of the BCL-2 family member BOK and functional implications

N Echeverry, D Bachmann, F Ke, A Strasser, HU Simon, T Kaufmann

Journal article  |  2013  |  Cell Death & Differentiation

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Liz J Valente, Daniel HD Gray, Ewa M Michalak, Josefina Pinon-Hofbauer, Alex Egle, Clare L Scott, Ana Janic, Andreas Strasser

Journal article  |  2013  |  Cell Reports

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness

Alessandro Terrinoni, Valeria Serra, Ernesto Bruno, Andreas Strasser, Elizabeth Valente, Elsa R Flores, Hans van Bokhoven, Xin Lu, Richard A Knight, Gerry Melino

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Paul Koenen, Susanne Heinzel, Emma M Carrington, Lina Happo, Warren S Alexander, Jian-Guo Zhang, Marco J Herold, Clare L Scott, Andrew M Lew, Andreas Strasser, Philip D Hodgkin

Journal article  |  2013  |  Nature Communications

Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering Fc gamma RIIb expression and monocyte homeostasis

Kate E Lawlor, Annemarie van Nieuwenhuijze, Karen L Parker, Sarah F Drake, Ian K Campbell, Scott D Smith, James E Vince, Andreas Strasser, Ian P Wicks

Journal article  |  2013  |  Journal of Leukocyte Biology

Mcl-1 is essential for the survival of plasma cells

Victor Peperzak, Ingela Vikstroem, Jennifer Walker, Stefan P Glaser, Melanie LePage, Christine M Coquery, Loren D Erickson, Kirsten Fairfax, Fabienne Mackay, Andreas Strasser, Stephen L Nutt, David M Tarlinton

Journal article  |  2013  |  Nature Immunology

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

Kylie D Mason, Ann Lin, Lorraine Robb, Emma C Josefsson, Katya J Henley, Daniel HD Gray, Benjamin T Kile, Andrew W Roberts, Andreas Strasser, David CS Huang, Paul Waring, Lorraine A O'Reilly

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

The FLIP Side of Life

John Silke, Andreas Strasser

Journal article  |  2013  |  Science Signaling

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice (vol 19, pg 915, 2012)

F Ke, A Voss, JB Kerr, LA O'Reilly, L Tai, N Echeverry, P Bouillet, A Strasser, T Kaufmann

Journal article  |  2013  |  Cell Death & Differentiation

Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice

PN Kelly, S Grabow, ARD Delbridge, JM Adams, A Strasser

Journal article  |  2013  |  Cell Death & Differentiation

Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection

KJ Campbell, DHD Gray, N Anstee, A Strasser, S Cory

Journal article  |  2012  |  Cell Death & Differentiation

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

Jeffrey B Kerr, Karla J Hutt, Ewa M Michalak, Michele Cook, Cassandra J Vandenberg, Seng H Liew, Philippe Bouillet, Alea Mills, Clare L Scott, Jock K Findlay, Andreas Strasser

Journal article  |  2012  |  Molecular Cell

The Role of the Apoptotic Machinery in Tumor Suppression

Alex RD Delbridge, Liz J Valente, Andreas Strasser

Journal article  |  2012  |  Cold Spring Harbor Perspectives in Biology

Bcl-2 family member Bcl-G is not a proapoptotic protein

M Giam, T Okamoto, JD Mintern, A Strasser, P Bouillet

Journal article  |  2012  |  Cell Death & Disease

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

LM Lindqvist, I Vikstroem, JM Chambers, K McArthur, M Ann Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DCS Huang

Journal article  |  2012  |  Cell Death & Disease

The role of the anti-apoptotic Bcl-2 proteins Bcl-x(L) and Mcl-1 in survival of T-cell Non-Hodgkin's lymphoma

PJ Jost, S Spinner, G Kelly, M Herold, M Yabal, A Strasser, C Peschel

Conference Proceedings  |  2012  |  ONKOLOGIE

The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens

Daniel HD Gray, Fiona Kupresanin, Stuart P Berzins, Marco J Herold, Lorraine A O'Reilly, Philippe Bouillet, Andreas Strasser

Journal article  |  2012  |  Immunity

Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

Christopher I Slape, Jesslyn Saw, Jeremy BM Jowett, Peter D Aplan, Andreas Strasser, Stephen M Jane, David J Curtis

Journal article  |  2012  |  Blood

The roles of Fas death receptor signalling and NF-kB transcription factors in autoimmune disease

LA O'Reilly, A Lin, D Gray, S Gerondakis, A Strasser

Conference Proceedings  |  2012  |  IMMUNOLOGY

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim

Sabine Jurado, Kimberly Gleeson, Kristy O'Donnell, David J Izon, Carl R Walkley, Andreas Strasser, David M Tarlinton, Joerg Heierhorst

Journal article  |  2012  |  Journal of Experimental Medicine

Is BID required for NOD signalling?

