Andrew Kompa

Cost-effectiveness of dapagliflozin in chronic heart failure: an analysis from the Australian healthcare perspective

Feby Savira, Bing H Wang, Andrew R Kompa, Zanfina Ademi, Alice J Owen, Sophia Zoungas, Andrew Tonkin, Danny Liew, Ella Zomer

Journal article  |  2020  |  European Journal of Preventive Cardiology

AIM: To assess the cost-effectiveness of dapagliflozin in addition to standard care versus standard care alone in patients with ch..

Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

Feby Savira, Bing H Wang, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa

Conference Proceedings  |  2020  |  International Journal of Cardiology

Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature

Feby Savira, Ruth Magaye, Danny Liew, Christopher Reid, Darren J Kelly, Andrew R Kompa, S Jeson Sangaralingham, John C Burnett, David Kaye, Bing H Wang

Journal article  |  2020  |  British Journal of Pharmacology

Cardiorenal syndrome (CRS) is a multi-organ disease, encompassing heart, kidney and vascular system dysfunction. CRS is a worldwid..

Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction.

Andrew R Kompa, David W Greening, Anne M Kong, Paul J McMillan, Haoyun Fang, Ritika Saxena, Raymond CB Wong, Jarmon G Lees, Priyadharshini Sivakumaran, Andrew E Newcomb, Bakhos A Tannous, Cameron Kos, Lina Mariana, Thomas Loudovaris, Derek J Hausenloy, Shiang Y Lim

Journal article  |  2020  |  Cardiovascular Research

AIMS: To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells..

Uremic toxin induced endothelial dysfunction can be restored by inhibition of the aryl hydrocarbon receptor: implications for cardiovascular disease treatment in chronic kidney disease patients

A Kompa, C Nguyen, AJ Edgley, DJ Kelly

Conference Proceedings  |  2019  |  EUROPEAN HEART JOURNAL

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis

Wendi Yang, Bing Hui Wang, Ian Wang, Li Huang, Feby Savira, Andrew Kompa, Beat M Jucker, Robert N Willette, Darren Kelly, Henry Krum, Zhiliang Li, Qian Fu

Journal article  |  2019  |  Heart, Lung and Circulation

Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model

Claire L Curl, Vennetia R Danes, James R Bell, Antonia JA Raaijmakers, Wendy TK Ip, Chanchal Chandramouli, Tristan W Harding, Enzo R Porrello, Jeffrey R Erickson, Fadi J Charchar, Andrew R Kompa, Amanda J Edgley, David J Crossman, Christian Soeller, Kimberley M Mellor, Jonathan M Kalman, StephenB Harrap, Lea MD Delbridge

Journal article  |  2018  |  Journal of the American Heart Association

Angiotensin receptor neprilysin inhibition provides superior cardioprotection compared to angiotensin converting enzyme inhibition after experimental myocardial infarction

Andrew R Kompa, Jiayu Lu, Thomas J Weller, Darren J Kelly, Henry Krum, Thomas G von Lueder, Bing H Wang

Journal article  |  2018  |  International Journal of Cardiology

Chronic kidney disease with comorbid cardiac dysfunction exacerbates cardiac and renal damage

Shan Liu, Bing H Wang, Darren J Kelly, Henry Krum, Andrew R Kompa

Journal article  |  2018  |  Journal of Cellular and Molecular Medicine

Do p38 mitogen-activated protein kinase inhibitors have a future for the treatment of cardiovascular disease?

Andrew R Kompa

Journal article  |  2016  |  Journal of Thoracic Disease

Protein-bound uremic toxins: a long overlooked culprit in cardiorenal syndrome

Suree Lekawanvijit, Andrew R Kompa, Henry Krum

Journal article  |  2016  |  American Journal of Physiology-Renal Physiology

THE RENOPROTECTIVE ROLE OF MICRORNAS FROM FIBROSIS CAUSED BY UREMIC TOXINS AFTER MYOCARDIAL INFARCTION

Fadi Charchar, Andrew Kompa, Suree Lekawanvijit, Ruby Lin

Conference Proceedings  |  2016  |  NEPHROLOGY DIALYSIS TRANSPLANTATION

Pathophysiological Interactions between Chronic Kidney Disease and Cardiac Remodelling

