Anthony White

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells.

Sweelin Chew, Riikka Lampinen, Liudmila Saveleva, Paula Korhonen, Nikita Mikhailov, Alexandra Grubman, Jose M Polo, Trevor Wilson, Mika Komppula, Teemu Rönkkö, Cheng Gu, Alan Mackay-Sim, Tarja Malm, Anthony R White, Pasi Jalava, Katja M Kanninen

Journal article  |  2020  |  Particle and Fibre Toxicology

BACKGROUND: The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly ..

Olfactory cell cultures to investigate health effects of air pollution exposure: Implications for neurodegeneration

KM Kanninen, R Lampinen, LM Rantanen, L Odendaal, P Jalava, S Chew, AR White

Journal article  |  2020  |  Neurochemistry International

Air pollution is a major, global public health concern. A growing body of evidence shows that exposure to air pollutants may impai..

Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery.

Lotta E Oikari, Rucha Pandit, Romal Stewart, Carla Cuní-López, Hazel Quek, Ratneswary Sutharsan, Laura M Rantanen, Minna Oksanen, Sarka Lehtonen, Carmela Maria de Boer, Jose M Polo, Jürgen Götz, Jari Koistinaho, Anthony R White

Journal article  |  2020  |  Stem Cell Reports

The blood-brain barrier (BBB) presents a barrier for circulating factors, but simultaneously challenges drug delivery. How the BBB..

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Lezanne Ooi, Mirella Dottori, Anthony L Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damian Hernandez, Anna E King, Simon Maksour, Helena Targa Dias Anastacio, Rachelle Balez, Alice Pebay, Colin Pouton, Michael Valenzuela, Anthony White, Robert Williamson

Journal article  |  2020  |  The Neuroscientist

Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a publ..

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups

Brett M Paterson, Carleen Cullinane, Peter J Crouch, Anthony R White, Kevin J Barnham, Peter D Roselt, Wayne Noonan, David Binns, Rodney J Hicks, Paul S Donnelly

Journal article  |  2019  |  Inorganic Chemistry

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

Paula Korhonen, Tarja Malm, Anthony R White

Journal article  |  2018  |  Neurochemistry International

Neurodegenerative disorders have an enormous impact on society and healthcare budgets. There has been a high degree of failure in ..

Failure of Autophagy-Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6(nclf) Mice

Philipp von Eisenhart-Rothe, Alexandra Grubman, Ursula Greferath, Linda J Fothergill, Andrew Jobling, Joanna A Phipps, Anthony R White, Erica L Fletcher, Kirstan A Vessey

Journal article  |  2018  |  Investigative Opthalmology & Visual Science

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage.

S Loppi, N Kolosowska, O Kärkkäinen, P Korhonen, M Huuskonen, A Grubman, H Dhungana, S Wojciechowski, Y Pomeshchik, M Giordano, H Kagechika, A White, S Auriola, J Koistinaho, G Landreth, K Hanhineva, K Kanninen, T Malm

Journal article  |  2018  |  Brain, Behavior, and Immunity

Ischemic stroke is amongst the leading causes of death and disabilities. The available treatments are suitable for only a fraction..

Cu-II(atsm) Attenuates Neuroinflammation

Xin Yi Choo, Jeffrey R Liddell, Mikko T Huuskonen, Alexandra Grubman, Diane Moujalled, Jessica Roberts, Kai Kysenius, Lauren Patten, Hazel Quek, Lotta E Oikari, Clare Duncan, Simon A James, Lachlan E McInnes, David J Hayne, Paul S Donnelly, Eveliina Pollari, Suvi Vahatalo, Katarina Lejavova, Mikko Kettunen, Tarja Malm, et al.

Journal article  |  2018  |  Frontiers in Neuroscience

The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1(G37R) mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1

James B Hilton, Kai Kysenius, Anthony R White, Peter J Crouch

Journal article  |  2018  |  Experimental Neurology

Nexus between mitochondrial function, iron, copper and glutathione in Parkinson's disease

Jeffrey R Liddell, Anthony R White

Journal article  |  2018  |  NEUROCHEMISTRY INTERNATIONAL

Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux

Karla M Acevedo, David J Hayne, Lachlan E McInnes, Asif Noor, Clare Duncan, Diane Moujalled, Irene Volitakis, Angela Rigopoulos, Kevin J Barnham, Victor L Villemagne, Anthony R White, Paul S Donnelly

Journal article  |  2018  |  Journal of Medicinal Chemistry

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

Kati-Sisko Vellonen, Jouni Ihalainen, Marie-Christine Boucau, Fabien Gosselet, Théo Picardat, Mikko Gynther, Katja M Kanninen, Anthony R White, Tarja Malm, Jari Koistinaho, Markus M Forsberg, Marika Ruponen

Journal article  |  2017  |  Pharmaceutical Research

PURPOSE: Alzheimer's disease (AD) may disturb functions of the blood-brain barrier and change the disposition of drugs to the brai..

