Andreas Strasser

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis.

Margaret A Potts, Shinsuke Mizutani, Alexandra L Garnham, Connie SN Li Wai Suen, Andrew J Kueh, Lin Tai, Martin Pal, Andreas Strasser, Marco J Herold

Journal article  |  2023  |  Cell Death Differ

Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of t..

Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser

Journal article  |  2023  |  Cell Death Differ

The original version of this article contained a mistake. When preparing the revised version of this paper the authors omitted a n..

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs.

Sarah T Diepstraten, Savannah Young, John E La Marca, Zilu Wang, Ruth M Kluck, Andreas Strasser, Gemma L Kelly

Journal article  |  2023  |  Cell Death Differ

BH3-mimetic drugs are an anti-cancer therapy that can induce apoptosis in malignant cells by directly binding and inhibiting pro-s..

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah TT Diepstraten, Catherine Chang, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver MM Sieber, Jane Visvader, Gemma LL Kelly, Andreas Strasser

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of ..

BCL-2 protein family: attractive targets for cancer therapy.

Deeksha Kaloni, Sarah T Diepstraten, Andreas Strasser, Gemma L Kelly

Journal article  |  2023  |  Apoptosis

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members play important roles in controlling ap..

Generation of a CRISPR activationmouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (vol 13, 4739, 2022)

Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Goknur Giner, Stephanie Trezise, Ashley P Ng, Gerry Healey, Serena R Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S Alexander, Jane E Visvader, Stephen L Nutt, Andreas Strasser, Benjamin Haley, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

In this article the affiliation details for Amy Heidersbach were incorrectly given as ‘School of Dentistry and Medical Sciences, C..

Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice.

Amy L Winship, Lauren R Alesi, Sneha Sant, Jessica M Stringer, Aldana Cantavenera, Teharn Hegarty, Carolina Lliberos Requesens, Seng H Liew, Urooza Sarma, Meaghan J Griffiths, Nadeen Zerafa, Stephen B Fox, Emmaline Brown, Franco Caramia, Pirooz Zareie, Nicole L La Gruta, Kelly-Anne Phillips, Andreas Strasser, Sherene Loi, Karla J Hutt

Journal article  |  2022  |  Nature Cancer

Loss of fertility is a major concern for female reproductive-age cancer survivors, since a common side-effect of conventional cyto..

Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance

Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Goeknur Giner, Stephanie Trezise, Ashley P Ng, Gerry Healey, Serena R Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S Alexander, Jane E Visvader, Stephen L Nutt, Andreas Strasser, Benjamin Haley, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation (CRISPRa) methods have not been exploited in thi..

The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK

Francine S Ke, Steven Holloway, Rachel T Uren, Agnes W Wong, Melissa H Little, Ruth M Kluck, Anne K Voss, Andreas Strasser

Journal article  |  2022  |  EMBO JOURNAL

The intrinsic apoptosis pathway, regulated by the BCL-2 protein family, is essential for embryonic development. Using mice lacking..

Should mutant TP53 be targeted for cancer therapy?

Zilu Wang, Andreas Strasser, Gemma L Kelly

Journal article  |  2022  |  Cell Death Differ

Mutations in the TP53 tumour suppressor gene are found in ~50% of human cancers [1-6]. TP53 functions as a transcription factor th..