James Ziogas

Using high-resolution Twin-Ion Metabolite Extraction (HiTIME) mass spectrometry with stable isotope labelling to investigate the metabolism of valproic acid in vivo

Michael G Leeming, Noel Cranswick, Christine E Wright, James Ziogas, Terence J O'Brien, William A Donald, Richard AJ O'Hair

Journal article  |  2019  |  International Journal of Mass Spectrometry

Association of copeptin, a surrogate marker of arginine vasopressin, with cerebral vasospasm and delayed ischemic neurologic deficit after aneurysmal subarachnoid hemorrhage

Sandra J Fernandez, Ibraham Barakat, James Ziogas, Tony Frugier, Stanley S Stylli, John D Laidlaw, Andrew H Kaye, Alexios A Adamides

Journal article  |  2019  |  Journal of Neurosurgery

Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions.

Maria Roitman, Laura E Edgington-Mitchell, Jon Mangum, James Ziogas, Alexios A Adamides, Paul Myles, Hearan Choo-Bunnett, Nigel W Bunnett, Jenny M Gunnersen

Journal article  |  2019  |  PAIN Reports

Introduction: Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain ..

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

Elena K Schneider-Futschik, Olivia KA Paulin, Daniel Hoyer, Kade D Roberts, James Ziogas, Mark A Baker, John Karas, Jian Li, Tony Velkov

Journal article  |  2018  |  ACS Infectious Diseases

miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage

Stanley S Stylli, Alexios A Adamides, Rachel M Koldej, Rodney B Luwor, David S Ritchie, James Ziogas, Andrew H Kaye

Journal article  |  2017  |  Journal of Neurosurgery

High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing

Michael G Leeming, Andrew P Isaac, Bernard J Pope, Noel Cranswick, Christine E Wright, James Ziogas, Richard AJ O'Hair, William A Donald

Journal article  |  2015  |  Analytical Chemistry

Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Bich Anh Chau, Grant Drummond, W Roy Jackson, Bevyn Jarrott, Alyson A Miller, Kamani R Subasinghe, Christina YR Tan, Paul J White, Christine E Wright, James Ziogas

Journal article  |  2015  |  MedChemComm

The role of voltage-operated and non-voltage-operated calcium channels in endothelin-induced vasoconstriction of rat cerebral arteries

Yohannes A Mamo, James A Angus, James Ziogas, Paul F Soeding, Christine E Wright

Journal article  |  2014  |  European Journal of Pharmacology

Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes

Francis HW Shand, Satoshi Ueha, Mikiya Otsuji, Suang Suang Koid, Shigeyuki Shichino, Tatsuya Tsukui, Mizuha Kosugi-Kanaya, Jun Abe, Michio Tomura, James Ziogas, Kouji Matsushima

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Aliskiren Reduces Myocardial Ischemia-Reperfusion Injury by a Bradykinin B-2 Receptor- and Angiotensin AT(2) Receptor-Mediated Mechanism

Suang Suang Koid, James Ziogas, Duncan John Campbell

Journal article  |  2014  |  Hypertension

An evaluation of pharmacology curricula in Australian science and health-related degree programs

Hilary Lloyd, Tina Hinton, Shane Bullock, Anna-Marie Babey, Elizabeth Davis, Lynette Fernandes, Joanne Hart, Ian Musgrave, James Ziogas

Journal article  |  2013  |  BMC Medical Education

Dual action molecules: Bioassays of combined novel antioxidants and angiotensin II receptor antagonists

Nitya V Jani, James Ziogas, James A Angus, Carl H Schiesser, Phoebe E Macdougall, Rebecca L Grange, Christine E Wright

Journal article  |  2012  |  European Journal of Pharmacology

Fluorescent Angiotensin AT(1) Receptor Antagonists

Marilena A Giarrusso, Michelle K Taylor, James Ziogas, Kate M Brody, Phoebe E Macdougall, Carl H Schiesser

Journal article  |  2012  |  Asian Journal of Organic Chemistry

ALISKIREN REDUCES MYOCARDIAL INFARCT SIZE IN SPRAGUE DAWLEY RATS AT A DOSE THAT DOES NOT REDUCE CIRCULATING OR CARDIAC ANGIOTENSIN II LEVELS

SS Koid, J Ziogas, DJ Campbell

Conference Proceedings  |  2012  |  HYPERTENSION

INITIAL ORTHOSTATIC HYPOTENSION-THE IMPORTANCE OF A RISE OR FALL IN CARDIAC OUTPUT?

