Judith Field

Development of [F-18]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease

Siu Wai Wong, Lucy Vivash, Ramesh Mudududdla, Nghi Nguyen, Stefan J Hermans, David M Shackleford, Judith Field, Lian Xue, Andrea Aprico, Nancy C Hancock, Mohammad Haskali, Michael A Stashko, Stephen Frye, Xiaodong Wang, Michele D Binder, Uwe Ackermann, Michael W Parker, Trevor J Kilpatrick, Jonathan B Baell

Journal article  |  2021  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MER tyrosine kinase (MERTK) upregulation is associated with M2 polarization of microglia, which plays a vital role in neuroregener..

Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells

Melissa M Gresle, Margaret A Jordan, Jim Stankovich, Tim Spelman, Laura J Johnson, Louise Laverick, Alison Hamlett, Letitia D Smith, Vilija G Jokubaitis, Josephine Baker, Jodi Haartsen, Bruce Taylor, Jac Charlesworth, Melanie Bahlo, Terence P Speed, Matthew A Brown, Judith Field, Alan G Baxter, Helmut Butzkueven

Journal article  |  2020  |  LIFE SCIENCE ALLIANCE

At least 200 single-nucleotide polymorphisms (SNPs) are associated with multiple sclerosis (MS) risk. A key function that could me..

Monoclonal antibodies in the treatment of multiple sclerosis: emergence of B-cell-targeted therapies

Nguyen Ai-Lan, Melissa Gresle, Tessa Marshall, Helmut Butzkueven, Judith Field

Journal article  |  2017  |  BRITISH JOURNAL OF PHARMACOLOGY

Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS, and one of the most common causes of disability in young adu..

The TAM Receptor Tyro3 Regulates Myelination in the Central Nervous System

Rainer Akkermann, Andrea Aprico, Ashwyn A Perera, Helena Bujalka, Alistair E Cole, Junhua Xiao, Judith Field, Trevor J Kilpatrick, Michele D Binder

Journal article  |  2017  |  GLIA

Myelin is an essential component of the mammalian nervous system, facilitating rapid conduction of electrical impulses by axons, a..

Interleukin-2 receptor-alpha proximal promoter hypomethylation is associated with multiple sclerosis

J Field, A Fox, MA Jordan, AG Baxter, T Spelman, M Gresle, H Butzkueven, TJ Kilpatrick, JP Rubio

Journal article  |  2017  |  GENES AND IMMUNITY

Genetic studies have demonstrated association between single-nucleotide polymorphisms within the IL2RA (interleukin-2 receptor α-s..

Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status

Michele D Binder, Andrew D Fox, Daniel Merlo, Laura J Johnson, Lauren Giuffrida, Sarah E Calvert, Rainer Akkermann, Gerry ZM Ma, Ashwyn A Perera, Melissa M Gresle, Louise Laverick, Grace Foo, Marzena J Fabis-Pedrini, Timothy Spelman, Margaret A Jordan, Alan G Baxter, Simon Foote, Helmut Butzkueven, Trevor J Kilpatrick, Judith Field

Journal article  |  2016  |  PLOS GENETICS

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk of developing MS i..

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis

Ben J Gu, Judith Field, Sebastien Dutertre, Amber Ou, Trevor J Kilpatrick, Jeannette Lechner-Scott, Rodney Scott, Rodney Lea, Bruce V Taylor, Jim Stankovich, Helmut Butzkueven, Melissa Gresle, Simon M Laws, Steven Petrou, Sabine Hoffjan, Denis A Akkad, Colin A Graham, Stanley Hawkins, Anna Glaser, Sahl Khalid Bedri, et al.

Journal article  |  2015  |  HUMAN MOLECULAR GENETICS

Multiple sclerosis (MS) is a chronic relapsing-remitting inflammatory disease of the central nervous system characterized by oligo..

The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function

Judith Field, Fernando Shahijanian, Stephen Schibeci, Laura Johnson, Melissa Gresle, Louise Laverick, Grant Parnell, Graeme Stewart, Fiona McKay, Trevor Kilpatrick, Helmut Butzkueven, David Booth

Journal article  |  2015  |  PLOS ONE

Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development of multiple sclerosis (MS). We..

Association of plasma levels of Protein S with disease severity in multiple sclerosis

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Journal article  |  2015  |  Multiple Sclerosis Journal - Experimental, Translational and Clinical

The TAM family of receptor tyrosine kinases (TYRO3, AXL and MERTK) play important roles in modulating innate immune responses and ..

Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution

Melissa M Gresle, Katrin Schulz, Anna Jonas, Victoria M Perreau, Tania Cipriani, Alan G Baxter, Socorro Miranda-Hernandez, Judith Field, Vilija G Jokubaitis, Robert Cherny, Irene Volitakis, Samuel David, Trevor J Kilpatrick, Helmut Butzkueven

Journal article  |  2014  |  JOURNAL OF NEUROSCIENCE RESEARCH

We conducted a microarray study to identify genes that are differentially regulated in the spinal cords of mice with the inflammat..