Chrishan Samuel

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  Scientific Reports

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..

The anti-fibrotic actions of relaxin are mediated through AT(2)R-associated protein phosphatases via RXFP1-AT(2)R functional crosstalk in human cardiac myofibroblasts

Chao Wang, Anita A Pinar, Robert E Widdop, Mohammed A Hossain, Ross AD Bathgate, Kate M Denton, Barbara K Kemp-Harper, Chrishan S Samuel

Journal article  |  2020  |  The FASEB Journal

Fibrosis is a hallmark of several cardiovascular diseases. The relaxin family peptide receptor 1 (RXFP1) agonist, relaxin, has rap..

Inflammasomes-A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia

Padma Murthi, Anita A Pinar, Evdokia Dimitriadis, Chrishan S Samuel

Journal article  |  2020  |  International Journal of Molecular Sciences

Preeclampsia (PE) is a pregnancy-specific multisystem disorder and is associated with maladaptation of the maternal cardiovascular..

The efficacy of pirfenidone in a sheep model of pulmonary fibrosis.

Sasika NV Dewage, Louise Organ, Emmanuel Koumoundouros, Habtamu B Derseh, Kopiyawaththage UE Perera, Chrishan S Samuel, Andrew W Stent, Ken J Snibson

Journal article  |  2020  |  Experimental Lung Research

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with unknown cause. While the drugs nintedanib ..

Serelaxin inhibits the profibrotic TGF-beta 1/IL-1 beta axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts

Felipe Tapia Caceres, Tracey A Gaspari, Chrishan S Samuel, Anita A Pinar

Journal article  |  2019  |  The FASEB Journal

The recombinant form of the peptide hormone relaxin, serelaxin (RLX), mediates its anti-fibrotic actions by impeding the profibrot..

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Bryna SM Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y Chew, Chao Wang, Sanja Bosnyak, Katrina M Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth KM Johnstone, Mohammed A Hossain, Kevin DG Pfleger, Kate M Denton, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2019  |  Journal of the American Society of Nephrology

BACKGROUND: Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein-coupled..

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction

Timothy D Hewitson, Stephen G Holt, Chrishan S Samuel, Belinda Wigg, Edward R Smith

Journal article  |  2019  |  American Journal of Physiology-Renal Physiology

Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease

Simon G Royce, Krupesh P Patel, WeiYi Mao, Dandan Zhu, Rebecca Lim, Chrishan S Samuel

Journal article  |  2019  |  British Journal of Pharmacology

iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid

Simon G Royce, WeiYi Mao, Rebecca Lim, Kilian Kelly, Chrishan S Samuel

Journal article  |  2019  |  The FASEB Journal

Understanding relaxin signalling at the cellular level

Adam L Valkovic, Ross AD Bathgate, Chrishan S Samuel, Martina Kocan

Journal article  |  2019  |  Molecular and Cellular Endocrinology

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Anna C Simcocks, Kayte A Jenkin, Lannie O'Keefe, Chrishan S Samuel, Michael L Mathai, Andrew J McAinch, Deanne H Hryciw

Journal article  |  2019  |  Endocrine Connections

Endothelial Progenitor Cells and Vascular Health in Dialysis Patients

Brooke M Huuskes, Ryan J DeBuque, Kevan R Polkinghorne, Chrishan S Samuel, Peter G Kerr, Sharon D Ricardo

Journal article  |  2018  |  Kidney International Reports

Relaxin contributes to the regulation of arterial pressure in adult female mice

Katrina M Mirabito Colafella, Chrishan S Samuel, Kate M Denton

Journal article  |  2017  |  Clinical Science

Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis

Chrishan S Samuel, Timothy D Hewitson

Journal article  |  2017  |  Frontiers in Pharmacology

Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease

Simon G Royce, Siddharth Rele, Brad RS Broughton, Kilian Kelly, Chrishan S Samuel

Journal article  |  2017  |  The FASEB Journal

Anti-fibrotic Potential of AT(2) Receptor Agonists

Yan Wang, Mark Del Borgo, Huey W Lee, Dhaniel Baraldi, Baydaa Hirmiz, Tracey A Gaspari, Kate M Denton, Marie-Isabel Aguilar, Chrishan S Samuel, Robert E Widdop