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder

Ekaterina Savchenko, Yajuvinder Singh, Henna Konttinen, Katarina Lejavova, Laura Mediavilla Santos, Alexandra Grubman, Virve Karkkainen, Velta Keksa-Goldsteine, Nikolay Naumenko, Pasi Tavi, Anthony R White, Tarja Malm, Jari Koistinaho, Katja M Kanninen

Journal article  |  2017  |  Disease Models & Mechanisms

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Diane Moujalled, Alexandra Grubman, Karla Acevedo, Shu Yang, Yazi D Ke, Donia M Moujalled, Clare Duncan, Aphrodite Caragounis, Nirma D Perera, Bradley J Turner, Mercedes Prudencio, Leonard Petrucelli, Ian Blair, Lars M Ittner, Peter J Crouch, Jeffrey R Liddell, Anthony R White

Journal article  |  2017  |  Human Molecular Genetics

Biometals in neurodegenerative diseases: mechanisms and therapeutics

AR White, M Aschner, LG Costa, AI Bush

Book  |  2017

Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases

KM Kanninen, AR White

Book Chapter  |  2017

Preface

AR White, M Aschner, LG Costa, AI Bush

Book  |  2017

Adamantyl- and other polycyclic cage-based conjugates of desferrioxamine B (DFOB) for treating iron-mediated toxicity in cell models of Parkinson's disease

Thomas J Telfer, Jeffrey R Liddell, Clare Duncan, Anthony R White, Rachel Codd

Journal article  |  2017  |  Bioorganic & Medicinal Chemistry Letters

The Copper bis(thiosemicarbazone) Complex Cu-II(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Mikko T Huuskonen, Qing-zhang Tuo, Sanna Loppi, Hiramani Dhungana, Paula Korhonen, Lachlan E McInnes, Paul S Donnelly, Alexandra Grubman, Sara Wojciechowski, Katarina Lejavova, Yuriy Pomeshchik, Laura Periviita, Lotta Kosonen, Martina Giordano, Frederick R Walker, Rong Liu, Ashley I Bush, Jari Koistinaho, Tarja Malm, Anthony R White, et al.

Journal article  |  2017  |  NEUROTHERAPEUTICS

Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone'

Katja M Kanninen, Anthony R White

Journal article  |  2017  |  Journal of Neurochemistry

Read the commented article 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone' on pa..

Cu-II(atsm) improves the neurological phenotype and survival of SOD1(G93A) mice and selectively increases enzymatically active SOD1 in the spinal cord

James B Hilton, Stephen W Mercer, Nastasia KH Lim, Noel G Faux, Gojko Buncic, Joseph S Beckman, Blaine R Roberts, Paul S Donnelly, Anthony R White, Peter J Crouch

Journal article  |  2017  |  Scientific Reports

Metals in the Brain Measurement and Imaging Introduction and Overview

Anthony R White

Book Chapter  |  2017  |  Neuromethods

Copper and Alzheimer's Disease.

Zoe K Mathys, Anthony R White

Book Chapter  |  2017  |  Advances in neurobiology

Alzheimer's disease (AD) is the most common form of adult neurode-generation and is characterised by progressive loss of cognitive..

A greater focus on metals in biomedicine and neuroscience is needed

Anthony R White

Journal article  |  2016  |  BMC PHARMACOLOGY & TOXICOLOGY

X-ray fluorescence microscopic measurement of elemental distribution in the mouse retina with age

Alexandra Grubman, Philipp Guennel, Kirstan A Vessey, Michael WM Jones, Simon A James, Martin D de Jonge, Anthony R White, Erica L Fletcher

Journal article  |  2016  |  Metallomics

COPPER AND MOLECULAR ASPECTS OF CELL SIGNALLING

A GRUBMAN, AR White

Book Chapter  |  2016

Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of..

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture

Alexandra I Mot, Jeffrey R Liddell, Anthony R White, Peter J Crouch

Journal article  |  2016  |  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Nirma D Perera, Rebecca K Sheean, Peter J Crouch, Anthony R White, Malcolm K Horne, Bradley J Turner

Journal article  |  2016  |  Human Molecular Genetics

Restoration of intestinal function in an MPTP model of Parkinson's Disease

LJ Ellett, LW Hung, R Munckton, NA Sherratt, J Culvenor, A Grubman, JB Furness, AR White, DI Finkelstein, KJ Barnham, VA Lawson

Journal article  |  2016  |  SCIENTIFIC REPORTS

Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis

Diane Moujalled, Anthony R White

Journal article  |  2016  |  CNS DRUGS

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

Jeffrey R Liddell, Sarka Lehtonen, Clare Duncan, Velta Keksa-Goldsteine, Anna-Liisa Levonen, Gundars Goldsteins, Tarja Malm, Anthony R White, Jari Koistinaho, Katja M Kanninen

Journal article  |  2016  |  JOURNAL OF NEUROINFLAMMATION

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS

JB Hilton, AR White, PJ Crouch

Journal article  |  2016  |  Metallomics

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, et al.

Journal article  |  2016  |  Autophagy

Intracellular Distribution of Fluorescent Copper and Zinc Bis(thiosemicarbazonato) Complexes Measured with Fluorescence Lifetime Spectroscopy

James L Hickey, Janine L James, Clare A Henderson, Katherine A Price, Alexandra I Mot, Gojko Buncic, Peter J Crouch, Jonathan M White, Anthony R White, Trevor A Smith, Paul S Donnelly

Journal article  |  2015  |  Inorganic Chemistry

Toward Hypoxia-Selective Rhenium and Technetium Tricarbonyl Complexes

Andrea J North, David J Hayne, Christine Schieber, Katherine Price, Anthony R White, Peter J Crouch, Angela Rigopoulos, Graeme J O'Keefe, Henri Tochon-Danguy, Andrew M Scott, Jonathan M White, Uwe Ackermann, Paul S Donnelly

Journal article  |  2015  |  Inorganic Chemistry

Protein Labelling with Versatile Phosphorescent Metal Complexes for Live Cell Luminescence Imaging

Timothy U Connell, Janine L James, Anthony R White, Paul S Donnelly

Journal article  |  2015  |  Chemistry – A European Journal

Zn-II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

Erin J McAllum, Blaine R Roberts, James L Hickey, Theresa N Dang, Alexandra Grubman, Paul S Donnelly, Jeffrey R Liddell, Anthony R White, Peter J Crouch