S Harrap, J Bourke, J Ziogas, M Hargreaves

Conference Proceedings  |  2012  |  HYPERTENSION

Exogenous glutathione is essential in the testing of antioxidant capacity using radical-induced haemolysis

Nitya Jani, James Ziogas, James A Angus, Christine E Wright

Journal article  |  2012  |  Journal of Pharmacological and Toxicological Methods

In Vitro and In Vivo Evidence for Anti-Inflammatory Properties of 2-Methoxyestradiol

FHW Shand, SY Langenbach, CR Keenan, SP Ma, BJ Wheaton, MJ Schuliga, J Ziogas, AG Stewart

Journal article  |  2011  |  Journal of Pharmacology and Experimental Therapeutics

Collagen remodelling by airway smooth muscle is resistant to steroids and beta(2)-agonists

JE Bourke, X Li, SR Foster, E Wee, H Dagher, J Ziogas, T Harris, JV Bonacci, AG Stewart

Journal article  |  2011  |  European Respiratory Journal

Tandem free-radical addition/substitution chemistry and its application to the preparation of novel AT(1) receptor antagonists

Maree K Staples, Rebecca L Grange, James A Angus, James Ziogas, Nichole PH Tan, Michelle K Taylor, Carl H Schiesser

Journal article  |  2011  |  Organic & Biomolecular Chemistry

Identification and Differential Distribution of the Prostatic Interstitial Cells in the Mouse Prostate: Implications for Prostate-specific Diseases

KM Brody, J Ziogas, S Kusljic

Journal article  |  2011  |  Journal of Cell and Tissue Research

Novel paramagnetic AT(1) receptor antagonists

Nichole PH Tan, Michelle K Taylor, Steven E Bottle, Christine E Wright, James Ziogas, Jonathan M White, Carl H Schiesser, Nitya V Jani

Journal article  |  2011  |  Chemical Communications

Ligand-Supported Purification of the Urotensin-II Receptor

Ann T Du, Doene Onan, Diem T Dinh, Michael J Lew, James Ziogas, Marie-Isabel Aguilar, Leonard K Pattenden, Walter G Thomas

Journal article  |  2010  |  Molecular Pharmacology

Selenosartans: Novel selenophene analogues of milfasartan and eprosartan

Rebecca L Grange, James Ziogas, Andrea J North, James A Angus, Carl H Schiesser

Journal article  |  2008  |  Bioorganic and Medicinal Chemistry Letters

Selenofonsartan analogues: novel selenium-containing antihypertensive compounds

Rebecca L Grange, James Ziogas, James A Angus, Carl H Schiesser

Journal article  |  2007  |  Tetrahedron Letters

2-methoxyestradiol - a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents

Tara E Sutherland, Robin L Anderson, Richard A Hughes, Emile Altmann, Michael Schuliga, James Ziogas, Alastair G Stewart

Journal article  |  2007  |  Drug Discovery Today

2-Methoxyestradiol – a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents

T SUTHERLAND, R ANDERSON, R HUGHES, E ALTMANN, M SCHULIGA, J ZIOGAS, A STEWART

Journal article  |  2007  |  Drug Discovery Today: Therapeutic Strategies

Molecular and cellular targets in tissue remodelling

AG Stewart, J Ziogas

Journal article  |  2006  |  Pulmonary Pharmacology and Therapeutics

Autonomic Nervous System

O WOODMAN, J ZIOGAS, C ANDERSON, G KENNEDY

Software / Code  |  2005

The two-state model of antagonist-AT(1) receptor interaction: an hypothesis defended but not tested

MJ Lew, J Ziogas

Journal article  |  2004  |  Biochemical Pharmacology

Involvement of T-type calcium channels in excitatory junction potentials in rat resistance mesenteric arteries

Q Xi, J Ziogas, JA Roberts, RJ Evans, JA Angus

Journal article  |  2002  |  British Journal of Pharmacology

Studies on the mechanism of enhancement of purinergic transmission by caffeine in the guinea-pig isolated vas deferens.

J Ziogas, M O'Farrell

Journal article  |  2002  |  Autonomic and Autacoid Pharmacology

1. Purinergic transmission from sympathetic nerves in the guinea-pig vas deferens was monitored using intracellular recording tech..

Neuronal NO mediates cerebral vasodilator responses to K in hypertensive rats

S Chrissobolis, J Ziogas, CR Anderson, Y Chu, FM Faraci, CG Sobey

Journal article  |  2002  |  Hypertension

Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors

AC Holloway, HW Qian, L Pipolo, J Ziogas, SI Miura, S Karnik, BR Southwell, MJ Lew, WG Thomas

Journal article  |  2002  |  Molecular Pharmacology

Pharmacokinetics Tutorial

J ZIOGAS, MJ LEW, GE KENNEDY, K SWEENEY

Software / Code  |  2002

Insurmountable AT(1) receptor antagonism: message in a model?

M Lew, A Christopoulos, J Ziogas

Journal article  |  2001  |  Trends in Pharmacological Sciences

Non-surmountable antagonism: transcending steady state - Response from Lew et al.

MJ Lew, A Christopoulos, J Ziogas

Journal article  |  2001  |  Trends in Pharmacological Sciences

Angiotensin-induced enhancement of excitatory junction potentials evoked by periarteriolar nerve stimulation and vasoconstriction in rat mesenteric arteries are both mediated by the angiotensin AT1 receptor

J Ziogas, K Vessey

Journal article  |  2001  |  Pharmacology

Response from Non-sumountable antagonism: transcending steady steady state

MJ LEW, A CHRISTOPOULOS, J ZIOGAS

Journal article  |  2001  |  Trends in Pharmacological Sciences

Role of inwardly rectifying K( ) channels in K( )-induced cerebral vasodilatation in vivo.

S Chrissobolis, J Ziogas, Y Chu, FM Faraci, CG Sobey

Journal article  |  2000  |  American Journal of Physiology-Heart and Circulatory Physiology

We tested whether activation of inwardly rectifying K(+) (Kir) channels, Na(+)-K(+)-ATPase, or nitric oxide synthase (NOS) play a ..

Dynamic mechanisms of non-classical antagonism by competitive AT(1) receptor antagonists

MJ Lew, J Ziogas, A Christopoulos

Journal article  |  2000  |  Trends in Pharmacological Sciences

Apamin- and nitric oxide-sensitive biphasic non-adrenergic non-cholinergic inhibitory junction potentials in the rat anococcygeus muscle.

S Selemidis, J Ziogas, TM Cocks

Journal article  |  1998  |  The Journal of Physiology

1. Changes in membrane potential following electrical field stimulation (EFS; 1, 2 and 5 pulses at 5 Hz, 0.5 ms duration, 60-80 V)..

Effects of N- and L-type calcium channel antagonists and ( /-)-Bay K8644 on nerve-induced catecholamine secretion from bovine perfused adrenal glands.

M O'Farrell, J Ziogas, PD Marley

Journal article  |  1997  |  British Journal of Pharmacology

1. The effects of N- and L-type calcium channel antagonists and (+/-)-Bay K8644 on catecholamine release from chromaffin cells and..

Angiotensin II-mediated inhibition of noradrenergic neuroeffector transmission in the rat caudal artery may involve ati receptors

SL Cox, DF Stow, J Ziogas

Journal article  |  1996  |  FASEB Journal

Multiple prejunctional actions of angiotensin II on noradrenergic transmission in the caudal artery of the rat.

SL Cox, DF Story, J Ziogas

Journal article  |  1996  |  British Journal of Pharmacology

1. Angiotensin II produced concentration-dependent enhancement of both stimulation-induced (S-I) efflux of [3H]-noradrenaline and ..

Angiotensin II receptors involved in the enhancement of noradrenergic transmission in the caudal artery of the spontaneously hypertensive rat.

SL Cox, DF Story, J Ziogas

Journal article  |  1996  |  British Journal of Pharmacology

1. The effects of the AT1 receptor antagonist losartan and the AT2 receptor antagonist PD 123319, on actions of angiotensin II in ..

Caffeine enhances sympathetic purinergic and noradrenergic transmission in the guinea-pig isolated vas deferens.

J Ziogas, M O'Farrell, M Slaughter

Journal article  |  1995  |  Naunyn-Schmiedeberg's Archives of Pharmacology

Intracellular recording techniques were used to monitor the resting membrane potential of smooth muscle cells and the excitatory j..

Evidence for the involvement of different receptor subtypes in the pre- and postjunctional actions of angiotensin II at rat sympathetic neuroeffector sites.

SL Cox, A Ben, DF Story, J Ziogas

Journal article  |  1995  |  British Journal of Pharmacology

1. The effects of the nonpeptide angiotensin II receptor (AT) antagonists losartan and PD 123319 on actions of angiotensin II in t..

Modulation of nerve activity recorded extracellularly from the surface of rat mesenteric arteries in vivo by α-adrenoceptor agonists

RJ Evans, J Ziogas, TC Cunnane

Conference Proceedings  |  1992  |  Journal of Physiology

An electrophysiological study of the actions of angiotensin II at the sympathetic neuroeffector junction in the guinea-pig vas deferens.