Journal article  |  2017  |  Frontiers in Pharmacology

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Martina Kocan, Mohsin Sarwar, Sheng Y Ang, Jingbo Xiao, Juan J Marugan, Mohammed A Hossain, Chao Wang, Dana S Hutchinson, Chrishan S Samuel, Alexander I Agoulnik, Ross AD Bathgate, Roger J Summers

Journal article  |  2017  |  Scientific Reports

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-beta 1 Stimulation

Timothy D Hewitson, Stephen G Holt, Sven-Jean Tan, Belinda Wigg, Chrishan S Samuel, Edward R Smith

Journal article  |  2017  |  Frontiers in Pharmacology

Anti-fibrotic actions of relaxin

CS Samuel, SG Royce, TD Hewitson, KM Denton, TE Cooney, RG Bennett

Journal article  |  2017  |  British Journal of Pharmacology

Inhibition of the K(Ca)3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model

Louise Organ, Barbara Bacci, Emmanuel Koumoundouros, Wayne G Kimpton, Chrishan S Samuel, Cameron J Nowell, Peter Bradding, Katy M Roach, Glen Westall, Jade Jaffar, Ken J Snibson

Journal article  |  2017  |  American Journal of Respiratory Cell and Molecular Biology

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Yeong Hann Ling, Shalini M Krishnan, Christopher T Chan, Henry Diep, Dorota Ferens, Jaye Chin-Dusting, Barbara K Kemp-Harper, Chrishan S Samuel, Timothy D Hewitson, Eicke Latz, Ashley Mansell, Christopher G Sobey, Grant R Drummond

Journal article  |  2017  |  Pharmacological Research

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

Simon G Royce, Anna M Tominaga, Matthew Shen, Krupesh P Patel, Brooke M Huuskes, Rebecca Lim, Sharon D Ricardo, Chrishan S Samuel

Journal article  |  2016  |  Clinical Science

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

Tim D Hewitson, Wah Chin Boon, Evan R Simpson, Edward R Smith, Chrishan S Samuel

Journal article  |  2016  |  Life Sciences

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate

Chao Wang, Barbara K Kemp-Harper, Martina Kocan, Sheng Yu Ang, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2016  |  Frontiers in Pharmacology

Qualitative and Quantitative Analysis of Histone Deacetylases in Kidney Tissue Sections

Katherine Ververis, Selly Marzully, Chrishan S Samuel, Tim D Hewitson, Tom C Karagiannis

Book Chapter  |  2016  |  Methods in Molecular Biology

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Mohammed Akhter Hossain, Martina Kocan, Song T Yao, Simon G Royce, Vinojini B Nair, Christopher Siwek, Nitin A Patil, Ian P Harrison, K Johan Rosengren, Stavros Selemidis, Roger J Summers, John D Wade, Ross AD Bathgate, Chrishan S Samuel

Journal article  |  2016  |  Chemical Science

Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension

Christopher T Chan, Christopher G Sobey, Maggie Lieu, Dorota Ferens, Michelle M Kett, Henry Diep, Hyun Ah Kim, Shalini M Krishnan, Caitlin V Lewis, Ekaterina Salimova, Peter Tipping, Antony Vinh, Chrishan S Samuel, Karlheinz Peter, Tomasz J Guzik, Tin S Kyaw, Ban-Hock Toh, Alexander Bobik, Grant R Drummond

Journal article  |  2015  |  Hypertension

Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease

Simon G Royce, Matthew Shen, Krupesh P Patel, Brooke M Huuskes, Sharon D Ricardo, Chrishan S Samuel

Journal article  |  2015  |  Stem Cell Research

M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure

Jeffrey P Moore, Antony Vinh, Kellie L Tuck, Samy Sakkal, Shalini M Krishnan, Christopher T Chan, Maggie Lieu, Chrishan S Samuel, Henry Diep, Barbara K Kemp-Harper, Marianne Tare, Sharon D Ricardo, Tomasz J Guzik, Christopher G Sobey, Grant R Drummond