Shan Liu, Andrew R Kompa, Bing H Wang, Henry Krum

Conference Proceedings  |  2016  |  FASEB JOURNAL

VCP746: a cardioprotective adenosine receptor agonist with minimal haemodynamic effects

CH Chuo, LT May, P Scammells, BH Wang, H Krum, AR Kompa, PJ White

Conference Proceedings  |  2015  |  EUROPEAN HEART JOURNAL

The angiotensin receptor neprilysin inhibitor LCZ696 improves systolic cardiac function compared to angiotensin converting enzyme inhibition in a rat model of myocardial infarction

AR Kompa, TJ Weller, T Von Lueder, BH Wang, H Krum

Conference Proceedings  |  2015  |  EUROPEAN HEART JOURNAL

UREMIC TOXINS CONTRIBUTE TO CARDIAC FIBROSIS AFTER MYOCARDIAL INFARCTION: ROLE OF microRNAs

I Rana, AR Kompa, J Skommer, BH Wang, S Lekawanvijit, DJ Kelly, H Krum, FJ Charchar

Conference Proceedings  |  2015  |  HYPERTENSION

Combined angiotensin receptor blockade and neprilysin inhibition attenuates angiotensin-II mediated renal cellular collagen synthesis

Bing H Wang, Thomas G von Lueder, Andrew R Kompa, Li Huang, Randy Webb, Pierre Jordaan, Dan Atar, Henry Krum

Journal article  |  2015  |  International Journal of Cardiology

Contribution of microRNA to pathological fibrosis in cardiorenal syndrome: impact of uremic toxins

Indrajeetsinh Rana, Andrew R Kompa, Joanna Skommer, Bing H Wang, Suree Lekawanvijit, Darren J Kelly, Henry Krum, Fadi J Charchar

Journal article  |  2015  |  Physiological Reports

Angiotensin Receptor Neprilysin Inhibitor LCZ696 Attenuates Cardiac Remodeling and Dysfunction After Myocardial Infarction by Reducing Cardiac Fibrosis and Hypertrophy

Thomas G von Lueder, Bing H Wang, Andrew R Kompa, Li Huang, Randy Webb, Pierre Jordaan, Dan Atar, Henry Krum

Journal article  |  2015  |  Circulation: Heart Failure

Attenuation of microglial and neuronal activation in the brain by ICV minocycline following myocardial infarction

Melissa Dworak, Martin Stebbing, Andrew R Kompa, Indrajeetsinh Rana, Henry Krum, Emilio Badoer

Journal article  |  2014  |  Autonomic Neuroscience

Protein kinases as cardiovascular therapeutic targets

Andrew R Kompa, Henry Krum

Journal article  |  2014  |  The Lancet

A practical guide to subtotal nephrectomy in the rat with subsequent methodology for assessing renal and cardiac function

Yuan Zhang, Andrew R Kompa

Journal article  |  2014  |  Nephrology

NEURONAL ACTIVATION IN THE HYPOTHALAMUS, MIDBRAIN AND MEDULLA FOLLOWING MYOCARDIAL INFARCTION IS INHIBITED BY MINOCYCLINE

M Dworak, M Stebbing, A Kompa, I Rana, H Krum, E Badoer

Conference Proceedings  |  2014  |  HYPERTENSION

RENAL DENERVATION IMPROVES INSULIN SENSITIVITY IN DIABETIC REN-2 (MREN2)27 TRANSGENIC RATS

Andrew Kompa, Masataka Watanabe, Bing Wang, Darren Kelly, Henry Krum

Conference Proceedings  |  2014  |  Journal of the American College of Cardiology

The Uremic Toxin Adsorbent AST-120 Abrogates Cardiorenal Injury Following Myocardial Infarction

Suree Lekawanvijit, Sirinart Kumfu, Bing H Wang, Minako Manabe, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum, Andrew R Kompa

Journal article  |  2013  |  PLoS One

Angiotensin-Receptor Neprilysin-Inhibitor Reduces Adverse Cardiac Remodeling after Experimental Myocardial Infarction by Direct Effect on Cardiac Hypertrophy and Fibrosis

Thomas G von Lueder, Bing H Wang, Andrew R Kompa, Randy Webb, Plerre Jordaan, Dan Atar, Henry Krum

