Moshe Olshansky

A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs

Matthew C Canver, Pratibha Tripathi, Michael J Bullen, Moshe Olshansky, Yogesh Kumar, Lee H Wong, Stephen J Turner, Samuel Lessard, Luca Pinello, Stuart H Orkin, Partha Pratim Das

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the noncoding genome and control..

Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource

Stephanie Portelli, Moshe Olshansky, Carlos HM Rodrigues, Elston N D'Souza, Yoochan Myung, Michael Silk, Azadeh Alavi, Douglas E Pires, David B Ascher

Journal article  |  2020  |  NATURE GENETICS

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8( ) T Cell-Lineage-Specific Function

Brendan E Russ, Moshe Olshansky, Jasmine Li, Michelle LT Nguyen, Linden J Gearing, Thi HO Nguyen, Matthew R Olson, Hayley A McQuilton, Simone Nussing, Georges Khoury, Damian FJ Purcell, Paul J Hertzog, Sudha Rao, Stephen J Turner

Journal article  |  2017  |  CELL REPORTS

Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the ge..

Differential Gene Expression in Menstrual Endometrium From Women With Self-Reported Heavy Menstrual Bleeding

Jane E Girling, Michelle G Lockhart, Moshe Olshansky, Premila Paiva, Nicole Woodrow, Jennifer L Marino, Martha Hickey, Peter AW Rogers

Journal article  |  2017  |  REPRODUCTIVE SCIENCES

Heavy menstrual bleeding (HMB) is a significant social and public health issue for menstruating women. Development of targeted tre..

A molecular threshold for effector CD8( ) T cell differentiation controlled by transcription factors Blimp-1 and T-bet

Annie Xin, Frederick Masson, Yang Liao, Simon Preston, Tianxia Guan, Renee Gloury, Moshe Olshansky, Jian-Xin Lin, Peng Li, Terence P Speed, Gordon K Smyth, Matthias Ernst, Warren J Leonard, Marc Pellegrini, Susan M Kaech, Stephen L Nutt, Wei Shi, Gabrielle T Belz, Axel Kallies

Journal article  |  2016  |  NATURE IMMUNOLOGY

T cell responses are guided by cytokines that induce transcriptional regulators, which ultimately control differentiation of effec..

Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus-specific CD8( ) T cells

Michelle LT Nguyen, Lauren Hatton, Jasmine Li, Moshe Olshansky, Anne Kelso, Brendan E Russ, Stephen J Turner

Journal article  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Numerous studies have focused on the molecular regulation of perforin (PFP) and granzyme B (GZMB) expression by activated cytotoxi..

Transcriptional Analysis of T Cells Resident in Human Skin

Jane Li, Moshe Olshansky, Francis R Carbone, Joel Z Ma

Journal article  |  2016  |  PLOS ONE

Human skin contains various populations of memory T cells in permanent residence and in transit. Arguably, the best characterized ..

Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8( ) T Cell Differentiation

Brendan E Russ, Moshe Olshanksy, Heather S Smallwood, Jasmine Li, Alice E Denton, Julia E Prier, Angus T Stock, Hayley A Croom, Jolie G Cullen, Michelle LT Nguyen, Stephanie Rowe, Matthew R Olson, David B Finkelstein, Anne Kelso, Paul G Thomas, Terry P Speed, Sudha Rao, Stephen J Turner

Journal article  |  2014  |  IMMUNITY

The molecular mechanisms that regulate the rapid transcriptional changes that occur during cytotoxic T lymphocyte (CTL) proliferat..

Id2-Mediated Inhibition of E2A Represses Memory CD8( ) T Cell Differentiation

Frederick Masson, Martina Minnich, Moshe Olshansky, Ivan Bilic, Adele M Mount, Axel Kallies, Terence P Speed, Meinrad Busslinger, Stephen L Nutt, Gabrielle T Belz

Journal article  |  2013  |  JOURNAL OF IMMUNOLOGY

The transcription factor inhibitor of DNA binding (Id)2 modulates T cell fate decisions, but the molecular mechanism underpinning ..

Fibroid-Associated Heavy Menstrual Bleeding: Correlation Between Clinical Features, Doppler Ultrasound Assessment of Vasculature, and Tissue Gene Expression Profiles

Sophia E Tsiligiannis, Marina Zaitseva, Peter R Coombs, Paul Shekleton, Moshe Olshansky, Martha Hickey, Beverley Vollenhoven, Peter AW Rogers

Journal article  |  2013  |  REPRODUCTIVE SCIENCES

Despite the prevalence of uterine fibroids (Fs), few studies have investigated the links between clinical features and the cellula..