Journal article  |  2015  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy

Brooke M Huuskes, Andrea F Wise, Alison J Cox, Ee X Lim, Natalie L Payne, Darren J Kelly, Chrishan S Samuel, Sharon D Ricardo

Journal article  |  2015  |  The FASEB Journal

NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis

CG Sobey, CP Judkins, J Rivera, CV Lewis, H Diep, HW Lee, BK Kemp-Harper, BRS Broughton, S Selemidis, TA Gaspari, CS Samuel, GR Drummond

Journal article  |  2015  |  Free Radical Research

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B Nair, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  BIOMED RESEARCH INTERNATIONAL

Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma

Simon G Royce, Krupesh P Patel, Chrishan S Samuel

Journal article  |  2014  |  Laboratory Investigation

Qualitative and quantitative analysis of fibrosis in the kidney

Tim D Hewitson, Edward R Smith, Chrishan S Samuel

Journal article  |  2014  |  Nephrology

Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease

SG Royce, CXF Lim, KP Patel, B Wang, CS Samuel, MLK Tang

Journal article  |  2014  |  Clinical & Experimental Allergy

Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease

Chrishan S Samuel, Hasangika Bodaragama, Jacqueline Y Chew, Robert E Widdop, Simon G Royce, Tim D Hewitson

Journal article  |  2014  |  Hypertension

Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood.

Vivian B Nguyen, Megan E Probyn, Fiona Campbell, Kom V Yin, Chrishan S Samuel, Monika A Zimanyi, John F Bertram, Mary Jane Black, Karen M Moritz

Journal article  |  2014  |  Physiological Reports

High alcohol consumption during pregnancy leads to deleterious effects on fetal cardiac structure and it also affects cardiomyocyt..

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Bryna S Man Chow, Martina Kocan, Sanja Bosnyak, Mohsin Sarwar, Belinda Wigg, Emma S Jones, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2014  |  Kidney International

Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury

Andrea F Wise, Timothy M Williams, Mensiena BG Kiewiet, Natalie L Payne, Christopher Siatskas, Chrishan S Samuel, Sharon D Ricardo

Journal article  |  2014  |  American Journal of Physiology-Renal Physiology

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

Simon G Royce, Yuben Moodley, Chrishan S Samuel

Journal article  |  2014  |  Pharmacology and Therapeutics

Therapeutic Effects of Serelaxin in Acute Heart Failure - Necessity for Bilateral Research Translation

Xiao-Jun Du, Tim D Hewitson, Nguyen My-Nhan, Chrishan S Samuel

Journal article  |  2014  |  Circulation Journal

Mechanistic Insights into the Contribution of Epithelial Damage to Airway Remodeling Novel Therapeutic Targets for Asthma

Simon G Royce, Xuelei Li, Stephanie Tortorella, Liana Goodings, Bryna SM Chow, Andrew S Giraud, Mimi LK Tang, Chrishan S Samuel

Journal article  |  2014  |  American Journal of Respiratory Cell and Molecular Biology

Does a Nephron Deficit Exacerbate the Renal and Cardiovascular Effects of Obesity?

Seshini Gurusinghe, Russell D Brown, Xiaochu Cai, Chrishan S Samuel, Sharon D Ricardo, Merlin C Thomas, Michelle M Kett

Journal article  |  2013  |  PLoS One

The Anti-fibrotic Hormone Relaxin is not Reno-protective, Despite Being Active, in an Experimental Model of Type 1 Diabetes

Su Ee Wong, Chrishan S Samuel, Darren J Kelly, Yuan Zhang, Gavin J Becker, Tim D Hewitson

Journal article  |  2013  |  Protein and Peptide Letters

Anti-Inflammatory Effects of Adult Stem Cells in Sustained Lung Injury: A Comparative Study

Yuben Moodley, Vijesh Vaghjiani, James Chan, Svetlana Baltic, Marisa Ryan, Jorge Tchongue, Chrishan S Samuel, Padma Murthi, Ornella Parolini, Ursula Manuelpillai