Ueli Nachbur, James E Vince, Lorraine A O'Reilly, Andreas Strasser, John Silke

Journal article  |  2012  |  Nature

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

Jeffrey B Kerr, Karla J Hutt, Michele Cook, Terence P Speed, Andreas Strasser, Jock K Findlay, Clare L Scott

Journal article  |  2012  |  Nature Medicine

Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies

M Giam, JD Mintern, GJP Rautureau, MG Hinds, A Strasser, P Bouillet

Journal article  |  2012  |  Cell Death & Disease

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

Kamil Wolyniec, Jake Shortt, Elisa de Stanchina, Yaara Levav-Cohen, Osnat Alsheich-Bartok, Igal Louria-Hayon, Vincent Corneille, Beena Kumar, Simone J Woods, Stephen Opat, Ricky W Johnstone, Clare L Scott, David Segal, Pier Paolo Pandolfi, Stephen Fox, Andreas Strasser, Yong-Hui Jiang, Scott W Lowe, Sue Haupt, Ygal Haupt

Journal article  |  2012  |  Blood

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression

D Merino, A Strasser, P Bouillet

Journal article  |  2012  |  Oncogene

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

Rune Busk Damgaard, Ueli Nachbur, Monica Yabal, Wendy Wei-Lynn Wong, Berthe Katrine Fiil, Mischa Kastirr, Eva Rieser, James Arthur Rickard, Aleksandra Bankovacki, Christian Peschel, Juergen Ruland, Simon Bekker-Jensen, Niels Mailand, Thomas Kaufmann, Andreas Strasser, Henning Walczak, John Silke, Philipp J Jost, Mads Gyrd-Hansen

Journal article  |  2012  |  Molecular Cell

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

F Ke, A Voss, JB Kerr, LA O'Reilly, L Tai, N Echeverry, P Bouillet, A Strasser, T Kaufmann

Journal article  |  2012  |  Cell Death & Differentiation

Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo

C Clybouw, D Merino, T Nebl, F Masson, M Robati, L O'Reilly, A Huebner, RJ Davis, A Strasser, P Bouillet

Journal article  |  2012  |  Cell Death & Differentiation

Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs

L Happo, B Phipson, GK Smyth, A Strasser, CL Scott

Journal article  |  2012  |  Cell Death & Disease

The primordial follicle reserve is not renewed after chemical or gamma-irradiation mediated depletion

JB Kerr, L Brogan, M Myers, KJ Hutt, T Mladenovska, S Ricardo, K Hamza, CL Scott, A Strasser, JK Findlay

Journal article  |  2012  |  REPRODUCTION

Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice

S Grabow, P Waring, L Happo, M Cook, KD Mason, PN Kelly, A Strasser

Journal article  |  2012  |  Cell Death & Differentiation

BH3-only proteins in apoptosis at a glance

Lina Happo, Andreas Strasser, Suzanne Cory

Journal article  |  2012  |  Journal of Cell Science

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

The NF-kappa B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

Raffi Gugasyan, Elisha Horat, Sarah A Kinkel, Fiona Ross, George Grigoriadis, Daniel Gray, Meredith O'Keeffe, Stuart P Berzins, Gabrielle T Belz, Raelene J Grumont, Ashish Banerjee, Andreas Strasser, Dale I Godfrey, Philip N Tsichlis, Steve Gerondakis

Journal article  |  2012  |  EMBO Journal

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

Stefan P Glaser, Erinna F Lee, Evelyn Trounson, Philippe Bouillet, Andrew Wei, W Douglas Fairlie, David J Izon, Johannes Zuber, Amy R Rappaport, Marco J Herold, Warren S Alexander, Scott W Lowe, Lorraine Robb, Andreas Strasser

Journal article  |  2012  |  Genes & Development

Fas death receptor signalling: roles of Bid and XIAP

T Kaufmann, A Strasser, PJ Jost

Journal article  |  2012  |  Cell Death & Differentiation

Death receptor-induced apoptosis signalling - essential guardian against autoimmune disease

Andreas Strasser, Lorraine A O'Reilly, Philipp Jost, Thomas Kaufmann, Stephanie Grabow, Elizabeth Kruse, Lin Tai, Mark Smyth, Philippe Bouillet

Conference Proceedings  |  2012  |  ARTHRITIS RESEARCH & THERAPY

Targeting BCL-2–expressing basal-like breast cancer with BH3-mimetics.

SR Oakes, F Vaillant, E Lim, L Lee, K Breslin, F Feleppa, S Deb, ME Ritchie, E Takano, T Ward, SB Fox, D Generali, GK Smyth, A Strasser, DCS Huang, JE Visvader, GJ Lindeman

Journal article  |  2012  |  Hereditary Cancer in Clinical Practice

Endogenous Bcl-x(L) is essential for Myc-driven lymphomagenesis in mice

Priscilla N Kelly, Stephanie Grabow, Alex RD Delbridge, Andreas Strasser, Jerry M Adams

Journal article  |  2011  |  Blood

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim(-/-) mice

Toshiyuki Bohgaki, Julien Mozo, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Miyuki Bohgaki, Otto Sanchez, Andreas Strasser, Anne Hakem, Razqallah Hakem

Journal article  |  2011  |  J. Cell Biol.

Regulation of memory B-cell survival by the BH3-only protein Puma

Cyril Clybouw, Silke Fischer, Marie Therese Auffredou, Patricia Hugues, Catherine Alexia, Philippe Bouillet, Martine Raphael, Gerald Leca, Andreas Strasser, David M Tarlinton, Aime Vazquez

Journal article  |  2011  |  Blood

A decade of molecular cell biology: achievements and challenges

Asifa Akhtar, Elaine Fuchs, Tim Mitchison, Reuben J Shaw, Daniel St Johnston, Andreas Strasser, Susan Taylor, Claire Walczak, Marino Zerial

Journal article  |  2011  |  Nat. Rev. Mol. Cell Biol.

Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?

A Villunger, V Labi, P Bouillet, J Adams, A Strasser

Journal article  |  2011  |  Cell Death Differ.

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

Andreas Strasser, Suzanne Cory, Jerry M Adams

Journal article  |  2011  |  EMBO Journal

Inhibition of NOD2 signalling by mutations in the RING domain of XIAP contribute to development of X-linked lymphoproliferative syndrome

M Yabal, RB Damgaard, U Nachbur, J Ruland, C Peschel, A Strasser, J Silke, M Gyrd-Hansen, PJ Jost

Conference Proceedings  |  2011  |  ONKOLOGIE

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

PN Kelly, A Strasser

Journal article  |  2011  |  Cell Death & Differentiation

Defects in the Bcl-2-Regulated Apoptotic Pathway Lead to Preferential Increase of CD25(low)Foxp3( ) Anergic CD4( ) T Cells

Yifan Zhan, Yuxia Zhang, Daniel Gray, Emma M Carrington, Philippe Bouillet, Hyun-Ja Ko, Lorraine O'Reilly, Ian P Wicks, Andreas Strasser, Andrew M Lew

Journal article  |  2011  |  Journal of Immunology

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1

Ben A Croker, Joanne A O'Donnell, Cameron J Nowell, Donald Metcalf, Grant Dewson, Kirsteen J Campbell, Kelly L Rogers, Yifang Hu, Gordon K Smyth, Jian-Guo Zhang, Michael White, Kurt Lackovic, Louise H Cengia, Lorraine A O'Reilly, Philippe Bouillet, Suzanne Cory, Andreas Strasser, Andrew W Roberts

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse

Zia UA Mollah, Jibran Wali, Mark D McKenzie, Balasubramanian Krishnamurthy, Kate L Graham, Stacey Fynch, Joshua Szanyi, Pere Santamaria, Thomas Brodnicki, Janette Allison, Andreas Strasser, Thomas WH Kay, Helen E Thomas

Journal article  |  2011  |  Apoptosis

Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells

Edwina Naik, Lorraine A O'Reilly, Marie-Liesse Asselin-Labat, Delphine Merino, Ann Lin, Michele Cook, Leigh Coultas, Philippe Bouillet, Jerry M Adams, Andreas Strasser

Journal article  |  2011  |  Journal of Experimental Medicine

Type I Interferon Drives Dendritic Cell Apoptosis via Multiple BH3-Only Proteins following Activation by PolyIC In Vivo

Silvia A Fuertes Marraco, Clare L Scott, Philippe Bouillet, Annette Ives, Slavica Masina, David Vremec, Elisa S Jansen, Lorraine A O'Reilly, Pascal Schneider, Nicolas Fasel, Ken Shortman, Andreas Strasser, Hans Acha-Orbea

Journal article  |  2011  |  PLoS One

Jurg Tschopp 1951-2011 OBITUARY

Ralph C Budd, Pascal Schneider, Fabienne Mackay, Andreas Strasser

Journal article  |  2011  |  Nature Immunology

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes

Erinna F Lee, Oliver B Clarke, Marco Evangelista, Zhiping Feng, Terence P Speed, Elissaveta B Tchoubrieva, Andreas Strasser, Bernd H Kalinna, Peter M Colman, W Douglas Fairlie

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

Bid and Bim Collaborate during Induction of T Cell Death in Persistent Infection

Frederick Masson, Fiona Kupresanin, Adele Mount, Andreas Strasser, Gabrielle T Belz

Journal article  |  2011  |  JOURNAL OF IMMUNOLOGY

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

Diane Moujalled, Ross Weston, Holly Anderton, Robert Ninnis, Pranay Goel, Andrew Coley, David CS Huang, Li Wu, Andreas Strasser, Hamsa Puthalakath

Journal article  |  2011  |  EMBO Rep.

The Essential Role of Evasion from Cell Death in Cancer

Gemma L Kelly, Andreas Strasser

Book Chapter  |  2011  |  Advances in Cancer Research

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Lina Happo, Mark S Cragg, Belinda Phipson, Jon M Haga, Elisa S Jansen, Marco J Herold, Grant Dewson, Ewa M Michalak, Cassandra J Vandenberg, Gordon K Smyth, Andreas Strasser, Suzanne Cory, Clare L Scott

Journal article  |  2010  |  Blood

Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory

Ingela Vikstrom, Sebastian Carotta, Katja Luethje, Victor Peperzak, Philipp J Jost, Stefan Glaser, Meinrad Busslinger, Philippe Bouillet, Andreas Strasser, Stephen L Nutt, David M Tarlinton

Journal article  |  2010  |  Science

Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation

Karen A Fortner, Philippe Bouillet, Andreas Strasser, Ralph C Budd

Journal article  |  2010  |  Eur. J. Immunol.

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

PN Kelly, MJ White, MW Goschnick, KA Fairfax, DM Tarlinton, SA Kinkel, P Bouillet, JM Adams, BT Kile, A Strasser

Journal article  |  2010  |  Cell Death & Differentiation

Anti-cancer SMAC-mimetic compounds accelerate hepatocyte cell death upon FAS or TNF-alpha signalling

PJ Jost, U Nachbur, S Grabow, DC Huang, P Bouillet, J Silke, A Strasser, T Kaufmann

Conference Proceedings  |  2010  |  ONKOLOGIE

CAML regulates Bim-dependent thymocyte death

CE Edgar, LD Lindquist, DL McKean, A Strasser, RJ Bram

Journal article  |  2010  |  Cell Death Differ.