Journal article  |  2015  |  NEUROBIOLOGY OF DISEASE

Editorial: Metals and neurodegeneration: restoring the balance

Anthony R White, Katja M Kanninen, Peter J Crouch

Journal article  |  2015  |  Frontiers in Aging Neuroscience

Metal-deficient SOD1 in amyotrophic lateral sclerosis

James B Hilton, Anthony R White, Peter J Crouch

Journal article  |  2015  |  Journal of Molecular Medicine

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Diane Moujalled, Janine L James, Shu Yang, Katharine Zhang, Clare Duncan, Donia M Moujalled, Sarah J Parker, Aphrodite Caragounis, Grace Lidgerwood, Bradley J Turner, Julie D Atkin, Alexandra Grubman, Jeffrey R Liddell, Christian Proepper, Tobias M Boeckers, Katja M Kanninen, Ian Blair, Peter J Crouch, Anthony R White

Journal article  |  2015  |  Human Molecular Genetics

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain

Nastasia KH Lim, Lin W Hung, Terence Y Pang, Catriona A Mclean, Jeffrey R Liddell, James B Hilton, Qiao-Xin Li, Anthony R White, Anthony J Hannan, Peter J Crouch

Journal article  |  2014  |  Human Molecular Genetics

Oral Treatment with Cu-II(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Blaine R Roberts, Nastasia KH Lim, Erin J McAllum, Paul S Donnelly, Dominic J Hare, Philip A Doble, Bradley J Turner, Katherine A Price, Sin Chun Lim, Brett M Paterson, James L Hickey, Timothy W Rhoads, Jared R Williams, Katja M Kanninen, Lin W Hung, Jeffrey R Liddell, Alexandra Grubman, Jean-Francois Monty, Roxana M Llanos, David R Kramer, et al.

Journal article  |  2014  |  JOURNAL OF NEUROSCIENCE

Copper as a key regulator of cell signalling pathways

Alexandra Grubman, Anthony R White

Journal article  |  2014  |  Expert Reviews in Molecular Medicine

Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

Karla M Acevedo, Carlos M Opazo, David Norrish, Leesa M Challis, Qiao-Xin Li, Anthony R White, Ashley I Bush, James Camakaris

Journal article  |  2014  |  Journal of Biological Chemistry

METALS ON OUR MIND

Anthony White

Journal article  |  2014  |  Scientist

Mitochondrial metals as a potential therapeutic target in neurodegeneration

A Grubman, AR White, JR Liddell

Journal article  |  2014  |  BRITISH JOURNAL OF PHARMACOLOGY

Neuroprotective Copper Bis(thiosemicarbazonato) Complexes Promote Neurite Elongation

Laura Bica, Jeffrey R Liddell, Paul S Donnelly, Clare Duncan, Aphrodite Caragounis, Irene Volitakis, Brett M Paterson, Roberto Cappai, Alexandra Grubman, James Camakaris, Peter J Crouch, Anthony R White

Journal article  |  2014  |  PLOS ONE

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Theresa NT Dang, Nastasia KH Lim, Alexandra Grubman, Qiao-Xin Li, Irene Volitakis, Anthony R White, Peter J Crouch

Journal article  |  2014  |  Frontiers in Aging Neuroscience

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

A Grubman, SA James, J James, C Duncan, I Volitakis, JL Hickey, PJ Crouch, PS Donnelly, KM Kanninen, JR Liddell, SL Cotman, MD de Jonge, AR White

Journal article  |  2014  |  CHEMICAL SCIENCE

Heterogeneous nuclear ribonucleoproteins in amyotrophic lateral sclerosis: What do we know?

D Moujalled, AR White

Journal article  |  2014  |  Future Neurology

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Alexandra Grubman, Grace E Lidgerwood, Clare Duncan, Laura Bica, Jiang-Li Tan, Sarah J Parker, Aphrodite Caragounis, Jodi Meyerowitz, Irene Volitakis, Diane Moujalled, Jeffrey R Liddell, James L Hickey, Malcolm Horne, Shoshanah Longmuir, Jari Koistinaho, Paul S Donnelly, Peter J Crouch, Imke Tammen, Anthony R White, Katja M Kanninen

Journal article  |  2014  |  ACTA NEUROPATHOLOGICA COMMUNICATIONS

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Alexandra Grubman, Eveliina Pollari, Clare Duncan, Aphrodite Caragounis, Tea Blom, Irene Volitakis, Andrew Wong, Jonathan Cooper, Peter J Crouch, Jari Koistinaho, Anu Jalanko, Anthony R White, Katja M Kanninen

Journal article  |  2014  |  Metallomics

Therapeutic effects of Cu-II(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

Erin J McAllum, Nastasia K-H Lim, James L Hickey, Brett M Paterson, Paul S Donnelly, Qiao-Xin Li, Jeffrey R Liddell, Kevin J Barnham, Anthony R White, Peter J Crouch

Journal article  |  2013  |  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Erratum: Copper modulates the large dense core vesicle secretory pathway in PC12 cells (Metallomics (2013) 5 (700-714) DOI:10.1039/C3MT20231C)

C Duncan, L Bica, PJ Crouch, A Caragounis, GE Lidgerwood, SJ Parker, J Meyerowitz, I Volitakis, JR Liddell, R Raghupathi, BM Paterson, MD Duffield, R Cappai, PS Donnelly, A Grubman, J Camakaris, DJ Keating, AR White

Journal article  |  2013  |  Metallomics

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

Jeffrey R Liddell, Daniel Obando, Joe Liu, George Ganio, Irene Volitakis, Su San Mok, Peter J Crouch, Anthony R White, Rachel Codd