Journal article  |  2013  |  PLOS ONE

Trefoil Factor-2 Reverses Airway Remodeling Changes in Allergic Airways Disease

Simon G Royce, Clarice Lim, Ruth C Muljadi, Chrishan S Samuel, Katherine Ververis, Tom C Karagiannis, Andrew S Giraud, Mimi LK Tang

Journal article  |  2013  |  American Journal of Respiratory Cell and Molecular Biology

Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease

Simon G Royce, Amelia Sedjahtera, Chrishan S Samuel, Mimi LK Tang

Journal article  |  2013  |  Clinical Science

Amino Acids, Peptides and Proteins

Book Chapter  |  2013

Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1.

KL Yong, GE Callander, R Bergin, CS Samuel, RAD Bathgate

Journal article  |  2013  |  Italian Journal of Anatomy and Embryology

To study the specific actions of relaxin through RXFP1 in human cells, it would be advantageous to develop cell populations with p..

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Linda J Chan, K Johan Rosengren, Sharon L Layfield, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed A Hossain, John D Wade

Journal article  |  2012  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Human relaxin-2: historical perspectives and role in cancer biology

Vinojini B Nair, Chrishan S Samuel, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2012  |  AMINO ACIDS

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS

Bryna Suet Man Chow, Elaine Guo Yan Chew, Chongxin Zhao, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2012  |  PLoS One

Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease

Michael Lian, Tim D Hewitson, Belinda Wigg, Chrishan S Samuel, Fiona Chow, Gavin J Becker

Journal article  |  2012  |  Nephrology, Dialysis, Transplantation

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Fazel Shabanpoor, Mohammad Alchter Hossain, Philip J Ryan, Alessia Belgi, Sharon Layfield, Martina Kocan, Suode Zhang, Chrishan S Samuel, Andrew L Gundlach, Ross AD Bathgate, Frances Separovic, John D Wade

Journal article  |  2012  |  Journal of Medicinal Chemistry

Relaxin and Castration in Male Mice Protect from, but Testosterone Exacerbates, Age-Related Cardiac and Renal Fibrosis, Whereas Estrogens Are an Independent Determinant of Organ Size

Tim D Hewitson, Chongxin Zhao, Belinda Wigg, Sin Wai Lee, Evan R Simpson, Wah Chin Boon, Chrishan S Samuel

Journal article  |  2012  |  Endocrinology

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

F Shabanpoor, M Hossain, PJ Ryan, A Belgi, SL Layfield, undefined Kocan, undefined Zhang, C Samuel, AL Gundlach, R Bathgate, F Separovic, JD Wade

Journal article  |  2012  |  Journal of Medicinal Chemistry

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis

Xiangwei Huang, Ying Gai, Naiheng Yang, Baogen Lu, Chrishan S Samuel, Victor J Thannickal, Yong Zhou

Journal article  |  2011  |  American Journal of Pathology

The Minimal Active Structure of Human Relaxin-2

Mohammed Akhter Hossain, K Johan Rosengren, Chrishan S Samuel, Fazel Shabanpoor, Linda J Chan, Ross AD Bathgate, John D Wade

Journal article  |  2011  |  Journal of Biological Chemistry

Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses

Maliha A Alikhan, Christina V Jones, Timothy M Williams, Anthony G Beckhouse, Anne L Fletcher, Michelle M Kett, Samy Sakkal, Chrishan S Samuel, Robert G Ramsay, James A Deane, Christine A Wells, Melissa H Little, David A Hume, Sharon D Ricardo

Journal article  |  2011  |  American Journal of Pathology

Relaxin remodels fibrotic healing following myocardial infarction

Chrishan S Samuel, Sofia Cendrawan, Xiao-Ming Gao, Ziqiu Ming, Chongxin Zhao, Helen Kiriazis, Qi Xu, Geoffrey W Tregear, Ross AD Bathgate, Xiao-Jun Du

Journal article  |  2011  |  Laboratory Investigation

H3 Relaxin Demonstrates Antifibrotic Properties via the RXFP1 Receptor

Mohammed Akhter Hossain, Bryna Chow Suet Man, Chongxin Zhao, Qi Xu, Xiao-Jun Du, John D Wade, Chrishan S Samuel