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor

Tobias Engel, Aurelien Caballero-Caballero, Clara K Schindler, Nikolaus Plesnila, Andreas Strasser, Jochen HM Prehn, David C Henshall

Journal article  |  2010  |  Journal of Neurochemistry

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

Ewa M Michalak, Cassandra J Vandenberg, Alex RD Delbridge, Li Wu, Clare L Scott, Jerry M Adams, Andreas Strasser

Journal article  |  2010  |  Genes & Development

Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis

M Karlberg, M Ekoff, V Labi, A Strasser, D Huang, G Nilsson

Journal article  |  2010  |  Cell Death Dis.

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

Caoimhin G Concannon, Liam P Tuffy, Petronela Weisova, Helena P Bonner, David Davila, Caroline Bonner, Marc C Devocelle, Andreas Strasser, Manus W Ward, Jochen HM Prehn

Journal article  |  2010  |  J. Cell Biol.

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus

BM Murphy, T Engel, A Paucard, S Hatazaki, G Mouri, K Tanaka, LP Tuffy, EM Jimenez-Mateos, I Woods, M Dunleavy, HP Bonner, R Meller, RP Simon, A Strasser, JHM Prehn, DC Henshall

Journal article  |  2010  |  Cell Death Differ.

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

Mark D McKenzie, Emma Jamieson, Elisa S Jansen, Clare L Scott, David CS Huang, Philippe Bouillet, Janette Allison, Thomas WH Kay, Andreas Strasser, Helen E Thomas

Journal article  |  2010  |  Diabetes

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

Stephen Malin, Shane McManus, Cesar Cobaleda, Maria Novatchkova, Alessio Delogu, Philippe Bouillet, Andreas Strasser, Meinrad Busslinger

Journal article  |  2010  |  Nature Immunology

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation

Anissa M Jabbour, Carmel P Daunt, Benjamin D Green, Sandra Vogel, Lavinia Gordon, Rachel S Lee, Natasha Silke, Richard B Pearson, Cassandra J Vandenberg, Priscilla N Kelly, Stephen L Nutt, Andreas Strasser, Christoph Borner, Paul G Ekert

Journal article  |  2010  |  Blood

MECHANISMS OF DISEASE Cell Death

Richard S Hotchkiss, Andreas Strasser, Jonathan E McDunn, Paul E Swanson

Journal article  |  2009  |  New England Journal of Medicine

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

Lorraine A O' Reilly, Lin Tai, Lily Lee, Elizabeth A Kruse, Stephanie Grabow, W Douglas Fairlie, Nicole M Haynes, David M Tarlinton, Jian-Guo Zhang, Gabrielle T Belz, Mark J Smyth, Philippe Bouillet, Lorraine Robb, Andreas Strasser

Journal article  |  2009  |  Nature

XIAP discriminates between type I and type II FAS-induced apoptosis

Philipp J Jost, Stephanie Grabow, Daniel Gray, Mark D McKenzie, Ueli Nachbur, David CS Huang, Philippe Bouillet, Helen E Thomas, Christoph Borner, John Silke, Andreas Strasser, Thomas Kaufmann

Journal article  |  2009  |  Nature

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

Delphine Merino, Maybelline Giam, Peter D Hughes, Owen M Siggs, Klaus Heger, Lorraine A O'Reilly, Jerry M Adams, Andreas Strasser, Erinna F Lee, Walter D Fairlie, Philippe Bouillet

Journal article  |  2009  |  Journal of Cell Biology

MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation

Lorraine A O'Reilly, Elizabeth A Kruse, Hamsa Puthalakath, Priscilla N Kelly, Thomas Kaufmann, David CS Huang, Andreas Strasser

Journal article  |  2009  |  Journal of Immunology

The Proapoptotic BH3-Only, Bcl-2 Family Member, Puma Is Critical for Acute Ethanol-Induced Neuronal Apoptosis

Arindam P Ghosh, Ken C Walls, Barbara J Klocke, Rune Toms, Andreas Strasser, Kevin A Roth

Journal article  |  2009  |  J. Neuropathol. Exp. Neurol.

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7

Nicholas D Huntington, Verena Labi, Ana Cumano, Paulo Vieira, Andreas Strasser, Andreas Villunger, James P Di Santo, Nuno L Alves

Journal article  |  2009  |  Int. Immunol.

The molecular signature of CD8( ) T cells undergoing deletional tolerance

Ian A Parish, Sudha Rao, Gordon K Smyth, Torsten Juelich, Gareth S Denyer, Gayle M Davey, Andreas Strasser, William R Heath

Journal article  |  2009  |  Blood

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

Mark S Cragg, Claire Harris, Andreas Strasser, Clare L Scott

Journal article  |  2009  |  Nat. Rev. Cancer

Impaired Lactation in Mice Expressing Dominant-Negative FADD in Mammary Epithelium

Mark Shackleton, Lorraine A O'Reilly, Kate D Sutherland, Mary L Bath, Sarah Ellis, Andreas Strasser, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Developmental Dynamics

The Many Roles of FAS Receptor Signaling in the Immune System

Andreas Strasser, Philipp J Jost, Shigekazu Nagata

Journal article  |  2009  |  Immunity

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNF alpha Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