Journal article  |  2013  |  FREE RADICAL BIOLOGY AND MEDICINE

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Diane Moujalled, Janine L James, Sarah J Parker, Grace E Lidgerwood, Clare Duncan, Jodi Meyerowitz, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, Alexandra Grubman, Jeffrey R Liddell, Peter J Crouch, Anthony R White

Journal article  |  2013  |  PLOS ONE

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

Katja M Kanninen, Alexandra Grubman, Aphrodite Caragounis, Clare Duncan, Sarah J Parker, Grace E Lidgerwood, Irene Volitakis, George Ganio, Peter J Crouch, Anthony R White

Journal article  |  2013  |  BIOLOGY OPEN

Erratum: Immunotherapeutic approaches in prion disease: Progress, hallenges and potential directions (Therapeutic Delivery (2013) 4:5 (615-628))

MW Brazier, AI Mot, AR White, SJ Collins

Journal article  |  2013  |  Therapeutic Delivery

Immunotherapeutic approaches in prion disease: progress, challenges and potential directions.

Marcus W Brazier, Alexandra I Mot, Anthony R White, Steven J Collins

Journal article  |  2013  |  Therapeutic Delivery

Therapeutic trials utilizing animal models of prion disease have explored a variety of compounds and a number of approaches with v..

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer's Disease Amyloid Precursor Protein

Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin

Journal article  |  2013  |  PLoS One

Oxidative stress and neurodegeneration

Anthony White, Carsten Culmsee, Philip Beart

Journal article  |  2013  |  Neurochemistry International

Biometals in rare neurodegenerative disorders of childhood

Sarah J Parker, Jari Koistinaho, Anthony R White, Katja M Kanninen

Journal article  |  2013  |  Frontiers in Aging Neuroscience

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

Katja M Kanninen, Alexandra Grubman, Jodi Meyerowitz, Clare Duncan, Jiang-Li Tan, Sarah J Parker, Peter J Crouch, Brett M Paterson, James L Hickey, Paul S Donnelly, Irene Volitakis, Imke Tammen, David N Palmer, Anthony R White

Journal article  |  2013  |  PLoS One

Copper modulates the large dense core vesicle secretory pathway in PC12 cells

Clare Duncan, Laura Bica, Peter J Crouch, Aphrodite Caragounis, Grace E Lidgerwood, Sarah J Parker, Jodi Meyerowitz, Irene Volitakis, Jeffrey R Liddell, Ravinarayan Raghupathi, Brett M Paterson, Michael D Duffield, Roberto Cappai, Paul S Donnelly, Alexandra Grubman, James Camakaris, Damien J Keating, Anthony R White

Journal article  |  2013  |  Metallomics: integrated biometal science

Neuroinflammation and copper in Alzheimer's disease.

Xin Yi Choo, Lobna Alukaidey, Anthony R White, Alexandra Grubman

Journal article  |  2013  |  International Journal of Alzheimer's Disease

Inflammation is the innate immune response to infection or tissue damage. Initiation of proinflammatory cascades in the central ne..

Copper modulates the large dense core vesicle secretory pathway in PC12 cells (vol 5, pg 700, 2013)

Clare Duncan, Laura Bica, Peter J Crouch, Aphrodite Caragounis, Grace E Lidgerwood, Sarah J Parker, Jodi Meyerowitz, Irene Volitakis, Jeffrey R Liddell, Ravinarayan Raghupathi, Brett M Paterson, Michael D Duffield, Roberto Cappai, Paul S Donnelly, Alexandra Grubman, James Camakaris, Damien J Keating, Anthony R White

Journal article  |  2013  |  METALLOMICS

Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43.

Anthony White, Diane Moujalled, Janine James, Alexandra Grubman, Katja Kanninen, Peter Crouch

Journal article  |  2013  |  Molecular Neurodegeneration

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

Dominic J Hare, Alexandra Grubman, Timothy M Ryan, Amber Lothian, Jeffrey R Liddell, Rudolf Grimm, Toshiaki Matsuda, Philip A Doble, Robert A Cherny, Ashley I Bush, Anthony R White, Colin L Masters, Blaine R Roberts

Journal article  |  2013  |  Metallomics: integrated biometal science

Inhibition of TDP-43 Accumulation by Bis(thiosemicarbazonato)-Copper Complexes

Sarah J Parker, Jodi Meyerowitz, Janine L James, Jeffrey R Liddell, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, SinChun Lim, Brett M Paterson, Paul S Donnelly, Peter J Crouch, Anthony R White

Journal article  |  2012  |  PLOS ONE

The hypoxia imaging agent Cu-II(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

Lin W Hung, Victor L Villemagne, Lesley Cheng, Nicki A Sherratt, Scott Ayton, Anthony R White, Peter J Crouch, SinChun Lim, Su Ling Leong, Simon Wilkins, Jessica George, Blaine R Roberts, Chi LL Pham, Xiang Liu, Francis CK Chiu, David M Shackleford, Andrew K Powell, Colin L Masters, Ashley I Bush, Graeme O'Keefe, et al.

