Paul Kalitsis

Topoisomerase II alpha is essential for maintenance of mitotic chromosome structure

Christian F Nielsen, Tao Zhang, Marin Barisic, Paul Kalitsis, Damien F Hudson

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for establishing mitotic chromosome condensatio..

Loss of TOP3B leads to increased R-loop formation and genome instability

Tao Zhang, Mathew Wallis, Vida Petrovic, Jackie Challis, Paul Kalitsis, Damien F Hudson

Journal article  |  2019  |  Open Biology

Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmati..

Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages

Poshmaal Dhar, Sohinee Sarkar, Garrett Z Ng, Paul Kalitsis, Muhammad A Saeed, Michael A McGuckin, Justine A Ellis, Philip Sutton

Journal article  |  2019  |  Human Immunology

Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infect..

A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect

Michael J McKay, Jeffery Craig, Paul Kalitsis, Sergei Kozlov, Sandra Verschoor, Phillip Chen, Pavel Lobachevsky, Raja Vasireddy, Yuqian Yan, Jacinta Ryan, George McGillivray, Ravi Savarirayan, Martin F Lavin, Robert G Ramsay, Huiling Xu

Journal article  |  2019  |  International Journal of Radiation Oncology*Biology*Physics

Knocking in Multifunctional Gene Tags into SMC Complex Subunits Using Gene Editing

Paul Kalitsis, Tao Zhang, Ji Hun Kim, Christian F Nielsen, Kathryn M Marshall, Damien F Hudson

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Condensin, a highly conserved pentameric chromosome complex, is required for the correct organization and folding of the genome. H..

Identification of an Immortalized Human Airway Epithelial Cell Line with Dyskinetic Cilia

Li Eon Kuek, Paul Griffin, Paul Martinello, Alison N Graham, Paul Kalitsis, Philip J Robinson, Graham A Mackay

Journal article  |  2018  |  American Journal of Respiratory Cell and Molecular Biology

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Cedric S Tremblay, Jesslyn Saw, Sung Kai Chiu, Nicholas C Wong, Kirill Tsyganov, Sarah Ghotb, Alison N Graham, Feng Yan, Andrew A Guirguis, Stefan E Sonderegger, Nicole Lee, Paul Kalitsis, John Reynolds, Stephen B Ting, David R Powell, Stephen M Jane, David J Curtis

Journal article  |  2018  |  Nature Communications

Polymyxin B causes DNA damage in HK-2 cells and mice

B Yun, T Zhang, MAK Azad, J Wang, CJ Nowell, P Kalitsis, T Velkov, DF Hudson, J Li

Journal article  |  2018  |  Archives of Toxicology

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Maheshi Udugama, Elaine Sanij, Hsiao PJ Voon, Jinbae Son, Linda Hii, Jeremy D Henson, F Lyn Chan, Fiona TM Chang, Yumei Liu, Richard B Pearson, Paul Kalitsis, Jeffrey R Mann, Philippe Collas, Ross D Hannan, Lee H Wong

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Condensin, master organizer of the genome

Paul Kalitsis, Tao Zhang, Kathryn M Marshall, Christian F Nielsen, Damien F Hudson

Journal article  |  2017  |  Chromosome Research

The Role of Centromere Defects in Cancer

Thian Thian Beh, Paul Kalitsis

Journal article  |  2017  |  Progress in molecular and subcellular biology

Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome

Damien F Hudson, David J Amor, Amber Boys, Kathy Butler, Lorna Williams, Tao Zhang, Paul Kalitsis

Journal article  |  2016  |  PLOS Genetics

Condensin I and II behaviour in interphase nuclei and cells undergoing premature chromosome condensation

Tao Zhang, James R Paulson, Muhammed Bakhrebah, Ji Hun Kim, Cameron Nowell, Paul Kalitsis, Damien F Hudson

Journal article  |  2016  |  Chromosome Research

Active centromere and chromosome identification in fixed cell lines

Thian T Beh, Ruth N MacKinnon, Paul Kalitsis

Journal article  |  2016  |  Molecular Cytogenetics

Centromeres in health, disease and evolution

TT Beh, P Kalitsis

Book Chapter  |  2015

Disruption of a Conserved CAP-D3 Threonine Alters Condensin Loading on Mitotic Chromosomes Leading to Chromosome Hypercondensation

Muhammed Bakhrebah, Tao Zhang, Jeff R Mann, Paul Kalitsis, Damien F Hudson

Journal article  |  2015  |  Journal of Biological Chemistry

Contribution of the Two Genes Encoding Histone Variant H3.3 to Viability and Fertility in Mice