Conference Proceedings  |  2013  |  CIRCULATION

Effects of Renal Sympathetic Denervation on Cardiac And Renal Function in Diabetic Ren-2 Rats With Diastolic Heart Failure

Masataka Watanabe, Andrew Kompa, Darren Kelly, Henry Krum

Conference Proceedings  |  2013  |  CIRCULATION

Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: Implications for cardiorenal syndrome

Shan Liu, Andrew R Kompa, Sirinart Kumfu, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum, Bing H Wang

Journal article  |  2013  |  International Journal of Cardiology

A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction

Yuan Zhang, Maros Elsik, Amanda J Edgley, Alison J Cox, Andrew R Kompa, Bing Wang, Christina Yan Ru Tan, Fay L Khong, David I Stapleton, Steven Zammit, Spencer J Williams, Richard E Gilbert, Henry Krum, Darren J Kelly

Journal article  |  2013  |  International Journal of Cardiology

The uremic toxin adsorbent AST-120 abrogates renal injury post-MI evidenced by normalization of KIM-1 protein expression and reduced collagen turnover

AR Kompa, S Kumfu, S Lekawanvijit, BH Wang, H Krum

Conference Proceedings  |  2013  |  EUROPEAN HEART JOURNAL

Myocardial infarction accelerates pathological cardiac remodeling and renal impairment post subtotal nephrectomy

S Liu, AR Kompa, D Kelly, H Krum, BH Wang

Conference Proceedings  |  2013  |  EUROPEAN HEART JOURNAL

Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction

Andrew R Kompa, Bing H Wang, Guoying Xu, Yuan Zhang, Pei-Yu Ho, Stephen Eisennagel, Reema K Thalji, Joseph P Marino, Darren J Kelly, David J Behm, Henry Krum

Journal article  |  2013  |  International Journal of Cardiology

Renin-Angiotensin Blockade Combined With Natriuretic Peptide System Augmentation Novel Therapeutic Concepts to Combat Heart Failure

Thomas G von Lueder, S Jeson Sangaralingham, Bing H Wang, Andrew R Kompa, Dan Atar, John C Burnett, Henry Krum

Journal article  |  2013  |  Circulation: Heart Failure

Early and Delayed Tranilast Treatment Reduces Pathological Fibrosis Following Myocardial Infarction

Fiona See, Masataka Watanabe, Andrew R Kompa, Bing H Wang, Andrew J Boyle, Darren J Kelly, Richard E Gilbert, Henry Krum

Journal article  |  2013  |  Heart, Lung and Circulation

The Uremic Toxin Adsorbent AST-120 Abrogates Renal Injury Post- Myocardial Infarction Evidenced By Bormalization Of Kidney Injury Molecule-1 Protein Expression

Andrew R Kompa, Suree Lekawanvijit, Darren J Kelly, Henry Krum

Conference Proceedings  |  2012  |  CIRCULATION

Cardiorenal Syndrome The Emerging Role of Protein-Bound Uremic Toxins

Suree Lekawanvijit, Andrew R Kompa, Bing H Wang, Darren J Kelly, Henry Krum

Journal article  |  2012  |  Circulation Research

Evaluation of the Effects of Urotensin II and Soluble Epoxide Hydrolase Inhibitor on Skin Microvessel Tone in Healthy Controls and Heart Failure Patients

Lavinia Tran, Andrew R Kompa, Bing H Wang, Henry Krum

Journal article  |  2012  |  Cardiovascular Therapeutics

Sustained activation of microglia in the hypothalamic PVN following myocardial infarction

Melissa Dworak, Martin Stebbing, Andrew R Kompa, Indrajeetsinh Rana, Henry Krum, Emilio Badoer

Journal article  |  2012  |  Autonomic Neuroscience

Tranilast reduces pathological cardiac fibrosis and improves diastolic function following kidney dysfunction: implication for cardio-renal syndrome

M Watanabe, F See, A Kompa, B Wang, S Lekawanvijit, A Boyle, R Gilbert, K Connelly, A Kelly, H Krum

Conference Proceedings  |  2012  |  EUROPEAN HEART JOURNAL

Cardiorenal syndrome: Pathophysiology, preclinical models, management and potential role of uraemic toxins