Journal article  |  2012  |  Journal of Experimental Medicine

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

Sarah J Parker, Jodi Meyerowitz, Janine L James, Jeffrey R Liddell, Peter J Crouch, Katja M Kanninen, Anthony R White

Journal article  |  2012  |  Neurochemistry International

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper(II)

Paul S Donnelly, Jeffrey R Liddell, SinChun Lim, Brett M Paterson, Michael A Cater, Maria S Savva, Alexandra I Mot, Janine L James, Ian A Trounce, Anthony R White, Peter J Crouch

Journal article  |  2012  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper complexes as therapeutic agents

Clare Duncan, Anthony R White

Journal article  |  2012  |  Metallomics: integrated biometal science

Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core-Shell Quantum Dots using Cyclooctyne Click Chemistry

Christine Schieber, Alessandra Bestetti, Jet Phey Lim, Anneke D Ryan, Nguyen Tich-Lam, Robert Eldridge, Anthony R White, Paul A Gleeson, Paul S Donnelly, Spencer J Williams, Paul Mulvaney

Journal article  |  2012  |  Angewandte Chemie - International Edition

The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells

Katherine A Price, James L Hickey, Zhiguang Xiao, Anthony G Wedd, Simon A James, Jeffrey R Liddell, Peter J Crouch, Anthony R White, Paul S Donnelly

Journal article  |  2012  |  CHEMICAL SCIENCE

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (Cu-II(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

Cynthia PW Soon, Paul S Donnelly, Bradley J Turner, Lin W Hung, Peter J Crouch, Nicki A Sherratt, Jiang-Li Tan, Nastasia K-H Lim, Linh Lam, Laura Bica, SinChun Lim, James L Hickey, Julia Morizzi, Andrew Powell, David I Finkelstein, Janetta G Culvenor, Colin L Masters, James Duce, Anthony R White, Kevin J Barnham, et al.

Journal article  |  2011  |  Journal of Biological Chemistry

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5

Tai Du, Aphrodite Caragounis, Sarah J Parker, Jodi Meyerowitz, Sharon La Fontaine, Katja M Kanninen, Victoria M Perreau, Peter J Crouch, Anthony R White

Journal article  |  2011  |  Free Radical Biology and Medicine

Mechanisms Controlling the Cellular Accumulation of Copper Bis(thiosemicarbazonato) Complexes

Katherine Ann Price, Peter J Crouch, Irene Volitakis, Brett M Paterson, SinChun Lim, Paul S Donnelly, Anthony R White

Journal article  |  2011  |  Inorganic Chemistry

The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity

Peter J Crouch, Maria S Savva, Lin W Hung, Paul S Donnelly, Alexandra I Mot, Sarah J Parker, Mark A Greenough, Irene Volitakis, Paul A Adlard, Robert A Cherny, Colin L Masters, Ashley I Bush, Kevin J Barnham, Anthony R White

Journal article  |  2011  |  Journal of Neurochemistry

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Jodi Meyerowitz, Sarah J Parker, Laura J Vella, Dominic CH Ng, Katherine A Price, Jeffrey R Liddell, Aphrodite Caragounis, Qiao-Xin Li, Colin L Masters, Takashi Nonaka, Masato Hasegawa, Marie A Bogoyevitch, Katja M Kanninen, Peter J Crouch, Anthony R White

Journal article  |  2011  |  MOLECULAR NEURODEGENERATION

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

Paul A Adlard, Laura Bica, Anthony R White, Milawaty Nurjono, Gulay Filiz, Peter J Crouch, Paul S Donnelly, Roberto Cappai, David I Finkelstein, Ashley I Bush

Journal article  |  2011  |  PLOS ONE

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

Laura Bica, Jodi Meyerowitz, Sarah J Parker, Aphrodite Caragounis, Tai Du, Brett M Paterson, Kevin J Barnham, Peter J Crouch, Anthony R White, Paul S Donnelly

Journal article  |  2011  |  Biometals

Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway.

Katja Kanninen, Anthony R White, Jari Koistinaho, Tarja Malm

Journal article  |  2011  |  International Journal of Alzheimer's Disease

Specific regions of the Alzheimer's disease (AD) brain are burdened with extracellular protein deposits, the accumulation of which..

Subcellular localization of a fluorescent derivative of Cu-II(atsm) offers insight into the neuroprotective action of Cu-II(atsm)

Katherine Ann Price, Peter J Crouch, SinChun Lim, Brett M Paterson, Jeffrey R Liddell, Paul S Donnelly, Anthony R White

Journal article  |  2011  |  Metallomics: integrated biometal science

Metals and Alzheimer's disease.

Anthony R White, Peter Faller, Craig S Atwood, Paolo Zatta

Journal article  |  2011  |  International journal of Alzheimer's disease

Water-soluble Bis(thiosemicarbazonato)copper(II) Complexes

Gojko Buncic, James L Hickey, Christine Schieber, Jonathan M White, Peter J Crouch, Anthony R White, Zhiguang Xiao, Anthony G Wedd, Paul S Donnelly

Journal article  |  2011  |  Australian Journal of Chemistry

Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3 beta inhibition due to intracellular delivery of copper

James L Hickey, Peter J Crouch, Sithorn Mey, Aphrodite Caragounis, Jonathan M White, Anthony R White, Paul S Donnelly

Journal article  |  2011  |  Dalton Transactions

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate.

Michael Ho, David E Hoke, Yee Jia Chua, Qiao-Xin Li, Janetta G Culvenor, Colin Masters, Anthony R White, Geneviève Evin

Journal article  |  2010  |  International Journal of Alzheimer's Disease

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor..

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

Marcus W Brazier, Irene Volitakis, Magda Kvasnicka, Anthony R White, John R Underwood, Jason E Green, Sen Han, Andrew F Hill, Colin L Masters, Steven J Collins

Journal article  |  2010  |  Journal of Neurochemistry

A domain level interaction network of amyloid precursor protein and A beta of Alzheimer's disease

Victoria M Perreau, Sandra Orchard, Paul A Adlard, Shayne A Bellingham, Roberto Cappai, Giuseppe D Ciccotosto, Tiffany F Cowie, Peter J Crouch, James A Duce, Genevieve Evin, Noel G Faux, Andrew F Hill, Ya Hui Hung, Simon A James, Qiao-Xin Li, Su San Mok, Deborah J Tew, Anthony R White, Ashley I Bush, Henning Hermjakob, et al.