Thomas Kaufmann, Philipp J Jost, Marc Pellegrini, Hamsa Puthalakath, Raffi Gugasyan, Steve Gerondakis, Erika Cretney, Mark J Smyth, John Silke, Razq Hakem, Philippe Bouillet, Tak W Mak, Vishva M Dixit, Andreas Strasser

Journal article  |  2009  |  Immunity

NF-kappa B1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

Ashish Banerjee, Raelene Grumont, Raffi Gugasyan, Christine White, Andreas Strasser, Steve Gerondakis

Journal article  |  2008  |  Blood

T cell survival and function requires the c-Abl tyrosine kinase

Isabelle Silberman, Ronit Vogt Sionov, Valentina Zuckerman, Sue Haupt, Zehavit Goldberg, Andreas Strasser, Zami S Ben-Sasson, Michal Baniyash, Anthony J Koleske, Ygal Haupt

Journal article  |  2008  |  Cell Cycle

Switch from Type II to I Fas/CD95 Death Signaling on In Vitro Culturing of Primary Hepatocytes

Dorothee Walter, Kathrin Schmich, Sandra Vogel, Robert Pick, Thomas Kaufmann, Florian Christoph Hochmuth, Angelika Haber, Karin Neubert, Sabine McNelly, Fritz von Weizsaecker, Irtugard Merfort, Ulrich MaUrer, Andreas Strasser, Christoph Borner

Journal article  |  2008  |  Hepatology

FADD and the NF-kappa B family member Bcl-3 regulate complementary pathways to control T-cell survival and proliferation

Svetla Rangelova, Susanne Kirschnek, Andreas Strasser, Georg Haecker

Journal article  |  2008  |  Immunology

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

Mark S Cragg, Elisa S Jansen, Michele Cook, Claire Harris, Andreas Strasser, Clare L Scott

Journal article  |  2008  |  J. Clin. Invest.

Loss of BH3-only protein bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in Bcl-x-deficient mice

Rizwan S Akhtar, Barbara J Klocke, Andreas Strasser, Kevin A Roth

Journal article  |  2008  |  J. Histochem. Cytochem.

Intrahepatic murine CD8 T-Cell activation associates with a distinct phenotype leading to Bim-dependent death

Lauren E Holz, Volker Benseler, David G Bowen, Philippe Bouillet, Andreas Strasser, Lorraine O'Reilly, William MH D'Avigdor, Alex G Bishop, Geoffrey W McCaughan, Patrick Bertolino

Journal article  |  2008  |  Gastroenterology

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

EM Michalak, A Villunger, JM Adams, A Strasser

Journal article  |  2008  |  Cell Death Differ.

Is tumor growth sustained by rare cancer stem cells or dominant clones?

Jerry M Adams, Andreas Strasser

Journal article  |  2008  |  Cancer Res.

The Role of the Bcl-2 Protein Family in Tumorigenesis and Cancer Therapy

E Naik, A Strasser

Book Chapter  |  2008

The BH3-only Proteins Puma and Noxa: Two Brothers in Arms

M Erlacher, EM Michalak, A Strasser, A Villunger

Book Chapter  |  2008

Proapoptotic BH3-only protein bid is essential for death receptor-induced apoptosis of pancreatic beta-cells

Mark D McKenzie, Emma M Carrington, Thomas Kaufmann, Andreas Strasser, David CS Huang, Thomas WH Kay, Janette Allison, Helen E Thomas

Journal article  |  2008  |  Diabetes

Double-stranded RNA induces apoptosis in spleen CD8a dendritic cells

S Fuertes Marraco, L O'Reilly, F Grosjean, P Romero, B Salaun, L Otten, A Strasser, H Acha-Orbea

Conference Proceedings  |  2008  |  SWISS MEDICAL WEEKLY

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development

Verena Labi, Miriam Erlacher, Stephan Kiessling, Claudia Manzl, Anna Frenzel, Lorraine O'Reilly, Andreas Strasser, Andreas Villunger

Journal article  |  2008  |  J. Exp. Med.

NFAT but not NF-kappa B is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells

Erik Ulleras, Mats Karlberg, Christine Moller Westerberg, Jessica Alfredsson, Steve Gerondakis, Andreas Strasser, Gunnar Nilsson

Journal article  |  2008  |  Blood

BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection

Silke F Fischer, Gabrielle T Belz, Andreas Strasser

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Fold up or perish: unfolded protein response and chemotherapy

A Strasser, H Puthalakath

Journal article  |  2008  |  Cell Death Differ.

Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

Peter D Hughes, Gabrielle T Belz, Karen A Fortner, Ralph C Budd, Andreas Strasser, Philippe Bouillet

Journal article  |  2008  |  Immunity

ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukaemias with diverse drug-resistance mechanisms

Junya Kuroda, Shinya Kimura, Michael Andreeff, Eishi Ashihara, Yuri Kamitsuji, Asumi Yokota, Eri Kawata, Miki Takeuchi, Ruriko Tanaka, Yoshihide Murotani, Yosuke Matsumoto, Hideo Tanaka, Andreas Strasser, Masafumi Taniwaki, Taira Maekawa

Journal article  |  2008  |  Br. J. Haematol.