Shan Liu, Suree Lekawanvijit, Andrew R Kompa, Bing H Wang, Darren J Kelly, Henry Krum

Journal article  |  2012  |  Clinical and Experimental Pharmacology and Physiology

Subtotal nephrectomy accelerates pathological cardiac remodeling post myocardial infarction: implications for the cardiorenal syndrome

S Liu, A Kompa, D Kelly, H Krum, B Wang

Conference Proceedings  |  2012  |  EUROPEAN HEART JOURNAL

Antagonists of organic anion transporters 1 and 3 ameliorate adverse cardiac remodelling induced by uremic toxin indoxyl sulfate

Shan Liu, Bing H Wang, Andrew R Kompa, Suree Lekawanvijit, Henry Krum

Journal article  |  2012  |  International Journal of Cardiology

Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate

Suree Lekawanvijit, Andrew R Kompa, Minako Manabe, Bing H Wang, Robyn G Langham, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum

Journal article  |  2012  |  PLoS One

Peptidomic profiles of post myocardial infarction rats affinity depleted plasma using matrix-assisted laser desorption/ionization time of flight (MALDI-ToF) mass spectrometry

BH Wang, S Reisman, M Bailey, A Kompa, M Ayhan, H Krum, G Rice

Journal article  |  2012  |  Clinical and Translational Medicine

Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome

Suree Lekawanvijit, Andrew R Kompa, Yuan Zhang, Bing H Wang, Darren J Kelly, Henry Krum

Journal article  |  2012  |  American Journal of Physiology - Heart and Circulatory Physiology

FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy

Yuan Zhang, Amanda J Edgley, Alison J Cox, Andrew K Powell, Bing Wang, Andrew R Kompa, David I Stapleton, Steven C Zammit, Spencer J Williams, Henry Krum, Richard E Gilbert, Darren J Kelly

Journal article  |  2012  |  European Journal of Heart Failure

ADDITION OF NEPROLYSIN INHIBITOR, LBQ-657 TO ANGIOTENSIN RECEPTOR BLOCKER, VALSARTAN PROVIDES SUPERIOR ANTI-FIBROTIC AND ANTI-HYPERTROPHIC EFFECTS IN VITRO

Bing H Wang, Thomas von Lueder, Li Huang, Andrew Kompa, Randy Webb, Pierre Jordaan, Henry Krum

Conference Proceedings  |  2012  |  Journal of the American College of Cardiology

Delayed Tranilast Treatment Reduces Pathological Fibrosis Following Myocardial Infarction And In Uremic Cardiomyopathy

Masataka Watanabe, Fiona See, Andrew R Kompa, Andrew J Boyle, Richard E Gilbert, Kim Connelly, Suree Lekawanvijit, Darren J Kelly J Kelly, Henry Krum

Conference Proceedings  |  2011  |  CIRCULATION

Reduction of Renal Fibrosis as Well as Cardiac Pro-fibrotic and Pro-Inflammatory mRNA Expression by an Oral Charcoal Adsorbent, AST-120, in Post-MI Rats

Suree Lekawanvijit, Andrew R Kompa, Minako Manabe, Darren J Kelly, Henry Krum

Conference Proceedings  |  2011  |  CIRCULATION

Apoptosis Signal-Regulating Kinase 1 Inhibition Attenuates Cardiac Myocyte Hypertrophy and Fibroblast Collagen Synthesis Stimulated by Angiotensin II-and TGF beta: Therapeutic Potential of ASK1 Inhibitors in Myocardial Remodelling

Bing H Wang, Guo Ying Xu, Pei-yu Ho, Andrew Kompa, Beat M Jucker, Robert N Willette, Henry Krum

Conference Proceedings  |  2011  |  CIRCULATION

Subtotal Nephrectomy Accelerates Pathological Cardiac Remodelling Post Myocardial Infarction: Recapitulating the Phenotype of Cardiorenal Syndrome?