Journal article  |  2010  |  Proteomics

Blood-Borne Amyloid-beta Dimer Correlates with Clinical Markers of Alzheimer's Disease

Victor L Villemagne, Keyla A Perez, Kerryn E Pike, W Mei Kok, Christopher C Rowe, Anthony R White, Pierrick Bourgeat, Olivier Salvado, Justin Bedo, Craig A Hutton, Noel G Faux, Colin L Masters, Kevin J Barnham

Journal article  |  2010  |  Journal of Neuroscience

Zinc induces depletion and aggregation of endogenous TDP-43

Aphrodite Caragounis, Katherine Ann Price, Cynthia PW Soon, Gulay Filiz, Colin L Masters, Qiao-Xin Li, Peter J Crouch, Anthony R White

Journal article  |  2010  |  Free Radical Biology and Medicine

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

Cynthia PW Soon, Peter J Crouch, Bradley J Turner, Catriona A McLean, Katrina M Laughton, Julie D Atkin, Colin L Masters, Anthony R White, Qiao-Xin Li

Journal article  |  2010  |  Neuromuscular Disorders

Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies

SinChun Lim, Katherine A Price, Siow-Feng Chong, Brett M Paterson, Aphrodite Caragounis, Kevin J Barnham, Peter J Crouch, Josephine M Peach, Jonathan R Dilworth, Anthony R White, Paul S Donnelly

Journal article  |  2010  |  Journal of Biological Inorganic Chemistry

Bis(thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease

Michelle T Fodero-Tavoletti, Victor L Villemagne, Brett M Paterson, Anthony R White, Qiao-Xin Li, James Camakaris, Graeme J O'Keefe, Roberto Cappai, Kevin J Barnham, Paul S Donnelly

Journal article  |  2010  |  Journal of Alzheimer's Disease

Sustained Activation of Glial Cell Epidermal Growth Factor Receptor by Bis(thiosemicarbazonato) Metal Complexes Is Associated with Inhibition of Protein Tyrosine Phosphatase Activity

Katherine Ann Price, Aphrodite Caragounis, Brett M Paterson, Gulay Filiz, Irene Volitakis, Colin L Masters, Kevin J Barnham, Paul S Donnelly, Peter J Crouch, Anthony R White

Journal article  |  2009  |  Journal of Medicinal Chemistry

MODULATING COPPER BIO-AVAILABILITY TO TREAT NEURODEGENERATIVE DISEASES

PJ Crouch, LW Hung, CP Soon, PA Adlard, A Bush, CL Masters, QX Li, PS Donnelly, KJ Barnham, AR White

Conference Proceedings  |  2009  |  JOURNAL OF NEUROCHEMISTRY

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

Peter J Crouch, Deborah J Tew, Tai Du, Diem Ngoc Nguyen, Aphrodite Caragounis, Gulay Filiz, Rachel E Blake, Ian A Trounce, Cynthia PW Soon, Katrina Laughton, Keyla A Perez, Qiao-Xin Li, Robert A Cherny, Colin L Masters, Kevin J Barnham, Anthony R White

Journal article  |  2009  |  Journal of Neurochemistry

Membrane-targeted strategies for modulating APP and A beta-mediated toxicity

Katherine A Price, Peter J Crouch, Paul S Donnelly, Colin L Masters, Anthony R White, Cyril C Curtain

Journal article  |  2009  |  Journal of Cellular and Molecular Medicine

Increasing Cu bioavailability inhibits A beta oligomers and tau phosphorylation

Peter J Crouch, Lin Wai Hung, Paul A Adlard, Mikhalina Cortes, Varsha Lal, Gulay Filiz, Keyla A Perez, Milawaty Nurjono, Aphrodite Caragounis, Tai Du, Katrina Laughton, Irene Volitakis, Ashley I Bush, Qiao-Xin Li, Colin L Masters, Roberto Cappai, Robert A Cherny, Paul S Donnelly, Anthony R White, Kevin J Barnham

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease

Laura Bica, Peter J Crouch, Roberto Cappai, Anthony R White

Journal article  |  2009  |  Mol. BioSyst.

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

Kevin J Barnham, Vijaya B Kenche, Giuseppe D Ciccotosto, David P Smith, Deborah J Tew, Xiang Liu, Keyla Perez, Greg A Cranston, Timothy J Johanssen, Irene Volitakis, Ashley I Bush, Colin L Masters, Anthony R White, Jeffrey P Smith, Robert A Cherny, Roberto Cappai

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

Tai Du, Sharon L La Fontaine, Michael Abdo, Shayne A Bellingham, Mark Greenough, Irene Volitakis, Robert A Cherny, Ashley I Bush, Peter J Hudson, James Camakaris, Julian F Mercer, Peter J Crouch, Colin L Masters, Victoria M Perreau, Anthony R White

Journal article  |  2008  |  Proteomics - Clinical Applications

The role of metals in modulating metalloprotease activity in the AD brain

Gulay Filiz, Katherine A Price, Aphrodite Caragounis, Tai Du, Peter J Crouch, Anthony R White

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

Selective intracellular release of copper and zinc ions from bis( thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

Paul S Donnelly, Aphrodite Caragounis, Tai Du, Katrina M Laughton, Irene Volitakis, Robert A Cherny, Robyn A Sharples, Andrew F Hill, Qiao-Xin Li, Colin L Masters, Kevin J Barnham, Anthony R White

Journal article  |  2008  |  Journal of Biological Chemistry

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

Katherine A Price, Gulay Filiz, Aphrodite Caragounis, Tai Du, Katrina M Laughton, Colin L Masters, Robyn A Sharples, Andrew F Hill, Qiao-Xin Li, Paul S Donnelly, Kevin J Barnham, Peter J Crouch, Anthony R White

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

Tai Du, Gulay Filiz, Aphrodite Caragounis, Peter J Crouch, Anthony R White

Journal article  |  2008  |  Journal of Pharmacology and Experimental Therapeutics

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation

Tai Du, Giuseppe D Ciccotosto, Greg A Cranston, Gulcan Kocak, Colin L Masters, Peter J Crouch, Roberto Cappai, Anthony R White

Journal article  |  2008  |  Free Radical Biology and Medicine

Metal delivery agents and therapeutic uses of the same

K BARNHAM, P DONNELLY, A WHITE

Patent  |  2008

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

Peter J Crouch, Susan-Marie E Harding, Anthony R White, James Camakaris, Ashley I Bush, Colin L Masters

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Neurotoxicity of prion peptides on cultured cerebellar neurons.