Role of "Cancer Stem Cells" and Cell Survival in Tumor Development and Maintenance

JM Adams, PN Kelly, A Dakic, S Carotta, SL Nutt, A Strasser

Journal article  |  2008  |  Cold Spring Harbor Laboratory - Symposia on Quantitative Biology

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain

Andreas Strasser, Hamsa Puthalakath, Lorraine A O'Reilly, Philippe Bouillet

Journal article  |  2008  |  Immunol. Cell Biol.

The BCL-2 protein family: opposing activities that mediate cell death

Richard J Youle, Andreas Strasser

Journal article  |  2008  |  Nat. Rev. Mol. Cell Biol.

Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

Dairin Kieran, Ina Woods, Andreas Villunger, Andreas Strasser, Jochen HM Prehn

Journal article  |  2007  |  Proc. Natl. Acad. Sci. U. S. A.

Response to comment on "tumor growth need not be driven by rare cancer stem cells"

Jerry M Adams, Priscilla N Kelly, Aleksandar Dakic, Stephen L Nutt, Andreas Strasser

Journal article  |  2007  |  Science

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

Silke F Fischer, Philippe Bouillet, Kristy O'Donnell, Amanda Light, David M Tarlinton, Andreas Strasser

Journal article  |  2007  |  Blood

Puma is a dominant regulator of oxidative stress induced bax activation and neuronal apoptosis

Diana Steckley, Meera Karajgikar, Lianne B Dale, Ben Fuerth, Patrick Swan, Chris Drummond-Main, Michael O Poulter, Stephen SG Ferguson, Andreas Strasser, Sean P Cregan

Journal article  |  2007  |  J. Neurosci.

The BH3-only protein Puma plays an essential role in cytokine deprivation-induced apoptosis of mast cells

Maria Ekoff, Thomas Kaufmann, Maria Engstrom, Noboru Motoyama, Andreas Villunger, Jan-Ingvar Jonsson, Andreas Strasser, Gunnar Nilsson

Journal article  |  2007  |  Blood

Haematopoietic cell apoptosis

Andreas Strasser

Journal article  |  2007  |  Current Opinion in Immunology

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

Mark S Cragg, Junya Kuroda, Hamsa Puthalakath, David CS Huang, Andreas Strasser

Journal article  |  2007  |  PLoS Med.

Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia

J Kuroda, S Kimura, A Strasser, M Andreeff, LA O'Reilly, E Ashihara, Y Kamitsuji, A Yokota, E Kawata, M Takeuchi, R Tanaka, Y Tabe, M Taniwaki, T Maekawa

Journal article  |  2007  |  Cell Death Differ.

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

A Olsson, C Manzl, A Strasser, A Villunger

Journal article  |  2007  |  Cell Death Differ.

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Nicholas D Huntington, Hamsa Puthalakath, Priscilla Gunn, Edwina Naik, Ewa M Michalak, Mark J Smyth, Hyacinth Tabarias, Mariapia A Degli-Esposti, Grant Dewson, Simon N Willis, Noboru Motoyama, David CS Huang, Stephen L Nutt, David M Tarlinton, Andreas Strasser

Journal article  |  2007  |  NATURE IMMUNOLOGY

Tumor growth need not be driven by rare cancer stem cells

Priscilla N Kelly, Aleksandar Dakic, Jerry M Adams, Stephen L Nutt, Andreas Strasser

Journal article  |  2007  |  SCIENCE

Response: Does bid play a role in the DNA damage response?

Thomas Kaufmann, Lin Tai, Paul G Ekert, David CS Huang, Fiona Norris, Ralph K Lindemann, Ricky W Johnstone, Vishva M Dixit, Damien Arnoult, Andreas Strasser

Journal article  |  2007  |  Cell

ER stress triggers apoptosis by activating BH3-only protein Bim

Hamsa Puthalakath, Lorraine A O'Reilly, Priscilla Gunn, Lily Lee, Priscilla N Kelly, Nicholas D Huntington, Peter D Hughes, Ewa M Michalak, Jennifer McKimm-Breschkin, Noburo Motoyama, Tomomi Gotoh, Shizuo Akira, Philippe Bouillet, Andreas Strasser

Journal article  |  2007  |  Cell

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis

Leigh Coultas, Susanna Terzano, Tim Thomas, Anne Voss, Kate Reid, Edouard G Stanley, Clare L Scott, Philippe Bouillet, Perry Bartlett, Jonathan Ham, Jerry M Adams, Andreas Strasser

Journal article  |  2007  |  J. Cell Sci.

Endogenous bcl-2 is not required for the development of Eμ-myc-induced B-cell lymphoma

PN Kelly, H Puthalakath, JM Adams, A Strasser

Journal article  |  2007  |  Blood

Endogenous bcl-2 is not required for the development of E mu-myc-induced B-cell lymphoma

Priscilla N Kelly, Hamsa Puthalakath, Jerry M Adams, Andreas Strasser

Journal article  |  2007  |  Blood

Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

Celine Perier, Jordi Bove, Du-Chu Wu, Benjamin Dehay, Dong-Kug Choi, Vernice Jackson-Lewis, Silvia Rathke-Hartlieb, Philippe Bouillet, Andreas Strasser, Joerg B Schulz, Serge Przedborski, Miquel Vila

Journal article  |  2007  |  Proc. Natl. Acad. Sci. U. S. A.