Shan Liu, Andrew R Kompa, Darren Kelly, Henry Krum, Bing H Wang

Conference Proceedings  |  2011  |  CIRCULATION

Inhibition of ASK1 attenuates angiotensin II- or TGF-beta-stimulated cardiomyocyte hypertrophy and fibroblast collagen synthesis: therapeutic potential of ASK1 inhibitors in myocardial remodelling

B Wang, GY Xu, PY Ho, A Kompa, BM Jucker, RN Willette, H Krum

Conference Proceedings  |  2011  |  EUROPEAN HEART JOURNAL

Reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate, ameliorates chronic kidney disease-induced cardiac fibrosis

S Lekawanvijit, AR Kompa, M Manabe, DJ Kelly, H Krum

Conference Proceedings  |  2011  |  EUROPEAN HEART JOURNAL

TIME COURSE OF ACTIVATED MICROGLIA FOLLOWING MYOCARDIAL INFARCTION IN RATS

M Dworak, A Kompa, I Rana, M Stebbing, H Krum, F Chen, E Badoer

Conference Proceedings  |  2011  |  HYPERTENSION

CHRONIC KIDNEY DISEASE-INDUCED CARDIAC FIBROSIS IS AMELIORATED BY REDUCING CIRCULATING LEVELS OF A NON-DIALYSABLE UREMIC TOXIN, INDOXYL SULFATE

Suree Lekawanvijit, Andrew Kompa, Minako Manabe, Darren J Kelly, Henry Krum

Conference Proceedings  |  2011  |  Journal of the American College of Cardiology

Inhibition of ASK1 attenuates angiotensin II- or TGF-beta-stimulated cardiomyocyte hypertrophy and fibroblast collagen synthesis: therapeutic potential of ASK1 inhibitors in myocardial remodelling

B Wang, GY Xu, PY Ho, A Kompa, BM Jucker, RN Willette, H Krum

Conference Proceedings  |  2011  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Atorvastatin on Cardiac Remodelling and Mortality in Rats Following Hyperglycemia and Myocardial Infarction

Jennifer H Martin, Kim A Connelly, Andrew Boyle, Andrew Kompa, Yuan Zhang, Darren Kelly, Richard E Gilbert, Henry Krum

Journal article  |  2010  |  International Journal of Cardiology

Soluble epoxide hydrolase inhibition attenuates cardiac remodelling post-myocardial infarction

AR Kompa, BH Wang, PY Ho, G Xu, DJ Behm, DJ Kelly, H Krum

Conference Proceedings  |  2010  |  EUROPEAN HEART JOURNAL

Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy

Andrew R Kompa, Bing H Wang, Arintaya Phrommintikul, Pei Y Ho, Darren J Kelly, David J Behm, Stephen A Douglas, Henry Krum

Journal article  |  2010  |  Peptides

Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?

Suree Lekawanvijit, Anastasia Adrahtas, Darren J Kelly, Andrew R Kompa, Bing H Wang, Henry Krum

Journal article  |  2010  |  European Heart Journal

MICROGLIA ARE ACTIVATED IN THE HYPOTHALAMUS FOLLOWING MYOCARDIAL INFARCTION

I Rana, M Stebbing, A Kompa, D Kelly, H Krum, E Badoer

Conference Proceedings  |  2010  |  HYPERTENSION

Microglia activation in the hypothalamic PVN following myocardial infarction

Indrajeetsinh Rana, Martin Stebbing, Andrew Kompa, Darren J Kelly, Henry Krum, Emilio Badoer

Journal article  |  2010  |  Brain Research

Chronic urotensin-II infusion induces diastolic dysfunction and enhances collagen production in rats

Lavinia Tran, Andrew R Kompa, Will Kemp, Arintaya Phrommintikul, Bing H Wang, Henry Krum

Journal article  |  2010  |  American Journal of Physiology - Heart and Circulatory Physiology

Myocardial Infarction Impairs Renal Function, Induces Renal Interstitial Fibrosis and Increases Kim-1 Expression: Implications for the Cardiorenal Syndrome

Suree Lekawanvijit, Andrew Kompa, Yuan Zhang, Bing H Wang, Darren J Kelly, Henry Krum

Conference Proceedings  |  2009  |  CIRCULATION

Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats

William Kemp, Andrew Kompa, Arintaya Phrommintikul, Chandana Herath, Zhiyuan Jia, Peter Angus, Catriona McLean, Stuart Roberts, Henry Krum