Michelle CW Tang, Shelley A Jacobs, Deidre M Mattiske, Yu May Soh, Alison N Graham, Tran An, Shu Ly Lim, Damien F Hudson, Paul Kalitsis, Moira K O'Bryan, Lee H Wong, Jeffrey R Mann

Journal article  |  2015  |  PLOS Genetics

Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo

Kathryn M Marshall, Marie Laval, Ortis Estacio, Damien F Hudson, Paul Kalitsis, Arthur Shulkes, Graham S Baldwina, Oneel Patel

Journal article  |  2015  |  Metallomics

The Role of Centromere Defects in Cancer Formation and Progression

T Beh, B Kim, P Kalitsis

Conference Proceedings  |  2014  |  MOLECULAR BIOLOGY OF THE CELL

Chromosome Y Centromere Array Deletion Leads to Impaired Centromere Function

Alison N Graham, Paul Kalitsis

Journal article  |  2014  |  PLoS One

Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes

Ji Hun Kim, Tao Zhang, Nicholas C Wong, Nadia Davidson, Jovana Maksimovic, Alicia Oshlack, William C Earnshaw, Paul Kalitsis, Damien F Hudson

Journal article  |  2013  |  Nature Communications

Normal DNA Methylation Dynamics in DICER1-Deficient Mouse Embryonic Stem Cells

Jonathan Ip, Paul Canham, KH Andy Choo, Yoshimi Inaba, Shelley A Jacobs, Paul Kalitsis, Deidre M Mattiske, Jane Ng, Richard Saffery, Nicholas C Wong, Lee H Wong, Jeffrey R Mann

Journal article  |  2012  |  PLOS GENETICS

The evolutionary life cycle of the resilient centromere

Paul Kalitsis, KH Andy Choo

Journal article  |  2012  |  CHROMOSOMA

Contrasting roles of condensin I and condensin II in mitotic chromosome formation

Lydia C Green, Paul Kalitsis, Tsz M Chang, Miri Cipetic, Ji Hun Kim, Owen Marshall, Lynne Turnbull, Cynthia B Whitchurch, Paola Vagnarelli, Kumiko Samejima, William C Earnshaw, KH Andy Choo, Damien F Hudson

Journal article  |  2012  |  Journal of Cell Science

Mitotic map of condensin I in vertebrate cells.

J Kim, N Wong, K Choo, WC Earnshaw, N Davidson, J Maksimovic, A O'Shlack, P Kalitsis, DF Hudson

Journal article  |  2012  |  MOLECULAR BIOLOGY OF THE CELL

Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex

Tsz M Chang, Alison N Graham, K Ha Choo, Paul Kalitsis, Damien F Hudson

Journal article  |  2010  |  BMC Biochemistry

Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability

Mark D Pertile, Alison N Graham, KH Andy Choo, Paul Kalitsis

Journal article  |  2009  |  Genome Research

Small CGG repeat expansion alleles of FMR1 gene are associated with parkinsonism

DZ Loesch, MS Khaniani, HR Slater, JP Rubio, QM Bui, K Kotschet, W D'Souza, A Venn, P Kalitsis, AKH Choo, T Burgess, L Johnson, A Evans, M Horne

Journal article  |  2009  |  Clinical Genetics

Inherent promoter bidirectionality facilitates maintenance of sequence integrity and transcription of parasitic DNA in mammalian genomes

Paul Kalitsis, Richard Saffery

Journal article  |  2009  |  BMC Genomics

Orchestrating Twosome and Foursome Chromosome Parties

Paul Kalitsis, KH Andy Choo

Journal article  |  2009  |  Developmental Cell

ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein

SL Bailey, SC Chang, B Griffiths, AN Graham, R Saffery, E Earle, KHA Choo, P Kalitsis

Journal article  |  2008  |  Chromosoma

An improved Diagnostic PCR Assay for identification of Cryptic Heterozygosity for CGG Triplet Repeat Alleles in the Fragile X Gene (FMR1)

Mahmoud S Khaniani, Paul Kalitsis, Trent Burgess, Howard R Slater

Journal article  |  2008  |  Molecular Cytogenetics

Identification and characterisation of a novel chromatin modifying protein

Sherry Chang, Andy Choo, Paul Kalitsis

Conference Proceedings  |  2007  |  CHROMOSOME RESEARCH

Mouse telocentric sequences reveal a high rate of homogenization and possible role in Robertsonian translocation

