Chrishan Samuel

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

Anita A Pinar, Alexander Yuferov, Tracey A Gaspari, Chrishan S Samuel

Journal article  |  2020  |  FRONTIERS IN PHARMACOLOGY

Introduction: The NLRP3 inflammasome produces interleukin (IL)-1β and IL-18, which when chronically activated by transforming grow..

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  SCIENTIFIC REPORTS

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..

The anti-fibrotic actions of relaxin are mediated through AT(2)R-associated protein phosphatases via RXFP1-AT(2)R functional crosstalk in human cardiac myofibroblasts

Chao Wang, Anita A Pinar, Robert E Widdop, Mohammed A Hossain, Ross AD Bathgate, Kate M Denton, Barbara K Kemp-Harper, Chrishan S Samuel

Journal article  |  2020  |  FASEB JOURNAL

Fibrosis is a hallmark of several cardiovascular diseases. The relaxin family peptide receptor 1 (RXFP1) agonist, relaxin, has rap..

Inflammasomes-A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia

Padma Murthi, Anita A Pinar, Evdokia Dimitriadis, Chrishan S Samuel

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preeclampsia (PE) is a pregnancy-specific multisystem disorder and is associated with maladaptation of the maternal cardiovascular..

The efficacy of pirfenidone in a sheep model of pulmonary fibrosis.

Sasika NV Dewage, Louise Organ, Emmanuel Koumoundouros, Habtamu B Derseh, Kopiyawaththage UE Perera, Chrishan S Samuel, Andrew W Stent, Ken J Snibson

Journal article  |  2020  |  Experimental Lung Research

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with unknown cause. While the drugs nintedanib ..

Serelaxin inhibits the profibrotic TGF-beta 1/IL-1 beta axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts

Felipe Tapia Caceres, Tracey A Gaspari, Chrishan S Samuel, Anita A Pinar

Journal article  |  2019  |  FASEB JOURNAL

The recombinant form of the peptide hormone relaxin, serelaxin (RLX), mediates its anti-fibrotic actions by impeding the profibrot..

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Bryna SM Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y Chew, Chao Wang, Sanja Bosnyak, Katrina M Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth KM Johnstone, Mohammed A Hossain, Kevin DG Pfleger, Kate M Denton, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2019  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

BACKGROUND: Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein-coupled..

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction

Timothy D Hewitson, Stephen G Holt, Chrishan S Samuel, Belinda Wigg, Edward R Smith

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

Posttranslational modification of nucleosomal histones is a major determinant of chromatin structure and gene activity. In the pre..

Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease

Simon G Royce, Krupesh P Patel, WeiYi Mao, Dandan Zhu, Rebecca Lim, Chrishan S Samuel

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: There is growing interest in stem cell-derived exosomes for their therapeutic and regenerative benefits gi..

Understanding relaxin signalling at the cellular level

Adam L Valkovic, Ross AD Bathgate, Chrishan S Samuel, Martina Kocan

Journal article  |  2019  |  MOLECULAR AND CELLULAR ENDOCRINOLOGY

The peptide hormone relaxin mediates many biological actions including anti-fibrotic, vasodilatory, angiogenic, anti-inflammatory,..