Chrishan Samuel

Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms

Simon G Royce, Paul V Licciardi, Raymond C Beh, Jane E Bourke, Chantal Donovan, Andrew Hung, Ishant Khurana, Julia J Liang, Scott Maxwell, Nadia Mazarakis, Eleni Pitsillou, Ya Yun Siow, Kenneth J Snibson, Mark J Tobin, Katherine Ververis, Jitraporn Vongsvivut, Mark Ziemann, Chrishan S Samuel, Mimi LK Tang, Assam El-Osta, et al.

Journal article  |  2022  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Sulforaphane has been investigated in human pathologies and preclinical models of airway diseases. To provide further mechanistic ..

Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors

Felipe Tapia Caceres, Tracey A Gaspari, Mohammed Akhter Hossain, Chrishan S Samuel

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic NLRP3 inflammasome activation can promote fibrosis through its production of interleukin (IL)-1β and IL-18. Conversely, re..

The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction

Irvan Alfian, Amlan Chakraborty, Hannah EJ Yong, Sheetal Saini, Ricky WK Lau, Bill Kalionis, Evdokia Dimitriadis, Nadia Alfaidy, Sharon D Ricardo, Chrishan S Samuel, Padma Murthi

Journal article  |  2022  |  CELLS

Fetal growth restriction (FGR) is commonly associated with placental insufficiency and inflammation. Nonetheless, the role played ..

A Novel Approach to Enhance the Regenerative Potential of Circulating Endothelial Progenitor Cells in Patients with End-Stage Kidney Disease

Amrilmaen Badawi, Osfred C Jefferson, Brooke M Huuskes, Sharon D Ricardo, Peter G Kerr, Chrishan S Samuel, Padma Murthi

Journal article  |  2022  |  BIOMEDICINES

Circulating bone marrow-derived endothelial progenitor cells (EPCs) facilitate vascular repair in several organs including the kid..

The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Jason QD Goodger, Jean-Pierre Y Scheerlinck, Chrishan S Samuel, Ian E Woodrow, Enzo A Palombo, Alistair Cumming, Ken Snibson

Journal article  |  2021  |  PLOS ONE

The primary flavonoid, pinocembrin, is thought to have a variety of medical uses which relate to its reported anti-oxidant, anti-i..

Atrial Fibrillation and Obesity Reverse Remodeling of Atrial Substrate With Weight Reduction

Rajiv Mahajan, Dennis H Lau, Anthony G Brooks, Nicholas J Shipp, John PM Wood, Jim Manavis, Chrishan S Samuel, Krupesh P Patel, John W Finnie, Muayad Alasady, Jonathan M Kalman, Prashanthan Sanders

Journal article  |  2021  |  JACC-CLINICAL ELECTROPHYSIOLOGY

OBJECTIVES: This study sought to evaluate the effect of weight loss on the atrial substrate for atrial fibrillation (AF). BACKGROU..

Assessment of renal fibrosis and anti-fibrotic agents using a novel diagnostic and stain-free second-harmonic generation platform

Sadman Bhuiyan, Matthew Shen, Sharenya Chelvaretnam, Andre Y Tan, Gideon Ho, Mohammed Akhter Hossain, Robert E Widdop, Chrishan S Samuel

Journal article  |  2021  |  FASEB JOURNAL

Current histological measurement techniques for interstitial collagen, the basis of interstitial fibrosis, are semi-quantitative a..

Pulmonary myeloid cell uptake of biodegradable nanoparticles conjugated with an anti-fibrotic agent provides a novel strategy for treating chronic allergic airways disease

Amlan Chakraborty, Anita A Pinar, Maggie Lam, Jane E Bourke, Simon G Royce, Cordelia Selomulya, Chrishan S Samuel

Journal article  |  2021  |  BIOMATERIALS

Asthma (chronic allergic airways disease, AAD) is characterized by airway inflammation (AI), airway remodeling (AWR) and airway hy..

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

Anita A Pinar, Alexander Yuferov, Tracey A Gaspari, Chrishan S Samuel

Journal article  |  2020  |  FRONTIERS IN PHARMACOLOGY

INTRODUCTION: The NLRP3 inflammasome produces interleukin (IL)-1β and IL-18, which when chronically activated by transforming grow..

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  SCIENTIFIC REPORTS

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..