Brad Gilbertson

A new route to vaccines using PROTACs

Brad Gilbertson, Kanta Subbarao

Journal article  |  2022  |  NATURE BIOTECHNOLOGY

Gene Segment Interactions Can Drive the Emergence of Dominant Yet Suboptimal Gene Constellations During Influenza Virus Reassortment

Sanja Trifkovic, Brad Gilbertson, Emily Fairmaid, Joanna Cobbin, Steven Rockman, Lorena EE Brown

Journal article  |  2021  |  FRONTIERS IN MICROBIOLOGY

A segmented genome enables influenza virus to undergo reassortment when two viruses infect the same cell. Although reassortment is..

The structure of the influenza A virus genome

Bernadeta Dadonaite, Brad Gilbertson, Michael L Knight, Sanja Trifkovic, Steven Rockman, Alain Laederach, Lorena E Brown, Ervin Fodor, David LV Bauer

Journal article  |  2019  |  NATURE MICROBIOLOGY

Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA s..

Inhibition of Influenza A Virus by Human Infant Saliva

Brad Gilbertson, Kathryn Edenborough, Jodie McVernon, Lorena E Brown

Journal article  |  2019  |  VIRUSES-BASEL

Innate antiviral factors in saliva play a role in protection against respiratory infections. We tested the anti-influenza virus ac..

The role of RNA-RNA interactions in the assembly and reassortment of influenza A viruses

Michael Knight, Bernadeta Dadonaite, Brad Gilbertson, Sanja Trifkovic, Steven Rockman, Alain Laederach, Lorena Brown, Ervin Fodor, David LV Bauer

Journal article  |  2019  |  Access Microbiology

Influenza Virus Neuraminidase Structure and Functions

Julie L McAuley, Brad P Gilbertson, Sanja Trifkovic, Lorena E Brown, Jennifer L McKimm-Breschkin

Journal article  |  2019  |  FRONTIERS IN MICROBIOLOGY

With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mec..

Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection

Julie McAuley, Yi-Mo Deng, Brad Gilbertson, Charley Mackenzie-Kludas, Ian Barr, Lorena Brown

Journal article  |  2017  |  VIROLOGY JOURNAL

Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-l..

Mouse Saliva Inhibits Transit of Influenza Virus to the Lower Respiratory Tract by Efficiently Blocking Influenza Virus Neuraminidase Activity

Brad Gilbertson, Wy Ching Ng, Simon Crawford, Jenny L McKimm-Breschkin, Lorena E Brown

Journal article  |  2017  |  JOURNAL OF VIROLOGY

We previously identified a novel inhibitor of influenza virus in mouse saliva that halts the progression of susceptible viruses fr..

Salivary Blockade Protects the Lower Respiratory Tract of Mice from Lethal Influenza Virus Infection

Karen Ivinson, Georgia Deliyannis, Leanne McNabb, Lara Grollo, Brad Gilbertson, David Jackson, Lorena E Brown

Journal article  |  2017  |  JOURNAL OF VIROLOGY

It is possible to model the progression of influenza virus from the upper respiratory tract to the lower respiratory tract in the ..

Influenza NA and PB1 Gene Segments Interact during the Formation of Viral Progeny: Localization of the Binding Region within the PB1 Gene

Brad Gilbertson, Tian Zheng, Marie Gerber, Anne Printz-Schweigert, Chi Ong, Roland Marquet, Catherine Isel, Steven Rockman, Lorena Brown

Journal article  |  2016  |  VIRUSES-BASEL

The influenza A virus genome comprises eight negative-sense viral RNAs (vRNAs) that form individual ribonucleoprotein (RNP) comple..