Rick Liu

RNA-targeting strategies as a platform for ocular gene therapy.

Satheesh Kumar, Lewis E Fry, Jiang-Hui Wang, Keith R Martin, Alex W Hewitt, Fred K Chen, Guei-Sheung Liu

Journal article  |  2023  |  Prog Retin Eye Res

Genetic medicine is offering hope as new therapies are emerging for many previously untreatable diseases. The eye is at the forefr..

Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization

Jiang-Hui Wang, Ching-Li Tseng, Fan-Li Lin, Jinying Chen, Erh-Hsuan Hsieh, Suraj Lama, Yu-Fan Chuang, Satheesh Kumar, Linxin Zhu, Myra B McGuinness, Jessika Hernandez, Leilei Tu, Peng-Yuan Wang, Guei-Sheung Liu

Journal article  |  2022  |  THERANOSTICS

Rationale: Corneal neovascularization (CoNV) is a severe complication of various types of corneal diseases, that leads to permanen..

Editorial: Advances in Cell and Gene Therapy in Treating Neural Diseases

Raymond Ching-Bong Wong, Kouichi Hasegawa, Gary SL Peh, Guei-Sheung Liu

Journal article  |  2021  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Bulk Gene Expression Deconvolution Reveals Infiltration of M2 Macrophages in Retinal Neovascularization

Jiang-Hui Wang, Satheesh Kumar, Guei-Sheung Liu

Journal article  |  2021  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

PURPOSE: This study interrogated the transcriptional features and immune cellular landscape of the retinae of rats subjected to ox..

TAK1 signaling is a potential therapeutic target for pathological angiogenesis

Linxin Zhu, Suraj Lama, Leilei Tu, Gregory J Dusting, Jiang-Hui Wang, Guei-Sheung Liu

Journal article  |  2021  |  ANGIOGENESIS

Angiogenesis plays a critical role in both physiological responses and disease pathogenesis. Excessive angiogenesis can promote ne..

Targeted delivery of LM22A-4 by cubosomes protects retinal ganglion cells in an experimental glaucoma model

Yue Ding, Seong H Chow, Jinying Chen, Anton P Le Brun, Chun-Ming Wu, Anthony P Duff, Yajun Wang, Jiangning Song, Jiang-Hui Wang, Vickie HY Wong, Da Zhao, Tomoharu Nishimura, Tzong-Hsien Lee, Charlotte E Conn, Hsien-Yi Hsu, Bang Bui, Guei-Sheung Liu, Hsin-Hui Shen

Journal article  |  2021  |  ACTA BIOMATERIALIA

Glaucoma, a major cause of irreversible blindness worldwide, is associated with elevated intraocular pressure (IOP) and progressiv..

Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation (vol 70, pg 14, 2014)

Guei-Sheung Liu, Jian-Ching Wu, Han-En Tsai, Gregory J Dusting, Elsa C Chan, Chieh-Shan Wu, Ming-Hong Tai

Journal article  |  2021  |  FREE RADICAL BIOLOGY AND MEDICINE

The authors regret the omission of one of the affiliations of Chieh-Shan Wu. Authors: Guei-Sheung Liu a,b,1, Jian-Ching Wu c,1, Ha..

Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update

Fan-Li Lin, Peng-Yuan Wang, Yu-Fan Chuang, Jiang-Hui Wang, Vickie HY Wong, Bang Bui, Guei-Sheung Liu

Journal article  |  2020  |  MOLECULAR THERAPY

Aberrant growth of blood vessels (neovascularization) is a key feature of severe eye diseases that can cause legal blindness, incl..

A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization

Jinying Chen, Fan-Li Lin, Jacqueline YK Leung, Leilei Tu, Jiang-Hui Wang, Yu-Fan Chuang, Fan Li, Hsin-Hui Shen, Gregory J Dusting, Vickie HY Wong, Leszek Lisowski, Alex W Hewitt, Bang V Bui, Jingxiang Zhong, Guei-Sheung Liu

Journal article  |  2020  |  ANGIOGENESIS

Gene therapies that chronically suppress vascular endothelial growth factor (VEGF) represent a new approach for managing retinal v..

Comparison of CRISPR/Cas Endonucleases forin vivoRetinal Gene Editing

Fan Li, Kristof Wing, Jiang-Hui Wang, Chi D Luu, James A Bender, Jinying Chen, Qi Wang, Qinyi Lu, Minh Thuan Nguyen Tran, Kaylene M Young, Raymond CB Wong, Alice Pebay, Anthony L Cook, Sandy SC Hung, Guei-Sheung Liu, Alex W Hewitt

Journal article  |  2020  |  FRONTIERS IN CELLULAR NEUROSCIENCE

CRISPR/Cas has opened the prospect of direct gene correction therapy for some inherited retinal diseases. Previous work has demons..