Rick Liu

Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update.

Fan-Li Lin, Peng-Yuan Wang, Yu-Fan Chuang, Jiang-Hui Wang, Vickie HY Wong, Bang V Bui, Guei-Sheung Liu

Journal article  |  2020  |  Molecular Therapy

Aberrant growth of blood vessels (neovascularization) is a key feature of severe eye diseases that can cause legal blindness, incl..

An oral bait vaccination approach for the Tasmanian devil facial tumor diseases

Andrew S Flies, Emily J Flies, Samantha Fox, Amy Gilbert, Shylo R Johnson, Guei-Sheung Liu, A Bruce Lyons, Amanda L Patchett, David Pemberton, Ruth J Pye

Journal article  |  2020  |  Expert Review of Vaccines

Introduction: The Tasmanian devil (Sarcophilus harrisii) is the largest extant carnivorous marsupial. Since 1996, its population h..

Development of Kaempferol-Loaded Gelatin Nanoparticles for the Treatment of Corneal Neovascularization in Mice

Yu-Lun Chuang, Hsu-Wei Fang, Aditya Ajitsaria, Ko-Hua Chen, Chen-Ying Su, Guei-Sheung Liu, Ching-Li Tseng

Journal article  |  2019  |  Pharmaceutics

Cornea is the transparent layer in front of the eye that does not contain blood vessels. Among eye diseases, corneal neovasculariz..

Utility of Self-Destructing CRISPR/Cas Constructs for Targeted Gene Editing in the Retina

Fan Li, Sandy SC Hung, Mohd Khairul Nizam Mohd Khalid, Jiang-Hui Wang, Vicki Chrysostomou, Vickie HY Wong, Vikrant Singh, Kristof Wing, Leilei Tu, James A Bender, Alice Pebay, Anna E King, Anthony L Cook, Raymond CB Wong, Bang Bui, Alex W Hewitt, Guei-Sheung Liu

Journal article  |  2019  |  Human Gene Therapy

CRISPR/Cas-mediated base editing of the AMD high-risk Y402H complement factor H variant

Alex W Hewitt, Peter Tran, Mohd Khairul Nizam Mohd Khalid, Alice Pebay, Anthony L Cook, Helena Liang, Raymond Wong, Jamie E Craig, Guei-Sheung Liu, Sandy Hung

Journal article  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

MicroRNA-143 plays a protective role in ischemia-induced retinal neovascularization

Guei-Sheung Liu, Jiang-Hui Wang, Jinying Chen, Leilei Tu, Vikrant Singh, Moeen Riaz, Fan Li, Alex W Hewitt, Peter van Wijngaarden, Gregory J Dusting

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Comparison of CRISPR/Cas endonuclease gene editing efficiency of retinal cells in vivo

Fan Li, Kristof Wing, Jiang-Hui Wang, James Bender, Chi D Luu, Jinying Chen, Vivienne Lu, Qi Wang, Qinyi Lu, Peter Tran, Kaylene Young, Anna King, Sandy Hung, Guei-Sheung Liu, Alex W Hewitt

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant

Thuan Nguyen Tran Minh, Mohd Khairul Nizam Mohd Khalid, Alice Pebay, Anthony L Cook, Helena H Liang, Raymond CB Wong, Jamie E Craig, Guei-Sheung Liu, Sandy S Hung, Alex W Hewitt

Journal article  |  2019  |  MOLECULAR VISION

Methods for Assessing Scaffold Vascularization In Vivo

Jiang-Hui Wang, Jinying Chen, Shyh-Ming Kuo, Geraldine M Mitchell, Shiang Y Lim, Guei-Sheung Liu

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

The success of tissue engineering hinges on the rapid and sufficient vascularization of the neotissue. For efficient vascular netw..

Gene therapy for visual loss: Opportunities and concerns

Jia Hui Lee, Jiang-Hui Wang, Jinying Chen, Fan Li, Thomas L Edwards, Alex W Hewitt, Guei-Sheung Liu

Journal article  |  2019  |  Progress in Retinal and Eye Research

Annexin V-containing cubosomes for targeted early detection of apoptosis in degenerative retinal tissue

Yue Ding, Seong Hoong Chow, Guei-Sheung Liu, Bo Wang, Tsung-Wu Lin, Hsien-Yi Hsu, Anthony P Duff, Anton P Le Brun, Hsin-Hui Shen

Journal article  |  2018  |  Journal of Materials Chemistry B

Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina.