Journal article  |  2009  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Peptidomic profiles of plasma from post myocardial infarction rats using affinity capture Matrix Assisted Laser Desorption Ionisation Time of Flight (MALDI-ToF) mass spectrometry

B Wang, S Reisman, M Ayhan, A Kompa, H Krum, G Rice

Conference Proceedings  |  2009  |  EUROPEAN HEART JOURNAL

Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial

William Kemp, John Colman, Kenneth Thompson, Anoop Madan, Margaret Vincent, Jaye Chin-Dusting, Andrew Kompa, Henry Krum, Stuart Roberts

Journal article  |  2009  |  Liver International

Effect of urotensin II on skin microvessel tone in diabetic patients without heart failure or essential hypertension

E Zomer, I de Ridder, A Kompa, P Komesaroff, RE Gilbert, H Krum

Journal article  |  2008  |  Clinical and Experimental Pharmacology and Physiology

Systemic urotensin II infusion induces diastolic dysfunction in normal rat heart with increased collagen deposition independent of systemic blood pressure effects: role of Rho kinase

L Tran, AR Kompa, W Kemp, A Phrommintikul, B Wang, H Krum

Conference Proceedings  |  2008  |  EUROPEAN HEART JOURNAL

Blockade of the urotensin II receptor does not attenuate cardiac remodeling in a model of pressure-overload hypertrophy: functional and histological assessment

AR Kompa, A Phrommintikul, SA Douglas, H Krum

Conference Proceedings  |  2008  |  EUROPEAN HEART JOURNAL

Rho kinase inhibition reduces angiotensinII- and urotensinII-stimulated cardiac hypertrophy and collagen synthesis via attenuation of reactive oxygen species production

L Tran, B Wang, A Kompa, A Adrahtas, M Bertucci, R Ritchie, G Drummond, W Thomas, H Krum

Conference Proceedings  |  2008  |  EUROPEAN HEART JOURNAL

Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction

AR Kompa, F See, DA Lewis, A Adrahtas, DM Cantwell, BH Wang, H Krum

Journal article  |  2008  |  Journal of Pharmacology and Experimental Therapeutics

Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction

Arintaya Phrommintikul, Lavinia Tran, Andrew Kompa, Bing Wang, Anastasia Adrahtas, Danielle Cantwell, Darren J Kelly, Henry Krum

Journal article  |  2008  |  American Journal of Physiology - Heart and Circulatory Physiology

Improvement in left ventricular function due to a reduction of myocardial fibrosis following myocardial infarction using a purpose designed novel anti fibrotic drug FT-011

Maros Elsilk, Yuan Zhang, Bing Wang, Andrew Kompa, Richard Gilbert, Henry Krum, Darren Kelly

Conference Proceedings  |  2007  |  CIRCULATION

Urotensin II increases portal pressure and induces hepatic fibrosis

William Kemp, Krum Henry, Andrew Kompa, Jia Zhiyuan, Peter W Angus, Stuart K Roberts

Conference Proceedings  |  2007  |  HEPATOLOGY

Heat Shock Protein 25 (HSP25) is implicated in signaling pathways involved post-myocardial infarction

AR Kompa, B Wang, A Adrahtas, F See, H Krum

Conference Proceedings  |  2007  |  EUROPEAN HEART JOURNAL

Tissue engineering of a vascularised myocardial patch

AN Morritt, SK Bortolotto, RJ Dilley, XL Han, AR Kompa, D McCombe, CE Wright, S Itescu, JA Angus, WA Morrison

Conference Proceedings  |  2007  |  TISSUE ENGINEERING

The effects of rho kinase inhibition on cardiac remodelling in a rat model of pressure-overload hypertrophy

L Tran, AR Kompa, B Wang, A Phrommintikul, H Krum

Conference Proceedings  |  2007  |  HYPERTENSION

Cardiac tissue engineering in an in vivo vascularized chamber

Andrew N Morritt, Susan K Bortolotto, Rodney J Dilley, XiaoLian Han, Andrew R Kompa, David McCombe, Christine E Wright, Silviu Itescu, James A Angus, Wayne A Morrison

Journal article  |  2007  |  Circulation

Rho kinase inhibition produces dose-dependent improvements in diastolic dysfunction, independent of changes in afterload, in a rat pressure overload model