J Ziogas, TC Cunnane

Journal article  |  1991  |  British Journal of Pharmacology

1. The effects of angiotensin II on sympathetic neuroeffector transmission in the guinea-pig vas deferens have been investigated b..

Angiotensin II generation in the rat vena cava: stimulation of local synthesis by beta-adrenoceptor activation.

J Ziogas, DF Story

Journal article  |  1991  |  Naunyn-Schmiedeberg's Archives of Pharmacology

There is considerable evidence to suggest that isolated tissues have the capacity to generate angiotensin II and that angiotensin ..

Metabolism of tetradecapeptide, angiotensinogen and angiotensin I and II by isolated perfused rat hindlimbs.

DJ Campbell, J Ziogas, A Kladis

Journal article  |  1990  |  Clinical and Experimental Pharmacology and Physiology

1. We investigated the mechanism of tetradecapeptide-induced vasoconstriction by studying the metabolism of tetradecapeptide (TDP)..

Actions of Angiotensin II on Sympathetic Noradrenergic and Purinergic Transmission in the Guinea Pig Vas Deferens

TC CUNNANE, CF WARDELL, J ZIOGAS

Journal article  |  1990  |  Annals of the New York Academy of Sciences

The effect of calcium on facilitation of sympathetic transmission in the guinea-pig isolated vas deferens

TC Cunnane, J Ziogas

Conference Proceedings  |  1990  |  Journal of Physiology

Local application of omega-conotoxin GVIA to sympathetic nerve terminals in the guinea-pig isolated vas deferens.

JA Brock, TC Cunnane, J Ziogas

Journal article  |  1989  |  British journal of pharmacology

Staphylococcus aureus 502A was grown in the presence of one-third of the minimal inhibitory concentration of clindamycin. Phagocyt..

INHIBITION OF TRANSMITTER RELEASE FROM SYMPATHETIC-NERVE ENDINGS BY OMEGA-CONOTOXIN

JA BROCK, TC CUNNANE, RJ EVANS, J ZIOGAS

Journal article  |  1989  |  Clinical and Experimental Pharmacology and Physiology

Effect of locally generated angiotensin II on noradrenergic neuroeffector function in the rat isolated caudal artery.

J Ziogas, DF Story

Journal article  |  1987  |  Journal of Hypertension

The effects of angiotensin II and its precursors angiotensin I and tetradecapeptide renin substrate were investigated in isolated ..

Interaction of angiotensin with noradrenergic neuroeffector transmission

DF Story, J Ziogas

Journal article  |  1987  |  Trends in Pharmacological Sciences

Modulation of neuroeffector transmission.

MJ Rand, H Majewski, H Wong-Dusting, DF Story, RE Loiacono, J Ziogas

Journal article  |  1987  |  Journal of Cardiovascular Pharmacology

Local mechanisms that regulate transmitter release at autonomic neuroeffector junctions may be classified into four main types: (a..

Effects of angiotensin converting enzyme inhibitors and saralasin on noradrenergic and cholinergic transmitter release in guinea pig isolated atria.

J Ziogas, DF Story, MJ Rand

Journal article  |  1987  |  Journal of Cardiovascular Pharmacology

The interactions of the converting enzyme inhibitors captopril and enalaprilat and the angiotensin II receptor antagonist saralasi..

Effects of tetradecapeptide renin substrate on isolated preparations of rat caudal artery, guinea-pig atria and on pithed rat blood pressure.

J Ziogas, DF Story, MJ Rand

Journal article  |  1986  |  Clinical and Experimental Pharmacology and Physiology

In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulati..

Role of the endothelium on the facilitatory effects of angiotensin I and angiotensin II on noradrenergic transmission in the caudal artery of the rat.

DF Story, J Ziogas

Journal article  |  1986  |  British Journal of Pharmacology

Perfusion of carbogen gas through the lumen of the rat caudal artery abolished the dilator response to acetylcholine (1 mumol 1(-1..

Effects of locally generated angiotensin II on noradrenergic transmission in guinea-pig isolated atria.

J Ziogas, DF Story, MJ Rand

Journal article  |  1984  |  European Journal of Pharmacology

The extent to which cardiac neuroeffector function may be modulated by angiotensin II (AII) generated locally from angiotensin I (..

Facilitation of noradrenergic transmission by locally generated angiotensin II in guinea-pig isolated atria and in the perfused caudal artery of the rat.

J Ziogas, DF Story, MJ Rand

Journal article  |  1984  |  Clinical and Experimental Pharmacology and Physiology

In guinea-pig isolated atria, angiotensin I and angiotensin II produced concentration dependent increases in the rate of spontaneo..