Madhu Sudhana Saddala, Anton Lennikov, Dennis J Grab, Guei-Sheung Liu, Shibo Tang, Hu Huang

Journal article  |  2018  |  Scientific Reports

Placental growth factor (PlGF or PGF), a member of the vascular endothelial growth factor (VEGF) sub-family, plays a crucial role ..

A GENOME-WIDE CRISPR/CAS9 SCREEN TO IDENTIFY NOVEL THERAPEUTIC TARGETS FOR UVEAL MELANOMA

Fan Li, Vikrant Singh, Vivienne Lu, Jinying Chen, Sandy SC Hung, Joanne L Dickinson, Phillippa Taberlay, Anthony L Cook, Alex W Hewitt, Guei-Sheung Liu

Conference Proceedings  |  2018  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Inhibition of Experimental Choroidal Neovascularization by a Novel Peptide Derived from Calreticulin Anti-Angiogenic Domain

Youn-Shen Bee, Yi-Ling Ma, Jinying Chen, Pei-Jhen Tsai, Shwu-Jiuan Sheu, Hsiu-Chen Lin, Hu Huang, Guei-Sheung Liu, Ming-Hong Tai

Journal article  |  2018  |  International Journal of Molecular Sciences

Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic Application

Cheng-Han Tsai, Peng-Yuan Wang, I-Chan Lin, Hu Huang, Guei-Sheung Liu, Ching-Li Tseng

Journal article  |  2018  |  International Journal of Molecular Sciences

Autophagic cell death participates in POMC-induced melanoma suppression

Jian-Ching Wu, Han-En Tsai, Guei-Sheung Liu, Chieh-Shan Wu, Ming-Hong Tai

Journal article  |  2018  |  Cell Death Discovery

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells

Ashfaqul Hogue, Priyadharshini Sivakumaran, Simon T Bond, Naomi XY Ling, Anne M Kong, John W Scott, Nadeeka Bandara, Damian Hernandez, Guei-Sheung Liu, Raymond CB Wong, Michael T Ryan, Derek J Hausenloy, Bruce E Kemp, Jonathan S Oakhill, Brian G Drew, Alice Pebay, Shiang Y Lim

Journal article  |  2018  |  Cell Death Discovery

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

Leilei Tu, Jiang-Hui Wang, Veluchamy A Barathi, Selwyn M Prea, Zheng He, Jia Hui Lee, James Bender, Anna E King, Grant J Logan, Ian E Alexander, Youn-Shen Bee, Ming-Hong Tai, Gregory J Dusting, Bang V Bui, Jingxiang Zhong, Guei-Sheung Liu

Journal article  |  2018  |  Angiogenesis

Public Attitudes toward Gene Therapy in China

Jiang-Hui Wang, Rong Wang, Jia Hui Lee, Tiara WU Iao, Xiao Hu, Yu-Meng Wang, Lei-Lei Tu, Yi Mou, Wen-Li Zhu, Ai-Yong He, Shen-Yu Zhu, Di Cao, Lei Yang, Xiao-Bo Tan, Qing Zhang, Guan-Lu Liang, Shu-Min Tang, Ye-Di Zhou, Li-Jun Feng, Li-Jun Zhan, et al.

Journal article  |  2017  |  Molecular Therapy - Methods & Clinical Development

Transforming Growth Factor beta 1-Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

Karl David Brown, Manisha H Shah, Guei-Sheung Liu, Elsa C Chan, Jonathan G Crowston, Hitesh M Peshavariya

Journal article  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Gene therapy for diabetic retinopathy: Are we ready to make the leap from bench to bedside?

Jiang-Hui Wang, Damien Ling, Leilei Tu, Peter van Wijngaarden, Gregory J Dusting, Guei-Sheung Liu

Journal article  |  2017  |  Pharmacology & Therapeutics

Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Che-Yi Chang, Ming-Chen Wang, Takuya Miyagawa, Zhi-Yu Chen, Feng-Huei Lin, Ko-Hua Chen, Guei-Sheung Liu, Ching-Li Tseng

Journal article  |  2017  |  International Journal of Nanomedicine

AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo

Sandy SC Hung, Vicki Chrysostomou, Fan Li, Jeremiah KH Lim, Jiang-Hui Wang, Joseph E Powell, Leilei Tu, Maciej Daniszewski, Camden Lo, Raymond C Wong, Jonathan G Crowston, Alice Pebay, Anna E King, Bang V Bui, Guei-Sheung Liu, Alex W Hewitt

