Paul Whitney

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

SARS-CoV-2 does not replicate in embryonated hen's eggs or in MDCK cell lines.

Ian G Barr, Cleve Rynehart, Paul Whitney, Julian Druce

Journal article  |  2020  |  Eurosurveillance

The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-C..

The regulation of T cell responses by cytohesins

A Solomatina, F Tolksdorf, PG Whitney, IR van Driel, EL Hartland, W Kolanus

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article  |  2019  |  Immunity

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection

Christopher M Harpur, Yu Kato, Shinta T Dewi, Sanda Stankovic, Darryl N Johnson, Sammy Bedoui, Paul G Whitney, Mireille H Lahoud, Irina Caminschi, William R Heath, Andrew G Brooks, Thomas Gebhardt

Journal article  |  2019  |  The Journal of Immunology

Unexpected overlapping roles of multiple caspases and programmed cell death pathways in the response to bacterial infection

Ranja Salvamoser, Paul G Whitney, Marcel Doerflinger, Sammy Bedoui, Andreas Strasser, Clare Bryant, Marco J Herold

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

Optimal protection against Salmonella infection requires noncirculating memory

Joseph M Benoun, Newton G Peres, Nancy Wang, Oanh H Pham, Victoria L Rudisill, Zachary N Fogassy, Paul G Whitney, Daniel Fernandez-Ruiz, Thomas Gebhardt, Pham Quynh-Mai, Lynn Puddington, Sammy Bedoui, Richard A Strugnell, Stephen J McSorley

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells

Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui

Journal article  |  2018  |  Journal of Virology

PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8( ) T cell responses

Toshiki Sekiya, Junya Yamagishi, John Henry V Gray, Paul G Whitney, Axel Martinelli, Weiguang Zeng, Chinn Yi Wong, Chihiro Sugimoto, David C Jackson, Brendon Y Chua

Journal article  |  2017  |  Biomaterials

ORCHESTRATION OF NUCLEIC ACID SENSING PATHWAYS IN HSV-SPECIFIC CD8 T CELL PRIMING

A Bachern, PG Whitney, M Greyer, C Tebartz, T Gebhardt, S Bedoui

Conference Proceedings  |  2016  |  CYTOKINE

DENDRITIC CELLS, DIVISION OF LABOR DURING PERIPHERAL HERPES SIMPLEX VIRUS-1 INFECTION

PG Whitney, C Tebartz, BL Macleod, A Bachem, A Turner, D Tscharke, S Bedoui

Conference Proceedings  |  2016  |  CYTOKINE

Spatiotemporally distinct interactions with DC subsets facilitates CD4 and CD8 T cell activation to localized viral infection

JL Hor, PG Whitney, A Zaid, AG Brooks, WR Heath, SN Mueller

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

T cell help amplifies innate signals in CD8 DC for optimal CD8 T cell priming

M Greyer, PG Whitney, AT Stock, GM Davey, C Tebartz, A Bachem, JD Mintern, RA Strugnell, SJ Turner, T Gebhardt, M O'Keeffe, WR Heath, S Bedoui

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Orchestration of nucleic acid sensing pathways in HSV-specific CD8( ) T cell priming

A Bachem, PG Whitney, M Greyer, C Tebartz, T Gebhardt, S Bedoui

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming

Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui

Journal article  |  2016  |  Cell Reports

Limited Internodal Migration of T Follicular Helper Cells after Peripheral Infection with Herpes Simplex Virus-1

Sanda Stankovic, Christopher M Harpur, Bethany L Macleod, Paul G Whitney, Thomas Gebhardt, Andrew G Brooks

Journal article  |  2015  |  The Journal of Immunology

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

Paul J Baker, Dave Boucher, Damien Bierschenk, Christina Tebartz, Paul G Whitney, Damian B D'Silva, Maria C Tanzer, Mercedes Monteleone, Avril AB Robertson, Matthew A Cooper, Silvia Alvarez-Diaz, Marco J Herold, Sammy Bedoui, Kate Schroder, Seth L Masters

Journal article  |  2015  |  European Journal of Immunology

Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4( ) and CD8( ) T Cell Activation to Localized Viral Infection (vol 43, pg 554, 2015)

Jyh Liang Hor, Paul G Whitney, Ali Zaid, Andrew G Brooks, William R Heath, Scott N Mueller

Journal article  |  2015  |  Immunity

Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4( ) and CD8( ) T Cell Activation to Localized Viral Infection

Jyh Liang Hor, Paul G Whitney, Ali Zaid, Andrew G Brooks, William R Heath, Scott N Mueller

Journal article  |  2015  |  Immunity

Altered Lymph Node Composition in Diphtheria Toxin Receptor-Based Mouse Models To Ablate Dendritic Cells

Janneke van Blijswijk, Barbara U Schraml, Neil C Rogers, Paul G Whitney, Santiago Zelenay, Sophie E Acton, Caetano Reis e Sousa

