Paul Kalitsis

Topoisomerase II alpha is essential for maintenance of mitotic chromosome structure

Christian F Nielsen, Tao Zhang, Marin Barisic, Paul Kalitsis, Damien F Hudson

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for establishing mitotic chromosome condensatio..

Loss of TOP3B leads to increased R-loop formation and genome instability

Tao Zhang, Mathew Wallis, Vida Petrovic, Jackie Challis, Paul Kalitsis, Damien F Hudson

Journal article  |  2019  |  OPEN BIOLOGY

Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmati..

Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages

Poshmaal Dhar, Sohinee Sarkar, Garrett Z Ng, Paul Kalitsis, Muhammad A Saeed, Michael A McGuckin, Justine A Ellis, Philip Sutton

Journal article  |  2019  |  HUMAN IMMUNOLOGY

Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infect..

A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect

Michael J McKay, Jeffery Craig, Paul Kalitsis, Sergei Kozlov, Sandra Verschoor, Phillip Chen, Pavel Lobachevsky, Raja Vasireddy, Yuqian Yan, Jacinta Ryan, George McGillivray, Ravi Savarirayan, Martin F Lavin, Robert G Ramsay, Huiling Xu

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PURPOSE: Roberts syndrome (RBS) is a rare, recessively transmitted developmental disorder characterized by growth retardation, cra..

Knocking in Multifunctional Gene Tags into SMC Complex Subunits Using Gene Editing

Paul Kalitsis, Tao Zhang, Ji Hun Kim, Christian F Nielsen, Kathryn M Marshall, Damien F Hudson

Journal article  |  2019  |  SMC COMPLEXES: METHODS AND PROTOCOLS

Condensin, a highly conserved pentameric chromosome complex, is required for the correct organization and folding of the genome. H..

Identification of an Immortalized Human Airway Epithelial Cell Line with Dyskinetic Cilia

Li Eon Kuek, Paul Griffin, Paul Martinello, Alison N Graham, Paul Kalitsis, Philip J Robinson, Graham A Mackay

Journal article  |  2018  |  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Primary ciliary dyskinesia is an inherited, currently incurable condition. In the respiratory system, primary ciliary dyskinesia c..

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Cedric S Tremblay, Jesslyn Saw, Sung Kai Chiu, Nicholas C Wong, Kirill Tsyganov, Sarah Ghotb, Alison N Graham, Feng Yan, Andrew A Guirguis, Stefan E Sonderegger, Nicole Lee, Paul Kalitsis, John Reynolds, Stephen B Ting, David R Powell, Stephen M Jane, David J Curtis

Journal article  |  2018  |  NATURE COMMUNICATIONS

Pre-leukemic stem cells (pre-LSCs) give rise to leukemic stem cells through acquisition of additional gene mutations and are an im..

Polymyxin B causes DNA damage in HK-2 cells and mice

B Yun, T Zhang, MAK Azad, J Wang, CJ Nowell, P Kalitsis, T Velkov, DF Hudson, J Li

Journal article  |  2018  |  ARCHIVES OF TOXICOLOGY

Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' anti..

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Maheshi Udugama, Elaine Sanij, Hsiao PJ Voon, Jinbae Son, Linda Hii, Jeremy D Henson, F Lyn Chan, Fiona TM Chang, Yumei Liu, Richard B Pearson, Paul Kalitsis, Jeffrey R Mann, Philippe Collas, Ross D Hannan, Lee H Wong

Journal article  |  2018  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATRX (alpha thalassemia/mental retardation X-linked) complexes with DAXX to deposit histone variant H3.3 into repetitive heterochr..

Condensin, master organizer of the genome

Paul Kalitsis, Tao Zhang, Kathryn M Marshall, Christian F Nielsen, Damien F Hudson

Journal article  |  2017  |  CHROMOSOME RESEARCH

A fundamental requirement in nature is for a cell to correctly package and divide its replicated genome. Condensin is a mechanical..