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

NADPH oxidase 2 plays a role in experimental corneal neovascularization

Elsa C Chan, Peter van Wijngaarden, Elsie Chan, Darleen Ngo, Jiang-Hui Wang, Hitesh M Peshavariya, Gregory J Dusting, Guei-Sheung Liu

Journal article  |  2016  |  Clinical Science

Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine

Guei-Sheung Liu, Hitesh M Peshavariya, Masayoshi Higuchi, Elsa C Chan, Gregory J Dusting, Fan Jiang

Journal article  |  2016  |  Journal of Tissue Engineering and Regenerative Medicine

Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications

Elsa C Chan, Shyh-Ming Kuo, Anne M Kong, Wayne A Morrison, Gregory J Dusting, Geraldine M Mitchell, Shiang Y Lim, Guei-Sheung Liu

Journal article  |  2016  |  PLOS ONE

Gene Delivery by Subconjunctival Injection of Adenovirus in Rats: A Study of Local Distribution, Transgene Duration and Safety

Guei-Sheung Liu, Jiang-Hui Wang, Jia Hui Lee, Pei-Jhen Tsai, Han-En Tsai, Shwu-Jiuan Sheu, Hsiu-Chen Lin, Gregory J Dusting, Ming-Hong Tai, Youn-Shen Bee

Journal article  |  2015  |  PLOS ONE

Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart

Yuan Zhang, Priyadharshini Sivakumaran, Andrew E Newcomb, Damian Hernandez, Nicole Harris, Ramin Khanabdali, Guei-Sheung Liu, Darren J Kelly, Alice Pebay, Alex W Hewitt, Andrew Boyle, Richard Harvey, Wayne A Morrison, David A Elliott, Gregory J Dusting, Shiang Y Lim

Journal article  |  2015  |  STEM CELLS

Differential effects of superoxide dismutase and superoxide dismutase/catalase mimetics on human breast cancer cells

Manisha H Shah, Guei-Sheung Liu, Erik W Thompson, Gregory J Dusting, Hitesh M Peshavariya

Journal article  |  2015  |  Breast Cancer Research and Treatment

Nox isoforms in thickened tissue

Elsa C Chan, Hitesh M Peshavariya, Guei-Sheung Liu, Gregory J Dusting

Journal article  |  2015  |  Experimental Dermatology

Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy

Selwyn M Prea, Elsa C Chan, Gregory J Dusting, Algis J Vingrys, Bang V Bui, Guei-Sheung Liu

Journal article  |  2015  |  JOURNAL OF OPHTHALMOLOGY

Redox mechanisms of the beneficial effects of heme oxygenase in hypertension

Elsa C Chan, Gregory J Dusting, Guei-Sheung Liu, Fan Jiang

Journal article  |  2014  |  Journal of Hypertension

Prostacyclin Signaling Boosts NADPH Oxidase 4 in the Endothelium Promoting Cytoprotection and Angiogenesis

Hitesh M Peshavariya, Guei-Sheung Liu, Catherine WT Chang, Fan Jiang, Elsa C Chan, Gregory J Dusting

Journal article  |  2014  |  Antioxidants and Redox Signaling

Transforming growth factor-beta 1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo

Hitesh M Peshavariya, Elsa C Chan, Guei Sheung Liu, Fan Jiang, Gregory J Dusting

Journal article  |  2014  |  Journal of Cellular and Molecular Medicine

Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation

Guei-Sheung Liu, Jian-Ching Wu, Han-En Tsai, Gregory J Dusting, Elsa C Chan, Chieh-Shan Wu, Ming-Hong Tai

Journal article  |  2014  |  FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase-dependent redox signaling in TGF-beta-mediated fibrotic responses

Fan Jiang, Guei-Sheung Liu, Gregory J Dusting, Elsa C Chan

Journal article  |  2014  |  Redox Biology

Expression of the proangiogenic protein hepatoma-derived growth factor in neovessels in an arterial venous loop-based tissue engineering chamber

EC Chan, MH Tai, PC Wu, HM Kuo, F Jiang, R Tee, WA Morrison, GJ Dusting, GS Liu

Journal article  |  2013  |  Biomedical Engineering: Applications, Basis and Communications

Boosting angiogenesis is a crucial process to enhance tissue growth in tissue engineering (TE). Hepatoma-derived growth factor (HD..

