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Therapeutics for dementia and Alzheimer's disease: New directions for precision medicine
Displaying the 6 most recent projects by James Duce.
Displaying the 45 most recent scholarly works by James Duce.
Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019)
Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johanssen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce
Journal article | 2019 | Molecular Neurobiology
The proteostasis network provides targets for neurodegeneration.
Timothy Mark Newton, James Alex Duce, Elliott David Bayle
Journal article | 2019 | British Journal of Pharmacology
The production, quality control, and degradation of proteins are a tightly controlled process necessary for cell health. In order ..
Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity
Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johannsen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce
Journal article | 2019 | Molecular Neurobiology
Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model.
Teresa R Taylor-Whiteley, Christine L Le Maitre, James A Duce, Caroline F Dalton, David P Smith
Journal article | 2019 | Disease Models & Mechanisms
Extensive loss of dopaminergic neurons and aggregation of the protein α-synuclein into ubiquitin-positive Lewy bodies represents a..
A ferroptosis-based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis.
David Devos, Caroline Moreau, Maeva Kyheng, Guillaume Garçon, Anne Sophie Rolland, Hélène Blasco, Patrick Gelé, T Timothée Lenglet, C Veyrat-Durebex, Philippe Corcia, Mary Dutheil, Peter Bede, Andreas Jeromin, Patrick Oeckl, Markus Otto, Vincent Meninger, Véronique Danel-Brunaud, Jean-Christophe Devedjian, James A Duce, Pierre François Pradat
Journal article | 2019 | Scientific Reports
Accurate patient stratification into prognostic categories and targeting Amyotrophic Lateral Sclerosis (ALS)-associated pathways m..
Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide.
Brian Dean, Andrew Tsatsanis, Linh Q Lam, Elizabeth Scarr, James A Duce
Journal article | 2019 | World J Biol Psychiatry
OBJECTIVES: The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis coul..
Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?
Caroline Moreau, Veronique Danel, Jean Christophe Devedjian, Guillaume Grolez, Kelly Timmerman, Charlotte Laloux, Maud Petrault, Flore Gouel, Aurelie Jonneaux, Mary Dutheil, Cedrick Lachaud, Renaud Lopes, Gregory Kuchcinski, Florent Auger, Maeva Kyheng, Alain Duhamel, Thierry Perez, Pierre Francois Pradat, Helene Blasco, Charlotte Veyrat-Durebex, et al.
Journal article | 2018 | Antioxidants & Redox Signaling
Continuous cerebroventricular administration of dopamine: A new treatment for severe dyskinesia in Parkinson's disease?
C Laloux, F Gouel, C Lachaud, K Timmerman, B Do Van, A Jonneaux, M Petrault, G Garcon, N Rouaix, C Moreau, R Bordet, JA Duce, JC Devedjian, D Devos
Journal article | 2017 | Neurobiology of Disease
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.
Charles Arber, Plamena R Angelova, Sarah Wiethoff, Yugo Tsuchiya, Francesca Mazzacuva, Elisavet Preza, Kailash P Bhatia, Kevin Mills, Ivan Gout, Andrey Y Abramov, John Hardy, James A Duce, Henry Houlden, Selina Wray
Journal article | 2017 | PLOS ONE
Mutations in PANK2 lead to neurodegeneration with brain iron accumulation. PANK2 has a role in the biosynthesis of coenzyme A (CoA..
Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of beta-Amyloid Precursor Protein
Scott Ayton, Peng Lei, Dominic J Hare, James A Duce, Jessica L George, Paul A Adlard, Catriona McLean, Jack T Rogers, Robert A Cherny, David I Finkelstein, Ashley I Bush
Journal article | 2015 | Journal of Neuroscience
Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators
David G Workman, Andrew Tsatsanis, Frank W Lewis, John P Boyle, Maryam Mousadoust, Nishani T Hettiarachchi, Michael Hunter, Chris S Peers, David Tetard, James A Duce
Journal article | 2015 | Metallomics
A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe2 under physiologically relevant conditions
Bruce X Wong, Scott Ayton, Linh Q Lam, Peng Lei, Paul A Adlard, Ashley I Bush, James A Duce
Journal article | 2014 | Biochimica et Biophysica Acta (BBA) - General Subjects
Oral Treatment with Cu-II(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Blaine R Roberts, Nastasia KH Lim, Erin J McAllum, Paul S Donnelly, Dominic J Hare, Philip A Doble, Bradley J Turner, Katherine A Price, Sin Chun Lim, Brett M Paterson, James L Hickey, Timothy W Rhoads, Jared R Williams, Katja M Kanninen, Lin W Hung, Jeffrey R Liddell, Alexandra Grubman, Jean-Francois Monty, Roxana M Llanos, David R Kramer, et al.
Journal article | 2014 | Journal of Neuroscience
Ceruloplasmin and beta-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron
Scott Ayton, Moses Zhang, Blaine R Roberts, Linh Q Lam, Monica Lind, Catriona McLean, Ashley I Bush, Tony Frugier, Peter J Crack, James A Duce
Journal article | 2014 | Free Radical Biology and Medicine
P2X7 Receptor-mediated Scavenger Activity of Mononuclear Phagocytes toward Non-opsonized Particles and Apoptotic Cells Is Inhibited by Serum Glycoproteins but Remains Active in Cerebrospinal Fluid
Ben J Gu, James A Duce, Valentina A Valova, Bruce Wong, Ashley I Bush, Steven Petrou, James S Wiley
Journal article | 2012 | Journal of Biological Chemistry
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce XW Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush
Journal article | 2012 | Nature Medicine
Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (Cu-II(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model
Cynthia PW Soon, Paul S Donnelly, Bradley J Turner, Lin W Hung, Peter J Crouch, Nicki A Sherratt, Jiang-Li Tan, Nastasia K-H Lim, Linh Lam, Laura Bica, SinChun Lim, James L Hickey, Julia Morizzi, Andrew Powell, David I Finkelstein, Janetta G Culvenor, Colin L Masters, James Duce, Anthony R White, Kevin J Barnham, et al.
Journal article | 2011 | Journal of Biological Chemistry
Iron-Export Ferroxidase Activity of beta-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
James A Duce, Andrew Tsatsanis, Michael A Cater, Simon A James, Elysia Robb, Krutika Wikhe, Su Ling Leong, Keyla Perez, Timothy Johanssen, Mark A Greenough, Hyun-Hee Cho, Denise Galatis, Robert D Moir, Colin L Masters, Catriona McLean, Rudolph E Tanzi, Roberto Cappai, Kevin J Barnham, Giuseppe D Ciccotosto, Jack T Rogers, et al.
Journal article | 2010 | Cell
A domain level interaction network of amyloid precursor protein and A beta of Alzheimer's disease
Victoria M Perreau, Sandra Orchard, Paul A Adlard, Shayne A Bellingham, Roberto Cappai, Giuseppe D Ciccotosto, Tiffany F Cowie, Peter J Crouch, James A Duce, Genevieve Evin, Noel G Faux, Andrew F Hill, Ya Hui Hung, Simon A James, Qiao-Xin Li, Su San Mok, Deborah J Tew, Anthony R White, Ashley I Bush, Henning Hermjakob, et al.
Journal article | 2010 | Proteomics
Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis
Shohei Watanabe, Seiichi Nagano, James Duce, Mahmoud Kiaei, Qiao-Xin Li, Stephanie M Tucker, Ashutosh Tiwari, Robert H Brown, M Flint Beal, Lawrence J Hayward, Valeria C Culotta, Satoshi Yoshihara, Saburo Sakoda, Ashley I Bush
Journal article | 2007 | Free Radical Biology and Medicine
Florey Department Of Neuroscience And Mental Health
Doctor of Philosophy
Postgraduate Diploma in Biochemical Methods
Bachelor of Science (honours)
University of Central Lancashire