Journal article  |  2015  |  The Journal of Immunology

Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection

Paul G Whitney, Eva Baer, Fabiola Osorio, Neil C Rogers, Barbara U Schraml, Safia Deddouche, Salome LeibundGut-Landmann, Caetano Reis e Sousa

Journal article  |  2014  |  PLOS PATHOGENS

IL-17 Regulates Systemic Fungal Immunity by Controlling the Functional Competence of NK Cells

Eva Baer, Paul G Whitney, Kathrin Moor, Caetano Reis e Sousa, Salome LeibundGut-Landmann

Journal article  |  2014  |  Immunity

Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage

Barbara U Schraml, Janneke van Blijswijk, Santiago Zelenay, Paul G Whitney, Andrew Filby, Sophie E Acton, Neil C Rogers, Natalia Moncaut, Jaime J Carvajal, Caetano Reis e Sousa

Journal article  |  2013  |  Cell

The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

Santiago Zelenay, Anna M Keller, Paul G Whitney, Barbara U Schraml, Safia Deddouche, Neil C Rogers, Oliver Schulz, David Sancho, Caetano Reis e Sousa

Journal article  |  2012  |  JOURNAL OF CLINICAL INVESTIGATION

NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8( ) T cells

Andreas Kupz, Greta Guarda, Thomas Gebhardt, Leif E Sander, Kirsty R Short, Dimitri A Diavatopoulos, Odilia LC Wijburg, Hanwei Cao, Jason C Waithman, Weisan Chen, Daniel Fernandez-Ruiz, Paul G Whitney, William R Heath, Roy Curtiss, Juerg Tschopp, Richard A Strugnell, Sammy Bedoui

Journal article  |  2012  |  Nature Immunology

Different patterns of peripheral migration by memory CD4( ) and CD8( ) T cells

Thomas Gebhardt, Paul G Whitney, Ali Zaid, Laura K Mackay, Andrew G Brooks, William R Heath, Francis R Carbone, Scott N Mueller

Journal article  |  2011  |  Nature

Gr-1( ) cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1

Magdalena Wojtasiak, Danielle L Pickett, Michelle D Tate, Sammy Bedoui, Emma R Job, Paul G Whitney, Andrew G Brooks, Patrick C Reading

Journal article  |  2010  |  Virology

Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice

Patrick C Reading, Paul G Whitney, Danielle L Pickett, Michelle D Tate, Andrew G Brooks

Journal article  |  2010  |  Immunology and Cell Biology

Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice

Patrick C Reading, Danielle L Pickett, Michelle D Tate, Paul G Whitney, Emma R Job, Andrew G Brooks

Journal article  |  2009  |  Respiratory Research

A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules

Amy Sexton, Paul G Whitney, Siow-Feng Chong, Alexander N Zelikin, Angus PR Johnston, Robert De Rose, Andrew G Brooks, Frank Caruso, Stephen J Kent

Journal article  |  2009  |  ACS NANO

P17-03. Nanoengineered layer-by-layer capsules as a novel delivery system for HIV vaccines

A Sexton, PG Whitney, R De Rose, AN Zelikin, S Chong, AP Johnston, F Caruso, SJ Kent

Journal article  |  2009  |  Retrovirology

Cross-presentation of viral and self antigens by skin-derived CD103( ) dendritic cells

Sammy Bedoui, Paul G Whitney, Jason Waithman, Liv Eidsmo, Linda Wakim, Irina Caminschi, Rhys S Allan, Magdalena Wojtasiak, Ken Shortman, Francis R Carbone, Andrew G Brooks, William R Heath

Journal article  |  2009  |  Nature Immunology

IL48, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type I infection

Patrick C Reading, Paul G Whitney, Daniel P Barr, Magdalena Wojtasiak, Justine D Mintern, Jason Waithman, Andrew G Brooks

Journal article  |  2007  |  Journal of Immunology

A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection

Daniel P Barr, Gabrielle T Belz, Patrick C Reading, Magdalena Wojtasiak, Paul G Whitney, William R Heath, Francis R Carbone, Andrew G Brooks

Journal article  |  2007  |  European Journal of Immunology

NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection

PC Reading, PG Whitney, DP Barr, MJ Smyth, AG Brooks

Journal article  |  2006  |  European Journal of Immunology

NK cells mediate control of viral replication in the nerves following HSV-1 flank zosteriform infection

M Wojtasiak, PG Whitney, DP Barr, PC Reading, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection

PG Whitney, PC Reading, DP Barr, M Wojtasiak, MJ Smyth, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Plasmacytoid and conventional dendritic cells mediate rapid cytokine-dependent activation of NK cells to herpes simplex virus type 1

DP Barr, PC Reading, M Wojtasiak, PG Whitney, GT Belz, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS