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Prof

Patrick Kwan

Honorary
Medicine - Royal Melbourne Hospital
science & technology
life sciences & biomedicine
humans
neurosciences & neurology
clinical neurology
epilepsy
female
male
adult
Patrick Kwan's Profile Picture
Prof

Patrick Kwan

 
Division
Medicine, Dentistry and Health Sciences
Patrick Kwan's Profile Picture
Prof

Patrick Kwan

 
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Projects

Displaying the 9 most recent projects by Patrick Kwan.

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Shenzhen Sanming project

2018 - 2023
Active
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First Seizure Assessment and Management

2018 - 2019
Completed
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Development of an Ultra-Sensitive Non-Invasive Point-of-Care Immunosensor for Malaria Elimination in the Asia Pacific Region

2016 - 2018
Completed
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EXPLORING SOMATIC MUTATION IN FOCAL EPILEPSIES

Epilepsy is a common disease in the Australian population affecting 3 percent of individuals. It incurs lifelong medical, social and educati..

2015 - 2017
Completed
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Rapid point-of-care detection of genomic variations for personalised medicine

Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconve..

2014 - 2017
Completed
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Rapid point-of-care detection of genomic variations for personalised medicine

Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconve..

2014 - 2017
Completed
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PHARMACOGENOMICS OF AED ASSOCIATED BIRTH DEFECTS

This project will investigate for genes that determine why certain women have an increased risk of having a baby with a birth defect if they..

2014 - 2016
Completed
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Consortium on pharmacogenetics impact on cerebrovascular disease outcome study

2014 - 2016
Completed
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DEVELOPING A RAPID SYSTEM TO DETECT GENOMIC VARIATIONS AND ADAPTING INTO A POINT-OF-CARE DEVICE FOR PERSONALIED MEDICINE

2013 - 2013
Completed

9

Projects

Project Types

6

Research Grant

2

Internal Research Grant

1

Research Contracts

Additional Information

Scholarly Works

Displaying the 10 most recent scholarly works by Patrick Kwan.

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Psychiatric and cognitive characteristics of older adults admitted to a Video-EEG monitoring (VEM) unit

Anthony Hew, Michael Lloyd, Genevieve Rayner, Alice Matson, Maria Rychkova, Rashida Ali, Toby Winton-Brown, Piero Perucca, Patrick Kwan, Terence J O'Brien, Dennis Velakoulis, Charles B Malpas, Samantha M Loi

Journal article  |  2021  |  EPILEPSY & BEHAVIOR

OBJECTIVE: To compare the clinical, psychiatric, and cognitive characteristics of older with younger patients presenting to a vide..

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Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals

Joshua E Motelow, Gundula Povysil, Ryan S Dhindsa, Kate E Stanley, Andrew S Allen, Yen-Chen Anne Feng, Daniel P Howrigan, Liam E Abbott, Katherine Tashman, Felecia Cerrato, Caroline Cusick, Tarjinder Singh, Henrike Heyne, Andrea E Byrnes, Claire Churchhouse, Nick Watts, Matthew Solomonson, Dennis Lal, Namrata Gupta, Benjamin M Neale, et al.

Journal article  |  2021  |  AMERICAN JOURNAL OF HUMAN GENETICS

Both mild and severe epilepsies are influenced by variants in the same genes, yet an explanation for the resulting phenotypic vari..

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One step closer towards personalized epilepsy management.

Zhibin Chen, Alison Anderson, Zongyuan Ge, Patrick Kwan

Journal article  |  2021  |  Brain

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Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease

Hattapark Dejakaisaya, Patrick Kwan, Nigel C Jones

Journal article  |  2021  |  EPILEPSIA

Alzheimer's disease (AD) can increase the risk of epilepsy by up to 10-fold compared to healthy age-matched controls. However, the..

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Study protocol for a phase II randomised, double-blind, placebo-controlled trial of perampanel as an antiepileptogenic treatment following acute stroke.

John-Paul Nicolo, Zhibin Chen, Bradford Moffat, David K Wright, Benjamin Sinclair, Rebecca Glarin, Andrew Neal, Vincent Thijs, Udaya Seneviratne, Bernard Yan, Geoffrey Cloud, Terence J O'Brien, Patrick Kwan

Journal article  |  2021  |  BMJ Open

INTRODUCTION: Stroke is a common cause of epilepsy that may be mediated via glutamate dysregulation. There is currently no evidenc..

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Development and validation of a clinical score to predict late seizures after intracerebral hemorrhage in Chinese

Yan Wang, Zhen Li, Xiaosai Zhang, Zhibin Chen, Dongmei Li, Wenxian Chen, Jiamei Gu, Dongyun Sun, Ting Rong, Patrick Kwan

Journal article  |  2021  |  EPILEPSY RESEARCH

BACKGROUND: Seizures are a frequent complication after intracerebral hemorrhage (ICH). The CAVE score was developed in Europeans t..

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Altered metabolic pathways in a transgenic mouse model suggest mechanistic role of amyloid precursor protein overexpression in Alzheimer's disease

Hattapark Dejakaisaya, Anna Harutyunyan, Patrick Kwan, Nigel C Jones

Journal article  |  2021  |  METABOLOMICS

INTRODUCTION: The mechanistic role of amyloid precursor protein (APP) in Alzheimer's disease (AD) remains unclear. OBJECTIVES: Her..

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The effect of injection time on rates of epileptogenic zone localization using SISCOM and STATISCOM

Gernot Hlauschek, Benjamin Sinclair, Benjamin Brinkmann, Joshua Fuge, Patrick Kwan, Terence J O'Brien, Lucy Vivash

Journal article  |  2021  |  EPILEPSY & BEHAVIOR

BACKGROUND: The identification of hyperperfusion on ictal single-photon emission computed tomography (SPECT) scan is a technique f..

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Heater Integrated Lab-on-a-Chip Device for Rapid HLA Alleles Amplification towards Prevention of Drug Hypersensitivity

Shah Mukim Uddin, Abkar Sayad, Jianxiong Chan, Duc Hau Huynh, Efstratios Skafidas, Patrick Kwan

Journal article  |  2021  |  SENSORS

HLA-B*15:02 screening before administering carbamazepine is recommended to prevent life-threatening hypersensitivity. However, the..

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7T Magnetic Resonance Imaging Quantification of Brain Glutamate in Acute Ischaemic Stroke

John-Paul Nicolo, Bradford Moffat, David K Wright, Benjamin Sinclair, Andrew Neal, Elaine Lui, Patricia Desmond, Rebecca Glarin, Kathryn A Davis, Ravinder Reddy, Bernard Yan, Terence J O'Brien, Patrick Kwan

Journal article  |  2021  |  Journal of stroke

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Scholarly Works

Keyword Analysis

Clinical Health
Neurosciences
Clinical Sciences
Pharmacology and Pharmaceutical Sciences
Biomedical Engineering
Expanding Knowledge
Human Pharmaceutical Products
Cardiovascular Medicine and Haematology
Health Services and Systems
Epidemiology

Honours, Awards and Fellowships

2016

Outstanding Achievement Epilepsy Award

Commission of Asian and Oceanian Affairs, International League Against Epilepsy
2014

FRACP - Fellow of the Royal Australasian College of Physicians

2007

FRCP - Fellow of the Royal College of Physicians of London

3

Awards

Credentials

Positions

Honorary

Medicine - Royal Melbourne Hospital

Education

Bachelor of Medical Sciences

University of Nottingham

Bachelor of Medicine and Surgery

University of Cambridge

Doctor of Philosophy

The University of Glasgow

Links