Journal article  |  2011  |  Biochemistry

The Relaxin Peptide Family-Structure, Function and Clinical Applications

Linda Jiaying Chan, Mohammed Akhter Hossain, Chrishan S Samuel, Frances Separovic, John D Wade

Journal article  |  2011  |  Protein and Peptide Letters

Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity

Alessandro Pini, Ronen Shemesh, Chrishan S Samuel, Ross AD Bathgate, Arie Zauberman, Chen Hermesh, Assaf Wool, Daniele Bani, Galit Rotman

Journal article  |  2010  |  Journal of Pharmacology and Experimental Therapeutics

Antifibrotic Properties of Relaxin: In Vivo Mechanism of Action in Experimental Renal Tubulointerstitial Fibrosis

Tim D Hewitson, Wen Yang Ho, Chrishan S Samuel

Journal article  |  2010  |  Endocrinology

Human Amnion Epithelial Cell Transplantation Abrogates Lung Fibrosis and Augments Repair

Yuben Moodley, Sivagami Ilancheran, Chrishan Samuel, Vijesh Vaghjiani, Daniel Atienza, Elizabeth D Williams, Graham Jenkin, Euan Wallace, Alan Trounson, Ursula Manuelpilla

Journal article  |  2010  |  American Journal of Respiratory and Critical Care Medicine

The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist

Mohammed Akhter Hossain, Chrishan S Samuel, Claudia Binder, Tim D Hewitson, Geoffrey W Tregear, John D Wade, Ross AD Bathgate

Journal article  |  2010  |  Amino Acids

Lectin Histochemistry for Light and Electron Microscopy

Su Ee Wong, Catherine E Winbanks, Chrishan S Samuel, Tim D Hewitson

Journal article  |  2010  |  Methods in molecular biology (Clifton, N.J.)

Transplantation of Human Amnion Epithelial Cells Reduces Hepatic Fibrosis in Immunocompetent CCl4-Treated Mice

Ursula Manuelpillai, Jorge Tchongue, Dinushka Lourensz, Vijesh Vaghjiani, Chrishan S Samuel, Alison Liu, Elizabeth D Williams, William Sievert

Journal article  |  2010  |  Cell Transplantation

Cardiovascular effects of relaxin: from basic science to clinical therapy

Xiao-Jun Du, Ross AD Bathgate, Chrishan S Samuel, Anthony M Dart, Roger J Summers

Journal article  |  2010  |  Nature Reviews Cardiology

Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy

Eleni Giannakis, Chrishan S Samuel, Tim D Hewitson, Wee-Ming Boon, Mary Macris, Shane Reeve, Josie Lawrence, A Ian Smith, Geoffrey W Tregear, John D Wade

Journal article  |  2009  |  Proteomics - Clinical Applications

Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury

Yuben Moodley, Daniel Atienza, Ursula Manuelpillai, Chrishan S Samuel, Jorge Tchongue, Sivakami Ilancheran, Richard Boyd, Alan Trounson

Journal article  |  2009  |  American Journal of Pathology

Relaxin Reverses Airway Remodeling and Airway Dysfunction in Allergic Airways Disease

Simon G Royce, Yu R Miao, Melissa Lee, Chrishan S Samuel, Geoffrey W Tregear, Mimi LK Tang

Journal article  |  2009  |  Endocrinology

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

Ishanee Mookerjee, Tim D Hewitson, Michelle L Halls, Roger J Summers, Michael L Mathai, Ross AD Bathgate, Geoffrey W Tregear, Chrishan S Samuel

Journal article  |  2009  |  FASEB Journal

Relaxin Family Peptide Receptor-1 Protects against Airway Fibrosis during Homeostasis But Not against Fibrosis Associated with Chronic Allergic Airways Disease

Chrishan S Samuel, Simon G Royce, Bin Chen, Huifang Cao, Jan A Gossen, Geoffrey W Tregear, Mimi LK Tang

Journal article  |  2009  |  Endocrinology

Relaxin: An Endogenous Renoprotective Factor?

