Vincenzo Russo

Serum IGFBP-2 levels are associated with reduced insulin sensitivity in obese children

SW Yau, BE Harcourt, K-T Kao, EJ Alexander, VC Russo, GA Werther, MA Sabin

Journal article  |  2018  |  CLINICAL OBESITY

Insulin-like growth factor binding protein 2 (IGFBP-2) may represent a critical link between body composition and insulin sensitiv..

Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour

N Schindler, J Mayer, S Saenger, U Gimsa, C Walz, J Brenmoehl, D Ohde, E Wirthgen, A Tuchscherer, VC Russo, M Frank, T Kirschstein, F Metzger, A Hoeflich

Journal article  |  2017  |  GROWTH HORMONE & IGF RESEARCH

Brain growth and function are regulated by insulin-like growth factors I and II (IGF-I and IGF-II) but also by IGF-binding protein..

A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers

Hansen J Kosasih, Karena Last, Fraser M Rogerson, Suzanne B Golub, Stephanie J Gauci, Vincenzo C Russo, Heather Stanton, Richard Wilson, Shireen R Lamande, Paul Holden, Amanda J Fosang

Journal article  |  2016  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The metalloproteinase ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs) degrades aggrecan, a proteoglycan ..

Turner syndrome patients with bicuspid aortic valves and renal malformations exhibit abnormal expression of X-linked inhibitor of apoptosis protein (XIAP)

Ganesh S Jevalikar, Margaret Zacharin, Mary White, Steven W Yau, Winnie Li, Charlotte Ijspeert, Vincenzo C Russo, George A Werther, Matthew A Sabin

Journal article  |  2015  |  JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

OBJECTIVE: We analyzed mRNA expression of X-linked inhibitor of apoptosis protein (XIAP) in patients with Turner syndrome (TS) and..

Physiology and pathophysiology of IGFBP-1 and IGFBP-2-Consensus and dissent on metabolic control and malignant potential

Andreas Hoeflich, Vincenzo C Russo

Journal article  |  2015  |  BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

IGFBP-1 and IGFBP-2 are suppressed by growth hormone and therefore represent less prominent members of the IGFBP family when compa..

IGFBP-2-taking the lead in growth, metabolism and cancer

Steven W Yau, Walid J Azar, Matthew A Sabin, George A Werther, Vincenzo C Russo

Journal article  |  2015  |  JOURNAL OF CELL COMMUNICATION AND SIGNALING

The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and transduced by various intracellula..

IGFBP-2: The dark horse in metabolism and cancer

VC Russo, WJ Azar, SW Yau, MA Sabin, GA Werther

Journal article  |  2015  |  CYTOKINE & GROWTH FACTOR REVIEWS

The ubiquitous nature of the IGF system, expressed early in embryonic development throughout postnatal and adult life, indicates a..

Gender-specific effects on food intake but no inhibition of age-related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif

Petra Wiedmer, Franziska Schwarz, Birgit Grosse, Nancy Schindler, Armin Tuchscherer, Vincenzo C Russo, Matthias H Tschoep, Andreas Hoeflich

Journal article  |  2015  |  JOURNAL OF CELL COMMUNICATION AND SIGNALING

IGFBP-2 affects growth and metabolism and is thought to impact on energy homeostasis and the accretion of body fat via its heparin..

IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes

SW Yau, VC Russo, IJ Clarke, FR Dunshea, GA Werther, MA Sabin

Journal article  |  2015  |  INTERNATIONAL JOURNAL OF OBESITY

BACKGROUND/OBJECTIVE: IGF-binding protein (IGFBP)-2 is the principal IGFBP produced by white adipocytes during adipogenesis, and c..

Leptin Enhances Insulin Sensitivity by Direct and Sympathetic Nervous System Regulation of Muscle IGFBP-2 Expression: Evidence From Nonrodent Models

Steven W Yau, Belinda A Henry, Vincenzo C Russo, Glenn K McConell, Iain J Clarke, George A Werther, Matthew A Sabin

Journal article  |  2014  |  ENDOCRINOLOGY

Leptin is produced from white adipose tissue and acts primarily to regulate energy balance. Obesity is associated with leptin resi..