Paul Kalitsis, Belinda Griffiths, KH Andy Choo

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice

P Kalitsis, KJ Fowler, B Griffiths, E Earle, CW Chow, K Jamsen, KHA Choo

Journal article  |  2005  |  Genes, Chromosomes & Cancer

Spef1, a conserved novel testis protein found in mouse sperm flagella

SW Chan, KJ Fowler, KHA Choo, P Kalitsis

Journal article  |  2005  |  Gene

Building the centromere: from foundation proteins to 3D organization

DJ Amor, P Kalitsis, H Sumer, KHA Choo

Journal article  |  2004  |  Trends in Cell Biology

Partially functional Cenpa-GFP fusion protein causes increased chromosome missegregation and apoptosis during mouse embryogenesis

P Kalitsis, KJ Fowler, E Earle, B Griffiths, E Howman, AJ Newson, KHA Choo

Journal article  |  2003  |  Chromosome Research

Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc

A Saxena, LH Wong, P Kalitsis, E Earle, LG Shaffer, KHA Choo

Journal article  |  2002  |  Human Molecular Genetics

Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated

A Saxena, R Saffery, LH Wong, P Kalitsis, KHA Choo

Journal article  |  2002  |  Journal of Biological Chemistry

A 330 kb CENP-A binding domain and altered replication timing at a human neocentromere

AWI Lo, JM Craig, R Saffery, P Kalitsis, DV Irvine, E Earle, DJ Magliano, KHA Choo

Journal article  |  2001  |  The EMBO Journal

A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA

AWI Lo, DJ Magliano, MC Sibson, P Kalitsis, JM Craig, KHA Choo

Journal article  |  2001  |  Genome Research

Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes

R Saffery, DV Irvine, B Griffiths, P Kalitsis, KHA Choo

Journal article  |  2000  |  Human Genetics

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

P Kalitsis, E Earle, KJ Fowler, KHA Choo

Journal article  |  2000  |  Genes & Development

Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice

EV Howman, KJ Fowler, AJ Newson, S Redward, AC MacDonald, P Kalitsis, KHA Choo

Journal article  |  2000  |  Proceedings of the National Academy of Sciences

Human centromeres and neocentromeres show identical distribution patterns of > 20 functionally important kinetochore-associated proteins

R Saffery, DV Irvine, B Griffiths, P Kalitsis, L Wordeman, KHA Choo

Journal article  |  2000  |  Human Molecular Genetics

Assignment of the Centromere Protein H (Cenph) gene to mouse chromosome band 13D1 by in situ hybridization and interspecific backcross analyses

AWI Lo, DFS Longmuir, KJ Fowler, P Kalitsis, KHA Choo

Journal article  |  2000  |  Cytogenetic and Genome Research

Trisomy 20p resulting from inverted duplication and neocentromere formation

Lucille Voullaire, Richard Saffery, Julie Davies, Elizabeth Earle, Paul Kalitsis, Howard Slater, Danielle V Irvine, KH Andy Choo

Journal article  |  1999  |  American Journal of Medical Genetics

Trisomy 20p resulting from inverted duplication and neocentromere formation

L Voullaire, R Saffery, J Davies, E Earle, P Kalitsis, H Slater, DV Irvine, KHA Choo

Conference Proceedings  |  1999  |  American Journal of Medical Genetics

Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice

SM Cutts, KJ Fowler, BT Kile, LLP Hii, RA O'Dowd, DF Hudson, R Saffery, P Kalitsis, E Earle, KHA Choo

Journal article  |  1999  |  Human Molecular Genetics

Conservation of centromere proteins in vertebrates

R Saffery, E Earle, DV Irvine, P Kalitsis, KHA Choo

Journal article  |  1999  |  Chromosome Research

Mouse mitotic spindle checkpoint Bub3 gene maps to the distal region of Chromosome 7 by interspecific backcross analysis

KJ Fowler, P Kalitsis, KHA Choo

Journal article  |  1999  |  Cytogenetic and Genome Research

Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights

DF Hudson, KJ Fowler, E Earle, R Saffery, P Kalitsis, H Trowell, J Hill, NG Wreford, DM de Kretser, MR Cancilla, E Howman, L Hii, SM Cutts, DV Irvine, KHA Choo

Journal article  |  1998  |  Journal of Cell Biology

Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death

P Kalitsis, KJ Fowler, E Earle, J Hill, KHA Choo

Journal article  |  1998  |  Proceedings of the National Academy of Sciences

Gene structure and sequence analysis of mouse centromere proteins A and C

P Kalitsis, A MacDonald, AJ Newson, DF Hudson, KHA Choo

Journal article  |  1998  |  Genomics

Structural and functional studies of mouse centromere protein C

P KALITSIS

Thesis / Dissertation  |  1998

A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA

D duSart, MR Cancilla, E Earle, JI Mao, R Saffery, KM Tainton, P Kalitsis, J Martyn, AE Barry, KHA Choo