Tim D Hewitson, Chrishan S Samuel

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Structure and Activity in the Relaxin Family of Peptides

Geoffrey W Tregear, Ross AD Bathgate, Mohammed Akhter Hossain, Feng Lin, Suode Zhang, Fazel Shabanpoor, Daniel J Scott, Sherie Ma, Andrew L Gundlach, Chrishan S Samuel, John D Wade

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Relaxin Family Peptide Receptor-1 Protects against Airway Fibrosis during Homeostasis But Not against Fibrosis Associated with Chronic Allergic Airways Disease

C SAMUEL, S ROYCE, B Chen, H Cao, JA Gossen, G TREGEAR, M TANG

Journal article  |  2009  |  Endocrinology

Role of Relaxin in Regulation of Fibrosis in the Lung Implications for Airway Remodeling in Asthma

Mimi LK Tang, Chrishan S Samuel, Simon G Royce

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Relaxin and the progression of kidney disease

Chrishan S Samuel, Tim D Hewitson

Journal article  |  2009  |  Current Opinion in Nephrology and Hypertension

Evaluation of Relaxin's Antifibrotic Action by SELDI-TOF Mass Spectrometry-Based Profiling of Relaxin Knockout Mice, a Model of Progressive Fibrosis

Eleni Giannakis, Mary Macris, Linda Chan, Geoffrey W Tregear, Chrishan S Samuel, John D Wade

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Investigations into the Inhibitory Effects of Relaxin on Renal Myofibroblast Differentiation

Chrishan S Samuel, Ishanee Mookerjee, Michelle L Halls, Roger J Summers, Elaine Chew, Ross AD Bathgate, Geoffrey W Tregear, Tim D Hewitson

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Reversal of Cardiac Fibrosis and Related Dysfunction by Relaxin Experimental Findings

Xiao-Jun Du, Qi Xu, Edna Lekgabe, Xiao-Ming Gao, Helen Kiriazis, Xiao-Lei Moore, Anthony M Dart, Geoffrey W Tregear, Ross AD Bathgate, Chrishan S Samuel

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

Determination of collagen content, concentration, and sub-types in kidney tissue.

Chrishan S Samuel

Journal article  |  2009  |  Methods in Molecular Biology

Fibrosis and sclerosis are widely recognized as hallmarks of progressive renal disease and are caused by the excessive accumulatio..

SELDI-TOF mass spectrometry-based protein profiling of kidney tissue.

Eleni Giannakis, Chrishan S Samuel, Wee-Ming Boon, Mary Macris, Tim D Hewitson, John D Wade

Book Chapter  |  2009  |  Methods in Molecular Biology

Protein profiling has numerous applications in renal research including the detection of protein biomarkers with aberrant expressi..

Relaxin family peptide receptors - from orphans to therapeutic targets

Emma T van der Westhuizen, Michelle L Halls, Chrishan S Samuel, Ross AD Bathgate, Elaine N Unemori, Steven W Sutton, Roger J Summers

Journal article  |  2008  |  Drug Discovery Today: Therapeutic Strategies

Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction

Lu Fang, Xiao-Ming Gao, Chrishan S Samuel, Yidan Su, Yean Leng Lim, Anthony M Dart, Xiao-Jun Du

Journal article  |  2008  |  Clinical Science

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

Chrishan S Samuel, Tim D Hewitson, Yuan Zhang, Darren J Kelly

Journal article  |  2008  |  Endocrinology

Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis

Qi Xu, Edna D Lekgabe, Xiao-Ming Gao, Ziqiu Ming, Geoffrey W Tregear, Anthony M Dart, Ross AD Bathgate, Chrishan S Samuel, Xiao-Jun Du

Journal article  |  2008  |  Endocrinology

Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

RAD Bathgate, ED Lekgabe, JT McGuane, Y Su, T Pham, T Ferraro, S Layfield, RD Hannan, WG Thomas, CS Samuel, X-J Du

Journal article  |  2008  |  Molecular and Cellular Endocrinology

Relaxin plays an important role in the regulation of airway structure and function