Arintaya Phrommintikul, Andrew R Kompa, Bing Wang, Lavinia Tran, Henry Krum

Conference Proceedings  |  2006  |  CIRCULATION

Effect of Rho kinase inhibition in a model of pressure-overload hypertrophy

A Kompa, A Phrommintikul, B Wang, D Cantwell, H Krum

Conference Proceedings  |  2006  |  Journal of Molecular and Cellular Cardiology

Urotensin II is a vasoconstrictor in diabetic patients without heart failure or essential hypertension

E Zomer, I De Ridder, A Kompa, P Komesaroff, H Krum

Conference Proceedings  |  2006  |  EUROPEAN HEART JOURNAL

Effects of specific rho kinase inhibition (GSK 576371) on collagen synthesis in isolated neonatal rat cardiac fibroblasts

A Phrommintikul, D Cantwell, A Kompa, H Krum

Conference Proceedings  |  2006  |  EUROPEAN HEART JOURNAL

Hyperglycemia has a detrimental effect on cardiac remodelling and mortality after myocardial infarction: benefit of statin therapy

JH Martin, K Connelly, A Boyle, DJ Kelly, A Kompa, M Zhang, R Gilbert, H Krum

Conference Proceedings  |  2006  |  EUROPEAN HEART JOURNAL

Effect of Rho kinase inhibition in a model of pressure-overload hypertrophy

AR Kompa, A Phrommintikul, B Wang, DM Cantwell, H Krum

Conference Proceedings  |  2006  |  EUROPEAN HEART JOURNAL

Effect of rho-kinase inhibition on collagen production in isolated cardiac fibroblasts

DM Cantwell, AK Kompa, H Krum

Conference Proceedings  |  2005  |  EUROPEAN HEART JOURNAL

Effect of exogenous urotensin-II on vascular tone in skin microcirculation of patients with essential hypertension

B Sondermeijer, A Kompa, P Komesaroff, H Krum

Journal article  |  2005  |  American Journal of Hypertension

Fibrosis as a therapeutic target post-myocardial infarction

F See, A Kompa, J Martin, DA Lewis, H Krum

Journal article  |  2005  |  Current Pharmaceutical Design

Long-term but not short-term p38 MAPK inhibition improves cardiac function and reduces pathological collagen deposition following myocardial infarclion in rats

AR Kompa, DA Lewis, DM Cantwell, S Wadsworth, H Krum

Conference Proceedings  |  2004  |  CIRCULATION

p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat

F See, W Thomas, K Way, A Tzanidis, A Kompa, D Lewis, S Itescu, H Krum

Journal article  |  2004  |  Journal of the American College of Cardiology

Cardiovascular role of urotensin II: effect of chronic infusion in the rat

AR Kompa, WG Thomas, F See, A Tzanidis, RD Hannan, H Krum

Journal article  |  2004  |  Peptides

p38 MAP kinase as a therapeutic target in cardiovascular disease

F See, A Kompa, H Krum

Journal article  |  2004  |  Drug Discovery Today: Therapeutic Strategies

Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure

M Lim, S Honisett, C Sparkes, R Kornesaroff, A Kompa, H Krum

Conference Proceedings  |  2004  |  EUROPEAN HEART JOURNAL

Does protein kinase CR (PKCP) inhibition directly reduce collagen production from cardiac fibroblasts?

D Cantwell, R Denver, J Martin, RD Hannan, KJ Way, AR Kompa, H Krum

Conference Proceedings  |  2004  |  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Differential effect of urotensin II on vascular tone in normal subjects & patients with chronic heart failure

ML Lim, SY Honisett, CD Sparkes, PA Komesaroff, A Kompa, H Krum

Conference Proceedings  |  2004  |  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure

M Lim, S Honisett, CD Sparkes, P Komesaroff, A Kompa, H Krum

Journal article  |  2004  |  Circulation

Emerging role of the urotensin II system in cardiovascular disease

H Krum, A Kompa, R Hannan, W Thomas

Journal article  |  2003  |  Heart Drug

Does interleukin-17 play a role in cardiac remodelling post-myocardial infarction?