Involvement of Nox2 NADPH Oxidase in Retinal Neovascularization

Elsa C Chan, Peter van Wijngaarden, Guei-Sheung Liu, Fan Jiang, Hitesh Peshavariya, Gregory J Dusting

Journal article  |  2013  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Downregulation of Hepatoma-Derived Growth Factor Contributes to Retarded Lung Metastasis via Inhibition of Epithelial-Mesenchymal Transition by Systemic POMC Gene Delivery in Melanoma

Han-En Tsai, Guei-Sheung Liu, Mei-Lang Kung, Li-Feng Liu, Jian-Ching Wu, Chia-Hua Tang, Ching-Hui Huang, San-Cher Chen, Hing-Chung Lam, Chieh-Shan Wu, Ming-Hong Tai

Journal article  |  2013  |  Molecular Cancer Therapeutics

Annexin Peptide Ac2-26 Suppresses TNF alpha-Induced Inflammatory Responses via Inhibition of Rac1-Dependent NADPH Oxidase in Human Endothelial Cells

Hitesh M Peshavariya, Caroline J Taylor, Celeste Goh, Guei-Sheung Liu, Fan Jiang, Elsa C Chan, Gregory J Dusting

Journal article  |  2013  |  PLoS One

Up-Regulation of Hepatoma-Derived Growth Factor Facilities Tumor Progression in Malignant Melanoma

Han-En Tsai, Jian-Ching Wu, Mei-Lang Kung, Li-Feng Liu, Lai-Hsin Kuo, Hsiao-Mei Kuo, San-Cher Chen, Elsa C Chan, Chieh-Shan Wu, Ming-Hong Tai, Guei-Sheung Liu

Journal article  |  2013  |  PLoS One

Differentiation of Human Adipose-Derived Stem Cells into Fat Involves Reactive Oxygen Species and Forkhead Box O1 Mediated Upregulation of Antioxidant Enzymes

Masayoshi Higuchi, Gregory J Dusting, Hitesh Peshavariya, Fan Jiang, Sarah Tzu-Feng Hsiao, Elsa C Chan, Guei-Sheung Liu

Journal article  |  2013  |  Stem Cells and Development

Nox4 modulates collagen production stimulated by transforming growth factor beta 1 in vivo and in vitro

Elsa C Chan, Hitesh M Peshavariya, Guei-Sheung Liu, Fan Jiang, Shiang-Yong Lim, Gregory J Dusting

Journal article  |  2013  |  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The pro-opiomelanocortin (POMC) and melanocortin system in regulation of human skin pigmentation

HE Tsai, EC Chan, GJ Dusting, GS Liu

Book Chapter  |  2013

Enhancement of neurite outgrowth in neuron cancer stem on 3-D collagen scaffolds

Chih-Hao Chen, Shyh Ming Kuo, Guei-Sheung Liu, Wan-Nan U Chen, Chin-Wen Chuang, Li-Feng Liu

Journal article  |  2012  |  Biochemical and Biophysical Research Communications

Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response.

Guei-Sheung Liu, Elsa C Chan, Masayoshi Higuchi, Gregory J Dusting, Fan Jiang

Journal article  |  2012  |  Cells

In this review, we summarize advances in our understanding of redox-sensitive mechanisms that regulate adipogenesis. Current evide..

Transplantation of Engineered Cardiac Muscle Flaps in Syngeneic Rats

Richard Tee, Wayne A Morrison, Gregory J Dusting, Guei-Sheung Liu, Yu Suk Choi, Sarah Tzu-Feng Hsiao, Rodney J Dilley

Journal article  |  2012  |  Tissue Engineering. Part A. Tissue Engineering

Hepatoma-derived growth factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of phosphatidylinositol 3-kinase/Akt pathway

Mei-Lang Kung, Han-En Tsai, Tsung-Hui Hu, Hsiao-Mei Kuo, Li-Fen Liu, San-Cher Chen, Pey-Ru Lin, Yi-Ling Ma, E-Ming Wang, Guei-Sheung Liu, Jong-Kang Liu, Ming-Hong Tai

Journal article  |  2012  |  Biochemical and Biophysical Research Communications

Microphthalmia-associated transcription factor modulates expression of NADPH oxidase type 4: A negative regulator of melanogenesis

Guei-Sheung Liu, Hitesh Peshavariya, Masayoshi Higuchi, Alison C Brewer, Catherine WT Chang, Elsa C Chan, Gregory J Dusting

Journal article  |  2012  |  Free Radical Biology and Medicine

Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas

Shu-Shong Hsu, Chih-Hao Chen, Guei-Sheung Liu, Ming-Hong Tai, Jyh-Seng Wang, Jain-Ching Wu, Mei-Lang Kung, Elsa C Chan, Li-Feng Liu