Giuseppe D Ciccotosto, Roberto Cappai, Anthony R White

Book Chapter  |  2008  |  Methods in Molecular Biology

Prion peptide (PrP) neurotoxicity has been modelled in vitro by using synthetic peptides derived from the PrP(C) sequence. The maj..

Preparation of metal complexes for therapeutic uses

K BARNHAM, P DONNELLY, A WHITE

Patent  |  2008

Neurotoxicity of prion peptides on cultured cerebellar neurons

GD Ciccotosto, R Cappai, AR White

Journal article  |  2008  |  Methods in Molecular Biology

Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

Gulay Filiz, Aphrodite Caragounis, Laura Bica, Tai Du, Colin L Masters, Peter J Crouch, Anthony R White

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands

Aphrodite Caragounis, Tai Du, Gulay Filiz, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Robert A Cherny, Colin L Masters, Simon C Drew, Andrew F Hill, Qiao-Xin Li, Peter J Crouch, Kevin J Barnham, Anthony R White

Journal article  |  2007  |  Biochemical Journal

Therapeutic treatment of Alzheimer's disease using metal complexing agents.

Katherine A Price, Peter J Crouch, Anthony R White

Journal article  |  2007  |  Recent Patents on CNS Drug Discovery

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by deposition of extracellular amyloid plaques,..

The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease

Peter J Crouch, Anthony R White, Ashley I Bush

Journal article  |  2007  |  FEBS Journal

Modulation of Alzheimer's disease amyloid beta peptide turnover by metal ligands

A Caragounis, T Du, G Filiz, KA Price, KM Laughton, CL Masters, AF Hill, Q Li, KJ Barnham, PJ Crouch, AR White

Conference Proceedings  |  2007  |  JOURNAL OF NEUROCHEMISTRY

Copper and zinc bis(thiosemicarbazonato) complexes for the treatment of Alzheimer's disease

P DONNELLY, K BARNHAM, A WHITE

Journal article  |  2007  |  Journal of Biological Inorganic Chemistry

Metals and Alzheimer's disease

Paul A Adlard, Ashley I Bush

Journal article  |  2006  |  Journal of Alzheimer's Disease

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

Peter J Crouch, Kevin J Barnham, Ashley I Bush, Anthony R White

Journal article  |  2006  |  Drug News & Perspectives

Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases

AR White, T Du, KM Laughton, I Volitakis, RA Sharples, DE Hoke, RMD Holsinger, G Evin, RA Cherny, AF Hill, KJ Barnham, QX Li, A Bush, CL Masters

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

Anthony R White, Tai Du, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Michel E Xilinas, David E Hoke, RM Damian Holsinger, Genevieve Evin, Robert A Cherny, Andrew F Hill, Kevin J Barnham, Qiao-Xin Li, Ashley I Bush, Colin L Masters

Journal article  |  2006  |  Journal of Biological Chemistry

Metal homeostasis in Alzheimer's disease

Anthony R White, Kevin J Barnham, Ashley I Bush

Journal article  |  2006  |  Expert Review of Neurotherapeutics

Metal homeostasis in Alzheimer's disease.

Anthony R White, Kevin J Barnham, Ashley I Bush

Journal article  |  2006  |  Expert Review of Neurotherapeutics

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by neuronal dysfunction and the formation of am..

Overexpression of A beta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model

QX Li, S San Mok, KM Laughton, CA McLean, I Volitakis, RA Cherny, NS Cheung, AR White, CL Masters

Journal article  |  2006  |  Aging Cell

Correlative studies support lipid peroxidation is linked to PrPres propagation as art early primary pathogenic event in prion disease

MW Brazier, V Lewis, GD Ciccotosto, GM Klub, VA Lawson, R Cappai, JW Ironside, CL Masters, AF Hill, AR White, S Collins

Journal article  |  2006  |  Brain Research Bulletin

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

DE Hoke, JL Tan, NT Ilaya, JG Culvenor, SJ Smith, AR White, CL Masters, GM Evin

Journal article  |  2005  |  The FEBS Journal

Peptide-oligonucleotide hybrids in antisense therapy

TL Pierce, AR White, GW Tregear, PM Sexton

Journal article  |  2005  |  Mini-Reviews in Medicinal Chemistry

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

SA Bellingham, GD Ciccotosto, BE Needham, LR Fodero, AR White, CL Masters, R Cappai, J Camakaris

Journal article  |  2004  |  Journal of Neurochemistry

SIRNA and antisense RNA mediated knockdown of mammalian PrP expression

AF Hill, H Sen, AR White, R Sharples, S Patrick, SJ Collins, R Cappai, CL Masters

Conference Proceedings  |  2004  |  Neurobiology of Aging

Iron inhibits neurotoxicity induced by trace copper and biological reductants

AR White, KJ Barnham, X Huang, I Voltakis, K Beyreuther, CL Masters, RA Cherny, AI Bush, R Cappai