AR Kompa, F See, R Denver, H Krum

Conference Proceedings  |  2003  |  European Heart Journal

Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria

YY Tan, NF Dawson, AR Kompa, CP Bond, A Claasz, JD Wade, GW Tregear, RJ Summers

Journal article  |  2002  |  European Journal of Pharmacology

Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin

AR Kompa, CS Samuel, RJ Summers

Journal article  |  2002  |  British Journal of Pharmacology

Structure-activity relationships of relaxin and relaxin-like factor/Insulin 3

YY Tan, NF Dawson, AR Kompa, C Bond, A Claasz, JD Wade, GW Tregear, RJ Summers

Conference Proceedings  |  2001  |  Relaxin 200. Proceedings of the Third International Conference on Relaxin and Related Peptides.

Lidocaine and surgical modification reduces mortality in a rat model of cardiac failure induced by coronary artery ligation

AR Kompa, RJ Summers

Journal article  |  2000  |  Journal of Pharmacological and Toxicological Methods

Desensitization and resensitization of beta(1)- and putative beta(4)-adrenoceptor mediated responses occur in parallel in a rat model of cardiac failure

AR Kompa, RJ Summers

Journal article  |  1999  |  British Journal of Pharmacology

Desensitization of cardiac beta-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins

AR Kompa, XH Gu, BA Evans, RJ Summers

Journal article  |  1999  |  Journal of Molecular and Cellular Cardiology

Regulation of beta-adrenoceptors in a rat model of cardiac failure: Effect of perindopril

XH Gu, AR Kompa, RJ Summers

Journal article  |  1998  |  Journal of Cardiovascular Pharmacology

beta-adrenoceptor subtypes and their desensitization mechanisms

RJ Summers, A Kompa, SJ Roberts

Journal article  |  1997  |  Journal of Autonomic Pharmacology

SIGNALING PATHWAYS IN CARDIAC-FAILURE

RJ SUMMERS, LR MCMARTIN, A KOMPA, XH GU, P MOLENAAR

Journal article  |  1995  |  Clinical and Experimental Pharmacology and Physiology

BETA-ADRENOCEPTOR REGULATION AND FUNCTIONAL-RESPONSES IN THE GUINEA-PIG FOLLOWING CHRONIC ADMINISTRATION OF THE LONG-ACTING BETA(2)-ADRENOCEPTOR AGONIST FORMOTEROL

AR KOMPA, P MOLENAAR, RJ SUMMERS

Journal article  |  1995  |  Naunyn-Schmiedeberg's Archives of Pharmacology

EFFECT OF CHEMICAL SYMPATHECTOMY ON (-)-ISOPRENALINE-INDUCED CHANGES IN CARDIAC BETA-ADRENOCEPTOR SUBTYPES IN THE GUINEA-PIG AND RAT

AR KOMPA, P MOLENAAR, RJ SUMMERS

Journal article  |  1994  |  Journal of Autonomic Pharmacology

REGULATION OF BETA-ADRENOCEPTORS IN THE GUINEA-PIG SINOATRIAL NODE

FD RUSSELL, AR KOMPA, P MOLENAAR, RJ SUMMERS

Journal article  |  1994  |  Naunyn-Schmiedeberg's Archives of Pharmacology

REGULATION OF BETA-1-ADRENOCEPTORS AND BETA-2-ADRENOCEPTORS IN GUINEA-PIG SINOATRIAL NODE AFTER CHRONIC (-)-ISOPRENALINE INFUSION

RJ SUMMERS, AR KOMPA, FD RUSSELL

Conference Proceedings  |  1992  |  BRITISH JOURNAL OF PHARMACOLOGY

LOCALIZATION OF (-)-[I-125]CYANOPINDOLOL BINDING IN GUINEA-PIG HEART - CHARACTERISTICS OF NON-BETA-ADRENOCEPTOR RELATED BINDING IN CARDIAC-PACEMAKER AND CONDUCTING REGIONS

P MOLENAAR, AR KOMPA, SJ ROBERTS, HS PAK, RJ SUMMERS

Journal article  |  1992  |  Neuroscience Letters

Regulation of guinea-pig cardiac β-adrenoceptor subtypes after (-)-adrenaline and (-)-noradrenaline treatment

AR Kompa, P Molenaar, RJ Summers

Journal article  |  1992  |  Molecular Neuropharmacology