Journal article  |  2012  |  Journal of Neuro-Oncology

Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Exerts Protective Effect on Axons in Sciatic Nerve Following Constriction-Induced Peripheral Nerve Injury

Jhih-Yin Shi, Guei-Sheung Liu, Li-Feng Liu, Shiao-Mei Kuo, Cha-Hwa Ton, Zhi-Hong Wen, Richard Tee, Chih-Hao Chen, Hung-Tu Huang, Chun-Lin Chen, David Chao, Ming-Hong Tai

Journal article  |  2011  |  Human Gene Therapy

Systemic Pro-opiomelanocortin Expression Induces Melanogenic Differentiation and Inhibits Tumor Angiogenesis in Established Mouse Melanoma

Guei-Sheung Liu, Han-En Tsai, Wen-Tsan Weng, Li-Feng Liu, Chien-Hui Weng, Ming-Ru Chuang, Hing-Chung Lam, Chieh-Shan Wu, Richard Tee, Zhi-Hong Wen, Shen-Long Howng, Ming-Hong Tai

Journal article  |  2011  |  Human Gene Therapy

Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis

Po-Chuan Shen, Ai-Li Shiau, I-Ming Jou, Che-Hsin Lee, Ming-Hong Tai, Hsin-Yi Juan, Pey-Ru Lin, Guei-Sheung Liu, Chao-Liang Wu, Jeng-Long Hsieh

Journal article  |  2011  |  Experimental Biology and Medicine

PROPHYLACTIC PROOPIOMELANOCORTIN EXPRESSION ALLEVIATES CAPSAICIN-INDUCED NEUROGENIC INFLAMMATION IN RAT TRACHEA

Guei-Sheung Liu, Hung-Tu Huang, Che-Jen Lin, Jhih-Yin Shi, Li-Feng Liu, Rue-Tseng Tseng, Wen-Tsan Weng, Hing-Chung Lam, Zhi-Hong Wen, Tian-Lu Cheng, Kuei-Sen Hsu, Ming-Hong Tai

Journal article  |  2009  |  Shock (Philadelphia)

Inhibition of choroidal neovascularization by topical application of angiogenesis inhibitor vasostatin

Shwu-Jiuan Sheu, Youn-Shen Bee, Yi-Ling Ma, Guei-Sheung Liu, Hsiu-Chen Lin, Tse-Liang Yeh, Jau-Chen Liou, Ming-Hong Tai

Journal article  |  2009  |  Molecular Vision

Peripheral Gene Transfer of Glial Cell-Derived Neurotrophic Factor Ameliorates Neuropathic Deficits in Diabetic Rats

Guei-Sheung Liu, Jhih-Yin Shi, Chiou-Lian Lai, Yi-Ren Hong, Shyi-Jang Shin, Hung-Tu Huang, Hing-Chung Lam, Zhi-Hong Wen, Kuei-Sen Hsu, Chih-Hao Chen, Shen-Long Howng, Ming-Hong Tai

Journal article  |  2009  |  Human Gene Therapy

Blockade of endothelin-1 release contributes to the anti-angiogenic effect by pro-opiomelanocortin overexpression in endothelial cells

Hing-Chung Lam, Shiao-Mei Kuo, Ming-Ju Chuang, Hsiu-Man Keng, Pey-Ru Lin, Guei-Sheung Liu, Ching-Mei Hsu, Shen-Long Howng, Ming-Hong Tai

Journal article  |  2006  |  Experimental Biology and Medicine

Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma: Involvement of alpha-melanocyte-stimulating hormone-mediated inhibition of the nuclear factor kappa B/cyclooxygenase-2 pathway

GS Liu, LF Liu, CJ Lin, JC Tseng, MJ Chuang, HC Lam, JK Lee, LC Yang, JHY Chan, SL Howng, MH Tai

Journal article  |  2006  |  Molecular Pharmacology

Intrathecal gene delivery of glial cell line-derived neurotrophic factor ameliorated paraplegia in rats after spinal ischemia

AK Chou, LC Yang, PC Wu, WT Wong, GS Liu, JT Chen, SL Howng, MH Tai

Journal article  |  2005  |  Molecular Brain Research

Gene delivery of endothelial nitric oxide synthase into nucleus tractus solitarii induces biphasic response in cardiovascular functions of hypertensive rats

MH Tai, M Hsiao, JYH Chan, WC Lo, FS Wang, GS Liu, SL Howng, CJ Tseng

Journal article  |  2004  |  American Journal of Hypertension