Journal article  |  1997  |  Nature Genetics

Chromosomal localization of mouse Cenpa gene

KJ Fowler, AJ Newson, AC MacDonald, P Kalitsis, MS Lyu, CA Kozak, KHA Choo

Journal article  |  1997  |  Cytogenetic and Genome Research

A NOVEL NUCLEAR-PROTEIN BINDS CENTROMERIC ALPHA-SATELLITE DNA

C GAFF, D DUSART, P KALITSIS, R IANNELLO, A NAGY, KHA CHOO

Journal article  |  1994  |  Human Molecular Genetics

A CHROMOSOME-13-SPECIFIC HUMAN SATELLITE-I DNA SUBFAMILY WITH MINOR PRESENCE ON CHROMOSOME-21 - FURTHER-STUDIES ON ROBERTSONIAN TRANSLOCATIONS

P KALITSIS, E EARLE, B VISSEL, LG SHAFFER, KHA CHOO

Journal article  |  1993  |  Genomics

A CHROMOSOME-14-SPECIFIC HUMAN SATELLITE-III DNA SUBFAMILY THAT SHOWS VARIABLE PRESENCE ON DIFFERENT CHROMOSOMES-14

KHA CHOO, E EARLE, B VISSEL, P KALITSIS

Journal article  |  1992  |  American Journal of Human Genetics

IDENTIFICATION OF DNA-SEQUENCES FLANKING THE BREAKPOINT OF HUMAN T(14Q21Q) ROBERTSONIAN TRANSLOCATIONS

E EARLE, LG SHAFFER, P KALITSIS, C MCQUILLAN, S DALE, KHA CHOO

Journal article  |  1992  |  American Journal of Human Genetics

NONINACTIVATION OF A PORTION OF XQ28 IN A BALANCED X-AUTOSOME TRANSLOCATION

D DUSART, P KALITSIS, M SCHMIDT

Journal article  |  1992  |  American Journal of Medical Genetics

A SURVEY OF THE GENOMIC DISTRIBUTION OF ALPHA-SATELLITE DNA ON ALL THE HUMAN-CHROMOSOMES, AND DERIVATION OF A NEW CONSENSUS SEQUENCE

KH CHOO, B VISSEL, A NAGY, E EARLE, P KALITSIS

Journal article  |  1991  |  Nucleic Acids Research

DUPLICATIONS OF THE X-CHROMOSOME IN MALES - EVIDENCE THAT MOST PARTS OF THE X-CHROMOSOME CAN BE ACTIVE IN 2 COPIES

M SCHMIDT, D DUSART, P KALITSIS, M LEVERSHA, S DALE, L SHEFFIELD, D TONIOLO

Journal article  |  1991  |  Human Genetics

X-CHROMOSOME INACTIVATION IN FIBROBLASTS OF MENTALLY-RETARDED FEMALE CARRIERS OF THE FRAGILE SITE XQ27.3 - APPLICATION OF THE PROBE M27-BETA TO EVALUATE X-INACTIVATION STATUS

M SCHMIDT, D DUSART, P KALITSIS, N FRASER, M LEVERSHA, L VOULLAIRE, D FOSTER, J DAVIES, L HILLS, V PETROVIC, R HUTCHINSON

Journal article  |  1991  |  American Journal of Medical Genetics

UNUSUAL X-CHROMOSOME INACTIVATION IN A MENTALLY-RETARDED GIRL WITH AN INTERSTITIAL DELETION XQ27 - IMPLICATIONS FOR THE FRAGILE X-SYNDROME

M SCHMIDT, A CERTOMA, D DUSART, P KALITSIS, M LEVERSHA, K FOWLER, L SHEFFIELD, I JACK, DM DANKS

Journal article  |  1990  |  Human Genetics

PLANT RETROTRANSPOSON FROM LILIUM-HENRYI IS RELATED TO TY3 OF YEAST AND THE GYPSY GROUP OF DROSOPHILA

DR SMYTH, P KALITSIS, JL JOSEPH, JW SENTRY

Journal article  |  1989  |  Proceedings of the National Academy of Sciences

Nucleic Acids: Hybridisation

Ji Hun Kim, Paul Kalitsis, Mark D Pertile, Dianna Magliano, Lee Wong, Andy Choo, Damien F Hudson

Book Chapter