The BH3-only protein bid is dispensable for DNA darnage- and replicative stress-induced apoptosis or cell-cycle arrest

Thomas Kaufmann, Lin Tai, Paul G Ekert, David CS Huang, Fiona Norris, Ralph K Lindemann, Ricky W Johnstone, Vishva M Dixit, Andreas Strasser

Journal article  |  2007  |  Cell

Fc epsilon RI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells

Maria Ekoff, Andreas Strasser, Gunnar Nilsson

Journal article  |  2007  |  JOURNAL OF IMMUNOLOGY

FcεRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells

M Ekoff, A Strasser, G Nilsson

Journal article  |  2007  |  Journal of Immunology

Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction

T Kaufmann, R Gugasyan, S Gerondakis, VM Dixit, A Strasser

Journal article  |  2007  |  Cell Death Differ.

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway

CG Concannon, BF Koehler, Claus Reimertz, BM Murphy, C Bonner, N Thurow, MW Ward, A Villunger, A Strasser, D Koegel, JHM Prehn

Journal article  |  2007  |  Oncogene

Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis

Katherine C Chang, Jacqueline Unsinger, Christopher G Davis, Steven J Schwulst, Jared T Muenzer, Andreas Strasser, Richard S Hotchkiss

Journal article  |  2007  |  FASEB J.

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa

Edwina Naik, Ewa M Michalak, Andreas Villunger, Jerry M Adams, Andreas Strasser

Journal article  |  2007  |  J. Cell Biol.

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Simon N Willis, Jamie I Fletcher, Thomas Kaufmann, Mark F van Delft, Lin Chen, Peter E Czabotar, Helen Ierino, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet, Andreas Strasser, Ruth M Kluck, Jerry M Adams, David CS Huang

Journal article  |  2007  |  Science

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

Arnaud A Mailleux, Michael Overholtzer, Tobias Schmelzle, Philippe Bouillet, Andreas Strasser, Joan S Brugge

Journal article  |  2007  |  Dev. Cell

Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death

Joslyn K Brunelle, Emelyn H Shroff, Harris Perlman, Andreas Strasser, Carlos T Moraes, Richard A Flavell, Nika N Danial, Brian Keith, Craig B Thompson, Navdeep S Chandel

Journal article  |  2007  |  Mol. Cell. Biol.

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

Miriam Erlacher, Verena Labi, Claudia Manzl, Guenther Boeck, Alexandar Tzankov, Georg Haecker, Ewa Michalak, Andreas Strasser, Andreas Villunger

Journal article  |  2006  |  J. Exp. Med.

BH3 mimetic augments the induction of apoptosis by INNO-406, a novel Bcr-Abl/Lyn inhibitor, in Bcr-Abl( ) leukemic cells.

Junya Kuroda, Shinya Kimura, Andreas Strasser, Michael Andreeff, Eishi Ashihara, Yoko Tabe, Masafumi Taniwaki, Taira Maekawa

Conference Proceedings  |  2006  |  Blood

Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia

Joseph Pierce, Jules Rir-Sima-Ah, Isaac Estrada, Julie Wilder, Andreas Strasser, Yohannes Tesfaigzi

Journal article  |  2006  |  Am. J. Physiol. Lung Cell. Mol. Physiol.

Erratum: Bim and Bad mediate imatinib-induced killing of Bcr/Abl leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (Proceedings of the National Academy of Sciences of the United States of America (October 3, 2006) 40, 103 (14907-14912) DOI: 10.1073/pnas.0606176103)

J Kuroda, H Puthalakath, MS Cragg, PN Kelly, P Bouillet, DCS Huang, S Kimura, OG Ottmann, BJ Druker, A Villunger, AW Roberts, A Strasser

Journal article  |  2006  |  Proceedings of the National Academy of Sciences

"Bim and Bad mediate imatinib-induced killing of Bcr/Abl( ) leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic" (vol 103, pg 14907, 2006)

Junya Kuroda, Hamsa Puthalakath, Mark S Cragg, Priscilla N Kelly, Philippe Bouillet, David CS Huang, Shinya Kimura, Oliver G Ottmann, Brian J Druker, Andreas Villunger, Andrew W Roberts, Andreas Strasser

Journal article  |  2006  |  Proc. Natl. Acad. Sci. U. S. A.

Functional characterization of the Bcl-2 gene family in the zebrafish

E Kratz, PM Eimon, K Mukhyala, H Stern, J Zha, A Strasser, R Hart, A Ashkenazi

Journal article  |  2006  |  Cell Death Differ.

The NF-kappa B regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

Anette Bauer, Andreas Villunger, Verena Labi, Silke F Fischer, Andreas Strasser, Hermann Wagner, Roland M Schmid, Georg Haecker

Journal article  |  2006  |  Proc. Natl. Acad. Sci. U. S. A.

Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia

Jayne M Ness, Cary A Harvey, Andreas Strasser, Philippe Bouillet, Barbara J Klocke, Kevin A Roth

Journal article  |  2006  |  Brain Res.

BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death

Rizwan S Akhtar, Ying Geng, Barbara J Klocke, Cecelia B Latham, Andreas Villunger, Ewa M Michalak, Andreas Strasser, Steven L Carroll, Kevin A Roth

Journal article  |  2006  |  J. Neurosci.

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms

P Hughes, M Robati, W Lu, J Zhou, A Strasser, P Bouillet

Journal article  |  2006  |  Cell Death Differ.

Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNF alpha in mice lacking RelA

R Gugasyan, A Christou, LA O'Reilly, A Strasser, S Gerondakis

Journal article  |  2006  |  Cell Death Differ.