Journal article  |  2004  |  Journal of Biological Inorganic Chemistry

Immunotherapy as a therapeutic treatment for neurodegenerative disorders

AR White, SH Hawke

Journal article  |  2003  |  Journal of Neurochemistry

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain - A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

AR White, F Maher, MW Brazier, MF Jobling, J Thyer, LR Stewart, A Thompson, R Gibson, CL Masters, G Multhaup, K Beyreuther, CJ Barrow, SJ Collins, R Cappai

Journal article  |  2003  |  Brain Research

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

AR White, R Cappai

Journal article  |  2003  |  Journal of Neuroscience Research

Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides

J Saez-Valero, LR Fodero, AR White, CJ Barrow, DH Small

Journal article  |  2003  |  Brain Research

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

AR White, P Enever, M Tayebi, R Mushens, J Linehan, S Brandner, D Anstee, J Collinge, S Hawke

Journal article  |  2003  |  Nature

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

CJ Maynard, R Cappai, I Volitakis, RA Cherny, AR White, K Beyreuther, CL Masters, AI Bush, QX Li

Journal article  |  2002  |  Journal of Biological Chemistry

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid - Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2

C Opazo, XD Huang, RA Cherny, RD Moir, AE Roher, AR White, R Cappai, CL Masters, RE Tanzi, NC Inestrosa, AI Bush

Journal article  |  2002  |  Journal of Biological Chemistry

Evidence for a copper-binding superfamily of the amyloid precursor protein

A Simons, T Ruppert, C Schmidt, A Schlicksupp, R Pipkorn, J Reed, CL Masters, AR White, R Cappai, K Beyreuther, TA Bayer, G Multhaup

Journal article  |  2002  |  Biochemistry

Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF)

JA Hamilton, G Whitty, AR White, MF Jobling, A Thompson, CJ Barrow, R Cappai, K Beyreuther, CL Masters

Journal article  |  2002  |  Brain Research

Isolation and growth of a cytopathic agent from multiple sclerosis brain tissue

AR White, NS Dutton, RD Cook

Journal article  |  2002  |  Journal of Neurovirology

Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein

AR White, G Multhaup, D Galatis, WJ McKinstry, MW Parker, R Pipkorn, K Beyreuther, CL Masters, R Cappai

Journal article  |  2002  |  Journal of Neuroscience

Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126

LR Stewart, AR White, MF Jobling, BE Needham, F Maher, J Thyer, K Beyreuther, CL Masters, SJ Collins, R Cappai

Journal article  |  2001  |  Journal of Neuroscience Research

Copper interaction with the amyloid precursor protein (APP)

G Multhaup, A Simons, C Schmidt, A Schlicksupp, J Reed, AR White, R Cappai, K Beyreuther

Journal article  |  2001  |  JOURNAL OF INORGANIC BIOCHEMISTRY

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126

MF Jobling, XD Huang, LR Stewart, KJ Barnham, C Curtain, I Volitakis, M Perugini, AR White, RA Cherny, CL Masters, CJ Barrow, SJ Collins, AI Bush, R Cappai

Journal article  |  2001  |  Biochemistry

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons

AR White, R Guirguis, MW Brazier, MF Jobling, AF Hill, K Beyreuther, CJ Barrow, CL Masters, SJ Collins, R Cappai

Journal article  |  2001  |  Neurobiology of Disease

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

AR White, XD Huang, MF Jobling, CJ Barrow, K Beyreuther, CL Masters, AI Bush, R Cappai

Journal article  |  2001  |  Journal of Neurochemistry

Amyloidgenicity and neurotoxicity of peptides corresponding to the helical regions of PrPC

A Thompson, AR White, C McLean, CL Masters, R Cappai, CJ Barrow

Journal article  |  2000  |  Journal of Neuroscience Research

The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures

AR White, G Multhaup, F Maher, S Bellingham, J Camakaris, H Zheng, AI Bush, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  The Journal of Neuroscience

Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity

AR White, SJ Collins, F Maher, MF Jobling, LR Stewart, JM Thyer, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  The American Journal of Pathology

The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126

MF Jobling, LR Stewart, AR White, C McLean, A Friedhuber, F Maher, K Beyreuther, CL Masters, CJ Barrow, SJ Collins, R Cappai

Journal article  |  1999  |  Journal of Neurochemistry

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

AR White, R Reyes, JFB Mercer, J Camakaris, H Zheng, AI Bush, G Multhaup, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  Brain Research

Amyloid beta

R Cappai, AR White

Journal article  |  1999  |  The International Journal of Biochemistry & Cell Biology

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione

AR White, AI Bush, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  Journal of Neurochemistry

Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: Implications for the mechanism of prion formation

R Cappai, L Stewart, MF Jobling, JM Thyer, AR White, K Beyreuther, SJ Collins, CL Masters, CJ Barrow

Journal article  |  1999  |  Biochemistry

The synthesis and spectroscopic analysis of the neurotoxic prion peptide 106-126: Comparative use of manual Boc and Fmoc chemistry

MF Jobling, CJ Barrow, AR White, CL Masters, SJ Collins, R Cappai

Journal article  |  1999  |  Letters in Peptide Science

The synthesis and spectroscopic analysis of the neurotoxic prion peptide 106-126: Comparative use of manual Boc and Fmoc chemistry

MF Jobling, CJ Barrow, AR White, CL Masters, SJ Collins, R Cappai

Journal article  |  1999  |  International Journal of Peptide Research and Therapeutics

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress

AR White, H Zheng, D Galatis, F Maher, L Hesse, G Multhaup, K Beyreuther, CL Masters, R Cappai

Journal article  |  1998  |  The Journal of Neuroscience