Chrishan S Samuel, Simon G Royce, Matthew D Burton, Chongxin Zhao, Geoffrey W Tregear, Mimi LK Tang

Journal article  |  2007  |  Endocrinology

Drugs of the future: the hormone relaxin

CS Samuel, TD Hewitson, EN Unemori, ML-K Tang

Journal article  |  2007  |  Cellular and Molecular Life Sciences

Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin

Chrishan S Samuel, Feng Lin, Mohammed Akhter Hossain, Chongxin Zhao, Tania Ferraro, Ross AD Bathgate, Geoffrey W Tregear, John D Wade

Journal article  |  2007  |  Biochemistry

Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis

Tim D Hewitson, Ishanee Mookerjee, Rosemary Masterson, Chongxin Zhao, Geoffrey W Tregear, Gavin J Becker, Chrishan S Samuel

Journal article  |  2007  |  Endocrinology

The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease

Chrishan S Samuel, Edna D Lekgabe, Ishanee Mookerjee

Journal article  |  2007  |  Advances in Experimental Medicine and Biology

'Relaxin' the stiffened heart and arteries: The therapeutic potential for relaxin in the treatment of cardiovascular disease

Chrishan S Samuel, Xiao-Jun Du, Ross AD Bathgate, Roger J Summers

Journal article  |  2006  |  Pharmacology and Therapeutics

Relaxin in cardiovascular and renal disease

CS Samuel, TD Hewitson

Journal article  |  2006  |  Kidney International

Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation

P Fu, P-J Shen, C-X Zhao, DJ Scott, CS Samuel, JD Wade, GW Tregear, RAD Bathgate, AL Gundlach

Journal article  |  2006  |  Journal of Endocrinology

Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease

I Mookerjee, NR Solly, SG Royce, GW Tregear, CS Samuel, MLK Tang

Journal article  |  2006  |  Endocrinology

Relaxin-3: Improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo

RAD Bathgate, F Lin, NF Hanson, L Otvos, A Guidolin, C Giannakis, S Bastiras, SL Layfield, T Ferraro, S Ma, CX Zhao, AL Gundlach, CS Samuel, GW Tregear, JD Wade

Journal article  |  2006  |  Biochemistry

Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat (vol 18, pg 346, 2005)

Carol A Tozzi, George J Poiani, Nansie A McHugh, Michael P Shakarjian, Beverly H Grove, Chrishan S Samuel, Elaine N Unemori, David J Riley

Journal article  |  2006  |  Pulmonary Pharmacology & Therapeutics

Renal structural and functional repair in a mouse model of reversal of ureteral obstruction

AL Cochrane, MM Kett, CS Samuel, NV Campanale, WP Anderson, DA Hume, MH Little, JF Bertram, SD Ricardo

Journal article  |  2005  |  Journal of the American Society of Nephrology

Relaxin: antifibrotic properties and effects in models of disease.

Chrishan S Samuel

Journal article  |  2005  |  Clinical Medicine

Fibrosis (progressive scarring) is a leading cause of organ failure worldwide and causes loss of organ function when normal tissue..

Actions of relaxin on non-reproductive tissues

CS Samuel, I Mookerjee, ED Lekgabe

Journal article  |  2005  |  Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents

The relaxin gene knockout mouse: A model of progressive scleroderma

CS Samuel, CX Zhao, Q Yang, H Wang, HS Tian, GW Tregear, ER Amento

Journal article  |  2005  |  Journal of Investigative Dermatology

Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats

ED Lekgabe, H Kiriazis, CX Zhao, Q Xu, XL Moore, YD Su, RAD Bathgate, XJ Du, CS Samuel

Journal article  |  2005  |  Hypertension

Relaxin modulates fibroblast function, collagen production, and matrix metalloproteinase-2 expression by cardiac fibroblasts

I Mookerjee, EN Unemori, XJ Du, GW Tregear, CS Samuel

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney

P Fu, PJ Shen, CX Zhao, DJ Scott, CS Samuel, JD Wade, GW Tregear, RAD Bathgate, AL Gundlach