The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

T Yano, K Ito, H Fukamachi, XZ Chi, HJ Wee, K Inoue, H Ida, P Bouillet, A Strasser, SC Bae, Y Ito

Journal article  |  2006  |  Mol. Cell. Biol.

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

VS Marsden, T Kaufmann, LA O'Reilly, JM Adams, A Strasser

Journal article  |  2006  |  Blood

CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers

ND Huntington, YK Xu, H Puthalakath, A Light, SN Willis, A Strasser, DM Tarlinton

Journal article  |  2006  |  Nat. Immunol.

Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases.

Peter Hughes, Philippe Bouillet, Andreas Strasser

Journal article  |  2006  |  Current directions in autoimmunity

Apoptosis is essential for the development, function and homeostasis of the immune system. Experiments with transgenic and gene kn..

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo

M Erlacher, EM Michalak, PN Kelly, V Labi, H Niederegger, L Coultas, JM Adams, A Strasser, A Villunger

Journal article  |  2005  |  Blood

Concomitant loss of proapoptotic BH3-only bcl-2 antagonists Bik and Bim arrests spermatogenesis

L Coultas, P Bouillet, KL Loveland, S Meachem, H Perlman, JM Adams, A Strasser

Journal article  |  2005  |  EMBO J.

NKT cell stimulation with glycolipid antigen in vivo

N Crowe, A Uldrich, P Schnorrer, Y Zhan, A Lew, P Bouillet, A Strasser, J Villadangos, M Smyth, D Godfrey

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells

M Ohgushi, S Kuroki, H Fukamachi, LA O'Reilly, K Kuida, A Strasser, S Yonehara

Journal article  |  2005  |  Mol. Cell. Biol.

Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite

HK Wong, M Fricker, A Wyttenbach, A Villunger, EM Michalak, A Strasser, AM Tolkovsky

Journal article  |  2005  |  Mol. Cell. Biol.

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

M Pellegrini, S Bath, VS Marsden, DCS Huang, D Metcalf, AW Harris, A Strasser

Journal article  |  2005  |  Blood

NKT cell stimulation with glycolipid antigen in vivo: Costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge

AP Uldrich, NY Crowe, K Kyparissoudis, DG Pellicci, YF Zhan, AM Lew, P Bouillet, A Strasser, MJ Smyth, DI Godfrey

Journal article  |  2005  |  Journal of Immunology

Polycystic kidney disease prevented by transgenic RNA interference

P Bouillet, M Robati, M Bath, A Strasser

Journal article  |  2005  |  Cell Death Differ.

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

J Hutcheson, JC Scatizzi, E Bickel, NJ Brown, P Bouillet, A Strasser, H Perlman

Journal article  |  2005  |  J. Exp. Med.

Death squads enlisted by the tumour suppressor p53

E Michalak, A Villunger, M Erlacher, A Strasser

Journal article  |  2005  |  Biochem. Biophys. Res. Commun.

Is Apaf-1 expression frequently abrogated in melanoma?

JD Allen, XD Zhang, CL Scott, GM Boyle, P Hersey, A Strasser

Journal article  |  2005  |  Cell Death Differ.

In vitro and in vivo assays for osteoclast apoptosis

T Akiyama, T Miyazaki, P Bouillet, K Nakamura, A Strasser, S Tanaka

Journal article  |  2005  |  Biol. Proc. Online

The role of BH3-only proteins in the immune system

A Strasser

Journal article  |  2005  |  Nat. Rev. Immunol.

Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-X-L upon IgE-receptor activation

J Alfredsson, H Puthalakath, H Martin, A Strasser, G Nilsson

Journal article  |  2005  |  Cell Death Differ.

Are we really on the right TRAIL?

E Cretney, AP Uldrich, SP Berzins, A Strasser, DI Godfrey, MJ Smyth

Journal article  |  2005  |  Immunologic Research

Subversion of the Bcl-2 life/death switch in cancer development and therapy

JM Adams, DCS Huang, A Strasser, S Willis, L Chen, A Wei, M Van Delft, JI Fletcher, H Puthalakath, J Kuroda, EM Michalak, PN Kelly, P Bouillet, A Villunger, L O'Reilly, ML Bath, DP Smith, A Egle, AW Harris, M Hinds, et al.

Journal article  |  2005  |  Cold Spring Harbor Symp. Quant. Biol.

Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim

A Liston, S Lesage, DHD Gray, LA O'Reilly, A Strasser, AM Fahrer, RL Boyd, J Wilson, AG Baxter, EM Gallo, GR Crabtree, KM Peng, SR Wilson, CC Goodnow

Journal article  |  2004  |  Immunity

Nuclear localization of FADD protein.

S Frisch

Journal article  |  2004  |  Cell Death Differ.

Nuclear localisation of FADD - rebuttal

L O'Reilly, S Crawford, DCS Huang, A Strasser

Journal article  |  2004  |  Cell Death & Differentiation

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

M Pellegrini, P Bouillet, M Robati, GT Belz, GM Davey, A Strasser

Journal article  |  2004  |  Journal of Experimental Medicine

Interleukin (IL)-7 receptor (R) signaling is essential for T and B lymphopoiesis by promoting proliferation, differentiation, and ..

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

M Pellegrini, P Bouillet, M Robati, GT Belz, GM Davey, A Strasser

Journal article  |  2004  |  J. Exp. Med.