Moshe Olshansky

SATB1 ensures appropriate transcriptional programs within naive CD8( ) T cells

Simone Nussing, Lisa A Miosge, Kah Lee, Moshe Olshansky, Adele Barugahare, Carla M Roots, Yovina Sontani, E Bridie Day, Marios Koutsakos, Katherine Kedzierska, Christopher C Goodnow, Brendan E Russ, Stephen R Daley, Stephen J Turner

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Special AT-binding protein 1 (SATB1) is a chromatin-binding protein that has been shown to be a key regulator of T-cell developmen..

Detection of Chimeric Cellular: HIV mRNAs Generated Through Aberrant Splicing in HIV-1 Latently Infected Resting CD4 T Cells

Michelle Y-H Lee, Georges Khoury, Moshe Olshansky, Secondo Sonza, Glen P Carter, James McMahon, Timothy P Stinear, Stephen J Turner, Sharon R Lewin, Damian FJ Purcell

Journal article  |  2022  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Latent HIV-1 provirus in infected individuals on suppressive therapy does not always remain transcriptionally silent. Both HIV-1 L..

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

MTR3D: identifying regions within protein tertiary structures under purifying selection

Michael Silk, Douglas E Pires, Carlos HM Rodrigues, Elston N D'Souza, Moshe Olshansky, Natalie Thorne, David B Ascher

Journal article  |  2021  |  NUCLEIC ACIDS RESEARCH

The identification of disease-causal variants is non-trivial. By mapping population variation from over 448,000 exome and genome s..

High expression of CD38 and MHC class II on CD8( ) T cells during severe influenza disease reflects bystander activation and trogocytosis

Xiaoxiao Jia, Brendon Y Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshansky, William R Heath, So Young Chang, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: Although co-expression of CD38 and HLA-DR reflects T-cell activation during viral infections, high and prolonged CD38+..

A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs

Matthew C Canver, Pratibha Tripathi, Michael J Bullen, Moshe Olshansky, Yogesh Kumar, Lee H Wong, Stephen J Turner, Samuel Lessard, Luca Pinello, Stuart H Orkin, Partha Pratim Das

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the noncoding genome and control..

Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource

Stephanie Portelli, Moshe Olshansky, Carlos HM Rodrigues, Elston N D'Souza, Yoochan Myung, Michael Silk, Azadeh Alavi, Douglas E Pires, David B Ascher

Journal article  |  2020  |  NATURE GENETICS

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8( ) T Cell-Lineage-Specific Function

Brendan E Russ, Moshe Olshansky, Jasmine Li, Michelle LT Nguyen, Linden J Gearing, Thi HO Nguyen, Matthew R Olson, Hayley A McQuilton, Simone Nussing, Georges Khoury, Damian FJ Purcell, Paul J Hertzog, Sudha Rao, Stephen J Turner

Journal article  |  2017  |  CELL REPORTS

Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the ge..

Differential Gene Expression in Menstrual Endometrium From Women With Self-Reported Heavy Menstrual Bleeding

Jane E Girling, Michelle G Lockhart, Moshe Olshansky, Premila Paiva, Nicole Woodrow, Jennifer L Marino, Martha Hickey, Peter AW Rogers

Journal article  |  2017  |  REPRODUCTIVE SCIENCES

Heavy menstrual bleeding (HMB) is a significant social and public health issue for menstruating women. Development of targeted tre..

A molecular threshold for effector CD8( ) T cell differentiation controlled by transcription factors Blimp-1 and T-bet

Annie Xin, Frederick Masson, Yang Liao, Simon Preston, Tianxia Guan, Renee Gloury, Moshe Olshansky, Jian-Xin Lin, Peng Li, Terence P Speed, Gordon K Smyth, Matthias Ernst, Warren J Leonard, Marc Pellegrini, Susan M Kaech, Stephen L Nutt, Wei Shi, Gabrielle T Belz, Axel Kallies

Journal article  |  2016  |  NATURE IMMUNOLOGY

T cell responses are guided by cytokines that induce transcriptional regulators, which ultimately control differentiation of effec..