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

The relaxin gene-knockout mouse - A model of progressive fibrosis

CS Samuel, CX Zhao, RAD Bathgate, XJ Du, RJ Summers, EP Amento, LL Walker, M McBurnie, L Zhao, GW Tregear

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat

CA Tozzi, GJ Poiani, NA McHugh, MP Sharkarjian, BH Grove, CS Samuel, EN Unemori, DJ Riley

Journal article  |  2005  |  Pulmonary Pharmacology and Therapeutics

Investigating the role of relaxin in the regulation of airway fibrosis in animal models of acute and chronic allergic airway disease

I Mookerjee, MLK Tang, N Solly, GW Tregear, CS Samuel

Journal article  |  2005  |  Annals of The New York Academy of Sciences

Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle

CP Bond, LJ Parry, CS Samuel, HM Gehring, FL Lederman, PAW Rogers, RJ Summers

Journal article  |  2005  |  Annals of The New York Academy of Sciences

Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis

CS Samuel, I Mookerjee, R Masterson, GW Tregear, TD Hewitson

Journal article  |  2005  |  Annals of The New York Academy of Sciences

Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

CS Samuel, EN Unemori, I Mookerjee, RAD Bathgate, SL Layfield, J Mak, GW Tregear, XJ Du

Journal article  |  2004  |  Endocrinology

Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle

CP Bond, LJ Parry, CS Samuel, HM Gehring, FL Lederman, PAW Rogers, RJ Summers

Journal article  |  2004  |  Journal of Clinical Endocrinology & Metabolism

Relaxin-1-deficient mice develop an age-related progression of renal fibrosis

CS Samuel, CX Zhao, CP Bond, TD Hewitson, EP Amento, RJ Summers

Journal article  |  2004  |  Kidney International

Relaxin is a key mediator of prostate growth and male reproductive tract development

CS Samuel, HS Tian, L Zhao, EP Amento

Journal article  |  2003  |  Laboratory Investigation

Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment

EM Wintour, KM Moritz, K Johnson, S Ricardo, CS Samuel, A Dodic

Journal article  |  2003  |  Journal of Physiology

Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin

CS Samuel, LY Sakai, EP Amento

Journal article  |  2003  |  Archives of Biochemistry and Biophysics

Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype

XJ Du, CS Samuel, XM Gao, L Zhao, LJ Parry, GW Tregear

Journal article  |  2003  |  Cardiovascular Research

Relaxin: New peptides, receptors and novel actions

RAD Bathgate, CS Samuel, TCD Burazin, AL Gundlach, GW Tregear

Journal article  |  2003  |  Trends in Endocrinology and Metabolism

Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis

CS Samuel, CX Zhao, RAD Bathgate, CP Bond, MD Burton, LJ Parry, RJ Summers, MLK Tang, EP Amento, GW Tregear

Journal article  |  2002  |  FASEB Journal

Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin

AR Kompa, CS Samuel, RJ Summers

Journal article  |  2002  |  British Journal of Pharmacology

Lower risk of postinfarct rupture in mouse heart overexpressing beta(2)-adrenergic receptors: Importance of collagen content

XM Gao, RJ Dilley, CS Samuel, E Percy, MJ Fullerton, AM Dart, XJ Du

Journal article  |  2002  |  Journal of Cardiovascular Pharmacology

Collagen studies in late pregnant relaxin null mice

L Zhao, CS Samuel, GW Tregear, F Beck, EM Wintour

Journal article  |  2000  |  Biology of Reproduction

Effects of relaxin, pregnancy and parturition on collagen metabolism in the rat pubic symphysis

CS Samuel, JP Coghlan, JF Bateman

Journal article  |  1998  |  Journal of Endocrinology

Collagen in the fetal membranes of sheep: changes throughout gestation and effects of dexamethasone at 60 days

L Shandley, KM Moritz, CS Samuel, EM Wintour

Journal article  |  1997  |  Reproduction, Fertility and Development

The effect of relaxin on collagen metabolism in the nonpregnant rat pubic symphysis: The influence of estrogen and progesterone in regulating relaxin activity

CS Samuel, A Butkus, JP Coghlan, JF Bateman

Journal article  |  1996  |  Endocrinology